Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
Open accessAbstract
A scavenger that protects the heart: Coronary heart disease is a tale of two forms of plasma cholesterol. In contrast to the well-established effects of “bad” cholesterol (LDL-C), the role of “good” cholesterol (HDL-C) is mysterious. Elevated HDL-C correlates with a lower risk of heart disease, yet drugs that raise HDL-C levels do not reduce risk. Zanoni et al. found that some people with exceptionally high levels of HDL-C carry a rare sequence variant in the gene encoding the major HDL-C receptor, scavenger receptor BI. This variant destroys the receptor's ability to take up HDL-C. Interestingly, people with this variant have a higher risk of heart disease despite having high levels of HDL-C. Science , this issue p. 1166
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Mutations of SR-BI (P279S, P376L) are associated with both significant increases in HDL-C and increased cardiovascular risk.
“Only recently, mutations of scavenger receptor (SR-BI) (P279S, P376L) have been described which are associated with both significant increases in HDL-C and increased cardiovascular risk [38–40].”
From HDL cholesterol: reappraisal of its clinical relevance (2017) · cites this paper as [40]
Recent studies have failed to demonstrate that high HDL-C acquired naturally or pharmacologically is associated with reduced CVD risk.
“In contrast, recent studies have failed to demonstrate that high HDL-C acquired naturally or pharmacologically, is associated with reduced CVD risk.5-11,18”
From Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?: New Insights From the Framingham Offspring Study (2016) · cites this paper as [18]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572 · see citing works
NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works
Harris, P. A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., & Conde, J. G. (2009) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2008.08.010 · Cited by 51,384 · see citing works
A method and server for predicting damaging missense mutations.
Adzhubei, I. A., Schmidt, S., Peshkin, L., Ramensky, V. E., Gerasimova, A., Bork, P., Kondrashov, A. S., & Sunyaev, S. R. (2010) · Nature Methods · doi:10.1038/nmeth0410-248 · Cited by 13,194 · see citing works
Cingolani, P., Platts, A., Wang, L. L., Coon, M., Nguyen, T., Wang, L., Land, S. J., Lu, X., & Ruden, D. M. (2012) · Fly · doi:10.4161/fly.19695 · Cited by 11,816 · see citing works
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,527 · see citing works
Self-citationStein, J. H., Korcarz, C. E., Hurst, R. T., Lonn, E., Kendall, C. B., Mohler, E. R., Najjar, S. S., Rembold, C. M., & Post, W. S. (2008) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2007.11.011 · Cited by 2,424 · see citing works
Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Acton, S. L., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., & Krieger, M. (1996) · Science · doi:10.1126/science.271.5248.518 · Cited by 2,347 · see citing works
Template-based protein structure modeling using the RaptorX web server
Källberg, M., Wang, H., Wang, S., Peng, J., Wang, Z., Lu, H. J., & Xu, J. (2012) · Nature Protocols · doi:10.1038/nprot.2012.085 · Cited by 1,576 · see citing works
Gnirke, A., Melnikov, A., Maguire, J., Rogov, P., LeProust, E. M., Brockman, W., Fennell, T., Giannoukos, G., Fisher, S., Russ, C., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1523 · Cited by 1,433 · see citing works
Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
Si-Tayeb, K., Noto, F. K., Nagaoka, M., Li, J., Battle, M. A., Duris, C., North, P. E., Dalton, S., & Duncan, S. A. (2010) · Hepatology · doi:10.1002/hep.23354 · Cited by 1,282 · see citing works
Hatch, F. T., & Lees, R. S. (1968) · Advances in lipid research · doi:10.1016/b978-1-4831-9942-9.50008-5 · Cited by 1,235 · see citing works
Nambi, V., Chambless, L. E., Folsom, A. R., He, M. M., Hu, Y., Mosley, T. H., Volcik, K. A., Boerwinkle, E., & Ballantyne, C. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.11.075 · Cited by 956 · see citing works
Self-citationRigotti, A., Trigatti, B. L., Penman, M., Rayburn, H., Herz, J., & Krieger, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12610 · Cited by 859 · see citing works
González-Pérez, A., & López-Bigas, N. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.03.004 · Cited by 765 · see citing works
Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
Kozarsky, K., Donahee, M. H., Rigotti, A., Iqbal, S. N., Edelman, E. R., & Krieger, M. (1997) · Nature · doi:10.1038/387414a0 · Cited by 697 · see citing works
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
Cuchel, M., Bloedon, L. T., Szapary, P. O., Kolansky, D. M., Wolfe, M. L., Sarkis, A., Millar, J. S., Ikewaki, K., Siegelman, E. S., Gregg, R. E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061189 · Cited by 580 · see citing works
Self-citationChapman, M. J., Goldstein, S., Lagrange, D., & Laplaud, P. M. (1981) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35376-1 · Cited by 553 · see citing works
Trigatti, B. L., Rayburn, H., Viñals, M., Braun, A., Miettinen, H. E., Penman, M., Hertz, M., Schrenzel, M. D., Amigo, L., Rigotti, A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9322 · Cited by 504 · see citing works
Braun, A., Trigatti, B. L., Post, M. J., Sato, K., Simons, M., Edelberg, J. M., ROSENBERG, R. D., Schrenzel, M. D., & Krieger, M. (2002) · Circulation Research · doi:10.1161/hh0302.104462 · Cited by 491 · see citing works
Rigotti, A., Miettinen, H. E., & Krieger, M. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0037 · Cited by 438 · see citing works
Babitt, J. L., Trigatti, B. L., Rigotti, A., Smart, E. J., Anderson, R. G. W., Xu, S., & Krieger, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13242 · Cited by 376 · see citing works
Kozarsky, K., Donahee, M. H., Glick, J. M., Krieger, M., & Rader, D. J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.721 · Cited by 337 · see citing works
Self-citationGenetic Variant of the Scavenger Receptor BI in Humans
Vergeer, M., Korporaal, S. J. A., Franssen, R., Meurs, I., Out, R., Hovingh, G. K., Hoekstra, M., Sierts, J. A., Dallinga-Thie, G. M., Motazacker, M. M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa0907687 · Cited by 317 · see citing works
Small, Dense High-Density Lipoprotein-3 Particles Are Enriched in Negatively Charged Phospholipids
Camont, L., Lhomme, M., Rached, F. H., Goff, W. L., Nègre‐Salvayre, A., Salvayre, R., Calzada, C., Lagarde, M., Chapman, M. J., & Kontush, A. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301468 · Cited by 317 · see citing works
Self-citationArai, T., Wang, N., Bezouevski, M., Welch, C. L., & Tall, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2366 · Cited by 312 · see citing works
Zhang, Y. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25327 · Cited by 307 · see citing works
Varban, M. L., Rinninger, F., Wang, N., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Gosselin, M. L., Dixon, K. L., Deeds, J. D., Acton, S. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4619 · Cited by 303 · see citing works
The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis?
