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CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Open accessAbstract
The C-C motif chemokine receptor-2 (CCR2) regulates monocyte and macrophage recruitment and is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis.Although adipose tissue expression and circulating concentrations of CCL2 (also known as MCP1), a high-affinity ligand for CCR2, are elevated in obesity, the role of CCR2 in metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation associated with obesity, has not been studied.To determine what role CCR2 plays in the development of metabolic phenotypes, we studied the effects of Ccr2 genotype on the development of obesity and its associated phenotypes.Genetic deficiency in Ccr2 reduced food intake and attenuated the development of obesity in mice fed a high-fat diet.In obese mice matched for adiposity, Ccr2 deficiency reduced macrophage content and the inflammatory profile of adipose tissue, increased adiponectin expression, ameliorated hepatic steatosis, and improved systemic glucose homeostasis and insulin sensitivity.In mice with established obesity, short-term treatment with a pharmacological antagonist of CCR2 lowered macrophage content of adipose tissue and improved insulin sensitivity without significantly altering body mass or improving hepatic steatosis.These data suggest that CCR2 influences the development of obesity and associated adipose tissue inflammation and systemic insulin resistance and plays a role in the maintenance of adipose tissue macrophages and insulin resistance once obesity and its metabolic consequences are established.
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In the citing paper
“Hypertrophy leads to multiple fold increase in infiltration of macrophages in WAT (55, 56), which promotes a pro-inflammatory and insulin resistant environment.”
From Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan (2025) · cites this paper as [55]
Experimental — accuracy not yet measuredIn the citing paper
“Adipose tissue macrophages (ATM) have been shown to comprise a significant proportion of the cellular component of adipose tissue in both lean and obese states [60–63].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [62]
In the citing paper
“In normal rodents and humans, ATMs make up as much as ten percent of the cellular constituents of the tissue [62]. In comparison, it has been shown that in obese subjects that number rises to as much as 40% [62].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [62]
In the citing paper
“Although a marginal relationship between CRP concentration and the Mediterranean diet was observed, this association was no longer significant when other cardiovascular risk factors were considered in the models.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [282]
In the citing paper
“This association was independent of several known cardiovascular risk factors, and persisted when twins within pairs were compared, suggesting that the results were not confounded by shared environmental and genetic factors.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [282]
In the citing paper
“Observational studies have examined the association of the Mediterranean diet with inflammatory markers in healthy persons (282,283,285) , and they generally report inverse correlations.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [282]
In the citing paper
“In a recent study (282) investigating psychological, behavioural and biological risk factors for subclinical CVD in 345 middleaged male twins, an inverse association between adherence to the Mediterranean diet and inflammation, as measured by plasma IL-6 concentration, was noted.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [282]
In the citing paper
“Ccl2 and/or Ccr2 expression is increased in obese adipose tissue (119-122)”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [120]
In the citing paper
“In addition, KO of Ccl2 or Ccr2 or neutralization of CCL2 leads to decreased macrophage recruitment to adipose tissue and protection from obesity-induced insulin resistance (120, 121).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [120]
In the citing paper
“Other factors produced by inflammatory cells have since been shown to inhibit insulin signaling in the adipocyte including IL-6, IFN-γ and CCL2 (72,73).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [73]
