The DOI matches its OpenAlex record; 55 of the 55 references it cites were found in a registry or an index.
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
Open accessAbstract
Glucagon-like peptide-1 (GLP-1) released from the gut functions as an incretin that stimulates insulin secretion. GLP-1 is also a brain neuropeptide that controls feeding and drinking behavior and gastric emptying and elicits neuroendocrine responses including development of conditioned taste aversion. Although GLP-1 receptor (GLP-1R) agonists are under development for the treatment of diabetes, GLP-1 administration may increase blood pressure and heart rate in vivo. We report here that centrally and peripherally administered GLP-1R agonists dose-dependently increased blood pressure and heart rate. GLP-1R activation induced c-fos expression in the adrenal medulla and neurons in autonomic control sites in the rat brain, including medullary catecholamine neurons providing input to sympathetic preganglionic neurons. Furthermore, GLP-1R agonists rapidly activated tyrosine hydroxylase transcription in brainstem catecholamine neurons. These findings suggest that the central GLP-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo.
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Cites
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Self-citation
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Cited by
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
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The biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210
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Metadata
- Authors
- Yamamoto, H., Lee, C. E., Marcus, J., Williams, T. D., Overton, J. M., Lopez, M. E., Hollenberg, A. N., Baggio, L. L., Saper, C. B., Drucker, D. J., & Elmquist, J. K.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-07-01
- Volume
- 110
- Issue
- 1
- Pages
- 43-52
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2141917858
- Cited by
- 473
- References
- 55
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Yamamoto, H., Lee, C. E., Marcus, J., Williams, T. D., Overton, J. M., Lopez, M. E., Hollenberg, A. N., Baggio, L. L., Saper, C. B., Drucker, D. J., & Elmquist, J. K. (2002). Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. Journal of Clinical Investigation. https://doi.org/10.1172/jci15595
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