The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Mitochondrial DNA mutations in human colonic crypt stem cells
Open accessAbstract
The mitochondrial genome encodes 13 essential subunits of the respiratory chain and has remarkable genetics based on uniparental inheritance. Within human populations, the mitochondrial genome has a high rate of sequence divergence with multiple polymorphic variants and thus has played a major role in examining the evolutionary history of our species. In recent years it has also become apparent that pathogenic mitochondrial DNA (mtDNA) mutations play an important role in neurological and other diseases. Patients harbor many different mtDNA mutations, some of which are mtDNA mutations, some of which are inherited, but others that seem to be sporadic. It has also been suggested that mtDNA mutations play a role in aging and cancer, but the evidence for a causative role in these conditions is less clear. The accumulated data would suggest, however, that mtDNA mutations occur on a frequent basis. In this article we describe a new phenomenon: the accumulation of mtDNA mutations in human colonic crypt stem cells that result in a significant biochemical defect in their progeny. These studies have important consequences not only for understanding of the finding of mtDNA mutations in aging tissues and tumors, but also for determining the frequency of mtDNA mutations within a cell.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“several studies have related mtDNA defects to human stem cell aging100–102.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [100]
In the citing paper
“Clonal expansion of mtDNA mutations has been described in numerous tissues from aged individuals, such as skeletal muscle (Fayet et al., 2002; Muller-Hocker et al., 1993), substantia nigra neurons (Cottrell et al., 2001; Kraytsberg et al., 2006), heart (Muller-Hocker, 1989) and colonic crypts (Taylor et al., 2003).”
From Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases (2017) · cites this paper as Taylor et al., 2003
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA
Andrews, R. M., Kubacka, I., Chinnery, P. F., Lightowlers, R. N., Turnbull, D. M., & Howell, N. (1999) · Nature Genetics · doi:10.1038/13779 · Cited by 3,337
Self-citationMitochondrial free radical generation, oxidative stress, and aging
Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010
Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774
Self-citationThe Multiple Leiomyoma Consortium (2002) · Nature Genetics · doi:10.1038/ng849 · Cited by 1,635
Germ-Line Mutations in Nonsyndromic Pheochromocytoma
Neumann, H. P. H., Bausch, B., McWhinney, S. R., Bender, B., Gimm, O., Franke, G., Schipper, J., Klisch, J., Altehoefer, C., Zerres, K., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020152 · Cited by 1,350
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214
MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES
Shadel, G. S., & Clayton, D. A. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.409 · Cited by 1,059
Somatic mutations of the mitochondrial genome in human colorectal tumours
Polyák, K., Li, Y., Zhu, H., Christoph Lengauer, C., Willson, J. K. V., Markowitz, S. D., Trush, M. A., Kinzler, K. W., & Vogelstein, B. (1998) · Nature Genetics · doi:10.1038/3108 · Cited by 834
Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids
Fliss, M., Usadel, H., Caballero, O. L., Wu, L. J., Buta, M. R., Eleff, S. M., Jen, J., & Sidransky, D. (2000) · Science · doi:10.1126/science.287.5460.2017 · Cited by 821
Detection of a specific mitochondrial DNA deletion in tissues of older humans
Cortopassi, G. A., & Arnheim, N. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.23.6927 · Cited by 788
