Cited by 151Pancreatic function and diabetesMetabolism, Diabetes, and CancerDiabetes Management and Research

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Transgenic rescue of insulin receptor–deficient mice

Open access

Okamoto, Haruka, Nakae, Jun, Kitamura, Tadahiro, Park, Byung-Chul, Dragatsis, Ioannis, Accili, Domenico·2004·Journal of Clinical Investigation

DOI 10.1172/jci200421645PMC PMC449751

Open this paper in CoChat — free account Open PDF

Abstract

The role of different tissues in insulin action and their contribution to the pathogenesis of diabetes remain unclear.To examine this question, we have used genetic reconstitution experiments in mice.Genetic ablation of insulin receptors causes early postnatal death from diabetic ketoacidosis.We show that combined restoration of insulin receptor function in brain, liver, and pancreatic β cells rescues insulin receptor knockout mice from neonatal death, prevents diabetes in a majority of animals, and normalizes adipose tissue content, lifespan, and reproductive function.In contrast, mice with insulin receptor expression limited to brain or liver and pancreatic β cells are rescued from neonatal death, but develop lipoatrophic diabetes and die prematurely.These data indicate, surprisingly, that insulin receptor signaling in noncanonical insulin target tissues is sufficient to maintain fuel homeostasis and prevent diabetes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci200421645

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R., Klein, R., & Schütz, G. (1999) · Nature Genetics · doi:10.1038/12703 · Cited by 1,841
Disruption of IRS-2 causes type 2 diabetes in mice
Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,276
A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
Brüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., & Kahn, C. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80155-0 · Cited by 1,173
Self-citation
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
Kulkarni, R., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., & Kahn, C. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80546-2 · Cited by 1,148
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904

