Cited by 180Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersAmino Acid Enzymes and Metabolism

A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function

Open access
Wang, Chih-Chieh, Held, Richard G., Chang, Shiao-Chi, Yang, Lingling, Delpire, Eric, Ghosh, Anirvan, Hall, Benjamin J.·2011·Neuron

Abstract

The subunit composition of N-methyl D-aspartate receptors (NMDARs) is tightly regulated during cortical development. NMDARs are initially dominated by GluN2B (NR2B), whereas GluN2A (NR2A) incorporation increases after birth. The function of GluN2B-containing NMDARs during development, however, is incompletely understood. We generated a mouse in which we genetically replaced GluN2B with GluN2A (2B→2A). Although this manipulation restored NMDAR-mediated currents at glutamatergic synapses, it did not rescue GluN2B loss of function. Protein translation-dependent homeostatic synaptic plasticity is occluded in the absence of GluN2B, and AMPA receptor contribution is enriched at excitatory cortical synapses. Our experiments indicate that specificity of GluN2B-mediated signaling is due to its unique interaction with the protein effector alpha calcium-calmodulin kinase II and the regulation of the mTOR pathway. Homozygous 2B→2A mice exhibited high rates of lethality, suppressed feeding, and depressed social exploratory behavior. These experiments indicate that GluN2B-containing NMDARs activate unique cellular processes that cannot be rescued by replacement with GluN2A.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2011.09.023

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wang, C.-C., Held, R. G., Chang, S.-C., Yang, L., Delpire, E., Ghosh, A., & Hall, B. J.
Affiliations
  • Tulane University (US)
  • Vanderbilt University Medical Center (US)
  • University of California San Diego (US)
Corresponding author
Hall, Benjamin J.
Venue
Neuron
Publisher
Elsevier BV
Published
2011-12
Volume
72
Issue
5
Pages
789-805
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2040330981
Cited by
180
References
60
Citations by year
2026: 5 · 2025: 9 · 2024: 9 · 2023: 9 · 2022: 21 · 2021: 7 · 2020: 9 · 2019: 17 · 2018: 16 · 2017: 9 · 2016: 10 · 2015: 18 · 2014: 9 · 2013: 16 · 2012: 16
FWCI
5.43
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Agriculture
  • National Institute on Alcohol Abuse and Alcoholism (U01AA013514)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
GluN2B, GluN2A, NMDA receptor, cortical development, subunit composition, homeostatic plasticity, calcium/calmodulin-dependent protein kinase II, mTOR signaling, glutamatergic synapses, lethality, feeding inhibition
MeSH terms
Animals, Cerebral Cortex, Immunosuppressive Agents, Piperidines, Social Behavior, Tetrodotoxin, Time Factors, Valine, Receptors, N-Methyl-D-Aspartate, Mice, Knockout, Patch-Clamp Techniques, Gene Expression Regulation, Developmental, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Sirolimus, Sodium Channel Blockers, RNA, Small Interfering, Ribosomal Protein S6 Kinases, 70-kDa, Green Fluorescent Proteins, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review