A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function
Open accessAbstract
The subunit composition of N-methyl D-aspartate receptors (NMDARs) is tightly regulated during cortical development. NMDARs are initially dominated by GluN2B (NR2B), whereas GluN2A (NR2A) incorporation increases after birth. The function of GluN2B-containing NMDARs during development, however, is incompletely understood. We generated a mouse in which we genetically replaced GluN2B with GluN2A (2B→2A). Although this manipulation restored NMDAR-mediated currents at glutamatergic synapses, it did not rescue GluN2B loss of function. Protein translation-dependent homeostatic synaptic plasticity is occluded in the absence of GluN2B, and AMPA receptor contribution is enriched at excitatory cortical synapses. Our experiments indicate that specificity of GluN2B-mediated signaling is due to its unique interaction with the protein effector alpha calcium-calmodulin kinase II and the regulation of the mTOR pathway. Homozygous 2B→2A mice exhibited high rates of lethality, suppressed feeding, and depressed social exploratory behavior. These experiments indicate that GluN2B-containing NMDARs activate unique cellular processes that cannot be rescued by replacement with GluN2A.
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GluN2B is particularly critical for social behaviors in animal models.
“Variations in the gene encoding GluN2B have been frequently identified in neuropsychiatric disorders 62, 63, and studies on animal models have shown that GluN2B is particularly critical for social behaviors 61, 64, 65.”
From Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. (2021) · cites this paper as [64]
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Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 2,989 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
Heteromeric NMDA receptors: molecular and functional distinction of subtypes
Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992) · Science · doi:10.1126/science.256.5060.1217 · Cited by 2,541 · see citing works
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
The self-tuning neuron: synaptic scaling of excitatory synapses
Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533 · see citing works
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
Sheng, M., Cummings, J., Roldan, L. A., Jan, Y. N., & Jan, L. Y. (1994) · Nature · doi:10.1038/368144a0 · Cited by 1,170 · see citing works
mTOR signaling: At the crossroads of plasticity, memory and disease
Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128 · see citing works
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H. (1999) · Cell · doi:10.1016/s0092-8674(00)81972-8 · Cited by 1,075 · see citing works
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit
Sakimura, K., Kutsuwada, T., Ito, I., Manabe, T., Takayama, C., Kushiya, E., Yagi, T., Aizawa, S., Inoue, Y., Sugiyama, H., et al. (1995) · Nature · doi:10.1038/373151a0 · Cited by 859 · see citing works
Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs
Meguro, H., Mori, H., Araki, K., Kushiya, E., Kutsuwada, T., Yamazaki, M., Kumanishi, T., Arakawa, M., Sakimura, K., & Mishina, M. (1992) · Nature · doi:10.1038/357070a0 · Cited by 798 · see citing works
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Belforte, J. E., Zsiros, V., Sklar, E. R., Jiang, Z., Yu, G., Li, Y., Quinlan, E. M., & Nakazawa, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2447 · Cited by 752 · see citing works
Interaction with the NMDA receptor locks CaMKII in an active conformation
Bayer, K.-U., De Koninck, P., Leonard, A. S., Hell, J. W., & Schulman, H. (2001) · Nature · doi:10.1038/35081080 · Cited by 732 · see citing works
NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII
Barria, A., & Malinow, R. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.034 · Cited by 709 · see citing works
Functional and Pharmacological Differences Between Recombinant N -Methyl- d -Aspartate Receptors
Vicini, S., Wang, J. F., Li, J. H., Zhu, W. J., Wang, Y. H., Luo, J. H., Wolfe, B. B., & Grayson, D. R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.555 · Cited by 674 · see citing works
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
Yashiro, K., & Philpot, B. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.046 · Cited by 649 · see citing works
Sutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633 · see citing works
Critical periods for experience-dependent synaptic scaling in visual cortex
Desai, N. S., Cudmore, R. H., Nelson, S. B., & Turrigiano, G. G. (2002) · Nature Neuroscience · doi:10.1038/nn878 · Cited by 582 · see citing works
Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice
Goebbels, S., Bormuth, I., Bode, U., Hermanson, O., Schwab, M. H., & Nave, K. (2006) · genesis · doi:10.1002/dvg.20256 · Cited by 579 · see citing works
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
Ju, W. H., Morishita, W., Tsui, J., Gaietta, G. M., Deerinck, T. J., Adams, S., Garner, C. C., Tsien, R. Y., Ellisman, M. H., & Malenka, R. C. (2004) · Nature Neuroscience · doi:10.1038/nn1189 · Cited by 524 · see citing works
Preskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 522 · see citing works
Subunit-Specific NMDA Receptor Trafficking to Synapses
Barria, A., & Malinow, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00776-6 · Cited by 515 · see citing works
Kutsuwada, T., Sakimura, K., Manabe, T., Takayama, C., Katakura, N., Kushiya, E., Natsume, R., Watanabe, M., Inoue, Y., Yagi, T., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80051-3 · Cited by 498 · see citing works
Kim, M. J., Dunah, A. W., Wang, Y. T., & Sheng, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.031 · Cited by 494 · see citing works
Erreger, K., Dravid, S. M., Banke, T. G., Wyllie, D. J. A., & Traynelis, S. F. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080028 · Cited by 421 · see citing works
Bringing Order to the Glutamate Chaos in Schizophrenia
Moghaddam, B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00757-8 · Cited by 403 · see citing works
Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity
Aoto, J., Nam, C. I., Poon, M. M., Ting, P., & Chen, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.012 · Cited by 397 · see citing works
Strack, S., McNeill, R. B., & Colbran, R. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001471200 · Cited by 356 · see citing works
Brigman, J. L., Wright, T., Talani, G., Prasad-Mulcare, S., Jinde, S., Seabold, G. K., Mathur, P., Davis, M. I., Bock, R., Gustin, R. M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0640-10.2010 · Cited by 339 · see citing works
Self-citationIntegrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse
Chavis, P., & Westbrook, G. L. (2001) · Nature · doi:10.1038/35077101 · Cited by 332 · see citing works
A developmental switch in the signaling cascades for LTP induction
Yasuda, H., Barth, A. L., Stellwagen, D., & Malenka, R. C. (2003) · Nature Neuroscience · doi:10.1038/nn985 · Cited by 325 · see citing works
Postsynaptic expression of homeostatic plasticity at neocortical synapses
Wierenga, C. J., Ibata, K., & Turrigiano, G. G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5217-04.2005 · Cited by 306 · see citing works
Thiagarajan, T. C., Piedras-Renterı́a, E. S., & Tsien, R. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)01049-8 · Cited by 288 · see citing works
Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events
Sutton, M. A., Wall, N. R., Aakalu, G., & Schuman, E. (2004) · Science · doi:10.1126/science.1096202 · Cited by 286 · see citing works
Rauner, C., & Köhr, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.182600 · Cited by 270 · see citing works
Subtype-Dependence of NMDA Receptor Channel Open Probability
Chen, N., Luo, T., & Raymond, L. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06844.1999 · Cited by 260 · see citing works
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons
Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600084103 · Cited by 260 · see citing works
von Engelhardt, J., Doganci, B., Jensen, V., Hvalby, Ø., Göngrich, C., Taylor, A., Barkus, C., Sanderson, D. J., Rawlins, J. N. P., Seeburg, P. H., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.039 · Cited by 250 · see citing works
Glutamate Receptors on Dopamine Neurons Control the Persistence of Cocaine Seeking
Engblom, D., Bilbao, A., Sanchis‐Segura, C., Dahan, L., Perreau‐Lenz, S., Balland, B., Parkitna, J. M. R., Luján, R., Halbout, B., Mameli, M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.010 · Cited by 241 · see citing works
The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity
Kim, J. H., Lee, H.-K., Takamiya, K., & Huganir, R. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01119.2003 · Cited by 240 · see citing works
Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term Potentiation
Foster, K. A., McLaughlin, N., Edbauer, D., Phillips, M., Bolton, A., Constantine-Paton, M., & Sheng, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4022-09.2010 · Cited by 219 · see citing works
SynGAP regulates spine formation
Vazquez, L. E., Chen, H.-J., Sokolova, I., Knuesel, I., & Kennedy, M. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3213-04.2004 · Cited by 203 · see citing works
Regulation of spine morphology and spine density by NMDA receptor signaling <i>in vivo</i>
Ultanir, S. K., Kim, J.-E., Hall, B. J., Deerinck, T., Ellisman, M., & Ghosh, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704031104 · Cited by 174 · see citing works
Self-citationErreger, K., Geballe, M. T., Kristensen, A. S., Chen, P. E., Hansen, K. B., Lee, C. J., Yuan, H., Le, P., Lyuboslavsky, P. N., Micale, N., et al. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.037333 · Cited by 167 · see citing works
Studies of the Regulatory Mechanism of Ca2+/Calmodulin-dependent protein kinase II
Fong, Y. L., Taylor, W. L., Means, A. R., & Soderling, T. R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84770-1 · Cited by 164 · see citing works
Akashi, K., Kakizaki, T., Kamiya, H., Fukaya, M., Yamasaki, M., Abe, M., Natsume, R., Watanabe, M., & Sakimura, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5531-08.2009 · Cited by 163 · see citing works
NMDA receptors inhibit synapse unsilencing during brain development
Adesnik, H., Li, G., During, M. J., Pleasure, S. J., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800946105 · Cited by 161 · see citing works
Interactions between Ifenprodil and the NR2B Subunit of the N-Methyl-D-aspartate Receptor
Gallagher, M. J., Huang, H., Pritchett, D. B., & Lynch, D. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9603 · Cited by 160 · see citing works
Stefani, M. R., & Moghaddam, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.031 · Cited by 157 · see citing works
NR2B Signaling Regulates the Development of Synaptic AMPA Receptor Current
Hall, B. J., Ripley, B. A., & Ghosh, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3793-07.2007 · Cited by 130 · see citing works
Self-citationGuo, X., Hamilton, P. J., Reish, N. J., Sweatt, J. D., Miller, C. A., & Rumbaugh, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.223 · Cited by 120 · see citing works
Oh, J. S., Manzerra, P., & Kennedy, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314109200 · Cited by 118 · see citing works
Regulation of AMPA receptor recruitment at developing synapses
Hall, B. J., & Ghosh, A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.11.010 · Cited by 91 · see citing works
Self-citationFast NMDA Receptor–Mediated Synaptic Currents in Neurons From Mice Lacking the ε2 (NR2B) Subunit
Tovar, K. R., Sprouffske, K., & Westbrook, G. L. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.1.616 · Cited by 70 · see citing works
Masking of the Endoplasmic Reticulum Retention Signals during Assembly of the NMDA Receptor
Horak, M., Chang, K., & Wenthold, R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5239-07.2008 · Cited by 68 · see citing works
Groth, R. D., Lindskog, M., Thiagarajan, T. C., Li, L., & Tsien, R. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018022108 · Cited by 64 · see citing works
Speed, H. E., & Dobrunz, L. E. (2008) · Hippocampus · doi:10.1002/hipo.20496 · Cited by 56 · see citing works
Glutamate and its role in psychiatric illness
Belsham, B. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.279 · Cited by 48 · see citing works
Postnatal protein malnutrition affects play behavior and other social interactions in juvenile rats
Almeida, S. S., & de Araújo, M. J. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00554-6 · Cited by 42 · see citing works
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NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
Paoletti, P., Bellone, C., & Zhou, Q. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3504 · Cited by 2,523 · see citing works
Mechanisms of ketamine action as an antidepressant