Show all 49 references

Research works printed but not linked: 1

Barrett, 2003, J. Clin. Invest., 111, 434

Sorted by citations

Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Diabetes, Obesity, and the Brain
Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841
Mechanisms of obesity-associated insulin resistance: many choices on the menuPreprint
Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 797
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
Fulzele, K. S., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., Monier‐Faugere, M., Aja, S. M., Hussain, M. A., Brüning, J. C., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.002 · Cited by 768
FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes
Biddinger, S. B., & Kahn, C. R. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124723 · Cited by 714
Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans
Kullmann, S., Heni, M., Hallschmid, M., Fritsche, A., Preissl, H. T., & Häring, H. (2016) · Physiological Reviews · doi:10.1152/physrev.00032.2015 · Cited by 654
Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms
Guo, S. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 648
Impaired Regulation of Hepatic Glucose Production in Mice Lacking the Forkhead Transcription Factor Foxo1 in Liver
Matsumoto, M., Pocai, A., Rossetti, L., DePinho, R. A., & Accili, D. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.006 · Cited by 624
Self-citation
FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction
Kitamura, Y., Kitamura, T., Kruse, J.-P., Raum, J. C., Stein, R. W., Gu, W. J., & Accili, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.08.004 · Cited by 565
Self-citation
Insulin resistance and pancreatic cell failure
Kasuga, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29189 · Cited by 433
Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility
Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.002 · Cited by 391
First-in-human Phase I study of Pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors
Sarker, D., Ang, J., Baird, R., Kristeleit, R., Shah, K., Moreno, V., Clarke, P., Raynaud, F., Levy, G., Ware, J., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0947 · Cited by 285
Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338
Pancreatic signals controlling food intake; insulin, glucagon and amylin
Woods, S. C., Lutz, T. A., Geary, N., & Langhans, W. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1858 · Cited by 301
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions
Han, S., Liang, C.-P., Seimon, T. A., Ranalletta, M., Welch, C. L., Collins-Fletcher, K., Accili, D., Tabas, I. A., & Tall, A. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.008 · Cited by 278
Self-citation
Insulin receptor and cancer
Belfiore, A., & Malaguarnera, R. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0074 · Cited by 272
Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus
Rachdaoui, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051770 · Cited by 294
Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue
Rosa, S. C. D. S., Nayak, N., Caymo, A. M., & Gordon, J. W. (2020) · Physiological Reports · doi:10.14814/phy2.14607 · Cited by 271
Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition
Veldhuis, J. D., Roemmich, J. N., Richmond, E. J., & Bowers, C. Y. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0006 · Cited by 236
Central nervous pathways of insulin action in the control of metabolism and food intake
Kullmann, S., Kleinridders, A., Small, D. M., Fritsche, A., Häring, H.-U., Preissl, H., & Heni, M. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30113-3 · Cited by 233
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
Dong, X. C., Park, S., Lin, X., Copps, K. D., Yi, X., & White, M. F. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25735 · Cited by 239
Contribution of Insulin and Akt1 Signaling to Endothelial Nitric Oxide Synthase in the Regulation of Endothelial Function and Blood Pressure
Symons, J. D., McMillin, S. L., Riehle, C., Tanner, J. M., Palionyte, M., Hillas, E., Jones, D., Cooksey, R. C., Birnbaum, M. J., McClain, D. A., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.189316 · Cited by 213
Glucose regulation of insulin gene expression in pancreatic β-cells
Andrali, S. S., Sampley, M. L., Vanderford, N. L., & Özcan, S. (2008) · Biochemical Journal · doi:10.1042/bj20081029 · Cited by 213
Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies
Gerozissis, K. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.050 · Cited by 204
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic β-cell mass
Buteau, J., Spatz, M. L., & Accili, D. (2006) · Diabetes · doi:10.2337/db05-0825 · Cited by 178
Self-citation
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes
Gelling, R. W., Morton, G. J., Morrison, C. D., Niswender, K. D., Myers, M. G., Rhodes, C. J., & Schwartz, M. W. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.013 · Cited by 169
Generation of functional insulin-producing cells in the gut by Foxo1 ablation
Talchai, S. C., Xuan, S., Kitamura, T., DePinho, R. A., & Accili, D. (2012) · Nature Genetics · doi:10.1038/ng.2215 · Cited by 173
Self-citation
Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta
Rudic, R. D., McNamara, P., Reilly, D., Grosser, T., Curtis, A.-M., Price, T. S., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2005) · Circulation · doi:10.1161/circulationaha.105.568626 · Cited by 157
Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons
Lin, H. V., Plum, L., Ono, H., Juárez, R. G., Shanabrough, M., Borók, E., Horváth, T. L., Rossetti, L., & Accili, D. (2009) · Diabetes · doi:10.2337/db09-1303 · Cited by 162
Self-citation
The Macrophage at the Crossroads of Insulin Resistance and Atherosclerosis
Liang, C.-P., Han, S., Senokuchi, T., & Tall, A. R. (2007) · Circulation Research · doi:10.1161/circresaha.107.152165 · Cited by 143
Getting the message across: mechanisms of physiological cross talk by adipose tissue
Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 140
Leptin Rapidly Improves Glucose Homeostasis in Obese Mice by Increasing Hypothalamic Insulin Sensitivity
Koch, C. E., Augustine, R. A., Steger, J., Ganjam, G. K., Benzler, J., Pracht, C., Lowe, C., Schwartz, M. W., Shepherd, P. R., Anderson, G. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3202-10.2010 · Cited by 139
Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes
Tiwari, S., Riazi, S., & ECELBARGER, C. A. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00149.2007 · Cited by 128
Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance
Benzler, J., Ganjam, G. K., Pretz, D., Oelkrug, R., Koch, C. E., Legler, K., Stöhr, S., Culmsee, C., Williams, L. M., & Tups, A. (2015) · Diabetes · doi:10.2337/db14-0093 · Cited by 129
Role of the forkhead protein FoxO1 in cell compensation to insulin resistance
Okamoto, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24967 · Cited by 127
Self-citation
Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
Okamoto, H., Obici, S., Accili, D., & Rossetti, L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23096 · Cited by 121
Self-citation
Mechanisms of Lipotoxicity in the Cardiovascular System
Wende, A. R., Symons, J. D., & Abel, E. D. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0307-2 · Cited by 110
Hypothalamic leptin regulation of energy homeostasis and glucose metabolism
Morton, G. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135590 · Cited by 114
PPARα mediates the hypolipidemic action of fibrates by antagonizing FoxO1
Qu, S., Su, D., Altomonte, J., Kamagaté, A., He, J., Perdomo, G., Tse, T. E., Jiang, Y., & Dong, H. H. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00157.2006 · Cited by 113
Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial
Kullmann, S., Hummel, J., Wagner, R. J., Dannecker, C., Vosseler, A., Fritsche, L., Veit, R., Kantartzis, K., Machann, J., Birkenfeld, A. L., et al. (2021) · Diabetes Care · doi:10.2337/dc21-1136 · Cited by 112
Lipotoxicity contributes to endothelial dysfunction: A focus on the contribution from ceramide
Symons, J. D., & Abel, E. D. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9235-3 · Cited by 112
Adipose tissue and reproductive health
Mathew, H., Castracane, V. D., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.006 · Cited by 109
Bone Cell Bioenergetics and Skeletal Energy Homeostasis
Riddle, R. C., & Clemens, T. L. (2017) · Physiological Reviews · doi:10.1152/physrev.00022.2016 · Cited by 108
Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons
Mayer, C., & Belsham, D. D. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.02.031 · Cited by 103
Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells
Tanaka, J., Qiang, L., Banks, A. S., Welch, C. L., Matsumoto, M., Kitamura, T., Ido-Kitamura, Y., DePinho, R. A., & Accili, D. (2009) · Diabetes · doi:10.2337/db09-0167 · Cited by 97
Self-citation
Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice
Han, S., Liang, C.-P., Westerterp, M., Senokuchi, T., Welch, C. L., Wang, Q., Matsumoto, M., Accili, D., & Tall, A. R. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36523 · Cited by 97
Self-citation
Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese
Kullmann, S., Goj, T., Veit, R., Fritsche, L., Wagner, L., Schneeweiß, P., Hoene, M., Hoffmann, C., Machann, J., Niess, A. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.161498 · Cited by 97
Androgen Receptor (AR) Pathophysiological Roles in Androgen Related Diseases in Skin, Metabolism Syndrome, Bone/Muscle and Neuron/Immune Systems: Lessons Learned from Mice Lacking AR in Specific Cells
Chang, C., Yeh, S., Lee, S. O., & Chang, T. (2013) · Nuclear Receptor Signaling · doi:10.1621/nrs.11001 · Cited by 92
Metabolic Diapause in Pancreatic β-Cells Expressing a Gain-of-function Mutant of the Forkhead Protein Foxo1
Buteau, J., Shlien, A., Foisy, S., & Accili, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606118200 · Cited by 90
Self-citation
The new biology of diabetes
Pajvani, U. B., & Accili, D. (2015) · Diabetologia · doi:10.1007/s00125-015-3722-5 · Cited by 92
Self-citation
Novel functions for insulin in bone
Fulzele, K. S., & Clemens, T. L. (2011) · Bone · doi:10.1016/j.bone.2011.06.018 · Cited by 92
Adiponectin Resistance Exacerbates Insulin Resistance in Insulin Receptor Transgenic/Knockout Mice
Lin, H. V., Kim, J., Pocai, A., Rossetti, L., Shapiro, L. S., Scherer, P. E., & Accili, D. (2007) · Diabetes · doi:10.2337/db07-0127 · Cited by 92
Self-citation
Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis
Berná, G., Oliveras‐López, M., Jurado‐Ruiz, E., Tejedo, J. R., Bedoya, F. J., Soria, B., & Martı́n, F. (2014) · Nutrients · doi:10.3390/nu6115338 · Cited by 95
Gut–Brain Axis: Regulation of Glucose Metabolism
Heijboer, A. C., Pijl, H., van den Hoek, A. M., Havekes, L. M., Romijn, J. A., & Corssmit, E. P. M. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01492.x · Cited by 91
Hormonal regulation of the hypothalamic melanocortin system
Kim, J. D., Leyva, S., & Diano, S. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00480 · Cited by 88
Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators
Bedinger, D., & Adams, S. H. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.013 · Cited by 85
Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival
Malakar, P., Chartarifsky, L., Hija, A., Leibowitz, G., Gläser, B., Dor, Y., & Karni, R. (2016) · Scientific Reports · doi:10.1038/srep31222 · Cited by 82
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease
Dongiovanni, P., Meroni, M., Baselli, G., Bassani, G. A., Rametta, R., Pietrelli, A., Maggioni, M., Facciotti, F., Trunzo, V., Badiali, S., et al. (2017) · Clinical Science · doi:10.1042/cs20170175 · Cited by 77
β-Cell Hyperplasia Induced by Hepatic Insulin Resistance
Escribano, Ó., Guillén, C., Nevado, C., Gómez‐Hernández, A., Kahn, C. R., & Benito, M. (2009) · Diabetes · doi:10.2337/db08-0551 · Cited by 73
Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism
Benzler, J., Ganjam, G. K., Krüger, M., Pinkenburg, O., Kutschke, M., Stöhr, S., Steger, J., Koch, C. E., Oelkrug, R., Schwartz, M. W., et al. (2012) · Biochemical Journal · doi:10.1042/bj20120834 · Cited by 70
Androgen Receptor Roles in Insulin Resistance and Obesity in Males: The Linkage of Androgen-Deprivation Therapy to Metabolic Syndrome
Yu, I.-C. I., Lin, H., Sparks, J. D., Yeh, S., & Chang, C. (2014) · Diabetes · doi:10.2337/db13-1505 · Cited by 71
Normal Bone Density Obtained in the Absence of Insulin Receptor Expression in Bone
Irwin, R., Lin, H. V., Motyl, K. J., & McCabe, L. R. (2006) · Endocrinology · doi:10.1210/en.2006-0700 · Cited by 69
Genetic and biochemical pathways of β‐cell failure in type 2 diabetes
Talchai, S. C., Lin, H. V., Kitamura, T., & Accili, D. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01115.x · Cited by 60
Self-citation
Acute effects of insulin on beta-cells from transplantable human islets
Luciani, D. S., & Johnson, J. D. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.06.006 · Cited by 60
Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues
Lin, H. V., Ren, H., Samuel, V. T., Lee, H., Lu, T. Y., Shulman, G. I., & Accili, D. (2011) · Diabetes · doi:10.2337/db10-1056 · Cited by 59
Self-citation
New aspects of melanocortin signaling: A role for PRCP in α-MSH degradation
Diano, S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.09.001 · Cited by 61
Molecular basis of insulin resistance: the role of IRS and Foxo1 in the control of diabetes mellitus and its complications
Guo, S. (2013) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2013.06.003 · Cited by 56
Novel phenotypes of prediabetes?
Häring, H. (2016) · Diabetologia · doi:10.1007/s00125-016-4015-3 · Cited by 54
The Effect of Insulin Signaling on Female Reproductive Function Independent of Adiposity and Hyperglycemia
Nandi, A. A., Wang, X., Accili, D., & Wolgemuth, D. J. (2010) · Endocrinology · doi:10.1210/en.2009-0788 · Cited by 50
Self-citation
Mouse models created to study the pathophysiology of Type 2 diabetes
LeRoith, D., & Gavrilova, O. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.01.019 · Cited by 51
Transgenic and Knockout Mice in Diabetes Research: Novel Insights into Pathophysiology, Limitations, and Perspectives
Plum, L., Wunderlich, F. T., Baudler, S., Krone, W., & Brüning, J. C. (2005) · Physiology · doi:10.1152/physiol.00049.2004 · Cited by 51
Diabetes and the Female Reproductive System
Nandi, A. A., & Poretsky, L. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.07.007 · Cited by 49
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
Skovsø, S., Panzhinskiy, E., Kolic, J., Cen, H. H., Dionne, D. A., Dai, X.-Q., Sharma, R. B., Elghazi, L., Ellis, C. E., Faulkner, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28039-8 · Cited by 48
Control of pancreatic β-cell fate by insulin signaling: The sweet spot hypothesis
Johnson, J. D., & Alejandro, E. U. (2008) · Cell Cycle · doi:10.4161/cc.7.10.5865 · Cited by 42
Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2
Gao, Y., Liu, C., Wan, G., Wang, X., Cheng, X., & Ou, Y. (2016) · Food & Function · doi:10.1039/c5fo01548k · Cited by 43
Recent Progress in Metabolic Signaling Pathways Regulating Aging and Life Span
Newgard, C. B., & Pessin, J. E. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu058 · Cited by 44
Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms
Fullmer, T. M., Pei, S., Zhu, Y., Sloan, C., Manzanares, R., Henrie, B., Pires, K. M. P., Cox, J. E., Abel, E. D., & Boudina, S. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.08.005 · Cited by 43
Insulin and glucagon signaling in the central nervous system
Filippi, B., Abraham, M. A., Yue, J. T. Y., & Lam, T. K. T. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9258-4 · Cited by 43
The brain–adipose axis: A review of involvement of molecules
