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Cited by 263

The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.

Stem cell factor stimulates neurogenesis in vitro and in vivo

Open access
Kunlin Jin, Xiao Ou Mao, Yunjuan Sun, Lin Xie, David A. Greenberg·2002·Journal of Clinical Investigation
DOI 10.1172/jci15251
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Abstract

Cerebral ischemia stimulates neurogenesis in proliferative zones of the rodent forebrain. To identify the signaling factors involved, cerebral cortical cultures prepared from embryonic mouse brains were deprived of oxygen. Hypoxia increased bromodeoxyuridine (BrdU) incorporation into cells that expressed proliferation markers and immature neuronal markers and that lacked evidence of DNA damage or caspase-3 activation. Hypoxia-conditioned medium and stem cell factor (SCF), which was present in hypoxia-conditioned medium at increased levels, also stimulated BrdU incorporation into normoxic cultures. The SCF receptor, c-kit, was expressed in neuronal cultures and in neuroproliferative zones of the adult rat brain, and in vivo administration of SCF increased BrdU labeling of immature neurons in these regions. Cerebral hypoxia and ischemia may stimulate neurogenesis through trophic factors, including SCF.

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Metadata

Authors
Jin, K., Mao, X. O., Sun, Y., Xie, L., & Greenberg, D. A.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2002-08-01
Volume
110
Issue
3
Pages
311-319
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci15251
OpenAlex
W2111136435
Cited by
263
References
1
FWCI
3.73
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Stem cell factor stimulates neurogenesis in vitro and in vivo. https://app.cochat.ai/papers/10.1172/jci15251
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Jin, K., Mao, X. O., Sun, Y., Xie, L., & Greenberg, D. A. (2002). Stem cell factor stimulates neurogenesis in vitro and in vivo. Journal of Clinical Investigation. https://doi.org/10.1172/jci15251

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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