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Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis
Open accessAbstract
Monocyte homing to the liver and adhesion to the liver sinusoidal endothelial cells (LSECs) are key elements in nonalcoholic steatohepatitis (NASH) pathogenesis. We reported previously that VCAM-1 mediates monocyte adhesion to LSECs. However, the pathogenic role of VCAM-1 in NASH is unclear. Herein, we report that VCAM-1 was a top upregulated adhesion molecule in the NASH mouse liver transcriptome. Open chromatin landscape profiling combined with genome-wide transcriptome analysis showed robust transcriptional upregulation of LSEC VCAM-1 in murine NASH. Moreover, LSEC VCAM-1 expression was significantly increased in human NASH. LSEC VCAM-1 expression was upregulated by palmitate treatment in vitro and reduced with inhibition of the mitogen-activated protein 3 kinase (MAP3K) mixed lineage kinase 3 (MLK3). Likewise, LSEC VCAM-1 expression was reduced in the Mlk3-/- mice with diet-induced NASH. Furthermore, VCAM-1 neutralizing Ab or pharmacological inhibition attenuated diet-induced NASH in mice, mainly via reducing the proinflammatory monocyte hepatic population as examined by mass cytometry by time of flight (CyTOF). Moreover, endothelium-specific Vcam1 knockout mice were also protected against NASH. In summary, lipotoxic stress enhances the expression of LSEC VCAM-1, in part, through MLK3 signaling. Inhibition of VCAM-1 was salutary in murine NASH and might serve as a potential therapeutic strategy for human NASH.
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“During MASH, lipotoxic stimulation leads to increased expression of endothelial vascular cell adhesion molecule 1 (VCAM1) [315].”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [315]
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“This activation involves the expression of adhesion proteins such as vascular cell adhesion molecule 1 (VCAM-1), which directly recruits pro-inflammatory and pro-fibrogenic immune cells into the liver, while also disrupting the quiescent state of HSCs (104) (105-109).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [108]
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Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
Younossi, Z., Anstee, Q. M., Marietti, M., Hardy, T., Henry, L., Eslam, M., George, J., & Bugianesi, E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.109 · Cited by 5,249
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354
Mechanisms of NAFLD development and therapeutic strategies
Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354
An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
Corces, M. R., Trevino, A. E., Hamilton, E. G., Greenside, P. G., Sinnott-Armstrong, N. A., Vesuna, S., Satpathy, A. T., Rubin, A. J., Montine, K. S., Wu, B., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4396 · Cited by 2,496
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
Ross-Innes, C. S., Stark, R., Teschendorff, A. E., Holmes, K. A., Ali, H. R., Dunning, M., Brown, G. D., Gojiš, O., Ellis, I. O., Green, A. R., et al. (2012) · Nature · doi:10.1038/nature10730 · Cited by 2,182
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Differential Oestrogen Receptor Binding is Associated with Clinical Outcome in Breast Cancer
Stark, R. (2012) · Lecture notes in computer science · doi:10.1007/978-3-642-29627-7_30 · Cited by 1,403
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Tao, X., Zhang, R., Du, R., Yu, T., Yang, H., Li, J., Wang, Y., Liu, Q., Zuo, S., Wang, X., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20212414 · Cited by 59
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Self-citationMullin, S. M., Kelly, A. J., Chathail, M. B. N., Norris, S., Shannon, C. E., & Roche, H. M. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100375 · Cited by 10
Liu, J., Deng, L., Yao, B., Zhang, Y., Huang, J., Huang, S., Liang, C., Shen, Y., & Wang, X. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.03.021 · Cited by 5
Nanotherapy targeting liver sinusoidal endothelial cells in liver fibrosis
Zhang, L., Ru, J.-W., Liang, S.-Q., Zhang, M.-M., Zhang, C.-Y., Liu, J.-Q., Wang, Y., Zhou, T., Cheng, X. W., Xing, L., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114864 · Cited by 7
Li, Y., Ye, H., & Ding, Y.-X. (2022) · Children · doi:10.3390/children9050697 · Cited by 5
