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CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Open accessAbstract
The C-C motif chemokine receptor-2 (CCR2) regulates monocyte and macrophage recruitment and is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis.Although adipose tissue expression and circulating concentrations of CCL2 (also known as MCP1), a high-affinity ligand for CCR2, are elevated in obesity, the role of CCR2 in metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation associated with obesity, has not been studied.To determine what role CCR2 plays in the development of metabolic phenotypes, we studied the effects of Ccr2 genotype on the development of obesity and its associated phenotypes.Genetic deficiency in Ccr2 reduced food intake and attenuated the development of obesity in mice fed a high-fat diet.In obese mice matched for adiposity, Ccr2 deficiency reduced macrophage content and the inflammatory profile of adipose tissue, increased adiponectin expression, ameliorated hepatic steatosis, and improved systemic glucose homeostasis and insulin sensitivity.In mice with established obesity, short-term treatment with a pharmacological antagonist of CCR2 lowered macrophage content of adipose tissue and improved insulin sensitivity without significantly altering body mass or improving hepatic steatosis.These data suggest that CCR2 influences the development of obesity and associated adipose tissue inflammation and systemic insulin resistance and plays a role in the maintenance of adipose tissue macrophages and insulin resistance once obesity and its metabolic consequences are established.
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In the citing paper
“Hypertrophy leads to multiple fold increase in infiltration of macrophages in WAT (55, 56), which promotes a pro-inflammatory and insulin resistant environment.”
From Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan (2025) · cites this paper as [55]
Experimental — accuracy not yet measuredIn the citing paper
“Adipose tissue macrophages (ATM) have been shown to comprise a significant proportion of the cellular component of adipose tissue in both lean and obese states [60–63].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [62]
In the citing paper
“In normal rodents and humans, ATMs make up as much as ten percent of the cellular constituents of the tissue [62]. In comparison, it has been shown that in obese subjects that number rises to as much as 40% [62].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [62]
In the citing paper
“Although a marginal relationship between CRP concentration and the Mediterranean diet was observed, this association was no longer significant when other cardiovascular risk factors were considered in the models.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [282]
In the citing paper
“This association was independent of several known cardiovascular risk factors, and persisted when twins within pairs were compared, suggesting that the results were not confounded by shared environmental and genetic factors.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [282]
In the citing paper
“Observational studies have examined the association of the Mediterranean diet with inflammatory markers in healthy persons (282,283,285) , and they generally report inverse correlations.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [282]
In the citing paper
“In a recent study (282) investigating psychological, behavioural and biological risk factors for subclinical CVD in 345 middleaged male twins, an inverse association between adherence to the Mediterranean diet and inflammation, as measured by plasma IL-6 concentration, was noted.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [282]
In the citing paper
“Ccl2 and/or Ccr2 expression is increased in obese adipose tissue (119-122)”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [120]
In the citing paper
“In addition, KO of Ccl2 or Ccr2 or neutralization of CCL2 leads to decreased macrophage recruitment to adipose tissue and protection from obesity-induced insulin resistance (120, 121).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [120]
In the citing paper
“Other factors produced by inflammatory cells have since been shown to inhibit insulin signaling in the adipocyte including IL-6, IFN-γ and CCL2 (72,73).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [73]
In the citing paper
“There is considerable evidence for the pathophysiological role of macrophage-and/or hypertrophic adipocytederived chemotactic MCP-1/CCR2 pathways in the regulation of monocyte accumulation in obese AT (16,17).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [17]
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Citations
Cites
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Self-citationAdipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Adipose Tissue, Inflammation, and Cardiovascular Disease
Berg, A. H., & Scherer, P. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163635.62927.34 · Cited by 2,113
