Aβ42 neurotoxicity in primary co-cultures: effect of apoE isoform and Aβ conformation

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263 · see citing works

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works

Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability

Dahlgren, K. N., Manelli, A. M., Stine, W. B., Baker, L. K., Krafft, G. A., & LaDu, M. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201750200 · Cited by 1,452 · see citing works

Culturing nerve cells

Banker, G. A., & Goslin, K. (1998) · Cited by 1,290 · see citing works

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

Krieger, M., & Krieger, J. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.003125 · Cited by 1,160 · see citing works

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123 · see citing works

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works

In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis

Stine, W. B., Dahlgren, K. N., Krafft, G. A., & LaDu, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210207200 · Cited by 1,015 · see citing works

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

Klein, W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01749-5 · Cited by 989 · see citing works

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., & Maeda, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4471 · Cited by 944 · see citing works

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

Miyata, M., & Smith, J. D. (1996) · Nature Genetics · doi:10.1038/ng0996-55 · Cited by 889 · see citing works

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829 · see citing works

Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786 · see citing works

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693 · see citing works

Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer’s disease

Arriagada, P. V., Marzloff, K., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.9.1681 · Cited by 638 · see citing works

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17972 · Cited by 575 · see citing works

Isoform-specific binding of apolipoprotein E to beta-amyloid.

LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S., & Frail, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31529-6 · Cited by 540 · see citing works

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

Irizarry, M. C., Soriano, F., McNamara, M., Page, K. J., Schenk, D., Games, D., & Hyman, B. T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-18-07053.1997 · Cited by 497 · see citing works

Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

Innerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433 · see citing works

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

Poirier, J., Hess, M. A., May, P. C., & Finch, C. E. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90111-a · Cited by 380 · see citing works

Isoform-specific effects of human apolipoprotein E on brain function revealed in <i>ApoE</i> knockout mice: Increased susceptibility of females

Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W., & Mucke, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10914 · Cited by 364 · see citing works

Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe−/−Mice: Isoform-Specific Effects on Neurodegeneration

Buttini, M., Orth, M., Bellosta, S., Akeefe, H., Pitas, R. E., Wyss‐Coray, T., Mucke, L., & Mahley, R. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04867.1999 · Cited by 355 · see citing works

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

Diedrich, J. F., Minnigan, H. J., Carp, R. I., Whitaker, J. N., Race, R., Frey, W. H., & Haase, A. T. (1991) · Journal of Virology · doi:10.1128/jvi.65.9.4759-4768.1991 · Cited by 295 · see citing works

Deciphering the Genetic Basis of Alzheimer's Disease

Selkoe, D. J., & Podlisny, M. B. (2002) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.3.022502.103022 · Cited by 293 · see citing works

Nascent astrocyte particles differ from lipoproteins in CSF

LaDu, M. J., Gilligan, S. M., Lukens, J. R., Cabana, V. G., Reardon, C. A., Van Eldik, L. J., & Holtzman, D. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052070.x · Cited by 285 · cited 4× · see citing works

Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target

Ye, S., Huang, Y., Müllendorff, K., Dong, L., Giedt, G., Meng, E. C., Cohen, F. E., Kuntz, I. D., Weisgraber, K. H., & Mahley, R. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508693102 · Cited by 275 · see citing works

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

TOKUDA, T., CALERO, M., MATSUBARA, E., VIDAL, R., KUMAR, A., PERMANNE, B., ZLOKOVIC, B., SMITH, J. D., LADU, M. J., ROSTAGNO, A., et al. (2000) · Biochemical Journal · doi:10.1042/bj3480359 · Cited by 272 · see citing works

Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity

Cummings, B. J., & Cotman, C. W. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92053-6 · Cited by 260 · see citing works

Astrocytes and Microglia Respond to Estrogen with Increased apoE mRNAin Vivoandin Vitro

Stone, D. J., Rozovsky, I., Morgan, T. E., Anderson, C. P., Hajian, H., & Finch, C. E. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6360 · Cited by 237 · see citing works

Apolipoprotein E and cognitive performance

Raber, J., Wong, D., Yu, G.-Q., Buttini, M., Mahley, R. W., Pitas, R. E., & Mucke, L. (2000) · Nature · doi:10.1038/35006165 · Cited by 237 · see citing works

Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation

White, J. A., Manelli, A. M., Holmberg, K. H., Eldik, L. J. V., & LaDu, M. J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.12.013 · Cited by 220 · see citing works

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

Sun, Y., Wu, S., Bu, G., Onifade, M. K., Patel, S. N., LaDu, M. J., Fagan, A. M., & Holtzman, D. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03261.1998 · Cited by 213 · see citing works

Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease

Dodart, J.-C., Marr, R. A., Koistinaho, M., Gregersen, B. M., Malkani, S., Verma, I. M., & Paul, S. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409072102 · Cited by 207 · see citing works

S100β Stimulates Inducible Nitric Oxide Synthase Activity and mRNA Levels in Rat Cortical Astrocytes

Hu, J., Castets, F., Guevara, J. L., & Eldik, L. J. V. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2543 · Cited by 204 · see citing works

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.

Ruiz, J., Kouiavskaia, D., Migliorini, M., Robinson, S., Saenko, E. L., Gorlatova, N., Li, D., Lawrence, D., Hyman, B. T., Weisgraber, K. H., et al. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500114-jlr200 · Cited by 204 · see citing works

Cytotoxic Amyloid Peptides Inhibit Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction by Enhancing MTT Formazan Exocytosis

Liu, Y., & Schubert, D. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062285.x · Cited by 195 · see citing works

Purification of Apolipoprotein E Attenuates Isoform-specific Binding to β-Amyloid

LaDu, M. J., Pederson, T. M., Frail, D. E., Reardon, C. A., Getz, G. S., & Falduto, M. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.16.9039 · Cited by 189 · see citing works

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J., Sullivan, P. M., Fagan, A. M., Han, X., & Holtzman, D. M. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00049-3 · Cited by 180 · see citing works

Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.

Gearing, M., Rebeck, G. W., Hyman, B. T., Tigges, J., & Mirra, S. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9382 · Cited by 179 · see citing works

Isoform-Specific Effect of Apolipoprotein E on Cell Survival and β-Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures

Jordán, J., Galindo, M. F., Miller, R. J., Reardon, C. A., Getz, G. S., & LaDu, M. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00195.1998 · Cited by 178 · see citing works

Human Apolipoprotein E2, E3, and E4 Isoform-Specific Transgenic Mice: Human-like Pattern of GlialandNeuronal Immunoreactivity in Central Nervous System Not Observed in Wild-Type Mice

Xu, P.-T., Schmechel, D., Rothrock-Christian, T., Burkhart, D. S., Qiu, H.-L., Popko, B., Sullivan, P., Maeda, N., Saunders, A. M., Roses, A. D., et al. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0023 · Cited by 178 · see citing works

Alzheimer disease therapy: Can the amyloid cascade be halted?

Golde, T. E. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17527 · Cited by 164 · see citing works

Apolipoprotein E serum concentration and polymorphism in six European countries: the ApoEurope Project

Schiele, F., Bacquer, D. D., Vincent‐Viry, M., Beisiegel†, U., Ehnholm, C., Evans, A., Kafatos, A., Martins, M. C., Sans, S., Sass, C., et al. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00501-8 · Cited by 143 · see citing works

Prominent Axonopathy and Disruption of Axonal Transport in Transgenic Mice Expressing Human Apolipoprotein E4 in Neurons of Brain and Spinal Cord

Tesseur, I. C., Dorpe, J. V., Bruynseels, K., Bronfman, F. C., Sciot, R., Lommel, A. V., & LEUVEN, F. V. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64788-8 · Cited by 141 · see citing works

The Low Density Lipoprotein Receptor Regulates the Level of CentralNervous System Human and Murine Apolipoprotein E but Does Not Modify AmyloidPlaque Pathology in PDAPPMice

Fryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502143200 · Cited by 139 · see citing works

Alzheimer disease therapy: Can the amyloid cascade be halted?