Zanos, P., & Gould, T. D. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.255 · Cited by 1,127 · see citing works
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Autism spectrum disorder: neuropathology and animal models
Varghese, M., Keshav, N., Jacot-Descombes, S., Warda, T., Wicinski, B., Dickstein, D. L., Harony-Nicolas, H., De Rubeis, S., Drapeau, E., Buxbaum, J. D., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1736-4 · Cited by 536 · see citing works
Miller, O. H., Yang, L., Wang, C.-C., Hargroder, E. A., Zhang, Y., Delpire, E., & Hall, B. J. (2014) · eLife · doi:10.7554/elife.03581 · Cited by 358 · see citing works
Self-citationGABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions
Gerhard, D. M., Pothula, S., Liu, R.-J., Wu, M., Li, X.-Y., Girgenti, M. J., Taylor, S. R., Duman, C. H., Delpire, E., Picciotto, M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci130808 · Cited by 345 · see citing works
Self-citationNMDA receptors in nervous system diseases
Zhou, Q., & Sheng, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.030 · Cited by 293 · see citing works
Glutamate Synapses in Human Cognitive Disorders
Volk, L. J., Chiu, S., Sharma, K., & Huganir, R. L. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033821 · Cited by 246 · see citing works
Miller, O. H., Moran, J. T., & Hall, B. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.028 · Cited by 200 · see citing works
Self-citationKarpova, A., Mikhaylova, M., Bera, S., Bär, J., Reddy, P. P., Behnisch, T., Rankovic, V., Spilker, C., Bethge, P., Şahin, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.002 · Cited by 194 · see citing works
Swanger, S. A., Chen, W., Wells, G., Burger, P. B., Tankovic, A., Bhattacharya, S., Strong, K. L., Hu, C., Kusumoto, H., Zhang, J., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.10.002 · Cited by 176 · see citing works
Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function
Duman, R. S., Shinohara, R., Fogaça, M. V., & Hare, B. D. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0400-x · Cited by 155 · see citing works
Li, C., Xiao, L., Liu, X., Yang, W., Shen, W., Hu, C., Yang, G., & He, C. (2013) · Glia · doi:10.1002/glia.22469 · Cited by 139 · see citing works
Teng, M., Zhao, X., Wu, F., Wang, C., Wang, C., White, J. C., Zhao, W., Zhou, L., Yan, S., & Tian, S. (2022) · Environment International · doi:10.1016/j.envint.2022.107154 · Cited by 120 · see citing works
Self-citationSensory inputs control the integration of neurogliaform interneurons into cortical circuits
De Marco García, N. V., Priya, R., Tuncdemir, S. N., Fishell, G., & Karayannis, T. (2015) · Nature Neuroscience · doi:10.1038/nn.3946 · Cited by 117 · see citing works
Lee, K.-I., Chiang, C.-W., Lin, H.-C., Zhao, J.-F., Li, C.-T., Shyue, S.-K., & Lee, T.-S. (2016) · Archives of Toxicology · doi:10.1007/s00204-015-1539-0 · Cited by 107 · see citing works
Guo, D., Peng, Y., Wang, L., Sun, X., Wang, X., Liang, C., Yang, X., Li, S., Xu, J., Ye, W.-C., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0472-7 · Cited by 102 · see citing works
Brady, M. L., Diaz, M. R., Iuso, A., Everett, J. C., Valenzuela, C. F., & Caldwell, K. K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1217-12.2013 · Cited by 99 · see citing works
Glutamine Metabolism in Brain Tumors
Natarajan, S. K., & Venneti, S. (2019) · Cancers · doi:10.3390/cancers11111628 · Cited by 96 · see citing works
Page, C. E., & Coutellier, L. D. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.08.030 · Cited by 95 · see citing works
A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior
Rossi, P. D., Harde, E., Dupuis, J. P., Martin, L., Chounlamountri, N., Bardin, M., Watrin, C., Benetollo, C., Pernet‐Gallay, K., Luhmann, H. J., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.195 · Cited by 92 · see citing works
A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons
Lin, Y., Frei, J. A., Kilander, M. B. C., Shen, W., & Blatt, G. J. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00263 · Cited by 91 · see citing works
Monaco, S. A., Gulchina, Y., & Gao, W. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.022 · Cited by 92 · see citing works
Kim, N., Chen, D., Zhou, X. Z., & Lee, T. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133131 · Cited by 87 · see citing works
