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Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
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The diminished surface levels of SR-BI accompanied by reduced selective hepatic HDL-CE uptake suggest that the functioning of SR-BI is dependent on the WASH complex.
“The diminished surface levels of SR-BI accompanied by reduced selective hepatic HDL-CE uptake suggest that the functioning of SR-BI-the main receptor for hepatic HDL-C uptake in mice (54, 55)-is dependent on the WASH complex.”
From The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance (2019) · cites this paper as [55]
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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
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Research works printed but not linked: 4
- Rigotti, A., et al. 1997. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc. Natl. Acad. Sci. U. S. A. 94:12610-12615.
- Varban, M.L., et al. 1998. Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol. Proc. Natl. Acad. Sci. U. S. A. 95:4619-4624.
- Trigatti, B., et al. 1999. Influence of the high densi- ty lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc. Natl. Acad. Sci. U. S. A. 96:9322-9327.
- Osono, Y., Woollett, L.A., Marotti, K.R., Melchior, G.W., and Dietschy, J.M. 1996. Centripetal choles- terol flux from extrahepatic organs to the liver is independent of the concentration of high density lipoprotein-cholesterol in plasma. Proc. Natl. Acad. Sci. U. S. A. 93:4114-4119.
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Metadata
- Authors
- Zhang, Y.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-10-01
- Volume
- 115
- Issue
- 10
- Pages
- 2870-2874
- ISSN
- 0021-9738
- Cited by
- 267
- References
- 1
- Language
- en
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