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Human RORγt + T H 17 cells preferentially differentiate from naive FOXP3 + Treg in the presence of lineage-specific polarizing factors

Valmori, D., Raffin, C., Raimbaud, I., & Ayyoub, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008247107 · Cited by 159 · see citing works

Distinctive role of CCR7 in migration and functional activity of naive‐ and effector/memory‐like Treg subsets

Menning, A., Höpken, U. E., Siegmund, K., Lipp, M., Hamann, A., & Huehn, J. (2007) · European Journal of Immunology · doi:10.1002/eji.200737201 · Cited by 160 · see citing works

CXCR3+ T Regulatory Cells Selectively Accumulate in Human Ovarian Carcinomas to Limit Type I Immunity

Redjimi, N., Raffin, C., Raimbaud, I., Pignon, P., Matsuzaki, J., Odunsi, K. O., Valmori, D., & Ayyoub, M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0579 · Cited by 153 · see citing works

Disturbed regulatory T cell homeostasis in multiple sclerosis

Venken, K., Hellings, N., Liblau, R., & Stinissen, P. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.12.003 · Cited by 149 · see citing works

TNF Activates a NF-κB–Regulated Cellular Program in Human CD45RA– Regulatory T Cells that Modulates Their Suppressive Function

Nagar, M., Jacob‐Hirsch, J., Vernitsky, H., Berkun, Y., Ben‐Horin, S., Amariglio, N., Bank, I., Kloog, Y., Rechavi, G., & Goldstein, I. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902070 · Cited by 150 · see citing works

Human blood T fr cells are indicators of ongoing humoral activity not fully licensed with suppressive function

Fonseca, V. R., Agua‐Doce, A., Maceiras, A. R., Pierson, W., Ribeiro, F., Romão, V. C., Pires, A. R., Silva, S. L., Fonseca, J. E., Sousa, A. E., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan1487 · Cited by 150 · see citing works

HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses

Owen, R. E., Heitman, J. W., Hirschkorn, D. F., Lanteri, M. C., Biswas, H. H., Martin, J. N., Krone, M., Deeks, S. G., & Norris, P. J. (2010) · AIDS · doi:10.1097/qad.0b013e3283377a1e · Cited by 141 · see citing works

Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Associated with Reduction of CD4+CD25+ Regulatory T Cells

Yan, H., Takamoto, M., & Sugane, K. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10829 · Cited by 141 · see citing works

Low number of regulatory T cells in skin lesions of patients with cutaneous lupus erythematosus

Franz, B., Fritzsching, B., Riehl, A., Oberle, N., Klemke, C. ‐., Sýkora, J., Quick, S., Stumpf, C., Hartmann, M., Enk, A., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22699 · Cited by 138 · see citing works

Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells

Hirakawa, M., Matos, T. R., Liu, H., Koreth, J., Kim, H. T., Paul, N. E., Murase, K., Whangbo, J., Alho, A. C., Nikiforow, S., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.89278 · Cited by 137 · see citing works

A Major Role for Bim in Regulatory T Cell Homeostasis

Chougnet, C. A., Tripathi, P., Lages, C. S., Raynor, J. L., Sholl, A., Fink, P. J., Plas, D. R., & Hildeman, D. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001505 · Cited by 137 · see citing works

Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation

Colamatteo, A., Carbone, F., Bruzzaniti, S., Galgani, M., Fusco, C., Maniscalco, G. T., Rella, F. D., de Candia, P., & Rosa, V. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03136 · Cited by 139 · see citing works

Perinatal Immunotoxicity: Why Adult Exposure Assessment Fails to Predict Risk

Dietert, R. R., & Piepenbrink, M. S. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8566 · Cited by 129 · see citing works

Impaired regulatory function in circulating CD4+CD25highCD127low/− T cells in patients with myasthenia gravis

Thiruppathi, M., Rowin, J., Ganesh, B. B., Sheng, J. R., Prabhakar, B. S., & Meriggioli, M. N. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.09.012 · Cited by 128 · see citing works