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Cortopassi, 1990, Nucleic Acids Res., 275, 169
- Howell, 1996, Am. J. Hum. Genet., 59, 501
- Valnot, 2000, Am. J. Hum. Genet., 67, 1104
Cited by
Sorted by citations
Items 401–500 of 528
Developmental plasticity of stem cells and diseases
Luo, G., Long, J., Zhang, B., Liu, C., Xu, J., Yu, X., & Ni, Q. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.07.007 · Cited by 5
Ren, Q., Zhang, F., & Xu, H. (2017) · Genes · doi:10.3390/genes8120397 · Cited by 5
Investigation of oxidative phosphorylation activity and complex composition in mitochondrial disease
Thompson, K., Stroud, D. A., Thorburn, D. R., & Taylor, R. W. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-12-821751-1.00008-7 · Cited by 4
Self-citationLesions of the mitochondrial genome and ways of its preservation
Gasiev, A. I., & Shaikhaev, G. O. (2008) · Russian Journal of Genetics · doi:10.1134/s1022795408040017 · Cited by 5
Homogenization Model for Aberrant Crypt Foci
Figueiredo, I. N., Leal, C., Romanazzi, G., & Engquist, B. (2016) · SIAM Journal on Applied Mathematics · doi:10.1137/140967660 · Cited by 5
A Method to Detect Cytochrome c Oxidase Activity and Mitochondrial Proteins in Oligodendrocytes
Campbell, G. R., & Mahad, D. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9072-6_19 · Cited by 5
Alzheimer's Disease, Mild Cognitive Impairment, and the Biology of Intrinsic Aging
Kirkwood, T. B. L. (2006) · Philosophy, psychiatry & psychology · doi:10.1353/ppp.2006.0043 · Cited by 5
Self-citationKraytsberg, Y., Nicholas, A., & Khrapko, K. (2007) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.1.1.109 · Cited by 5
Computer Modeling in the Study of Aging
Kirkwood, T. B. L., Boys, R. J., Gillespie, C. S., Procter, C. J., Shanley, D. P., & Wilkenson, D. J. (2005) · Elsevier eBooks · doi:10.1016/b978-012088387-5/50015-7 · Cited by 5
Self-citationStem cell dynamics and pretumor progression in the intestinal tract
Ma, H., Morsink, F. H. M., Offerhaus, G. J. A., & de Leng, W. W. J. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1211-3 · Cited by 5
Alison, M. R., Burkert, J., Wright, N. A., & Leedham, S. J. (2007) · The Cancer Handbook · doi:10.1002/9780470025079.chap202 · Cited by 5
Ancestries Hidden in Plain Sight: Methylation Patterns for Clonal Analysis
Fearon, E. R., & Bommer, G. T. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.027 · Cited by 5
Franco, M., Cote-L’Heureux, A., Fleischmann, Z., Chen, Z., Khrapko, M., Vyshedskiy, B., Braverman, M., Popadin, K. Y., Pickett, S. J., Woods, D. C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.21.568140 · Cited by 5
Self-citationMitochondrial clone tracing within spatially intact human tissuesPreprint
Bracht, S. A., Rong, J., Gier, R. A., DeMarshall, M., Golden, H., Dhakal, D., McDevitt, J. C., Mo, F., Furth, E. E., Strauss, A. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.664452 · Cited by 6
Kowald, A., Kemeth, F. P., & Kirkwood, T. B. L. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgac192 · Cited by 4
Self-citationVariant load of mitochondrial DNA in single human mesenchymal stem cells
Hipps, D., Pyle, A., Porter, A. L. R., Dobson, P. F., Tuppen, H. A. L., Lawless, C., Russell, O. M., Turnbull, D. M., Deehan, D. J., & Hudson, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-71822-4 · Cited by 4
Self-citationInvestigating The Fixation and Spread of Mutations in The Gastrointestinal Epithelium
Graham, T. A., & Wright, N. A. (2008) · Future Oncology · doi:10.2217/14796694.4.6.825 · Cited by 4
Adam, A. C., Faudou, V., Paschen, S. A., Adam, O., Kahl, P., Drebber, U., Fischer, H., & Büttner, R. (2012) · The Journal of Pathology · doi:10.1002/path.4060 · Cited by 4
A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach
Houston, M. T., Cameron, A., & Gutiérrez, J. B. (2016) · PLoS Currents · doi:10.1371/currents.md.6af74d0cec0834554dac78f0045cfded · Cited by 6
Refinetti, P., Arstad, C., Thilly, W. G., Morgenthaler, S., & Ekstrøm, P. O. (2017) · BMC Clinical Pathology · doi:10.1186/s12907-017-0042-3 · Cited by 4
Mitochondrial Disease: Maintenance of Mitochondrial Genome and Molecular Diagnostics
Kang, D., & Hamasaki, N. (2006) · Advances in clinical chemistry · doi:10.1016/s0065-2423(06)42006-0 · Cited by 4
Frequencies of mtDNA mutations in primary tissues of colorectal adeno-polyps
Adams, G. (2013) · Frontiers in Bioscience-Elite · doi:10.2741/e661 · Cited by 4
An update on the pathophysiology of the intestinal crypt
Deheragoda, M. G., & Wright, N. (2006) · Current Diagnostic Pathology · doi:10.1016/j.cdip.2006.05.007 · Cited by 4
Tumorgenese aus pathologischer Sicht
Gaisa, N. T. (2016) · Der Pathologe · doi:10.1007/s00292-016-0207-3 · Cited by 4
Subcellular phenomena in colorectal cancer
Mirams, G. R. (2008) · Nottingham ePrints (University of Nottingham) · Cited by 4
Mutational landscapes of normal breast during age and pregnancy determine cancer riskPreprint
Cereser, B., Tabassum, N., Belluz, L. D. B., Yiu, A. W. P., Zagorac, S., Miere, C., Werner, B., Moderau, N., Jeffries-Jones, A. R., & Stebbing, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.04.277715 · Cited by 4
The ‘Stem’ and the ‘Workers’ of the mtDNA population of the cell. Evidence from mutational analysisPreprint
Cote‐L’Heureux, A., Franco, M., Maithania, Y. N. K., Popadin, K. Y., Woods, D. C., Tilly, J. L., & Khrapko, K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.14.536897 · Cited by 4
Mechanism of age-related accumulation of mitochondrial DNA mutations in human bloodPreprint
Gupta, R., Durham, T., Chau, G., Uddin, M. M., Lu, W., Karczewski, K. J., Howrigan, D. P., Natarajan, P., Zhou, W., Neale, B. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.25.655566 · Cited by 4
WRIGHT, N. A. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.00023.x · Cited by 3
Sperka, T., & Rudolph, K. L. (2010) · Else Kröner-Fresenius Symposia · doi:10.1159/000312650 · Cited by 3
Machado, M. C. C., & de Souza, H. P. (2018) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2018.09.018 · Cited by 3
Nomura, Y., Fuchigami, H., Kii, H., Feng, Z., Nakamura, T., & Kinjo, M. (2006) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.11.006 · Cited by 3
The caloric restriction fallacy, rodent diet aids and the tumor suppression theory of agingPreprint
Wolf, A. M. (2021) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/a2689 · Cited by 2
Measuring stem cell dynamics in the human colon – where there's a wiggle, there's a way
Leedham, S. J. (2014) · The Journal of Pathology · doi:10.1002/path.4422 · Cited by 2
Cracking the enigma of mitochondrial-DNA variants and cancer
Wei, W., & Chinnery, P. F. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0180-2 · Cited by 2
Self-citationBoscenco, S., Cumming, E. M., Kim, M., Lareau, C. A., & Reznik, E. (2024) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-080124-102241 · Cited by 2
Microdissection and Analytical PCR for the Investigation of mtDNA Lesions
Williams, S. L., & Moraes, C. T. (2007) · Methods in cell biology · doi:10.1016/s0091-679x(06)80024-5 · Cited by 2
Mitochondrial DNA Mutations and Cancer
Popadin, K. Y., Владимирович, Г. К., & Khrapko, K. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.09.001 · Cited by 2
Read-through therapy for mitochondrial DNA nonsense mutations
Pacheu‐Grau, D., Gómez-Durán, A., López‐Gallardo, E., Montoya, J., & Ruiz‐Pesini, E. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.04.012 · Cited by 2
A Multiscale Model for Aberrant Crypt Foci
