Cited by 113Immune Response and InflammationNanoparticle-Based Drug DeliveryLipid metabolism and disorders

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Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo.

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Rensen, P C, Oosten, M, Bilt, E, Eck, M, Kuiper, J, Berkel, T J·1997·Journal of Clinical Investigation

DOI 10.1172/jci119427PMC PMC508084

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Abstract

Chylomicrons have been shown to protect mice and rats against a lethal dose of lipopolysaccharide and may serve as a therapeutic means to protect against endotoxemia. However, the requisite of isolation from human lymph hampers pharmaceutical application. Recently, we developed recombinant chylomicrons from commercially available lipids and human recombinant apolipoprotein E. The current study explored the effectiveness of these apoE-enriched emulsions in redirecting LPS from Kupffer cells to liver parenchymal cells. Upon injection into rats, 125I-LPS rapidly and specifically associated with the liver (64.3+/-3.1% of the injected dose) and spleen (4.1+/-0.7%). The uptake of LPS by the spleen was four- to fivefold reduced upon incubation with the apoE-enriched emulsion or free apoE (P < 0.0001), but not with emulsion alone or Lipofundin. Within the liver, 125I-LPS mainly associated with Kupffer cells. The uptake by Kupffer cells was eight- to ninefold reduced by the apoE-enriched emulsion or apoE alone (P < 0.01), and a 19.6-fold increased uptake ratio by liver parenchymal cells over Kupffer cells was observed. The emulsion without apoE had no effect on the in vivo kinetics of LPS. LPS interacted selectively with the apoE moiety of the recombinant chylomicron. Emulsion-associated and free apoE bound approximately two molecules of LPS, possibly by its exposed hydrophilic domain involving arginine residues. We anticipate that the protecting effect of endogenous chylomicrons against LPS-induced endotoxemia may result from the apoE moiety and that human recombinant apoE may serve as a therapeuticum to protect against endotoxemia.

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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986
Pathogenetic Mechanisms of Septic Shock
Epstein, F. H., & Parrillo, J. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282008 · Cited by 1,548
Cachectin: More Than a Tumor Necrosis Factor
Epstein, F. H., Beutler, B., & Cerami, A. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702123160705 · Cited by 1,423
Septic Shock in Humans
Parrillo, J. E., Parker, M. M., Natanson, C., Suffredini, A. F., Danner, R. L., Cunnion, R. E., & Ognibene, F. P. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-227 · Cited by 1,188
The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.
Waage, A., Brandtzaeg, P., Halstensen, A. I., Kierulf, P., & Espevik, T. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.1.333 · Cited by 1,175
Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study.
Blouin, A., Bolender, R. P., & Weibel, E. R. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.72.2.441 · Cited by 879
Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides
Morrison, D. C., & Jacobs, D. M. (1976) · Immunochemistry · doi:10.1016/0019-2791(76)90181-6 · Cited by 819
A new and improved microassay to determine 2-keto-3-deoxyoctonate in lipopolysaccharide of gram-negative bacteria
Karkhanis, Y. D., Zeltner, J. Y., Jackson, J. J., & Carlo, D. J. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90260-9 · Cited by 704
In vivo protection against endotoxin by plasma high density lipoprotein.
Levine, D. M., Parker, T. S., Donnelly, T. M., Walsh, A., & Rubin, A. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.12040 · Cited by 485
Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS.
Wurfel, M. M., Kunitake, S. T., Lichenstein, H., Kane, J. P., & Wright, S. D. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.3.1025 · Cited by 442

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Authors: Rensen, P. C., Oosten, M., Bilt, E., Eck, M., Kuiper, J., & Berkel, T. J.
Affiliations: Leiden University (NL)
ORCID: Rensen, P C
Eck, M
Kuiper, J
Berkel, T J
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1997-05-15
Volume: 99
Issue: 10
Pages: 2438-2445
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci119427
PMC: PMC508084
OpenAlex: W2044756436
Cited by: 113
References: 50
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 4
FWCI: 1.61
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: apolipoprotein E, lipopolysaccharide, endotoxemia, Kupffer cells, liver parenchymal cells, spleen, arginine residues
MeSH terms: Animals, Apolipoproteins E, Drug Combinations, Emulsions, Humans, Iodine Radioisotopes, Kupffer Cells, Lipopolysaccharides, Liver, Male, Metabolic Clearance Rate, Phospholipids, Recombinant Proteins, Sorbitol, Spleen, Tissue Distribution, Rats, Wistar, Mice, Rats

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Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo.

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