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Cited by 45Sleep and related disordersSleep and Wakefulness ResearchSleep and Work-Related Fatigue

The interactive effects of nocturnal sleep and daytime naps in relation to serum C-reactive protein

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Mantua, Janna, Spencer, Rebecca M.C.·2015·Sleep Medicine
DOI 10.1016/j.sleep.2015.06.014PMC PMC4592522
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Abstract

Background and aim C-reactive protein (CRP) is a general marker of inflammation that has been differentially linked with sleep. Elevated CRP (ie, high inflammation) has been associated with either short/insufficient sleep duration or long sleep duration, both, or neither. Daytime napping has also been tied to increased and decreased inflammation. We attempted to unify these findings by examining the relationship between CRP and sleep duration in conjunction with napping in a healthy young adult cohort.Participants Participants were young adults (mean age = 29.05 years, n = 2147) from the National Longitudinal Study of Adolescent Health (Add Health) cohort, a nationally representative longitudinal sample.Methods/results Analysis of covariance (ANCOVA) tests examined whether self-reported sleep duration (short, medium, or long) and nap frequency (none-few days/week; most days/week; every day) interacted in relation to CRP. Standard covariates (ie, age, gender, race/ethnicity, body mass index, physical activity, depression, snoring, systolic blood pressure, clinical symptoms, and household income) were used. There was a linear increase in CRP with increased napping [contrast estimate = 0.265, 95% confidence interval (CI) (0.045-0.485), P = 0.018]. There was also an interaction between sleep duration and napping frequency in relation to CRP (F4,2128 = 2.90, P = 0.021). Inflammation differed between nap groups within the long and short sleep groups.Conclusions Our results suggest that increased napping is an independent predictor of inflammation in young adults. These results also provide evidence for interactive effects of inflammation, nocturnal sleep, and daytime naps. Our findings confirm that excess sleep, insufficient sleep, frequent napping, and infrequent napping can all be linked with elevated CRP, but these relationships depend on both nocturnal and daytime sleep patterns. These analyses will guide future work to more specifically examine sleep-inflammation processes and directionality.

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  • In a young population of over 2,100 adolescents, increased napping was associated with elevated CRP.

    “An association between increased napping and elevated CRP has been also found in a young population of over 2,100 adolescents (358).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [358]

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Authors
Mantua, J., & Spencer, R. M. C.
Affiliations
University of Massachusetts Amherst (US)
Corresponding author
Spencer, Rebecca M.C.
ORCID
Spencer, Rebecca M.C.
Venue
Sleep Medicine
Publisher
Elsevier BV
Published
2015-10
Volume
16
Issue
10
Pages
1213-1216
ISSN
1389-9457 (ISSN-L)
DOI
10.1016/j.sleep.2015.06.014
PMC
PMC4592522
OpenAlex
W1858799106
Cited by
45
References
22
Citations by year
2025: 5 · 2024: 8 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4
FWCI
5.47
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Sleep Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (R01 AG040133)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01-HD31921)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
C-reactive protein, inflammation, sleep duration, daytime napping, short sleep duration, long sleep, young adults
MeSH terms
Adult, C-Reactive Protein, Female, Humans, Inflammation, Longitudinal Studies, Male, Sleep, Sleep Deprivation

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