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Ramsaran, A. I., Schlichting, M. L., & Frankland, P. W. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.09.002 · Cited by 82 · see citing works
Wang, C.-C., Held, R. G., & Hall, B. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083941 · Cited by 84 · see citing works
Self-citationYamada, J., & Jinno, S. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107710 · Cited by 75 · see citing works
SYNGAP1 mutations: Clinical, genetic, and pathophysiological features
Agarwal, M., Johnston, M. V., & Stafstrom, C. E. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.08.003 · Cited by 72 · see citing works
NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning
Widmer, F. C., O'Toole, S. M., & Keller, G. B. (2022) · eLife · doi:10.7554/elife.71476 · Cited by 72 · see citing works
Interaction Between CaMKII and GluN2B Controls ERK-Dependent Plasticity
Gaamouch, F. E., Buisson, A., Moustié, O., Lemieux, M., Labrecque, S., Bontempi, B., Koninck, P. D., & Nicole, O. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5622-11.2012 · Cited by 73 · see citing works
Retrograde changes in presynaptic function driven by dendritic mTORC1
Henry, F. E., McCartney, A. J., Neely, R., Perez, A. S., Carruthers, C., Stuenkel, E., Inoki, K., & Sutton, M. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2149-12.2012 · Cited by 68 · see citing works
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Self-citationActivation of extrasynaptic NMDA receptors induces LTD in rat hippocampal CA1 neurons
Liu, D.-D., Yang, Q., & Li, S. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.12.003 · Cited by 68 · see citing works
Mutations of N-Methyl-D-Aspartate Receptor Subunits in Epilepsy
Xu, X., & Luo, J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0191-5 · Cited by 70 · see citing works
Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding
Blumer, M., Brown, T., Freitas, M. B., Destro, A. L., Oliveira, J. A., Morales, A. E., Schell, T., Greve, C., Pippel, M., Jebb, D., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm6494 · Cited by 65 · see citing works
Ketamine as a therapeutic agent for depression and pain: mechanisms and evidence
Subramanian, S., Haroutounian, S., Palanca, B. J. A., & Lenze, E. J. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120152 · Cited by 68 · see citing works
GRIN2B-related neurodevelopmental disorder: current understanding of pathophysiological mechanisms
Sabo, S. L., Lahr, J. M., Offer, M., Weekes, A. L., & Sceniak, M. P. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.1090865 · Cited by 63 · see citing works
He, H., Mahnke, A. H., Doyle, S., Fan, N., Wang, C.-C., Hall, B. J., Tang, Y., Inglis, F. M., Chen, C., & Erickson, J. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4505-11.2012 · Cited by 64 · see citing works
Self-citationWhat we can learn from a genetic rodent model about autism
Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 59 · see citing works
Butko, M. T., Savas, J. N., Friedman, B., Delahunty, C. M., Ebner, F. F., Yates, J. R., & Tsien, R. Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300424110 · Cited by 60 · see citing works
Albani, S. H., McHail, D. G., & Dumas, T. C. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.04.009 · Cited by 59 · see citing works
The Genetics of Treatment-Resistant Depression: A Critical Review and Future Perspectives
Fabbri, C., Corponi, F., Souery, D., Kasper, S. F., Montgomery, S., Zohar, J., Rujescu, D., Mendlewicz, J., & Serretti, A. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy024 · Cited by 59 · see citing works
Lv, S., Yao, K., Zhang, Y., & Zhu, S. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109378 · Cited by 57 · see citing works
Genetic Deletion of NR3A Accelerates Glutamatergic Synapse Maturation
Henson, M. A., Larsen, R. S., Lawson, S. N., Pérez‐Otaño, I., Nakanishi, N., Lipton, S. A., & Philpot, B. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042327 · Cited by 58 · see citing works
Elevated lead levels from e-waste exposure are linked to decreased olfactory memory in children
Zhang, B., Huo, X., Xu, L., Cheng, Z., Cong, X., Lu, X., & Xu, X. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.07.015 · Cited by 57 · see citing works
The role of tryptophan metabolism in postpartum depression