Regulatory T cells in the central nervous system

Lowther, D. E., & Hafler, D. A. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01130.x · Cited by 123 · see citing works

Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells

Chen, X., & Oppenheim, J. J. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.05.018 · Cited by 126 · see citing works

Central Role of CD45RA− Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance

Braza, F., Dugast, E., Panov, I., Paul, C., Vogt, K., Pallier, A., Chesneau, M., Baron, D., Guérif, P., Lei, H., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014050480 · Cited by 121 · see citing works

Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4+CD25+FOXP3+CD31+ T-cells in patients with multiple sclerosis

Haas, J., Korporal, M., Balint, B., Fritzsching, B., Schwarz, A., & Wildemann, B. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.011 · Cited by 119 · see citing works

Are regulatory T-cells linked with aging?

Dejaco, C., Duftner, C., & Schirmer, M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.008 · Cited by 118 · see citing works

The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro

Yates, J., Rovis, F., Mitchell, P., Afzali, B., Tsang, J. Y., Garin, M. I., Lechler, R. I., Lombardi, G., & Garden, O. A. (2007) · International Immunology · doi:10.1093/intimm/dxm047 · Cited by 114 · see citing works

De Novo Generation and Enhanced Suppression of Human CD4+CD25+ Regulatory T Cells by Retinoic Acid

Wang, J., Huizinga, T. W. J., & Toes, R. E. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901065 · Cited by 112 · see citing works

Treg activation defect in type 1 diabetes: correction with TNFR2 agonism

Okubo, Y., Torrey, H., Butterworth, J., Zheng, H., & Faustman, D. L. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2015.43 · Cited by 111 · see citing works

HSC Aging and Senescent Immune Remodeling

Denkinger, M. D., Leins, H., Schirmbeck, R., Florian, M. C., & Geiger, H. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.10.008 · Cited by 105 · see citing works

Impact of Immunosuppressive Drugs on CD4+CD25+FOXP3+ Regulatory T Cells

Demirkıran, A., Hendrikx, T. K., Baan, C. C., & van der Laan, L. J. W. (2008) · Transplantation · doi:10.1097/tp.0b013e318166910b · Cited by 103 · see citing works

Moving to tolerance: Clinical application of T regulatory cells

McMurchy, A. N., Bushell, A., Levings, M. K., & Wood, K. J. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.04.001 · Cited by 101 · see citing works

Expression of the Autoimmune Susceptibility Gene FcRL3 on Human Regulatory T Cells Is Associated with Dysfunction and High Levels of Programmed Cell Death-1

Swainson, L. A., Mold, J. E., Bajpai, U. D., & McCune, J. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903943 · Cited by 99 · see citing works

Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3+ precursors and impaired activated population

Laakso, S. M., Laurinolli, T.-T., Rossi, L. H., Lehtoviita, A., Sairanen, H. I., Perheentupa, J., Kekäläinen, E., & Arstila, T. P. (2010) · Journal of Autoimmunity · doi:10.1016/j.jaut.2010.07.008 · Cited by 99 · see citing works

Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions

Mathian, A., Parizot, C., Dorgham, K., Trad, S., Arnaud, L., Larsen, M., Miyara, M., Hié, M., Pietté, J. C., Francès, C., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200709 · Cited by 99 · see citing works

Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction

Tanaka, Y., Mori, T., Ito, F., Koshiba, A., Takaoka, O., Kataoka, H., Maeda, E., Okimura, H., Mori, T., & Kitawaki, J. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00052 · Cited by 95 · see citing works

Human Peripheral Blood T Regulatory Cells (Tregs), Functionally Primed CCR4+ Tregs and Unprimed CCR4− Tregs, Regulate Effector T Cells Using FasL

Baatar, D., Olkhanud, P. B., Sumitomo, K., Taub, D. D., Gress, R. E., & Biragyn, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4891 · Cited by 95 · see citing works

Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion

Miyara, M., Wing, K., & Sakaguchi, S. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.001 · Cited by 95 · see citing works

Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases

Koyabu, M., Uchida, K., Miyoshi, H., Sakaguchi, Y., Fukui, T., Ikeda, H., Takaoka, M., Hirohara, J., Nishio, A., Uemura, Y., et al. (2010) · Journal of Gastroenterology · doi:10.1007/s00535-010-0199-3 · Cited by 94 · see citing works

Prognostic value of circulating regulatory T cell subsets in untreated non-small cell lung cancer patients

Kotsakis, A. P., Koinis, F., Katsarou, A., Gioulbasani, M., Aggouraki, D., Kentepozidis, N. K., Georgoulias, V., & Vetsika, E. (2016) · Scientific Reports · doi:10.1038/srep39247 · Cited by 94 · see citing works

Altered homeostasis of CD4+ FoxP3+regulatory T‐cell subpopulations in systemic lupus erythematosus

Suen, J., Li, H., Jong, Y., Chiang, B., & Yen, J. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02937.x · Cited by 92 · see citing works

The Impact of Aging on Regulatory T-Cells

Fessler, J., Ficjan, A., Duftner, C., & Dejaco, C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00231 · Cited by 88 · see citing works

The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations

Schmidl, C., Hansmann, L., Lassmann, T., Balwierz, P. J., Kawaji, H., Itoh, M., Kawai, J., Nagao-Sato, S., Suzuki, H., Andreesen, R., et al. (2014) · Blood · doi:10.1182/blood-2013-02-486944 · Cited by 86 · see citing works

Human regulatory T cells in autoimmune diseases

Cvetanovich, G. L., & Hafler, D. A. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.08.012 · Cited by 88 · see citing works

Regulatory T cells in skin regeneration and wound healing

Knoedler, S. A., Knoedler, L., Kauke‐Navarro, M., Rinkevich, Y., Hundeshagen, G., Harhaus, L., Kneser, U., Pomahač, B., Orgill, D. P., & Panayi, A. C. (2023) · Military Medical Research · doi:10.1186/s40779-023-00484-6 · Cited by 89 · see citing works

In vivo expansion of naive and activated CD4 + CD25 + FOXP3 + regulatory T cell populations in interleukin-2–treated HIV patients

Weiss, L., Letimier, F. A., Carrière, M., Maiella, S., Donkova-Petrini, V., Targat, B., Benecke, A., Rogge, L., & Lévy, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000027107 · Cited by 85 · see citing works

Ex vivo expansion of CD4+CD25+ T regulatory cells for immunosuppressive therapy

Trzonkowski, P., Szaryńska, M., Myśliwska, J. M., & Myśliwski, A. (2008) · Cytometry Part A · doi:10.1002/cyto.a.20659 · Cited by 85 · see citing works

Naive Precursors of Human Regulatory T Cells Require FoxP3 for Suppression and Are Susceptible to HIV Infection

Antons, A. K., Wang, R., Oswald-Richter, K. A., Tseng, M., Arendt, C., Kalams, S. A., & Unutmaz, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.2.764 · Cited by 80 · see citing works

Expression and Function of TNF and IL-1 Receptors on Human Regulatory T Cells

Mercer, F. K., Kozhaya, L., & Unutmaz, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008639 · Cited by 80 · see citing works

Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis

Behrens, F., Himsel, A., Rehart, S., Stanczyk, J., Beutel, B., Zimmermann, S. Y., Koehl, U., Möller, B., Gay, S., Kaltwasser, J., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.068320 · Cited by 80 · see citing works

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

Dong, S., Maiella, S., Xhaard, A., Pang, Y., Wenandy, L., Larghero, J., Bécavin, C., Benecke, A., Bianchi, E., Socié, G., et al. (2013) · Blood · doi:10.1182/blood-2013-02-482539 · Cited by 79 · see citing works

Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c + Myeloid Dendritic Cell Maturation Arrest, Induction of the Kynurenine Pathway, and Regulatory T Cell Activation

Woodberry, T., Loughland, J. R., Minigo, G., Burel, J. G., Amante, F. H., Piera, K. A., McNeil, Y., Yeo, T. W., Good, M. F., Doolan, D. L., et al. (2017) · Infection and Immunity · doi:10.1128/iai.00986-16 · Cited by 79 · see citing works

TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis

Nyirenda, M. H., Morandi, E., Vinkemeier, U., Constantin‐Teodosiu, D., Drinkwater, S., Mee, M., King, L. D. W., Podda, G., Zhang, G., Ghaemmaghami, A. M., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1400472 · Cited by 77 · see citing works

DNA damage, metabolism and aging in pro-inflammatory T cells

Li, Y., Goronzy, J. J., & Weyand, C. M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.027 · Cited by 78 · see citing works

FOXP3 Expression Is Upregulated in CD4+T Cells in Progressive HIV-1 Infection and Is a Marker of Disease Severity

Suchard, M. S., Mayne, E. S., Green, V. A., Shalekoff, S., Donninger, S. L., Stevens, W. S., Gray, C. M., & Tiemessen, C. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011762 · Cited by 76 · see citing works

Selective accumulation of differentiated FOXP3+ CD4+ T cells in metastatic tumor lesions from melanoma patients compared to peripheral blood

Jandus, C., Bioley, G., Speiser, D. E., & Romero, P. J. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0507-4 · Cited by 75 · see citing works

The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer

Li, L., & Boussiotis, V. A. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.05.003 · Cited by 75 · see citing works

Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response?

Groth, B. F. D. S., & LANDAY, A. L. (2008) · AIDS · doi:10.1097/qad.0b013e3282f466da · Cited by 73 · see citing works

Mechanisms of T cell organotropism

Fu, H., Ward, E. J., & Marelli‐Berg, F. M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2211-4 · Cited by 73 · see citing works

Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype

Santner-Nanan, B., Seddiki, N., Zhu, E., Quent, V., Kelleher, A., de St Groth, B. F., & Nanan, R. (2008) · International Immunology · doi:10.1093/intimm/dxm151 · Cited by 70 · see citing works

Characterisation of Regulatory T Cells in Nasal Associated Lymphoid Tissue in Children: Relationships with Pneumococcal Colonization

Zhang, Q., Leong, S. C., McNamara, P. S., Mubarak, A., Malley, R., & Finn, A. H. R. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002175 · Cited by 70 · see citing works

T Cell-Signaling Network Analysis Reveals Distinct Differences between CD28 and CD2 Costimulation Responses in Various Subsets and in the MAPK Pathway between Resting and Activated Regulatory T Cells

Kalland, M. E., Oberprieler, N. G., Vang, T., Taskén, K., & Torgersen, K. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101804 · Cited by 70 · see citing works

Naturally Occurring and Inducible T-Regulatory Cells Modulating Immune Response in Allergic Asthma

McGee, H. S., & Agrawal, D. K. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200809-1505oc · Cited by 69 · see citing works

FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer

Zhuo, C., Xu, Y., Ying, M., Li, Q., Huang, L., Li, D., Cai, S., & Li, B. (2015) · Immunologic Research · doi:10.1007/s12026-014-8616-y · Cited by 69 · see citing works

Persistence of naive CD45RA+ regulatory T cells in adult life

Seddiki, N., Santner-Nanan, B., Tangye, S. G., Alexander, S. I., Solomon, M., Lee, S., Nanan, R., & de Saint Groth, B. F. (2006) · Blood · doi:10.1182/blood-2005-06-2403 · Cited by 284 · see citing works

Thymic regulatory T cells

Maggi, E., Cosmi, L., Liotta, F., Romagnani, P., Romagnani, S., & Annunziato, F. (2005) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.04.010 · Cited by 183 · see citing works

Regulatory T cells

Blazar, B. R., & Taylor, P. A. (2005) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2004.11.005 · Cited by 28 · see citing works

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

Piccirillo, C. A. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2003.12.003 · Cited by 392 · see citing works

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

Ng, W. F., Duggan, P., Ponchel, F., Matarese, G., Lombardi, G., Edwards, A. J., Isaacs, J. D., & Lechler, R. (2001) · Newcastle University ePrints (Newcastle Univesity) · doi:10.25405/ncl.34580130