Figueiredo, I. N., Romanazzi, G., Leal, C., & Engquist, B. (2013) · Procedia Computer Science · doi:10.1016/j.procs.2013.05.268 · Cited by 2
Human Mitochondrial Mutations and Repair
Druzhyna, N., Wilson, G. L., & LeDoux, S. P. (2010) · Springer eBooks · doi:10.1007/978-0-387-89781-3_19 · Cited by 2
The Stem Cell Hypothesis of Aging
Meiliana, A., & Wijaya, A. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i1.108 · Cited by 2
Langeveld, D., Jansen, M., Brosens, L. A. A., Morsink, F. H. M., Offerhaus, G. J. A., & de Leng, W. W. J. (2011) · American Journal of Clinical Pathology · doi:10.1309/ajcpp3i5hdywmhja · Cited by 2
Adult Stem Cells in Normal Gastrointestinal Function and Inflammatory Disease
Brittan, M., & Wright, N. A. (2007) · Elsevier eBooks · doi:10.1016/b978-012370615-7/50049-4 · Cited by 2
Mitochondrial Function in Aging
Morales-Rosales, S. L., Rivero-Segura, N. A., & Königsberg, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-40955-5_4 · Cited by 3
Stem Cells in the Gastrointestinal Tract
Wright, N. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00012-9 · Cited by 2
Is Genome Instability a Significant Cause of Aging? A Review
Xing, Y. (2022) · Advances in Social Science, Education and Humanities Research/Advances in social science, education and humanities research · doi:10.2991/assehr.k.220504.260 · Cited by 2
Pickard, B. S., & Blackwood, D. (2010) · Wiley eBooks · doi:10.1002/9780470669600.ch9 · Cited by 2
Su, T., Gomes, T. M. B., Smith, A. L. M., Whitehall, J. C., Blain, A. P., Simard, M., Scholten, L., Stewart, J. B., Turnbull, D. M., Lawless, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.06.535821 · Cited by 2
Self-citationCellular Senescence and Stem Cell Exhaustion: Implications for Aging and Regeneration
Kumar, N., & Walia, H. K. (2025) · Cellular Senescence, Age-Related Disorders, and Emerging Treatments · doi:10.1007/978-981-96-1041-9_6 · Cited by 1
Mitochondrial transfer technologies with molecular insights into clinical applications
Martirosian, V., Peng, B., & Teitell, M. A. (2026) · Stem Cells · doi:10.1093/stmcls/sxag026 · Cited by 1
Telomeres, Senescence, Oxidative Stress, and Heterogeneity
Passos, J. F., Nelson, G., & von Zglinicki, T. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_3 · Cited by 1
Zanssen, S. (2008) · Springer eBooks · doi:10.1007/978-0-387-84835-8_10 · Cited by 1
On modeling of mutation probabilities
Juhola, M., Saarikoski, J., & Jacobs, H. T. (2007) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2007.04.005 · Cited by 1
Deep sequencing of the X chromosome reveals the proliferation history of colorectal adenomas
Grassi, A., Iannelli, F., Cereda, M., Volorio, S., Melocchi, V., Viel, A., Basso, G., Laghi, L., Caselle, M., & Ciccarelli, F. D. (2014) · Genome biology · doi:10.1186/preaccept-1975202131282374 · Cited by 1
Lympho-Hematopoietic Stem Cells and Their Aging
Geiger, H., & Zant, G. E. V. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_30 · Cited by 1
Somatic cell evolution: how to improve with age
Shibata, D. K. (2018) · The Journal of Pathology · doi:10.1002/path.5173 · Cited by 1
Schon, E. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320249 · Cited by 1
Alimentation, Bacterial Metabolites, and Host Intestinal Epithelium
Blachier, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-26322-4_4 · Cited by 1
Fit for purpose: Selecting the best mitochondrial DNA for the job
Pickett, S. J., Taylor, R. W., & McFarland, R. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.06.011 · Cited by 1
Self-citationGolden, T. R., Morten, K., Johnson, F., Samper, E., & Melov, S. (2005) · Elsevier eBooks · doi:10.1016/b978-012088387-5/50008-x · Cited by 1
Age-related changes of mitochondrial transcription factor a expression in rotator cuff degeneration.
