The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Androgens stimulate early stages of follicular growth in the primate ovary
Open accessAbstract
The concept that androgens are atretogenic, derived from murine ovary studies, is difficult to reconcile with the fact that hyperandrogenic women have more developing follicles than normal-cycling women. To evaluate androgen's effects on primate follicular growth and survival, normal-cycling rhesus monkeys were treated with placebo-, testosterone-(T), or dihydrotestosterone-sustained release implants, and ovaries were taken for histological analysis after 3-10 d of treatment. Growing preantral and small antral follicles up to 1 mm in diameter were significantly and progressively increased in number and thecal layer thickness in T-treated monkeys from 3-10 d. Granulosa and thecal cell proliferation, as determined by immunodetection of the Ki67 antigen, were significantly increased in these follicles. Preovulatory follicles (> 1 mm), however, were not increased in number in androgen-treated animals. Follicular atresia was not increased and there were actually significantly fewer apoptotic granulosa cells in the T-treated groups. Dihydrotestosterone treatment had identical effects, indicating that these growth-promoting actions are mediated by the androgen receptor. These findings show that, over the short term at least, androgens are not atretogenic and actually enhance follicular growth and survival in the primate. These new data provide a plausible explanation for the pathogenesis of "polycystic" ovaries in hyperandrogenism.
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Regulation of ovarian follicular development in primates: facts and hypotheses
GOUGEON, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-121 · Cited by 1,497
Gerdes, J., Li, L., Schlueter, C. J., Duchrow, M., Wohlenberg, C., Gerlach, C., Stahmer, I., Kloth, S., Brandt, E., & Flad, H. D. (1991) · PubMed Central · Cited by 894
Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis.
Billig, H., Furuta, I., & Hsueh, A. J. W. (1993) · Endocrinology · doi:10.1210/endo.133.5.8404672 · Cited by 556
Morphology and Morphogenesis of the Stein-Leventhal Ovary and of So-called “Hyperthecosis”
Hughesdon, P. E. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198202000-00001 · Cited by 429
Weil, S. J., Vendola, K., Zhou, J., Adesanya, O. O., Wang, J., Okafor, J., & Bondy, C. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.7.4917 · Cited by 359
Self-citationSchmitz, G. G., Walter, T., Seibl, R., & Keßler, C. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90212-c · Cited by 318
MacDougall, M. J., Tan, S. L., Balen, A. H., & Jacobs, H. S. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138029 · Cited by 240
Dunaif, A. E. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80057-6 · Cited by 235
Spinder, T., Spijkstra, J. J., van den Tweel, J. G., Burger, C. W., van Kessel, H. I., Hompes, P. G. A., & Gooren, L. J. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-1-151 · Cited by 206
Pache, T. D., Chadha, S., Gooren, L. J., Hop, W. C. J., JAARSMA, K. W., Dommerholt, H. B. R., & Fauser, B. C. J. M. (1991) · Histopathology · doi:10.1111/j.1365-2559.1991.tb00235.x · Cited by 194
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Initial and cyclic recruitment of ovarian follicles
McGee, E. A., & Hsueh, A. J. W. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0394 · Cited by 1,771
Rosenfield, R. L., & Ehrmann, D. A. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1104 · Cited by 1,603
Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61345-2 · Cited by 1,360
Franks, S. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.77.1.89 · Cited by 802
Anti-Mullerian hormone: a new marker for ovarian function
Visser, J. A., de Jong, F. H., Laven, J. S. E., & Themmen, A. P. N. (2005) · Reproduction · doi:10.1530/rep.1.00529 · Cited by 801
Metadata
- Authors
- Vendola, K. A., Zhou, J., Adesanya, O. O., Weil, S. J., & Bondy, C. A.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Zhou, J
- Venue
- Journal of Clinical Investigation
- Published
- 1998-06-15
- Volume
- 101
- Issue
- 12
- Pages
- 2622-2629
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC508852
- OpenAlex
- W2114124243
- Cited by
- 712
- References
- 33
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 19 · 2023: 17 · 2022: 22 · 2021: 44 · 2020: 24 · 2019: 33 · 2018: 31 · 2017: 61 · 2016: 26 · 2015: 51 · 2014: 38 · 2013: 40 · 2012: 40
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Keywords
- androgens, folliculogenesis, follicular atresia, rhesus monkeys, testosterone, dihydrotestosterone, androgen receptor, granulosa cell proliferation, Ki-67, apoptosis, preantral follicles, polycystic ovary syndrome, hyperandrogenism, ovary
- MeSH terms
- Androgens, Animals, Cell Count, Cell Division, Female, Ovarian Follicle, Macaca mulatta, Organ Size, Ovary, Cell Death
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