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C-reactive protein: a critical update
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“Via APPs, hepatocytes directly contribute to extracellular pathogen clearance via complement-mediated antigen opsonization [34–36].”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [35]
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Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354
Self-citationKöenig, W., Sund, M., Fröhlich, M., Fischer, H.-G., Löwel, H., Döring, A., Hutchinson, W. L., & Pepys, M. B. (1999) · Circulation · doi:10.1161/01.cir.99.2.237 · Cited by 1,952
Self-citationThompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses
Danesh, J. (2000) · BMJ · doi:10.1136/bmj.321.7255.199 · Cited by 1,692
Ridker, P. M., Rifai, N., Clearfield, M., Downs, J. R., Weis, S. E., Miles, J. S., & Gotto, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442601 · Cited by 1,557
Production of C-reactive protein and risk of coronary events in stable and unstable angina
Haverkate, E., Thompson, S. G., Pyke, S., Gallimore, J. R., & Mark B Pepys Group (1997) · The Lancet · doi:10.1016/s0140-6736(96)07591-5 · Cited by 1,511
Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein
Ridker, P. M., Rifai, N., Pfeffer, M. A., Sacks, F. M., & Braunwald, E. (1999) · Circulation · doi:10.1161/01.cir.100.3.230 · Cited by 1,471
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Research works printed but not linked: 4
- de Beer, 1982, Immunology., 45, 55
- Pepys, 1985, Int. Rev. Exp. Pathol., 27, 83
- Tracy, 1996, Circulation., 93, 622
- Danesh, 1998, J. Am. Coll. Cardiol., 279, 1477
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Hod, K., Dickman, R., Sperber, A., Melamed, S., Dekel, R., Ron, Y., Halpern, Z., Berliner, S., & Maharshak, N. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01788.x · Cited by 36
Bruch’s Membrane and the Choroid in Age-Related Macular Degeneration
Edwards, M., & Lutty, G. A. (2021) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-66014-7_4 · Cited by 32
Denard, J., Marolleau, B., Jenny, C., Rao, T. N., Fehling, H. J., Voit, T., & Svinartchouk, F. (2013) · Journal of Virology · doi:10.1128/jvi.01813-13 · Cited by 31
Sin, D. D., & Man, S. F. P. (2008) · Chest · doi:10.1378/chest.07-2085 · Cited by 25
C-reactive protein and the acute phase reaction in geriatric patients
Bertsch, T., Triebel, J., Bollheimer, C., Christ, M., Sieber, C., Fassbender, K., & Heppner, H. J. (2015) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-015-0938-4 · Cited by 24
Degree of gingivitis correlates to systemic inflammation parameters
Wohlfeil, M., Wehner, J., Schacher, B., Oremek, G. M., Sauer-Eppel, H., & Eickholz, P. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.11.017 · Cited by 23
Rajendran, S., Bobby, Z., Habeebullah, S., & Elizabeth Jacob, S. (2022) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2020.1722996 · Cited by 22
Suleri, A., Blok, E., Durkut, M., Rommel, A.-S., Witte, L. D., Jaddoe, V., Bergink, V., & White, T. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.03.018 · Cited by 18
New Clinical Markers Predictive of Cardiovascular Disease: The Role of Inflammatory Mediators
Rackley, C. E. (2004) · Cardiology in Review · doi:10.1097/01.crd.0000126083.86717.5b · Cited by 14
Inflammation Through a Psychoneuroimmunological Lens
Bennett, J. M., Gillie, B. L., Lindgren, M. E., Fagundes, C. P., & Kiecolt-Glaser, J. K. (2013) · Handbook of Systems and Complexity in Health · doi:10.1007/978-1-4614-4998-0_19 · Cited by 15
Tang, Z.-M., Yuan, P., Gao, N., Lei, J.-G., Ahmed, M., Hua, Y.-X., Yang, Z.-R., Li, Q.-Y., & Li, H.-Y. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.02.008 · Cited by 4
Factors for inhibition of early discharge from the psychiatric emergency ward for elderly patients
Adachi, S., Komiya, T., Nomura, K., & Shima, M. (2018) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-018-0738-8 · Cited by 3
Metadata
- Authors
- Pepys, M. B., & Hirschfield, G. M.
- Affiliations
- The Royal Free Hospital (GB)
- Corresponding author
- Pepys, Mark B.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-06-15
- Volume
- 111
- Issue
- 12
- Pages
- 1805-1812
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4232045253
- Cited by
- 3,436
- References
- 55
- Citations by year
- 2026: 188 · 2025: 161 · 2024: 149 · 2023: 198 · 2022: 247 · 2021: 210 · 2020: 218 · 2019: 192 · 2018: 179 · 2017: 178 · 2016: 154 · 2015: 165 · 2014: 163 · 2013: 130 · 2012: 141
- FWCI
- 24.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Funders
- Wellcome Trust
- Wolfson Foundation
- Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- C-reactive protein, acute phase response, inflammation, serum biomarkers, innate immunity
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