In the citing paper
“There is considerable evidence for the pathophysiological role of macrophage-and/or hypertrophic adipocytederived chemotactic MCP-1/CCR2 pathways in the regulation of monocyte accumulation in obese AT (16,17).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [17]
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Cites
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Self-citationAdipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Adipose Tissue, Inflammation, and Cardiovascular Disease
Berg, A. H., & Scherer, P. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163635.62927.34 · Cited by 2,113
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
Self-citationYuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
Research works printed but not linked: 4
- 10.1172/JCI200525102 · DOI · Paper page
- Fried, 1998, J. Clin. Endocrinol. Metab., 83, 847
- 10.1172/JCI200421752 · DOI · Paper page
- Dandona, 1998, J. Clin. Endocrinol. Metab., 83, 2907
Cited by
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Items 901–1,000 of 1,002
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Rakotoarivelo, V., Variya, B. C., Langlois, M., & Ramanathan, S. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154953 · Cited by 28
Hu, W., Kang, Q., Zhang, C., Ma, H., Xu, C., Wan, Y., & Hu, J. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114474 · Cited by 26
Moruzzi, M., Klöting, N., Blüher, M., Martinelli, I., Tayebati, S. K., Gabrielli, M. G., Roy, P., Bonaventura, M. V. M. D., Cifani, C., Lupidi, G., et al. (2021) · Molecules · doi:10.3390/molecules26051403 · Cited by 26
Adipose tissue macrophage heterogeneity in the single-cell genomics era
Kang, H., & Lee, J. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100031 · Cited by 25
Mouse and human macrophages and their roles in cardiovascular health and disease
Gallerand, A., Han, J., Ivanov, S., & Randolph, G. J. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00580-3 · Cited by 26
Ekta, Gupta, M., Kaur, A., Singh, T. G., & Bedi, O. (2020) · Inflammation Research · doi:10.1007/s00011-020-01373-7 · Cited by 26
Li, Y., Li, J., Jiang, F., Yan, J. Y., Lü, Y., Yang, Q., Zhang, Y., Zhang, H., Yu, H., Zhang, Y., et al. (2021) · Diabetes · doi:10.2337/db21-0064 · Cited by 25
Innate-Immunity Genes in Obesity
Михайлова, С. В., & Иванощук, Д. Е. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111201 · Cited by 25
Ben‐Shlomo, S., Zvibel, I., Varol, C., Spektor, L., Shlomai, A., Santo, E. M., Halpern, Z., Oren, R., & Fishman, S. (2013) · Obesity · doi:10.1002/oby.20340 · Cited by 27
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Dahlman, I. A., & Arner, P. (2010) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-375003-7.00003-0 · Cited by 25
Potential role of omega‐3‐derived resolution mediators in metabolic inflammation
White, P. J., & Marette, A. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2013.112 · Cited by 26
Deiuliis, J. A., Kampfrath, T., Ying, Z., Maiseyeu, A., & Rajagopalan, S. (2011) · Lipids · doi:10.1007/s11745-011-3603-8 · Cited by 27
Borges, M. C., Vinolo, M. A. R., Crisma, A. R., Fock, R. A., Borelli, P., Tirapegui, J., Curi, R., & Rogero, M. M. (2012) · Nutrition · doi:10.1016/j.nut.2012.06.008 · Cited by 25
Kim, H., Lee, E. Y., Lee, B., Yadav, D., Kim, Y. M., Ko, H., Park, K., Lee, E. Y., & Chung, C. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120711 · Cited by 25
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Patel, H., & Patel, V. H. (2015) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.3.3.10 · Cited by 25
Golbus, J. R., Stitziel, N. O., Zhao, W., Xue, C., Farrall, M., McPherson, R., Erdmann, J., Deloukas, P., Watkins, H. C., Schunkert, H., et al. (2016) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.115.001374 · Cited by 25
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Keuper, M. (2019) · Endocrine Connections · doi:10.1530/ec-19-0016 · Cited by 26
Arivazhagan, L., Ruiz, H. H., Wilson, R. A., Manigrasso, M. B., Gugger, P. F., Fisher, E. A. A., Moore, K. J., Ramasamy, R., & Schmidt, A. M. (2020) · Circulation Research · doi:10.1161/circresaha.120.315900 · Cited by 25
