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Cited by 712Ovarian function and disordersReproductive Biology and FertilityReproductive Physiology in Livestock

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Androgens stimulate early stages of follicular growth in the primate ovary

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Vendola, K A, Zhou, J, Adesanya, O O, Weil, S J, Bondy, C A·1998·Journal of Clinical Investigation
DOI 10.1172/jci2081PMC PMC508852
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Abstract

The concept that androgens are atretogenic, derived from murine ovary studies, is difficult to reconcile with the fact that hyperandrogenic women have more developing follicles than normal-cycling women. To evaluate androgen's effects on primate follicular growth and survival, normal-cycling rhesus monkeys were treated with placebo-, testosterone-(T), or dihydrotestosterone-sustained release implants, and ovaries were taken for histological analysis after 3-10 d of treatment. Growing preantral and small antral follicles up to 1 mm in diameter were significantly and progressively increased in number and thecal layer thickness in T-treated monkeys from 3-10 d. Granulosa and thecal cell proliferation, as determined by immunodetection of the Ki67 antigen, were significantly increased in these follicles. Preovulatory follicles (> 1 mm), however, were not increased in number in androgen-treated animals. Follicular atresia was not increased and there were actually significantly fewer apoptotic granulosa cells in the T-treated groups. Dihydrotestosterone treatment had identical effects, indicating that these growth-promoting actions are mediated by the androgen receptor. These findings show that, over the short term at least, androgens are not atretogenic and actually enhance follicular growth and survival in the primate. These new data provide a plausible explanation for the pathogenesis of "polycystic" ovaries in hyperandrogenism.

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Crossref · 10.1172/jci2081

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Metadata

Authors
Vendola, K. A., Zhou, J., Adesanya, O. O., Weil, S. J., & Bondy, C. A.
Affiliations
National Institutes of Health (US)
ORCID
Zhou, J
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1998-06-15
Volume
101
Issue
12
Pages
2622-2629
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci2081
PMC
PMC508852
OpenAlex
W2114124243
Cited by
712
References
33
Citations by year
2026: 12 · 2025: 10 · 2024: 19 · 2023: 17 · 2022: 22 · 2021: 44 · 2020: 24 · 2019: 33 · 2018: 31 · 2017: 61 · 2016: 26 · 2015: 51 · 2014: 38 · 2013: 40 · 2012: 40
FWCI
7.09
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
Keywords
androgens, folliculogenesis, follicular atresia, rhesus monkeys, testosterone, dihydrotestosterone, androgen receptor, granulosa cell proliferation, Ki-67, apoptosis, preantral follicles, polycystic ovary syndrome, hyperandrogenism, ovary
MeSH terms
Androgens, Animals, Cell Count, Cell Division, Female, Ovarian Follicle, Macaca mulatta, Organ Size, Ovary, Cell Death

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