Shimizu, H., & Mori, M. (2005) · Nutritional Neuroscience · doi:10.1080/10284150500047245 · Cited by 40
Neurotransmitters in Type 2 Diabetes and the Control of Systemic and Central Energy Balance
Al-Sayyar, A., Hammad, M. M., Williams, M. R., Al‐Onaizi, M., Abubaker, J. A., & Alzaïd, F. (2023) · Metabolites · doi:10.3390/metabo13030384 · Cited by 45
Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver
Visinoni, S., Fam, B. C., Blair, A. R., Rantzau, C., Lamont, B. J., Bouwman, R. D., Watt, M. J., Proietto, J., Favaloro, J. M., & Andrikopoulos, S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90552.2008 · Cited by 39
mir-101-3p Downregulation Promotes Fibrogenesis by Facilitating Hepatic Stellate Cell Transdifferentiation During Insulin Resistance
Meroni, M., Longo, M., Erconi, V., Valenti, L. V. C., Gatti, S., Fracanzani, A. L., & Dongiovanni, P. (2019) · Nutrients · doi:10.3390/nu11112597 · Cited by 38
Use of mouse models in studying type 2 diabetes mellitus
Lee, A., & Cox, R. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001729 · Cited by 37
Cross-talk between metabolism and reproduction: the role of POMC and SF1 neurons
Xu, Y. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00098 · Cited by 36
Glucokinase Regulates Reproductive Function, Glucocorticoid Secretion, Food Intake, and Hypothalamic Gene Expression
Yang, X.-J., Mastaitis, J. W., Mizuno, T. M., & Mobbs, C. V. (2007) · Endocrinology · doi:10.1210/en.2006-1312 · Cited by 34
Restoration of insulin receptor improves diabetic phenotype in T2DM mice
Wang, Y., Zhou, H. H., Palyha, O. C., & Mu, J. (2019) · JCI Insight · doi:10.1172/jci.insight.124945 · Cited by 36
Effects of phycocyanin on INS-1 pancreatic β-cell mediated by PI3K/Akt/FoxO1 signaling pathway
Gao, Y., Liao, G., Xiang, C., Yang, X., Cheng, X., & Ou, Y. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.11.054 · Cited by 32
Acute Inhibition of Central c‐Jun N‐terminal Kinase Restores Hypothalamic Insulin Signalling and Alleviates Glucose Intolerance in Diabetic Mice
Benzler, J., Ganjam, G. K., Legler, K., Stöhr, S., Krüger, M., Steger, J., & Tups, A. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12018 · Cited by 31
Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan
Merry, T. L., Kuhlow, D., Laube, B., Pöhlmann, D., Pfeiffer, A. F. H., Kahn, C. R., Ristow, M., & Zarse, K. (2017) · Aging Cell · doi:10.1111/acel.12610 · Cited by 30
The dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signalling
Koch, C. E., Ganjam, G. K., Steger, J., Legler, K., Stöhr, S., Schumacher, D., Hoggard, N., Heldmaier, G., & Tups, A. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003005 · Cited by 30
Prenatal testosterone exposure decreases colocalization of insulin receptors in kisspeptin/neurokinin B/dynorphin and agouti‐related peptide neurons of the adult ewe
Cernea, M., Phillips, R., Padmanabhan, V., Coolen, L. M., & Lehman, M. N. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13373 · Cited by 28
Hormonal Signaling Systems of the Brain in Diabetes Mellitus
Shpakov, A. O., Chistyakova, O. V., Derkach, K. V., & Bondarev, V. (2011) · InTech eBooks · doi:10.5772/28930 · Cited by 28
Actin Disorganization Plays a Vital Role in Impaired Embryonic Development of In Vitro-Produced Mouse Preimplantation Embryos
Tan, K., An, L., Wang, S., Wang, X., Zhang, Z., Miao, K., Sui, L., He, S.-Z., Nie, J.-Z., Wu, Z., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130382 · Cited by 27
Maternal vitamin D-restricted diet has consequences in the formation of pancreatic islet/insulin-signaling in the adult offspring of mice
Ceciliano, T. C., Vianna, A. R. D. C. B., Barbosa‐da‐Silva, S., Águila, M. B., Faria, T. D. S., & Mandarim‐de‐Lacerda, C. A. (2016) · Endocrine · doi:10.1007/s12020-016-0973-y · Cited by 23
Women with Type 1 diabetes (T1D) experience a shorter reproductive period compared with nondiabetic women: the Pittsburgh Epidemiology of Diabetes Complications (EDC) study and the Study of Women's Health Across the Nation (SWAN)
Yi, Y., Khoudary, S. R. E., Buchanich, J. M., Miller, R. G., Rubinstein, D., Matthews, K. A., Orchard, T. J., & Costacou, T. (2021) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001758 · Cited by 22
Genetic Rodent Models of Obesity-Associated Ovarian Dysfunction and Subfertility: Insights into Polycystic Ovary Syndrome
Huang‐Doran, I., & Franks, S. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00053 · Cited by 23
n-3 Fatty Acids Decrease Arterial Low-Density Lipoprotein Cholesterol Delivery and Lipoprotein Lipase Levels in Insulin-Resistant Mice
Chang, C. L., Seo, T., Du, C. B., Accili, D., & Deckelbaum, R. J. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.215848 · Cited by 22
Self-citation
Reconstitution of Insulin Action in Muscle, White Adipose Tissue, and Brain of Insulin Receptor Knock-out Mice Fails to Rescue Diabetes
Lin, H. V., & Accili, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.210807 · Cited by 19
Self-citation
Mechanisms of Vascular Insulin Resistance
Fulton, D. J. (2009) · Circulation Research · doi:10.1161/circresaha.109.198028 · Cited by 19
Minireview: Metabolic Control of the Reproductive Physiology: insights from genetic mouse models
Bellefontaine, N., & Elias, C. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.04.007 · Cited by 15