Xia, M., Hou, C., DeMong, D. E., Pollack, S. R., Pan, M., Brackley, J. A., Jain, N. F., Gerchak, C., Singer, M. M., Malaviya, R., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070902b · Cited by 25
Kim, M., Cho, H., Kwon, G. T., Kang, Y., Kwon, S., Her, S., Park, T., Kim, Y., Kee, Y., & Park, J. H. Y. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22159 · Cited by 24
M1-M2 balancing act in white adipose tissue browning – a new role for RIP140
Liu, P.-S., Lin, Y.-W., Burton, F. H., & Wei, L. (2014) · Adipocyte · doi:10.4161/21623945.2014.981428 · Cited by 26
Tretjakovs, P., Jurka, A., Bormane, I., Mackēvičs, V., Miķelsone, I., Balode, L., Reihmane, D., Stuķēna, I., Bahs, G., Aivars, J. I., et al. (2009) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2009.08.004 · Cited by 24
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Choi, Y., Abdelmegeed, M. A., Akbar, M. D., & Song, B. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.12.005 · Cited by 26
Memetimin, H., Li, D., Tan, K., Zhou, C., Liang, Y., Wu, Y., & Wang, S. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00273.2018 · Cited by 24
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Boura‐Halfon, S., Pecht, T., Jung, S., & Rudich, A. (2018) · European Journal of Immunology · doi:10.1002/eji.201747389 · Cited by 24
Blaszczak, A. M., Jalilvand, A., Liu, J., Wright, V. P., Suzo, A. J., NEEDLEMAN, B. J., Noria, S. F., Lafuse, W. P., Hsueh, W. A., & Bradley, D. P. (2019) · Journal of Diabetes Research · doi:10.1155/2019/8124563 · Cited by 24
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Kuroda, M., Nishiguchi, M., Naho, U., Ishikawa, E., Yasuyo, K., Okamoto, S., Sasaki, W., Miyatake, Y., Sebe, M., Masumoto, S., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233390 · Cited by 25
Wang, Q., Perrard, X. D., Perrard, J. L., Mansoori, A., Smith, C. W., Ballantyne, C. M., & Wu, H. (2010) · Obesity · doi:10.1038/oby.2010.213 · Cited by 24
Jang, J. H., Sung, J. H., & Huh, J. Y. (2025) · Immune Network · doi:10.4110/in.2025.25.e12 · Cited by 25
AlZaim, I., Al-Saidi, A., Hammoud, S. H., Darwiche, N., Al-Dhaheri, Y., Eid, A. H., & EL‐Yazbi, A. F. (2022) · Cancers · doi:10.3390/cancers14071679 · Cited by 23
Yang, J., He, J., Feng, Y., & Xiang, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1166440 · Cited by 25
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Mazaki‐Tovi, S., Vaisbuch, E., Tarca, A. L., Kusanovic, J. P., Than, N. G., Chaiworapongsa, T., Dong, Z., Hassan, S. S., & Romero, R. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143779 · Cited by 24
Monk, J. M., Liddle, D. M., Brown, M. J., Zarepoor, L., Boer, A. A. D., David, W. L., Power, K. A., & Robinson, L. E. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500541 · Cited by 23
Vasamsetti, S. B., Coppin, E., Zhang, X., Florentin, J., Koul, S. M., Götberg, M., Clugston, A. S., Thoma, F. W., Sembrat, J., Bullock, G. C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw0638 · Cited by 23
The Pathophysiology of Obesity and Obesity-Related Disease
O’Rourke, R. W. (2019) · Springer eBooks · doi:10.1007/978-3-030-27021-6_2 · Cited by 22
IL-6 signaling drives self-renewal and alternative activation of adipose tissue macrophages
Ackermann, J., Arndt, L., Fröba, J. S., Lindhorst, A., Glaß, M., Kirstein, M., Hobusch, C., Wunderlich, F. T., Braune, J., & Gericke, M. T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1201439 · Cited by 22
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Qiu, Y., Shan, B., Yang, L., & Liu, Y. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-0155-1 · Cited by 22
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Fukui, R., Murakami, Y., & Miyake, K. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0068-7 · Cited by 22
Zhong, L., Yuan, J., Huang, L., Li, S., & Deng, L. (2020) · BioMed Research International · doi:10.1155/2020/6953421 · Cited by 22
Fan, Z., Zhang, X., Zhang, X., Zou, M., Zou, M., Qiukai, E., Fei, S., Chen, W., Li, J., Zhang, X., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094797 · Cited by 22
Kim, Y., Lee, Y., Lee, M. N., Nah, J., Yun, N., Wu, D., & Pae, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1054875 · Cited by 22
Zhang, M., Tian, S. Y., Shuo, Y., Zhou, X., Zheng, X. H., Li, B., Guo, G. Y., Yu, J. H., Su, R. J., Yang, F. F., et al. (2023) · Liver International · doi:10.1111/liv.15547 · Cited by 22