Duan, K., Ma, J., Wang, S., Huang, Z., Zhou, Y., & Yu, H. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-017-0178-y · Cited by 56 · see citing works
Gromova, K. V., Muhia, M., Rothammer, N., Gee, C. E., Thies, E., Schaefer, I., Kress, S., Kilimann, M. W., Shevchuk, O., Oertner, T. G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.112 · Cited by 51 · see citing works
Neurobiology of the rapid-acting antidepressant effects of ketamine: impact and opportunities
Shinohara, R., Aghajanian, G. K., & Abdallah, C. G. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.006 · Cited by 54 · see citing works
de Bartolomeis, A., Simone, G. D., Prisco, M. D., Barone, A., Napoli, R., Beguinot, F., Billeci, M., & Fornaro, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02065-4 · Cited by 52 · see citing works
The mTOR Inhibitor Rapamycin Has Limited Acute Anticonvulsant Effects in Mice
Hartman, A. L., Santos, P. T., Dolce, A. M., & Hardwick, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045156 · Cited by 54 · see citing works
Qi, C., Chen, X.-X., Gao, X., Xu, J., Liu, S., & Ge, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.633495 · Cited by 52 · see citing works
Mechanisms Underlying Circuit Dysfunction in Neurodevelopmental Disorders
Exposito-Alonso, D., & Rico, B. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072820-023642 · Cited by 49 · see citing works
Ferreira, J. S., Schmidt, J., Rio, P., Águas, R., Rooyakkers, A., Li, K. W., Smit, A. B., Craig, A. M., & Carvalho, A. L. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-14.2015 · Cited by 50 · see citing works
Khalil, O. S., Pisar, M., Forrest, C., Vincenten, M. C., Darlington, L., & Stone, T. W. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12535 · Cited by 52 · see citing works
Sauerbeck, A. D., Gangolli, M., Reitz, S. J., Salyards, M. H., Kim, S., Hemingway, C., Gratuze, M., Makkapati, T., Kerschensteiner, M., Holtzman, D. M., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.04.012 · Cited by 49 · see citing works
N -Methyl d-Aspartate Receptor Expression Patterns in the Human Fetal Cerebral Cortex
Bagasrawala, I., Memi, F., Radonjić, N. V., & Zečević, N. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw289 · Cited by 50 · see citing works
Ionotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex
Hadzic, M., Jäck, A., & Wahle, P. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24103 · Cited by 49 · see citing works
Wang, Y., Zhang, N., Liu, L., Jiang, H., Hu, D., Wang, Z., Chen, N., & Zhang, Y. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.01.024 · Cited by 46 · see citing works
Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development
Nishimura, S., Bilgüvar, K., Ishigame, K., Šestan, N., Günel, M., & Louvi, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124295 · Cited by 47 · see citing works
Sceniak, M. P., Fedder-Semmes, K. N., Wang, Q., Droubi, S., Babcock, K., Patwardhan, S., Wright-Zornes, J., Pham, L., & Sabo, S. L. (2019) · Journal of Cell Science · doi:10.1242/jcs.232892 · Cited by 47 · see citing works
Zhang, B., Yang, X., Ye, L., Liu, R., Ye, B., Du, W., Shen, F., Li, Q., Guo, F., Liu, J., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108382 · Cited by 45 · see citing works
Dendritic protein synthesis in the normal and diseased brain
Swanger, S., & Bassell, G. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.003 · Cited by 46 · see citing works
Pisar, M., Forrest, C., Khalil, O. S., McNair, K., Vincenten, M. C., Qasem, S., Darlington, L., & Stone, T. W. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.016 · Cited by 45 · see citing works
Berg, J. M., Lee, C., Chen, L., Galvan, L., Cepeda, C., Chen, J. Y., Peñagarikano, O., Stein, J. L., Li, A., Oguro-Ando, A., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.031 · Cited by 45 · see citing works
Specific Roles of NMDA Receptor Subunits in Mental Disorders
Yamamoto, H., Hagino, Y., Kasai, S., & Ikeda, K. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150330142807 · Cited by 45 · see citing works
Vieira, M. M., Schmidt, J., Ferreira, J. S., She, K., Oku, S., Mele, M., Santos, A. E., Duarte, C. B., Craig, A. M., & Carvalho, A. L. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.11.007 · Cited by 43 · see citing works
Pervolaraki, E., Hall, S. P., Foresteire, D., Saito, T., Saido, T. C., Whittington, M. A., Lever, C., & Dachtler, J. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.040550 · Cited by 42 · see citing works