Authors: Okamoto, H., Nakae, J., Kitamura, T., Park, B.-C., Dragatsis, I., & Accili, D.
Affiliations: Columbia University Irving Medical Center (US)
Columbia University (US)
Corresponding author: Accili, Domenico
ORCID: Okamoto, Haruka
Kitamura, Tadahiro
Dragatsis, Ioannis
Accili, Domenico
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2004-07-15
Volume: 114
Issue: 2
Pages: 214-223
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci200421645
PMC: PMC449751
OpenAlex: W1982060139
Cited by: 151
References: 49
Citations by year: 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 9 · 2013: 10 · 2012: 14
FWCI: 10.42
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (DK58282, DK63608)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK057539, DK63608, R01DK058282, R37DK058282, DK58282, DK 57539, P30DK063608)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: insulin receptor, transgenic rescue, diabetic ketoacidosis, neonatal lethality, lipoatrophic diabetes, fuel homeostasis, adipose tissue, pancreatic beta cells, brain insulin signaling, lifespan, reproductive function
MeSH terms: Adipose Tissue, Animals, Animals, Newborn, Body Weight, Brain, Glucose, Insulin, Islets of Langerhans, Liver, Mice, Transgenic, Receptor, Insulin, Tissue Distribution, Signal Transduction, Mice, Knockout, Transgenes, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Transgenic rescue of insulin receptor–deficient mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks