Alzheimer disease therapy: Can the amyloid cascade be halted?
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Nonstandard abbreviations used: Alzheimer disease (AD); amyloid β peptide (Aβ); late-onset AD (LOAD); amyloid β protein precursor (APP
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Cerebral accumulation of amyloidogenic peptides in familial British and familial Danish dementias and Alzheimer's disease is associated with neurodegeneration.
“Analyses of the biologic effects of mutations in the BRI2 (ITM2b) and the amyloid  precursor protein (APP) genes support the hypothesis that cerebral accumulation of amyloidogenic peptides in familial British and familial Danish dementias and Alzheimer's disease (AD) is associated with neurodegeneration.”
From BRI2 (ITM2b) Inhibits A Deposition In Vivo (2008) · cites this paper as Golde, 2003
Genetic analyses of FBD, FDD, and familial forms of AD support a unifying pathologic mechanism in which accumulation of amyloidogenic peptides triggers a complex pathological cascade leading to neurodegeneration.
“Indeed, genetic analyses of FBD, FDD, and familial forms of AD support a unifying pathologic mechanism in which accumulation of amyloidogenic peptides triggers a complex pathological cascade leading to neurodegeneration (Golde, 2003).”
From BRI2 (ITM2b) Inhibits A Deposition In Vivo (2008) · cites this paper as Golde, 2003
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- Authors
- Golde, T. E.
- Affiliations
- Mayo Clinic in Florida (US)
- Corresponding author
- Golde, Todd E.
- ORCID
- Golde, Todd E.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-01-01
- Volume
- 111
- Issue
- 1
- Pages
- 11-18
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC151845
- OpenAlex
- W1993198499
- Cited by
- 164
- References
- 14
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 10 · 2012: 4
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, amyloid hypothesis, amyloid-beta, amyloid precursor protein, late-onset Alzheimer's disease, anti-amyloid therapy
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cholesterol, Humans, Models, Biological, Risk Factors, Biomarkers, Amyloid beta-Peptides
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