GluN2B-Containing NMDA Receptors Promote Wiring of Adult-Born Neurons into Olfactory Bulb Circuits
Kelsch, W., Li, Z., Eliava, M., Goengrich, C., & Monyer, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1459-12.2012 · Cited by 40 · see citing works
Roles of Aldosterone and Oxytocin in Abnormalities Caused by Sevoflurane Anesthesia in Neonatal Rats
Cao, W., Pavlinec, C., Gravenstein, N. L., Seubert, C. N., & Martynyuk, A. E. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318266c62d · Cited by 41 · see citing works
GOFF, D. C. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160225154812 · Cited by 40 · see citing works
Montigny, A. D., Elhiri, I., Allyson, J., Cyr, M., & Massicotte, G. (2013) · Neural Plasticity · doi:10.1155/2013/261593 · Cited by 39 · see citing works
The needs of a synapse—How local organelles serve synaptic proteostasis
Grochowska, K. M., Andres‐Alonso, M., Karpova, A., & Kreutz, M. R. (2022) · The EMBO Journal · doi:10.15252/embj.2021110057 · Cited by 38 · see citing works
Distance-dependent regulation of NMDAR nanoscale organization along hippocampal neuron dendrites
Ferreira, J. S., Dupuis, J. P., Kellermayer, B., Bénac, N., Manso, C., Bouchet, D., Levet, F., Butler, C., Sibarita, J., & Groc, L. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922477117 · Cited by 39 · see citing works
Mori, T., Kasem, E. A., Suzuki‐Kouyama, E., Cao, X., Li, X., Kurihara, T., Uemura, T., Yanagawa, T., & Tabuchi, K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0338-4 · Cited by 36 · see citing works
GluN2B-Containing NMDA Receptors Promote Glutamate Synapse Development in Hippocampal Interneurons
Kelsch, W., Li, Z., Wieland, S., Senkov, O., Herb, A., Göngrich, C., & Monyer, H. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1210-14.2014 · Cited by 37 · see citing works
Kořínek, M., Serra, M. C., Rahman, F. E. S. A., Dobrovolski, M., Kuchtiak, V., Abramova, V., Fili, K., Tomović, E., Krausová, B. H., Krůšek, J., et al. (2024) · Physiological Research · doi:10.33549/physiolres.935346 · Cited by 37 · see citing works
Snyder, M. A., Adelman, A. E., & Gao, W. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.180 · Cited by 37 · see citing works
Chung, S., Jeong, J., Ko, S., Yu, X., Kim, Y.-H., Isaac, J. T. R., & Koretsky, A. P. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.018 · Cited by 37 · see citing works
Müller, M., Jacobi, E., Sakimura, K., Malinow, R., & von Engelhardt, J. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0611-4 · Cited by 38 · see citing works
Juliá-Palacios, N., Olivella, M., Sigatullina Bondarenko, M., Ibáñez-Micó, S., Muñoz-Cabello, B., Alonso-Luengo, O., Soto-Insuga, V., García-Navas, D., Cuesta-Herraiz, L., Andreo-Lillo, P., et al. (2024) · Brain · doi:10.1093/brain/awae041 · Cited by 36 · see citing works
Role of the mesolimbic dopamine pathway in the antidepressant effects of ketamine
Cardona-Acosta, A. M., & Bolaños‐Guzmán, C. A. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109374 · Cited by 36 · see citing works
Rislenemdaz treatment in the lateral habenula improves despair-like behavior in mice
Lei, T., Dong, D. F., Song, M., Sun, Y., Liu, X., & Zhao, H. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0652-9 · Cited by 35 · see citing works
Scotton, E., Antqueviezc, B., Vasconcelos, M., Dalpiaz, G., Géa, L. P., Goularte, J. F., Colombo, R., & Rosa, A. R. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114963 · Cited by 36 · see citing works
Jackson, T. C., Kotermanski, S. E., Jackson, E. K., & Kochanek, P. M. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.11.013 · Cited by 34 · see citing works
Priya, A., Johar, K., & Wong-Riley, M. T. T. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.07.002 · Cited by 33 · see citing works
The Rac1 Inhibitor NSC23766 Suppresses CREB Signaling by Targeting NMDA Receptor Function
Hou, H., Chávez, A. E., Wang, C.-C., Yang, H. S., Gu, H., Siddoway, B. A., Hall, B. J., Castillo, P. E., & Xia, H. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1659-14.2014 · Cited by 33 · see citing works
Self-citationLassus, B., Naudé, J., Fauré, P., Guédin, D., von Boxberg, Y., la Cour, C. M., Millan, M. J., & Peyrin, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-35802-9 · Cited by 32 · see citing works
Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets
Lang, E., Mallien, A. S., Vasilescu, A.-N., Hefter, D., Luoni, A., Riva, M. A., Borgwardt, S., Sprengel, R., Lang, U. E., Gass, P., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.012 · Cited by 33 · see citing works
Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain
Mu, Y., Zhao, C., Toni, N., Yao, J., & Gage, F. H. (2015) · eLife · doi:10.7554/elife.07871 · Cited by 30 · see citing works
ON or OFF?: Modulating the N-Methyl-D-Aspartate Receptor in Major Depression
Chan, S. Y., Matthews, E., & Burnet, P. W. J. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00169 · Cited by 30 · see citing works
Fedder-Semmes, K. N., & Sabo, S. L. (2015) · Biomolecules · doi:10.3390/biom5043448 · Cited by 30 · see citing works
Woodburn, S. C., Asrat, H. S., Flurer, J. K., Schwierling, H. C., Bollinger, J. L., Vollmer, L. L., & Wohleb, E. S. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.01.014 · Cited by 28 · see citing works
Ai, P.-H., Chen, S. X., Liu, X., Zhu, X., Pan, Y., Feng, D., Chen, S., Xu, N., & Sun, S. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00194-2 · Cited by 27 · see citing works
Grochecki, P., Smaga, I., Łopatyńska-Mazurek, M., Gibuła‐Tarłowska, E., Kędzierska, E., Listos, J., Talarek, S., Marszałek‐Grabska, M., Hubalewska‐Mazgaj, M., Korga-Plewko, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020589 · Cited by 25 · see citing works
Vines, L., Sotelo, D., Johnson, A., Dennis, E., Manza, P., Volkow, N. D., & Wang, G. (2022) · Intelligent Medicine · doi:10.1016/j.imed.2022.03.001 · Cited by 26 · see citing works
Interstitial 12p13.1 deletion involving GRIN2B in three patients with intellectual disability
Dimassi, S., Andrieux, J., Labalme, A., Lesca, G., Cordier, M., Boute, O., Neut, D., Edery, P., Sanlaville, D., & Schluth‐Bolard, C. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36079 · Cited by 25 · see citing works
Xu, Y., Lian, Y., Li, J., Zhang, Y., Liu, Y., Wang, X., Ma, J., & Li, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.939169 · Cited by 23 · see citing works
Mori, T., Kasem, E. A., Suzuki‐Kouyama, E., Cao, X., Li, X., Kurihara, T., Uemura, T., Yanagawa, T., & Tabuchi, K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0362-z · Cited by 23 · see citing works
Elmasri, M., Lotti, J. S., Aziz, W., Steele, O. G., Karachaliou, E., Sakimura, K., Hansen, K. B., & Penn, A. C. (2022) · Brain Sciences · doi:10.3390/brainsci12060789 · Cited by 22 · see citing works
Shi, X., Zhang, Q., Li, J., Liu, X., Zhang, Y., Huang, M., Fang, W., Xu, J., Yuan, T., Xiao, L., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109612 · Cited by 21 · see citing works
- Authors
- Wang, C.-C., Held, R. G., Chang, S.-C., Yang, L., Delpire, E., Ghosh, A., & Hall, B. J.
- Affiliations
- Tulane University (US)
- Vanderbilt University Medical Center (US)
- University of California San Diego (US)
- Corresponding author
- Hall, Benjamin J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 72
- Issue
- 5
- Pages
- 789-805
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2040330981
- Cited by
- 180
- References
- 60
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 9 · 2023: 9 · 2022: 21 · 2021: 7 · 2020: 9 · 2019: 17 · 2018: 16 · 2017: 9 · 2016: 10 · 2015: 18 · 2014: 9 · 2013: 16 · 2012: 16
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 594 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- National Institute on Alcohol Abuse and Alcoholism (U01AA013514)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- GluN2B, GluN2A, NMDA receptor, cortical development, subunit composition, homeostatic plasticity, calcium/calmodulin-dependent protein kinase II, mTOR signaling, glutamatergic synapses, lethality, feeding inhibition
- MeSH terms
- Animals, Cerebral Cortex, Immunosuppressive Agents, Piperidines, Social Behavior, Tetrodotoxin, Time Factors, Valine, Receptors, N-Methyl-D-Aspartate, Mice, Knockout, Patch-Clamp Techniques, Gene Expression Regulation, Developmental, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Sirolimus, Sodium Channel Blockers, RNA, Small Interfering, Ribosomal Protein S6 Kinases, 70-kDa, Green Fluorescent Proteins, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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