Ichiseki, T., Ueda, S., Ueda, Y., Kaneuji, A., Kawahara, N., & Matsumoto, T. (2015) · Europe PMC (PubMed Central) · Cited by 1
The role of mechanics in the growth and homeostasis of the intestinal crypt
Almet, A. A., Byrne, H. M., Maini, P. K., & Moulton, D. E. (2020) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-020-01402-8 · Cited by 1
Coenzyme Q, mtDNA and Mitochondrial Dysfunction During Aging
Quiles, J. L., Varela‐López, A., Navarro‐Hortal, M. D., & Battino, M. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-45642-9_10 · Cited by 1
Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations
Refinetti, P., Morgenthaler, S., Thilly, W. G., Arstad, C., & Ekstrøm, P. O. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.523860 · Cited by 1
Monitoring vascular normalization: new opportunities for mitochondrial inhibitors in breast cancer
Mouron, S. A., Bueno, M. J., Muñoz, M., & Quintela-Fino, M. (2021) · Oncoscience · doi:10.18632/oncoscience.523 · Cited by 1
Longevity genes across species: Conservation versus evolvability
Salvioli, S., Tieri, P., Castellani, G., Capri, M., Barbi, C., Santoro, A., Altilia, S., Invidia, L., Pierini, M., Bellavista, E., et al. (2007) · Invertebrate survival journal · Cited by 1
Molecular mechanisms of aging in MTDNA mutator mice
Edgar, D. (2011) · Figshare · Cited by 1
Mitochondrial DNA mutations in the haematopoietic system
Taylor, R. W., He, L., Proctor, S., Middleton, P. G., & Turnbull, D. M. (2003) · Leukemia · doi:10.1038/sj.leu.2403208 · Cited by 1
Self-citationLieber, D. S. (2013) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 1
Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: Link to colon cancer?
Greaves, L. C., Mathers, J. C., Taylor, R. W., & Turnbull, D. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903000106 · Cited by 1
Self-citationMitochondrial hematology and oncology
Gattermann, N., & Zanssen, S. (2006) · CRC Press eBooks · doi:10.1201/b14623-12 · Cited by 1
Human genetic analyses of organelles highlight the nucleus in age-related trait heritabilityPreprint
Gupta, R., Karczewski, K. J., Howrigan, D., Neale, B. M., & Mootha, V. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.22.427431 · Cited by 2
Passman, A. M., Haughey, M. J., Carlotti, E., Williams, M. J., Cereser, B., Lin, M., Devkumar, S., Gabriel, J. P., Russo, F. P., Hoare, M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.02.450704 · Cited by 1
A Gut Reaction: Aging Affect Gut-Associated Immunity
Albright, J. F., & Albright, J. W. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-327-1_9 · Cited by 1
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing micePreprint
Kremer, L. S., Gao, G., Rigoni, G., Filograna, R., Mennuni, M., Wibom, R., Végvári, Á., Koolmeister, C., & Larsson, N. (2025) · eLife · doi:10.7554/elife.104461.1 · Cited by 1
Probabilistic cell lineage inference from mitochondrial mutationsPreprint
Seidel, S., Hård, J., Ferreira, P., Berkes, P., Jahn, K., Eriksson, C., Mold, J. E., Michaëlsson, J., Kuipers, J., & Beerenwinkel, N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.28.640740 · Cited by 2
Cancer Stem Cells in Colorectal Cancer
Biffoni, M., Fabrizi, E., & Ricci‐Vitiani, L. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-246-5_4
Mitochondrial Respiratory Function Decline in Aging and Life-Span Extension by Caloric Restriction
Wu, S., Wu, Y., Wang, C., Lee, W., & Wei, Y. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-602-3_7
The effects of mitochondrial DNA mutagenesis on somatic stem cells and ageing
Ahlqvist, K. J. (2015) · Työväentutkimus Vuosikirja
The developmental environment: implications for ageing and life span
Kirkwood, T. B. L. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544699.033
