The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection.
Open accessAbstract
The plasma membrane remodeling, including the early transverse redistribution of phosphatidylserine, is a general feature occurring in cells in which a death program has been induced. In most cases, studies of this kind have focused mainly on cells. In this study, we report a clear correlation between the degree of apoptosis induced by a variety of agents in several types of cultured cells and the amount of shed membrane microparticles captured in the corresponding supernatants by insolubilized annexin V, a protein showing a strong affinity for phosphatidylserine. Such particles carry membrane antigens specific of the cells they stem from, and through which capture is also feasible. Homologous circulating microparticles were captured in peripheral blood from individuals with HIV-1 infection. A substantial proportion bore CD4 antigen. In some cases, CD4+ particles could be detected even in the absence of circulating CD4+ T cells, testifying to the presence of such resident cells in lymphoid tissues. These results suggest that shed membrane particles are one of the hallmarks of programmed cell death, of particular interest when the corresponding cells are hardly accessible.
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Cites
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Programmed Death of T Cells in HIV-1 Infection
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Cited by
Classification, Functions, and Clinical Relevance of Extracellular Vesicles
van der Pol, E., Böing, A. N., Harrison, P., Sturk, A., & Nieuwland, R. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005983 · Cited by 1,754
Microparticles in Hemostasis and Thrombosis
Owens, A. P., & Mackman, N. (2011) · Circulation Research · doi:10.1161/circresaha.110.233056 · Cited by 835
Membrane Microparticles: Two Sides of the Coin
Hugel, B., Martínez, M. C., Kunzelmann, C., & Freyssinet, J.-M. (2005) · Physiology · doi:10.1152/physiol.00029.2004 · Cited by 698
Self-citationApoptosis: a basic biological phenomenon with wide‐ranging implications in human disease
FADEEL, B., & ORRENIUS, S. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01570.x · Cited by 698
TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex
Blanchard, N., Lankar, D., Faure, F., Regnault, A., Dumont, C., Raposo, G., & Hivroz, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3235 · Cited by 660
Metadata
- Authors
- Aupeix, K., Hugel, B., Martin, T., Bischoff, P., Lill, H., Pasquali, J. L., & Freyssinet, J. M.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-04-01
- Volume
- 99
- Issue
- 7
- Pages
- 1546-1554
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1977538788
- Cited by
- 274
- References
- 45
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Aupeix, K., Hugel, B., Martin, T., Bischoff, P., Lill, H., Pasquali, J. L., & Freyssinet, J. M. (1997). The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection. Journal of Clinical Investigation. https://doi.org/10.1172/jci119317
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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