Cited by 3,436Biomarkers in Disease MechanismsAdipokines, Inflammation, and Metabolic DiseasesInflammation biomarkers and pathways

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C-reactive protein: a critical update

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Pepys, Mark B., Hirschfield, Gideon M.·2003·Journal of Clinical Investigation

DOI 10.1172/jci200318921

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C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
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Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354
Self-citation
C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men
Köenig, W., Sund, M., Fröhlich, M., Fischer, H.-G., Löwel, H., Döring, A., Hutchinson, W. L., & Pepys, M. B. (1999) · Circulation · doi:10.1161/01.cir.99.2.237 · Cited by 1,952
Self-citation
Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris
Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses
Danesh, J. (2000) · BMJ · doi:10.1136/bmj.321.7255.199 · Cited by 1,692
Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
Ridker, P. M., Rifai, N., Clearfield, M., Downs, J. R., Weis, S. E., Miles, J. S., & Gotto, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442601 · Cited by 1,557
Production of C-reactive protein and risk of coronary events in stable and unstable angina
Haverkate, E., Thompson, S. G., Pyke, S., Gallimore, J. R., & Mark B Pepys Group (1997) · The Lancet · doi:10.1016/s0140-6736(96)07591-5 · Cited by 1,511
Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein
Ridker, P. M., Rifai, N., Pfeffer, M. A., Sacks, F. M., & Braunwald, E. (1999) · Circulation · doi:10.1161/01.cir.100.3.230 · Cited by 1,471

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Tracy, 1996, Circulation., 93, 622
Danesh, 1998, J. Am. Coll. Cardiol., 279, 1477

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Authors: Pepys, M. B., & Hirschfield, G. M.
Affiliations: The Royal Free Hospital (GB)
Corresponding author: Pepys, Mark B.
ORCID: Pepys, Mark B.
Hirschfield, Gideon M.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2003-06-15
Volume: 111
Issue: 12
Pages: 1805-1812
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci200318921
OpenAlex: W4232045253
Cited by: 3,436
References: 55
Citations by year: 2026: 188 · 2025: 161 · 2024: 149 · 2023: 198 · 2022: 247 · 2021: 210 · 2020: 218 · 2019: 192 · 2018: 179 · 2017: 178 · 2016: 154 · 2015: 165 · 2014: 163 · 2013: 130 · 2012: 141
FWCI: 24.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Funders: Wellcome Trust
Wolfson Foundation
Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: C-reactive protein, acute phase response, inflammation, serum biomarkers, innate immunity

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