Endotheliopathy of liver sinusoidal endothelial cells in liver disease
Kondo, R., Iwakiri, Y., Kage, M., & Yano, H. (2023) · Pathology International · doi:10.1111/pin.13361 · Cited by 5
Fu, R., Zhang, F., Fu, J., Li, Y., Zhu, X., Ding, Q., & Zhu, Y. Z. (2025) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2025.163 · Cited by 6
Wei, H., Yin, Y., Yang, W., Zhu, J., Chen, L., Guo, R., Yang, Z., & Li, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1264324 · Cited by 5
Ouyang, H., Miao, H., Zhang, H., Lu, B., Zhang, J., Zhang, T., Zhu, J., Wang, Z., & Ji, L. (2025) · Phytotherapy Research · doi:10.1002/ptr.70095 · Cited by 4
Ma, R., Gong, L., Dong, C., Utsumi, T., Qi, J., Zhuang, Z. W., Zhang, X., Yang, Y., McConnell, M. J., Huang, H., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101728 · Cited by 4
Wang, C., Hezam, K., Fu, E., Pan, K., Liu, Y., & Li, Z. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114013 · Cited by 5
Species differences of fatty liver diseases: comparisons between human and feline
Ling, L., Li, R., Xu, M., Zhou, J., Hu, M., Zhang, X., & Zhang, X.-J. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00014.2024 · Cited by 5
Panara, V., Monteiro, R. M., & Koltowska, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.891538 · Cited by 4
Yue, Y.-X., Huang, S., Weng, Y., Lu, Y., Jia, B., & Yang, Z. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128311596240723113624 · Cited by 4
Melchinger, I., Guo, K., Guo, J.-K., & Xu, L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.15.508151 · Cited by 4
Wu, Y., Le, W., Zhang, H., & Zhu, Y. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123879 · Cited by 4
Huang, R., Deng, J., Wang, K., Zhu, C., Ding, C., Chen, F., Zhang, X., & Xie, W. (2025) · Liver International · doi:10.1111/liv.70227 · Cited by 3
Sen, D., Bisht, S., & Gupta, S. (2025) · Egyptian Liver Journal · doi:10.1186/s43066-025-00446-8 · Cited by 3
Ge, W., Ma, L., Huang, Y., Weigao, E., Lai, S., Cui, B., Wang, J., Ji, Y., Liu, D., Ye, S., et al. (2025) · Liver International · doi:10.1111/liv.70262 · Cited by 3
Role of miRNA signalling in the pathogenesis of MASLD
Cheng, S., Hao, J., & Qin, H.-Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1756805 · Cited by 3
Chen, W., Yang, A., Zhang, N., & You, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95262-0.00014-0 · Cited by 3
El-Sabawi, B. R., Tanrıverdi, K., Gajjar, P., Nayor, M. G., Landman, J. M., Below, J. E., Haff, M. G., Long, M. T., Ezpeleta, M., Freedman, J. E., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.037100 · Cited by 3
Zhang, C., Sui, Y., Liu, S., & Yang, M. J. (2023) · Exploration of Digestive Diseases · doi:10.37349/edd.2023.00029 · Cited by 3
Zou, C., Cai, R., Li, Y., Yu, X., Zhang, G., Alitongbieke, G., Pan, Y., & Zhang, S. Q. (2024) · iScience · doi:10.1016/j.isci.2024.110766 · Cited by 3
Metadata
- Authors
- Furuta, K., Guo, Q., Pavelko, K. D., Lee, J.-H., Robertson, K. D., Nakao, Y., Melek, J., Shah, V. H., Hirsova, P., & Ibrahim, S. H.
- Affiliations
- Mayo Clinic (US)
- Charles University (CZ)
- Corresponding author
- Ibrahim, Samar H.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2021-03-15
- Volume
- 131
- Issue
- 6
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC7954604
- OpenAlex
- W3125313120
- Cited by
- 136
- References
- 61
- Citations by year
- 2026: 23 · 2025: 31 · 2024: 24 · 2023: 27 · 2022: 18 · 2021: 13
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Digestive And Kidney Diseases of the National Institutes of Health (DK 122948)
- American Association of Study of liver Disease (Pinnacle Research Award, Bridge Award)
- NIH Silvio O. Conte Digestive Diseases Research Core Centers P30 grant mechanism (DK084567)
- Japan Society for the Promotion of Science (202060532)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- nonalcoholic steatohepatitis, VCAM-1, liver sinusoidal endothelial cells, monocyte adhesion, lipotoxicity, palmitate, MLK3, MAP3K signaling, endothelial adhesion molecules, diet-induced NASH, NASH therapy
- MeSH terms
- Animals, Disease Models, Animal, Humans, Liver, Mice, Inbred C57BL, Palmitates, RNA, Messenger, Up-Regulation, Mice, Knockout, Vascular Cell Adhesion Molecule-1, Gene Expression Profiling, MAP Kinase Signaling System, Endothelial Cells, Mice, Antibodies, Neutralizing, Non-alcoholic Fatty Liver Disease
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