Golde, T. E. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317527 · Cited by 139 · see citing works

Two Distal Downstream Enhancers Direct Expression of the Human Apolipoprotein E Gene to Astrocytes in the Brain

Grehan, S., Tse, E., & Taylor, J. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00812.2001 · Cited by 138 · see citing works

Astroglial Regulation of Apolipoprotein E Expression in Neuronal Cells

Harris, F. M., Tesseur, I., Brecht, W. J., Xu, Q., Mullendorff, K., Chang, S., Wyss-Coray, T., Mahley, R. W., & Huang, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309475200 · Cited by 135 · see citing works

Apolipoprotein E modulates Alzheimer’s Aβ(1–42)-induced oxidative damage to synaptosomes in an allele-specific manner

Lauderback, C. M., Kański, J., Hackett, J. M., Maeda, N., Kindy, M. S., & Butterfield, D. A. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03228-0 · Cited by 132 · see citing works

Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy.

Urmoneit, B., Prikulis, I., Wihl, G. E., D’Urso, D., Frank, R. W., Heeren, J., Beisiegel†, U., & Prior, R. (1997) · PubMed · Cited by 124 · see citing works

Expression of apolipoprotein E mRNA in rat microglia

Nakai, M., Kawamata, T., Taniguchi, T., Maeda, K., & Tanaka, C. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12716-6 · Cited by 118 · see citing works

Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses

LaDu, M. J., Shah, J. A., Reardon, C. A., Getz, G. S., Bu, G., Hu, J., Guo, L., & Van Eldik, L. J. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00050-x · Cited by 118 · see citing works

S100β induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway

Hu, J., & Eldik, L. J. V. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(96)00095-x · Cited by 118 · see citing works

Marked regional differences of brain human apolipoprotein e expression in targeted replacement mice

Sullivan, P. M., Mace, B. E., Maeda, N., & Schmechel, D. E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.011 · Cited by 113 · see citing works

Multiple pathways of apolipoprotein E signaling in primary neurons

Hoe, H., Harris, D. C., & Rebeck, G. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.03007.x · Cited by 111 · see citing works

Alzheimer Aβ neurotoxicity: Promotion by antichymotrypsin, ApoE4; inhibition by Aβ-related peptides

Ma, J., Brewer, H. B., & Potter, H. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00112-1 · Cited by 108 · see citing works

Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures

LaDu, M. J., Shah, J. A., Reardon, C. A., Getz, G. S., Bu, G., Hu, J., Guo, L., & Eldik, L. J. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000602200 · Cited by 101 · see citing works

ApoE and Aβ1–42 Interactions: Effects of Isoform and Conformation on Structure and Function

Manelli, A. M., Stine, W. B., Van Eldik, L. J., & LaDu, M. J. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:235 · Cited by 95 · see citing works

Apolipoprotein E Receptors Mediate Neurite Outgrowth through Activation of p44/42 Mitogen-activated Protein Kinase in Primary Neurons

Qiu, Z., Hyman, B. T., & Rebeck, G. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401055200 · Cited by 93 · see citing works

Apolipoprotein E modulates γ‐secretase cleavage of the amyloid precursor protein

Irizarry, M. C., Deng, A., Lleo, A., Berezovska, O., Von Arnim, C. A. F., Martin‐Rehrmann, M., Manelli, A., LaDu, M. J., Hyman, B. T., & Rebeck, G. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02581.x · Cited by 89 · see citing works

Effect of Domain Interaction on Apolipoprotein E Levels in Mouse Brain

Ramaswamy, G., Xu, Q., Huang, Y., & Weisgraber, K. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1922-05.2005 · Cited by 87 · see citing works

ApoE isoforms affect neuronal N-methyl-d-aspartate calcium responses and toxicity via receptor-mediated processes

Qiu, Z., Crutcher, K. A., Hyman, B. T., & Rebeck, G. W. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.017 · Cited by 86 · see citing works

ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-β1–42

Trommer, B. L., Shah, C., Yun, S. H., Gamkrelidze, G., Pasternak, E. S., Blaine Stine, W., Manelli, A., Sullivan, P., Pasternak, J. F., & LaDu, M. J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.08.011 · Cited by 82 · see citing works

Attenuation of the Neurotoxic Effect of Aβ Amyloid Peptide by Apolipoprotein E

Whitson, J. S., Mims, M. P., Strittmatter, W. J., Yamaki, T., Morrisett, J. D., & Appel, S. H. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1209 · Cited by 66 · see citing works

Characterization and Partial Purification of AIM: A Plasma Protein That Induces Rat Cerebral Type 2 Astroglia from Bipotential Glial Progenitors

Levison, S. W., & McCarthy, K. D. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08220.x · Cited by 64 · see citing works

Apolipoprotein E Attenuates β‐Amyloid‐Induced Astrocyte Activation

Hu, J., LaDu, M. J., & Eldik, L. J. V. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71041626.x · Cited by 62 · see citing works

Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex: Colocalization with amyloid plaques

Mufson, E. J., Benzing, W. C., Cole, G. M., Wang, H., Emerich, D. F., Sladek, J. R., Morrison, J. H., & Kordower, J. H. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00064-6 · Cited by 58 · see citing works

Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's β-amyloid peptide in cultured vascular smooth muscle cells

Mazur‐Kolecka, B., Frackowiak, J., & Wı́sniewski, H. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00873-o · Cited by 57 · see citing works

ApoE-Dependent Plasticity in Alzheimer's Disease

Teter, B. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:167 · Cited by 56 · see citing works

ApoE protects cortical neurones against neurotoxicity induced by the non‐fibrillar C‐terminal domain of the amyloid‐β peptide

Drouet, B., Fifre, A., Pinçon‐Raymond, M., Vandekerckhove, J. S., Rosseneu, M., Guéant, J., Chambaz, J., & Pillot, T. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00047.x · Cited by 56 · see citing works

Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide

Stratman, N. C., Castle, C. K., Taylor, B. M., Epps, D. E. V., Melchior, G. W., & Carter, D. B. (2005) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2005.06.005 · Cited by 42 · see citing works

Aging, gender and APOE isotype modulate metabolism of Alzheimer's Aβ peptides and F2‐isoprostanes in the absence of detectable amyloid deposits

Yao, J., Petanceska, S. S., Montine, T. J., Holtzman, D. M., Schmidt, S. D., Parker, C. A., Callahan, M. J., Lipinski, W. J., Bisgaier, C. L., Turner, B. A., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02532.x · Cited by 41 · see citing works

Self-Assembly of HEK Cell-Secreted ApoE Particles Resembles ApoE Enrichment of Lipoproteins as a Ligand for the LDL Receptor-Related Protein

LaDu, M. J., Stine, Narita, M., Getz, G. S., Reardon, C. A., & Bu, G. (2006) · Biochemistry · doi:10.1021/bi051765s · Cited by 36 · see citing works

Amidation of β‐Amyloid Peptide Strongly Reduced the Amyloidogenic Activity Without Alteration of the Neurotoxicity

Forloni, G., Lucca, E., Angeretti, N., Torre, P. D., & Salmona, M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052048.x · Cited by 35 · see citing works

Type III Hyperlipoproteinemia: A Focus on Lipoprotein Receptor-Apolipoprotein E2 Interactions

Innerarity, T. L., Hui, D. Y., Bersot, T. P., & Mahley, R. W. (1986) · Springer eBooks · doi:10.1007/978-1-4684-1262-8_24 · Cited by 34 · see citing works

Human apolipoprotein E allele-specific brain expressing transgenic mice

Smith, J. D., Sikes, J. L., & Levin-Allerhand, J. A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00076-1 · Cited by 33 · see citing works

Apolipoprotein E is found in astrocytes but not in microglia in the normal mouse brain

Fujita, S. C., Sakuta, K., Tsuchiya, R., & Hamanaka, H. (1999) · Neuroscience Research · doi:10.1016/s0168-0102(99)00075-9 · Cited by 32 · see citing works

Discovery of a brain promoter from the human transferrin gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles.

Bowman, B. H., Jansen, L., Yang, F., Adrian, G. S., Zhao, M., Atherton, S. S., Buchanan, J. M., Greene, R., Walter, C. A., & Herbert, D. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12115 · Cited by 26 · see citing works

The effect of oxidative stress on accumulation of apolipoprotein E3 and E4 in a cell culture model of β-amyloid angiopathy (CAA)

Mazur‐Kolecka, B., Kowal, D., Sukontasup, T., Dickson, D. W., & Frackowiak, J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03026-9 · Cited by 22 · see citing works

Accumulation of Alzheimer Amyloid-β Peptide in Cultured Myocytes is Enhanced by Serum and Reduced by Cerebrospinal Fluid

Mazur‐Kolecka, B., Frackowiak, J., Carroll, R. T., & Wı́sniewski, H. M. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199703000-00005 · Cited by 22 · see citing works

Characterization of transgenic mice expressing apolipoprotein E4(C112R) and apolipoprotein E4(L28P; C112R)

Huber, G., März, W., Martin, J. R., Malherbe, P., Richards, J. G., Sueoka, N., Ohm, T., & Hoffmann, M. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00341-9 · Cited by 20 · see citing works

Apolipoprotein E Alters Metabolism of AβPP in Cells Engaged in β-Amyloidosis

Mazur‐Kolecka, B., Frackowiak, J., Krzeslowska, J., et al. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199903000-00008 · Cited by 19 · see citing works

TGFβ1 enhances formation of cellular Aβ/apoE deposits in vascular myocytes

Mazur‐Kolecka, B., Frackowiak, J., LeVine, H., Haske, T., Evans, L. M., Sukontasup, T., & Golabek, A. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00095-7 · Cited by 15 · see citing works

Association of human, rat, and rabbit apolipoprotein E with β‐amyloid

LaDu, M. J., Lukens, J. R., Reardon, C. A., & Getz, G. S. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970701)49:1

Defeating Alzheimer's disease and other dementias: a priority for European science and society

Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676 · see citing works

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Bu, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2620 · Cited by 1,168 · see citing works

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870 · see citing works

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

Youmans, K. L., Tai, L. M., Nwabuisi-Heath, E., Jungbauer, L., Kanekiyo, T., Gan, M., Kim, J., Eimer, W. A., Estus, S., Rebeck, G. W., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407957 · Cited by 259 · see citing works

Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?

Franco, R., & Cedazo-Minguez, A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00146 · Cited by 183 · see citing works

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

Tzioras, M., Davies, C., Newman, A., Jackson, R., & Spires‐Jones, T. (2019) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12529 · Cited by 147 · see citing works

Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid β Neurotoxicity in in Vitro and in Vivo Models of Alzheimer’s Disease

Doi, Y., Mizuno, T., Maki, Y., Jin, S., Mizoguchi, H., Ikeyama, M., Doi, M., Michikawa, M., Takeuchi, H., & Suzumura, A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090418 · Cited by 135 · see citing works

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

Liraz, O., Boehm-Cagan, A., & Michaelson, D. M. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-16 · Cited by 118 · see citing works

The generation and function of soluble apoE receptors in the CNS

Rebeck, G. W., LaDu, M. J., Estus, S., Bu, G., & Weeber, E. J. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-15 · Cited by 66 · see citing works

Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms

Yang, Y., & Wang, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170788 · Cited by 46 · see citing works

Disease-associated protein seeding suggests a dissociation between misfolded protein accumulation and neurodegeneration in prion disease

Alibhai, J. D., Diack, A. B., & Manson, J. C. (2017) · Prion · doi:10.1080/19336896.2017.1378289 · Cited by 5 · see citing works

A Possible Neurodegeneration Mechanism Triggered by Diabetes

Farhadi, A., Vosough, M., Zhang, J., Tahamtani, Y., & Shahpasand, K. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.012 · Cited by 31 · see citing works

Temperature-Sensitive Paralytic Mutants Are Enriched For Those Causing Neurodegeneration in Drosophila

Palladino, M. J., Hadley, T. J., & Ganetzky, B. (2002) · Genetics · doi:10.1093/genetics/161.3.1197 · Cited by 98 · see citing works

Nanoparticles, Neurotoxicity and Neurodegenerative Diseases

Mushtaq, G., Khan, J. A., Joseph, E., & Kamal, M. A. (2015) · Current Drug Metabolism · doi:10.2174/1389200216666150812122302 · Cited by 66 · see citing works