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Cited by 720

The DOI matches its OpenAlex record; 4 of the 4 references it cites were found in a registry or an index.

Bone marrow–derived progenitor cells in pulmonary fibrosis

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Naozumi Hashimoto, Hongjian Jin, Tianju Liu, Stephen W. Chensue, Sem Hin Phan·2004·Journal of Clinical Investigation
DOI 10.1172/jci18847
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Abstract

The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary origin and especially derivation from bone marrow (BM) progenitor cells has not been ruled out. To examine this possibility directly, adult mice were durably engrafted with BM isolated from transgenic mice expressing enhanced GFP. Induction of pulmonary fibrosis in such chimera mice by endotracheal bleomycin (BLM) injection caused large numbers of GFP(+) cells to appear in active fibrotic lesions, while only a few GFP(+) cells could be identified in control lungs. Flow-cytometric analysis of lung cells confirmed the BLM-induced increase in GFP(+) cells in chimera mice and revealed a significant increase in GFP(+) cells that also express type I collagen. GFP(+) lung fibroblasts isolated from chimera mice expressed collagen and telomerase reverse transcriptase but not alpha-smooth muscle actin. Treatment of isolated GFP(+) fibroblasts with TGF-beta failed to induce myofibroblast differentiation. Cultured lung fibroblasts expressed the chemokine receptors CXCR4 and CCR7 and responded chemotactically to their cognate ligands, stromal cell-derived factor-1 alpha and secondary lymphoid chemokine, respectively. Thus the collagen-producing lung fibroblasts in pulmonary fibrosis can also be derived from BM progenitor cells.

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Metadata

Authors
Hashimoto, N., Jin, H., Liu, T., Chensue, S. W., & Phan, S. H.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2004-01-15
Volume
113
Issue
2
Pages
243-252
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci18847
OpenAlex
W2003976042
Cited by
720
References
4
FWCI
52.05
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Bone marrow–derived progenitor cells in pulmonary fibrosis. https://app.cochat.ai/papers/10.1172/jci18847
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Hashimoto, N., Jin, H., Liu, T., Chensue, S. W., & Phan, S. H. (2004). Bone marrow–derived progenitor cells in pulmonary fibrosis. Journal of Clinical Investigation. https://doi.org/10.1172/jci18847

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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