Androgens Promote Oocyte Insulin-Like Growth Factor I Expression and Initiation of Follicle Development in the Primate Ovary1
Abstract
In the study reported here, we investigated the effect of androgens on recruitment of resting, primordial follicles into the actively growing pool. Healthy, random-cycling female rhesus monkeys were treated with testosterone, dihydrotestosterone (DHT), or vehicle for 3-10 days, after which ovaries were collected for histological analysis. The first stage of follicle growth is the formation of the primary follicle, consisting of an oocyte surrounded by a single layer of cuboidal granulosa cells. The number of primary follicles was significantly increased over time in testosterone-treated animals. In situ hybridization showed that androgen treatment resulted in an increase to 3-fold in insulin-like growth factor I (IGF-I) and to 5-fold in IGF-I receptor mRNA in primordial follicle oocytes. DHT effects were comparable to those of testosterone, showing that these are androgen receptor-mediated phenomena. These data show that androgens promote initiation of primordial follicle growth and implicate oocyte-derived IGF-I in this activation process.
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Several recent publications support a role for androgens in the stimulation of follicular growth in primates through amplification of FSH receptor gene expression.
“Several recent publications support a role for androgens in the stimulation of follicular growth in primates through amplification of FSH receptor gene expression (22)(23)(24).”
From A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women (2002) · cites this paper as [23]
Testosterone augments follicular FSH receptor expression in primates.
“Testosterone was found to augment follicular FSH receptor expression in primates suggesting that follicular growth may be improved by amplification of FSH effects (18 -20).”
From Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders (2002) · cites this paper as [19]
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- Authors
- Vendola, K., Zhou, J., Wang, J., Famuyiwa, O. A., Bievre, M., & Bondy, C. A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Bondy, Carolyn A.
- ORCID
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08-01
- Volume
- 61
- Issue
- 2
- Pages
- 353-357
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2122893492
- Cited by
- 324
- References
- 26
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 13 · 2021: 16 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 9 · 2016: 14 · 2015: 21 · 2014: 19 · 2013: 16 · 2012: 19
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- androgens, insulin-like growth factor I, IGF-1 receptor, primordial follicles, folliculogenesis, oocytes, testosterone, dihydrotestosterone, androgen receptor, rhesus monkeys, ovary
- MeSH terms
- Androgens, Animals, Female, Ovarian Follicle, Insulin-Like Growth Factor I, Macaca mulatta, Oocytes, RNA, Messenger, Dihydrotestosterone, Testosterone, Receptor, IGF Type 1
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