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Shahid, M., Javed, A. A., Chandra, D., Ramsey, H. E., Shah, D., Khan, M. F., Zhao, L., & Wu, M. X. (2016) · Scientific Reports · doi:10.1038/srep24135 · Cited by 22
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Pei, X., Zheng, D., She, S., Ma, J., Guo, C., Mo, X., Zhang, Y., Song, Q., Zhang, Y., Ma, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05255-7 · Cited by 22
Shi, P., Su, Y., Li, Y. L., Zhang, L., Lu, D., Li, R., Zhang, L., & Huang, J. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.09.019 · Cited by 22
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Harakeh, S., Gauthaman, K., Pushparaj, P. N., Al-Hejin, A. M., Alfadul, S. M., Alamri, T. A., Barnawi, S., Sadoun, H. A., Mirza, A. A., & Azhar, E. I. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2019.03.006 · Cited by 22
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Modulation of glomerulosclerosis
Ma, L., & Fogo, A. B. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0087-y · Cited by 22
Kaneko, H., Anzai, T., Nagai, T., Anzai, A., Takahashi, T., Mano, Y., Morimoto, K., Maekawa, Y., Itoh, H., Yoshikawa, T., et al. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr088 · Cited by 24
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Rull, A., Beltrán‐Debón, R., Aragonès, G., Rodríguez-Sanabria, F., Alonso‐Villaverde, C., Camps, J., & Joven, J. (2010) · Cytokine · doi:10.1016/j.cyto.2010.02.010 · Cited by 21
Kim, E., Kim, E. J., Seo, S.-W., Hur, C., McGregor, R. A., & Choi, M. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.619283 · Cited by 22
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Subasinghe, N. L., Lanter, J. C., Markotan, T. P., Opas, E. E., McKenney, S. L., Crysler, C. S., Hou, C., O’Neill, J., Johnson, D. L., & Sui, Z. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.12.017 · Cited by 21
Inoue, E., Ichiki, T., Takeda, K., Matsuura, H., Hashimoto, T., Ikeda, J., Kamiharaguchi, A., & Sunagawa, K. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0014 · Cited by 21
Kim, D. H., Sartor, M. A., Bain, J. R., Sandoval, D. A., Stevens, R. D., Medvedovic, M., Newgard, C. B., Woods, S. C., & Seeley, R. J. (2012) · Diabetes · doi:10.2337/db11-1579 · Cited by 21
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Huang, W., Chen, C., & Wu, S. (2017) · Journal of Medicinal Food · doi:10.1089/jmf.2016.3806 · Cited by 21
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Teper, Y., & Eibl, G. (2020) · Cancers · doi:10.3390/cancers12071946 · Cited by 21
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Hu, Q., Lu, Y., Hu, F., He, S., Xu, X., Niu, Y., Zhang, H., Li, X., & Su, Q. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.45723 · Cited by 21
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Introduction: The inflammation orchestra in adipose tissue
Arner, P. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01850.x · Cited by 21
Poon, K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.591559 · Cited by 20
Ahlin, S., Sjöholm, K., Jacobson, P., Andersson‐Assarsson, J. C., Walley, A. J., Tordjman, J., Poitou, C., Prifti, E., Jansson, P., Borén, J., et al. (2013) · Obesity · doi:10.1002/oby.20443 · Cited by 20
Zhang, X., Hufnagel, H. R., Markotan, T. P., Lanter, J. C., Cai, C., Hou, C., Singer, M. M., Opas, E. E., McKenney, S. L., Crysler, C. S., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.06.080 · Cited by 20
Estrogens, inflammation and obesity: an overview
Miller, C. N., Brown, L. M., Rayalam, S., Della‐Fera, M. A., & Baile, C. A. (2012) · Frontiers in Biology · doi:10.1007/s11515-011-1174-y · Cited by 20
Zhang, Q., Hao, H., Xie, Z., Cheng, Y., Yin, Y., Xie, M., Huang, H., Gao, J., Liu, H., Tong, C., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.005 · Cited by 20
Caracciolo, V., Young, J., Gonzales, D. M., Ni, Y., Flowers, S. J., Summer, R. S., Waldman, S. A., Kim, J. K., Jung, D. Y., Noh, H. L., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00224.2017 · Cited by 20
Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats
Shehata, M. (2008) · Cardiovascular Diabetology · doi:10.1186/1475-2840-7-19 · Cited by 20
Li, L., & Renier, G. (2007) · Obesity · doi:10.1038/oby.2007.311 · Cited by 19
The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue
Sprenkle, N. T., Winn, N. C., Bunn, K. E., Zhao, Y., Park, D. J., Giese, B. G., Karijolich, J. J., Ansel, K. M., Serezani, C. H., Hasty, A. H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112928 · Cited by 19
Mir, R., Alfaifi, J. A., Sohail, S. K., Rizvi, S. F., Akhtar, M. T., Alghamdi, M. A. A., Mir, R., Wani, J. I., Sabah, Z. U., Alhumaydhi, F. A., et al. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14070743 · Cited by 19
Interleukin-20 circulating levels in obese women: Effect of weight loss
Maiorino, M. I., Schisano, B., Palo, C. D., Vietri, M. T., Cioffi, M., Giugliano, G., Giugliano, D., & Esposito, K. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.03.006 · Cited by 19
Morooka, N., Ueguri, K., Yee, K. K., Yanase, T., & Sato, T. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.155 · Cited by 19
Micronutrient deficiency, a novel nutritional risk factor for insulin resistance and Syndrom X
Ekpenyong, C. E. (2018) · Archive of Food and Nutritional Science · doi:10.29328/journal.afns.1001013 · Cited by 19
Gálvez, I., Navarro, M. D. C., Martín-Cordero, L., Otero, E., Hinchado, M. D., & Ortega, E. (2022) · Nutrients · doi:10.3390/nu14030612 · Cited by 21
A Novel Role for Adipose Ephrin-B1 in Inflammatory Response
Mori, T., Maeda, N., Inoue, K., Sekimoto, R., Tsushima, Y., Matsuda, K., Yamaoka, M., Suganami, T., Nishizawa, H., Ogawa, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076199 · Cited by 19
Voruganti, V. S., Laston, S., Haack, K., Mehta, N. R., Smith, C. W., Cole, S. A., Butte, N. F., & Comuzzie, A. G. (2012) · Cytokine · doi:10.1016/j.cyto.2012.08.029 · Cited by 19
Gutierrez, D. A., & Hasty, A. H. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0338 · Cited by 19
Perivascular Fat: Innocent Bystander or Active Player in Vascular Disease?
Stern, N., & Marcus, Y. (2006) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4564.2006.05510.x · Cited by 19
(1980) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-8914-9 · Cited by 19
Hu, J., Guo, L., He, X., Gao, X., Pan, D., Dong, X., Huang, W., Qiu, F., Chen, L., & Hu, X. (2024) · Communications Biology · doi:10.1038/s42003-024-07437-2 · Cited by 18
A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity
O’Brien, C. J. O., Haberman, E. R., & Domingos, A. I. (2021) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120319-114106 · Cited by 23
Jun, J. K., Lee, W. L., Park, H. G., Lee, S. K., Jeong, S. H., & Lee, Y. R. (2014) · Physical Activity and Nutrition · doi:10.5717/jenb.2014.18.1.119 · Cited by 18
Benson, T. W., Weintraub, D. S., Crowe, M., Yiew, N. K. H., Popoola, O., Pillai, A., Joseph, J. P., Archer, K., Greenway, C., Chatterjee, T. K., et al. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.01.006 · Cited by 20
Pirzgalska, R. M., & Domingos, A. I. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.04.014 · Cited by 18
Harmon, D. B., Wu, C., Dedousis, N. L., SIPULA, I. J., Stefanović-Račić, M., Schoiswohl, G., O'Donnell, C. P., Alonso, L. C., Kershaw, E. E., Kelley, E. E., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00172.2018 · Cited by 18
Metadata
- Authors
- Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F.
- Affiliations
- Columbia University Irving Medical Center (US)
- Incyte (United States) (US)
- Columbia University (US)
- Gladstone Institutes (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2006-01-04
- Volume
- 116
- Issue
- 1
- Pages
- 115-124
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1307559
- OpenAlex
- W4250725029
- Cited by
- 1,497
- References
- 47
- Citations by year
- 2026: 32 · 2025: 53 · 2024: 42 · 2023: 59 · 2022: 53 · 2021: 71 · 2020: 67 · 2019: 65 · 2018: 74 · 2017: 77 · 2016: 104 · 2015: 76 · 2014: 83 · 2013: 108 · 2012: 93
- FWCI
- 43.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Journal of Clinical Investigation (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- Funders
- National Institutes of Health (DK066525)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-063608, DK59960, R56DK066525, (DK066525, K08DK059960, P30DK063608, R01DK066525)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- CCR2, obesity, high-fat diet, adipose tissue inflammation, macrophage recruitment, insulin resistance, hepatic steatosis, glucose homeostasis, adiponectin, CCR2 knockout mice, CCR2 antagonist, metabolic inflammation
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