Cited by 558Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Contribution of adipogenesis to healthy adipose tissue expansion in obesity

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Vishvanath, Lavanya, Gupta, Rana K.·2019·Journal of Clinical Investigation

DOI 10.1172/jci129191PMC PMC6763245

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Abstract

The manner in which white adipose tissue (WAT) expands and remodels directly impacts the risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT is associated with increased risk for insulin resistance, whereas subcutaneous WAT expansion is protective. Moreover, pathologic WAT remodeling, typically characterized by adipocyte hypertrophy, chronic inflammation, and fibrosis, is associated with insulin resistance. Healthy WAT expansion, observed in the "metabolically healthy" obese, is generally associated with the presence of smaller and more numerous adipocytes, along with lower degrees of inflammation and fibrosis. Here, we highlight recent human and rodent studies that support the notion that the ability to recruit new fat cells through adipogenesis is a critical determinant of healthy adipose tissue distribution and remodeling in obesity. Furthermore, we discuss recent advances in our understanding of the identity of tissue-resident progenitor populations in WAT made possible through single-cell RNA sequencing analysis. A better understanding of adipose stem cell biology and adipogenesis may lead to novel strategies to uncouple obesity from metabolic disease.

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Authors: Vishvanath, L., & Gupta, R. K.
Affiliations: The University of Texas at Dallas (US)
Touchstone (China) (CN)
Corresponding author: Gupta, Rana K.
ORCID: Vishvanath, Lavanya
Gupta, Rana K.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2019-10-01
Volume: 129
Issue: 10
Pages: 4022-4031
ISSN: 0021-9738 (ISSN-L)
1558-8238
DOI: 10.1172/jci129191
PMC: PMC6763245
OpenAlex: W2978642359
Cited by: 558
References: 98
Citations by year: 2026: 77 · 2025: 72 · 2024: 89 · 2023: 92 · 2022: 98 · 2021: 85 · 2020: 43 · 2019: 2
FWCI: 8.39
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119163, R56DK119163)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adipogenesis, obesity, metabolically healthy obesity, adipose tissue remodeling, visceral adipose tissue, subcutaneous adipose tissue, insulin resistance, adipocyte hypertrophy, adipose tissue inflammation, adipose tissue fibrosis, adipose-derived stem cells, single-cell RNA sequencing
MeSH terms: RNA-Seq, Animals, Energy Metabolism, Humans, Insulin Resistance, Obesity, Risk Factors, Stem Cells, Metabolic Syndrome, Adipogenesis, Mice, Adipose Tissue, White, Adipocytes, White, Single-Cell Analysis

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Contribution of adipogenesis to healthy adipose tissue expansion in obesity

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