Self-citationThe Stem Cell Environment: Kinetics, Signaling and Markers
George, D. J., & Bryan, J. (2012) · InTech eBooks · doi:10.5772/28119
Effect of Dietary Restriction on Muscle Performance in Drosophila
Hsu, P. (2011) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Deciphering the transcriptional regulation code in colorectal cancer genome
Yan, J. (2014) · Figshare
Mitochondrial dysfunction in ageing and degenerative disease
Wredenberg, A. (2007) · Figshare
Strategies in Perforated Diverticulitis
Vermeulen, J. (2010)
Wharton, N. (2013) · UEA Digital Repository (University of East Anglia)
Reactive Oxygen Species Generation and Skeletal Muscle Wasting – Implications for Sarcopenia
McArdle, A., & Jackson, M. J. (2010) · Springer eBooks · doi:10.1007/978-90-481-9713-2_14
Treatment, follow-up and microbiota in acute diverticulitis
Daniels, L. (2015) · UvA-DARE (University of Amsterdam)
Random chromosome segregation in mouse intestinal epithelial stem cells
Legraverend, C., & Jay, P. (2013) · Chromosome Research · doi:10.1007/s10577-013-9351-2
Re: Mitochondria and Tumor Progression in Ulcerative Colitis
Jawad, N., Graham, T. A., McDonald, S. A. C., & Wright, N. A. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt436
Cell lineage tracing in the human pancreas
Engqvist, J. (2008) · Epsilon Archive for Student Projects (University of Southampton)
Mistakes Make History: Visualizing Intestinal Tectonics
Shibata, D. K. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.12.016
Mitochondrial DNA mutations. Brain developmental and ageing consequences, and possible treatments
Ross, J. M. (2012) · Figshare
Davenport, R. J. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.44.nw150
Computational Models of Mitochondrial DNA in Aging
Samuels, D. C. (2006) · Elsevier eBooks · doi:10.1016/b978-012369391-4/50049-7
Self-citationCidón, E. U., & Hickish, T. (2014) · Springer eBooks · doi:10.1007/978-94-017-8754-3_6
mtDNA Mutations in Brain Aging and Neurodegeneration
Krishnan, K. J., & Reeve, A. K. (2011) · Springer eBooks · doi:10.1007/978-0-85729-701-3_5
Mitochondrial Genome Rearrangements and Copy Number Changes in Cancer
Dakubo, G. D. (2010) · Springer eBooks · doi:10.1007/978-3-642-11416-8_8
The influence of aging on oocyte quality and the importance of mitochondria
Trull, K. (2014) · Digital Repository Service (Northeastern University) · doi:10.17760/d20005089
Metadata
- Authors
- Taylor, R. W., Barron, M. J., Borthwick, G. M., Gospel, A., Chinnery, P. F., Samuels, D. C., Taylor, G. A., Plusa, S. M., Needham, S. J., Greaves, L. C., Kirkwood, T. B. L., & Turnbull, D. M.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Turnbull, Douglass M.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2003-11-01
- Volume
- 112
- Issue
- 9
- Pages
- 1351-1360
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC228466
- OpenAlex
- W2158615962
- Cited by
- 530
- References
- 48
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 12 · 2023: 14 · 2022: 15 · 2021: 20 · 2020: 23 · 2019: 13 · 2018: 17 · 2017: 18 · 2016: 25 · 2015: 16 · 2014: 40 · 2013: 25 · 2012: 23
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust
- Cancer Research UK
- Medical Research Council
- Biotechnology and Biological Sciences Research Council (BEP17 042)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- mitochondrial DNA mutations, mitochondrial genome, electron transport chain, uniparental inheritance, mtDNA polymorphisms, aging, cancer, mutation frequency
- MeSH terms
- Aged, Aged, 80 and over, Colon, DNA Replication, DNA, Mitochondrial, Electron Transport, Humans, Mathematics, Middle Aged, Models, Genetic, Mutation, Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
