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Contribution of adipogenesis to healthy adipose tissue expansion in obesity
Open accessAbstract
The manner in which white adipose tissue (WAT) expands and remodels directly impacts the risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT is associated with increased risk for insulin resistance, whereas subcutaneous WAT expansion is protective. Moreover, pathologic WAT remodeling, typically characterized by adipocyte hypertrophy, chronic inflammation, and fibrosis, is associated with insulin resistance. Healthy WAT expansion, observed in the "metabolically healthy" obese, is generally associated with the presence of smaller and more numerous adipocytes, along with lower degrees of inflammation and fibrosis. Here, we highlight recent human and rodent studies that support the notion that the ability to recruit new fat cells through adipogenesis is a critical determinant of healthy adipose tissue distribution and remodeling in obesity. Furthermore, we discuss recent advances in our understanding of the identity of tissue-resident progenitor populations in WAT made possible through single-cell RNA sequencing analysis. A better understanding of adipose stem cell biology and adipogenesis may lead to novel strategies to uncouple obesity from metabolic disease.
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“The distribution of body fat in obesity is closely correlated with metabolic health. The expansion of visceral fat depots increases risks for metabolic disorders, whereas subcutaneous fat depots pose lesser risks or can even offer protection (Vishvanath and Gupta, 2019).”
From Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity (2025) · cites this paper as Vishvanath and Gupta, 2019
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Metadata
- Authors
- Vishvanath, L., & Gupta, R. K.
- Affiliations
- The University of Texas at Dallas (US)
- Touchstone (China) (CN)
- Corresponding author
- Gupta, Rana K.
- Venue
- Journal of Clinical Investigation
- Published
- 2019-10-01
- Volume
- 129
- Issue
- 10
- Pages
- 4022-4031
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC6763245
- OpenAlex
- W2978642359
- Cited by
- 558
- References
- 98
- Citations by year
- 2026: 77 · 2025: 72 · 2024: 89 · 2023: 92 · 2022: 98 · 2021: 85 · 2020: 43 · 2019: 2
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119163, R56DK119163)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipogenesis, obesity, metabolically healthy obesity, adipose tissue remodeling, visceral adipose tissue, subcutaneous adipose tissue, insulin resistance, adipocyte hypertrophy, adipose tissue inflammation, adipose tissue fibrosis, adipose-derived stem cells, single-cell RNA sequencing
- MeSH terms
- RNA-Seq, Animals, Energy Metabolism, Humans, Insulin Resistance, Obesity, Risk Factors, Stem Cells, Metabolic Syndrome, Adipogenesis, Mice, Adipose Tissue, White, Adipocytes, White, Single-Cell Analysis
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