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
Self-citationYuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
Research works printed but not linked: 4
- 10.1172/JCI200525102 · DOI · Paper page
- Fried, 1998, J. Clin. Endocrinol. Metab., 83, 847
- 10.1172/JCI200421752 · DOI · Paper page
- Dandona, 1998, J. Clin. Endocrinol. Metab., 83, 2907
Cited by
Sorted by citations
Items 201–300 of 1,002
Inflammation, Cytokines and Insulin Resistance: A Clinical Perspective
Wieser, V. E., Moschen, A. R., & Tilg, H. (2013) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0210-1 · Cited by 245
Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells
Singer, K., DelProposto, J. L., Morris, D. L., Zamarron, B. F., Mergian, T. A., Maley, N., Cho, K. W., Geletka, L. M., Subbaiah, P., Muir, L. A., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.06.005 · Cited by 243
Liu, C., Xu, X., Bai, Y., Wang, T.-Y., Rao, X., Wang, A., Sun, L., Ying, Z., Gushchina, L. V., Maiseyeu, A., et al. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306841 · Cited by 237
IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity
Braune, J., Weyer, U., Hobusch, C., Mauer, J., Brüning, J. C., Bechmann, I., & Gericke, M. T. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600476 · Cited by 242
Li, X., Qin, L., Bergenstock, M., Bevelock, L. M., Novack, D. V., & Partridge, N. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611781200 · Cited by 240
Qatanani, M., Szwergold, N. R., Greaves, D. R., Ahima, R. S., & Lazar, M. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37273 · Cited by 230
TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation
Perino, A., Pols, T. W. H., Nomura, M., Stein, S., Pellicciari, R., & Schoonjans, K. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76289 · Cited by 233
CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue
Kéophiphath, M., Rouault, C., Divoux, A., Clément, K., & Lacasa, D. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.197442 · Cited by 244
Deveaux, V., Cadoudal, T., Ichigotani, Y., Teixeira-Clerc, F., Louvet, A., Manin, S., Nhieu, J. T. V., Belot, M., Zimmer, A., Even, P. C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005844 · Cited by 232
Central and Peripheral Inflammation Link Metabolic Syndrome and Major Depressive Disorder
Chan, K. L., Cathomas, F., & Russo, S. J. (2019) · Physiology · doi:10.1152/physiol.00047.2018 · Cited by 227
Role of visceral adipose tissue in aging
Huffman, D. M., & Barzilai, N. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.01.008 · Cited by 220
A decade of progress in adipose tissue macrophage biology
Hill, A. A., Bolus, W. R., & Hasty, A. H. (2014) · Immunological Reviews · doi:10.1111/imr.12216 · Cited by 227
Adipokines: masterminds of metabolic inflammation
Tilg, H., Ianiro, G., Gasbarrini, A., & Adolph, T. E. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01103-8 · Cited by 234
From chronic overnutrition to insulin resistance: The role of fat-storing capacity and inflammation
Lionetti, L., Mollica, M. P., Lombardi, A., Cavaliere, G., Gifuni, G., & Barletta, A. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.10.010 · Cited by 223
Ohmura, K., Ishimori, N., Ohmura, Y., Tokuhara, S., Nozawa, A., Horii, S., Andoh, Y., Fujii, S., Iwabuchi, K., Onoé, K., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.198614 · Cited by 227
Adipose tissue plasticity from WAT to BAT and in between
Lee, Y., Mottillo, E. P., & Granneman, J. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.011 · Cited by 236
The Immune System as a Sensor of the Metabolic State
Odegaard, J. I., & Chawla, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.001 · Cited by 219
Adipose Inflammation, Insulin Resistance, and Cardiovascular Disease
Shah, A. D., Mehta, N. N., & Reilly, M. P. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108325251 · Cited by 218
Nagy, L., Szántó, A., Szatmári, I., & Széles, L. (2012) · Physiological Reviews · doi:10.1152/physrev.00004.2011 · Cited by 218
Rastogi, D., Fraser, S., Oh, J. G., Huber, A. M., Schulman, Y., Bhagtani, R. H., Khan, Z., Tesfa, L., Hall, C. B., & Macián, F. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201409-1587oc · Cited by 218
Ziółkowska, S., Binienda, A., Jabłkowski, M., Szemraj, J., & Czarny, P. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011128 · Cited by 219
Adipokines, diabetes and atherosclerosis: an inflammatory association
Freitas‐Lima, L. C., Braga, V. A., de França-Silva, M. D. S., Cruz, J. C., Santos, S. H. S., Monteiro, M. M. D. O., & Balarini, C. M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00304 · Cited by 218
Macrophage function in obesity-induced inflammation and insulin resistance
Lauterbach, M., & Wunderlich, F. T. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1955-5 · Cited by 216
Gut Microbiota, Host Organism, and Diet Trialogue in Diabetes and Obesity
Lazăr, V., Diţu, L.-M., Pîrcălăbioru, G. G., Picu, A. A., Petcu, L. M., Cucu, N., & Chifiriuc, M. C. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00021 · Cited by 211
RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice
Song, F., del Pozo, C. H., Rosario, R., Zou, Y. S., Ananthakrishnan, R., Xu, X., Patel, P. R., Benoit, V. M., Yan, S. F., Li, H., et al. (2014) · Diabetes · doi:10.2337/db13-1636 · Cited by 209
Adipose tissue and adipocyte dysregulation
Lafontan, M. (2013) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.08.002 · Cited by 218
Maher, J. J., León, P., & Ryan, J. C. (2008) · Hepatology · doi:10.1002/hep.22399 · Cited by 208
Kawano, Y., Nakae, J., Watanabe, N., Kikuchi, T., Tateya, S., Tamori, Y., Kaneko, M., Abe, T., Onodera, M., & Itoh, H. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.009 · Cited by 207
Adipose tissue inflammation and ectopic lipid accumulation [Review]
Suganami, T., Tanaka, M., & Ogawa, Y. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0271 · Cited by 207
Clinical Relevance of Adipokines
Blüher, M. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.5.317 · Cited by 210
Multiple Roles for the Non-Coding RNA SRA in Regulation of Adipogenesis and Insulin Sensitivity
Xu, B., Gerin, I., Miao, H. Z., Vu-Phan, D. L., Johnson, C. N., Xu, R., Chen, X., Cawthorn, W. P., MacDougald, O. A., & Koenig, R. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014199 · Cited by 201
Insulin Resistance and Atherosclerosis
Razani, B., Chakravarthy, M. V., & Semenkovich, C. F. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.05.001 · Cited by 201
Cerebral ischemic damage in diabetes: an inflammatory perspective
Shukla, V., Shakya, A. K., Pérez‐Pinzón, M. A., & Dave, K. R. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0774-5 · Cited by 210
Neutralization of Osteopontin Inhibits Obesity-Induced Inflammation and Insulin Resistance
Kiefer, F. W., Zeyda, M., Gollinger, K., Pfau, B., Neuhofer, A., Weichhart, T., Säemann, M. D., Geyeregger, R., Schlederer, M., Kenner, L., et al. (2010) · Diabetes · doi:10.2337/db09-0404 · Cited by 200
Kennedy, D. J., Kuchibhotla, S., Westfall, K. M., Silverstein, R. L., Morton, R. E., & Febbraio, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq360 · Cited by 211
Low-grade inflammation and its relation to obesity and chronic degenerative diseases
Castro, A. M., la Concha, L. E. M.-D., & Pantoja-Melendez, C. A. (2016) · Revista Médica Del Hospital General De México · doi:10.1016/j.hgmx.2016.06.011 · Cited by 209
Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis
Griffin, T. M., Huebner, J. L., Kraus, V. B., & Guilak, F. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24854 · Cited by 203
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Craven, M. D., Egan, C. E., Dowd, S. E., McDonough, S. P., Dogan, B., Denkers, E., Bowman, D. D., Scherl, E., & Simpson, K. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041594 · Cited by 197
Jiao, P., Ma, J., Feng, B., Zhang, H., Diehl, J. A., Eugene‐Chin, Y., Yan, W., & Xu, H. (2010) · Obesity · doi:10.1038/oby.2010.200 · Cited by 203
O’Rourke, R. W., Metcalf, M. D., White, A. E., Madala, A., Winters, B. R., Maizlin, I. I., Jobe, B. A., Roberts, C. T., Slifka, M. K., & Marks, D. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.133 · Cited by 206
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Singer, K., & Lumeng, C. N. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88882 · Cited by 194
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Dali‐Youcef, N., Mecili, M., Ricci, R., & Andrès, E. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.705015 · Cited by 201
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Recent developments in CCR2 antagonists
Xia, M., & Sui, Z. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902755129 · Cited by 193
Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress
Eguchi, A., Lazić, M., Armando, A. M., Phillips, S. A., Katebian, R., Maraka, S., Quehenberger, O., Sears, D. D., & Feldstein, A. E. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1446-8 · Cited by 192
Kang, J., Kim, C.-S., Han, I., Kawada, T., & Yu, R. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.082 · Cited by 188
Stienstra, R., Duval, C., Keshtkar, S., van der Laak, J. A. W. M., Kersten, S., & Müller, M. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710314200 · Cited by 194
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Yang, Z., Miyahara, H., Takeo, J., & Katayama, M. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-32 · Cited by 192
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Xu, L., Kitade, H., Ni, Y., & Ota, T. (2015) · Biomolecules · doi:10.3390/biom5031563 · Cited by 190
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Subramanian, S., Han, C. Y., Chiba, T., McMillen, T. S., Wang, S. A., Haw, A., Kirk, E. A., O’Brien, K. D., & Chait, A. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.157685 · Cited by 182
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Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells
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Nagata, N., Xu, L., Kohno, S., Ushida, Y., Aoki, Y., Umeda, R., Fuke, N., Zhuge, F., Ni, Y., Nagashimada, M., et al. (2017) · Diabetes · doi:10.2337/db16-0662 · Cited by 177
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Nara, N., Nakayama, Y., Okamoto, S., Tamura, H., Kiyono, M., Muraoka, M., Tanaka, K., Taya, C., Shitara, H., Ishii, R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700412200 · Cited by 176
Spite, M. R., Hellmann, J. L., Tang, Y., Mathis, S., Kosuri, M., Bhatnagar, A., Jala, V. R., & Haribabu, B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100196 · Cited by 182
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The link between abdominal obesity and the metabolic syndrome
Phillips, L. K., & Prins, J. B. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0029-7 · Cited by 178
Inflammasomes and Metabolic Disease
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The Human Visceral Fat Depot Has a Unique Inflammatory Profile
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Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice
O’Rourke, R. W., White, A. E., Metcalf, M. D., Winters, B. R., Diggs, B. S., Zhu, X., & Marks, D. L. (2012) · Metabolism · doi:10.1016/j.metabol.2012.01.018 · Cited by 177
Medříková, D., Jílková, Z. M., Bardová, K., Janovská, P., Rossmeisl, M., & Kopecký, J. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.87 · Cited by 177
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Goldfine, A. B., & Shoelson, S. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88884 · Cited by 176
Kobayashi, M., Ohsugi, M., Sasako, T., Awazawa, M., Umehara, T., Iwane, A., Kobayashi, N., Okazaki, Y., Kubota, N., Suzuki, R., et al. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00116-18 · Cited by 170
Alisi, A., Carpino, G., de Oliveira, F. L., Panera, N., Nobili, V., & Gaudio, E. (2017) · Mediators of Inflammation · doi:10.1155/2017/8162421 · Cited by 172
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Hahn, W. S., Longo, K. A., Dolinsky, V. W., Gerin, I., Kang, S., Bennett, C. N., Chiang, S.-H., Prestwich, T. C., Gress, C., Burant, C., et al. (2007) · Diabetes · doi:10.2337/db06-1339 · Cited by 172
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Trim, W. V., Turner, J. E., & Thompson, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00169 · Cited by 178
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Gerdes, S., Rostami‐Yazdi, M., & Mrowietz, U. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01210.x · Cited by 165
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Kunz, H., Hart, C. R., Gries, K. J., Parvizi, M., LAURENTI, M. C., Man, C. D., Moore, N., Zhang, X., Ryan, Z., Polley, E. C., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00070.2021 · Cited by 170
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Zamarron, B. F., Mergian, T. A., Cho, K. W., Martinez-Santibañez, G., Luan, D., Singer, K., DelProposto, J. L., Geletka, L. M., Muir, L. A., & Lumeng, C. N.-K. (2016) · Diabetes · doi:10.2337/db16-0500 · Cited by 159
Dixit, V. D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108028 · Cited by 163
Moloney, F., Toomey, S., Noone, E., Nugent, A. P., Allan, B. B., Loscher, C. E., & Roche, H. M. (2007) · Diabetes · doi:10.2337/db06-0384 · Cited by 160
Lee, J. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0023-8 · Cited by 161
Ko, H. J., Zhang, Z., Jung, D. Y., Jun, J. Y., Ma, Z., Jones, K. E., Chan, S. Y., & Kim, J. K. (2009) · Diabetes · doi:10.2337/db08-1361 · Cited by 160
Ito, A., Suganami, T., 山内, 明., Degawa‐Yamauchi, M., Tanaka, M., Kouyama, R., Kobayashi, Y., Nitta, N., Yasuda, K., Hirata, Y., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804220200 · Cited by 156
Metadata
- Authors
- Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F.
- Affiliations
- Columbia University Irving Medical Center (US)
- Incyte (United States) (US)
- Columbia University (US)
- Gladstone Institutes (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2006-01-04
- Volume
- 116
- Issue
- 1
- Pages
- 115-124
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1307559
- OpenAlex
- W4250725029
- Cited by
- 1,497
- References
- 47
- Citations by year
- 2026: 32 · 2025: 53 · 2024: 42 · 2023: 59 · 2022: 53 · 2021: 71 · 2020: 67 · 2019: 65 · 2018: 74 · 2017: 77 · 2016: 104 · 2015: 76 · 2014: 83 · 2013: 108 · 2012: 93
- FWCI
- 43.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Journal of Clinical Investigation (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- Funders
- National Institutes of Health (DK066525)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-063608, DK59960, R56DK066525, (DK066525, K08DK059960, P30DK063608, R01DK066525)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- CCR2, obesity, high-fat diet, adipose tissue inflammation, macrophage recruitment, insulin resistance, hepatic steatosis, glucose homeostasis, adiponectin, CCR2 knockout mice, CCR2 antagonist, metabolic inflammation
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