The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor–1 (Pref-1)
Open accessAbstract
Preadipocyte factor-1 (Pref-1) is a transmembrane protein highly expressed in preadipocytes. Pref-1 expression is, however, completely abolished in adipocytes. The extracellular domain of Pref-1 undergoes two proteolytic cleavage events that generate 50 and 25 kDa soluble products. To understand the function of Pref-1, we generated transgenic mice that express the full ectodomain corresponding to the large cleavage product of Pref-1 fused to human immunoglobulin-gamma constant region. Mice expressing the Pref-1/hFc transgene in adipose tissue, driven by the adipocyte fatty acid-binding protein (aP2, also known as aFABP) promoter, showed a substantial decrease in total fat pad weight. Moreover, adipose tissue from transgenic mice showed reduced expression of adipocyte markers and adipocyte-secreted factors, including leptin and adiponectin, whereas the preadipocyte marker Pref-1 was increased. Pref-1 transgenic mice with a substantial, but not complete, loss of adipose tissue exhibited hypertriglyceridemia, impaired glucose tolerance, and decreased insulin sensitivity. Mice expressing the Pref-1/hFc transgene exclusively in liver under the control of the albumin promoter also showed a decrease in adipose mass and adipocyte marker expression, suggesting an endocrine mode of action of Pref-1. These findings demonstrate the inhibition of adipogenesis by Pref-1 in vivo and the resulting impairment of adipocyte function that leads to the development of metabolic abnormalities.
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Metadata
- Authors
- Lee, K., Villena, J. A., Moon, Y. S., Kim, K.-H., Lee, S., Kang, C., & Sul, H. S.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-02-15
- Volume
- 111
- Issue
- 4
- Pages
- 453-461
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2115630287
- Cited by
- 264
- References
- 52
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, K., Villena, J. A., Moon, Y. S., Kim, K.-H., Lee, S., Kang, C., & Sul, H. S. (2003). Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor–1 (Pref-1). Journal of Clinical Investigation. https://doi.org/10.1172/jci15924
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