Rader, D., & Tall, A. (2012) · Nature Medicine · doi:10.1038/nm.2937 · Cited by 293 · see citing works
Self-citationStructure of LIMP-2 provides functional insights with implications for SR-BI and CD36
Neculai, D., Schwake, M., Ravichandran, M., Zunke, F., Collins, R. F., Peters, J., Neculai, A. M., Plumb, J. D., Loppnau, P., Pizarro, J. C., et al. (2013) · Nature · doi:10.1038/nature12684 · Cited by 288 · see citing works
Self-citationHaase, C. L., Tybjærg-Hansen, A., Ali Qayyum, A., Schou, J., Nordestgaard, B. G., & Frikke-Schmidt, R. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1846 · Cited by 282 · see citing works
Self-citationWang, N., Arai, T., Ji, Y. I., Rinninger, F., & Tall, A. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32920 · Cited by 275 · see citing works
Ji, Y. I., Wang, N., Ramakrishnan, R., Sehayek, E., Huszar, D., Breslow, J. L., & Tall, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33398 · Cited by 263 · see citing works
Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans
Schwartz, C. C., VandenBroek, J. M., & Cooper, P. S. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300511-jlr200 · Cited by 250 · see citing works
Calvo, D., Gómez‐Coronado, D., Lasunción, M. A., & Vega, M. A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2341 · Cited by 242 · see citing works
Action of Atorvastatin in Combined Hyperlipidemia
Guérin, M., Lassel, T. S., Goff, W. L., Farnier, M., & Chapman, M. J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.1.189 · Cited by 238 · see citing works
Eck, M. V., Twisk, J., Hoekstra, M., Rij, B. T. V., van der Lans, C. A. C., Bos, I. S. T., Kruijt, J. K., Kuipers, F., & van Berkel, T. J. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211233200 · Cited by 238 · see citing works
Ueda, Y., Royer, L. J., Gong, E. L., Zhang, J., Cooper, P. N., Francone, O. L., & Rubin, E. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7165 · Cited by 226 · see citing works
Connelly, M. A., Klein, S. M., Azhar, S., Abumrad, N. A., & Williams, D. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.41 · Cited by 208 · see citing works
Miettinen, H. E., Rayburn, H., & Krieger, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13288 · Cited by 192 · see citing works
Tietge, U., Maugeais, C., Cain, W. J., Grass, D., Glick, J., de Beer, F. D., & Rader, D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10077 · Cited by 190 · see citing works
Self-citationMeta-analysis of gene-level tests for rare variant association
Liu, D. J., Peloso, G. M., Zhan, X., Holmen, O. L., Zawistowski, M., Feng, S., Nikpay, M., Auer, P. L., Goel, A., Zhang, H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2852 · Cited by 189 · see citing works
Self-citationHuszar, D., Varban, M. L., Rinninger, F., Feeley, R., Arai, T., Fairchild-Huntress, V., Donovan, M. J., & Tall, A. R. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.4.1068 · Cited by 173 · see citing works
Kocher, O. N., Yesilaltay, A., Cirovic, C., Pal, R., Rigotti, A., & Krieger, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310482200 · Cited by 172 · see citing works
Ueda, Y., Gong, E. L., Royer, L. J., Cooper, P. N., Francone, O. L., & Rubin, E. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000730200 · Cited by 166 · see citing works
Ghodsizadeh, A., Taei, A., Totonchi, M., Seifinejad, A., Gourabi, H., Pournasr, B., Aghdami, N., Malekzadeh, R., Almadani, N., Salekdeh, G. H., et al. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9189-3 · Cited by 154 · see citing works
Cayo, M., Cai, J., DeLaForest, A., Noto, F., Nagaoka, M., Clark, B. S., Collery, R., Si-Tayeb, K., & Duncan, S. (2012) · Hepatology · doi:10.1002/hep.25871 · Cited by 150 · see citing works
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Voight, B. F., Peloso, G. M., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M. K., Hindy, G., Hólm, H., Ding, E. L., Johnson, T., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60312-2 · Cited by 148 · see citing works
Self-citationLagrost, L., Gandjini, H., Athias, A., Guyard‐Dangremont, V., Lallemant, C., & Gambert, P. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.6.815 · Cited by 133 · see citing works
Differentiation of Hepatocytes from Pluripotent Stem Cells
Mallanna, S. K., & Duncan, S. A. (2013) · Current Protocols in Stem Cell Biology · doi:10.1002/9780470151808.sc01g04s26 · Cited by 121 · see citing works
Brundert, M., Ewert, A., Heeren, J., Behrendt, B., Ramakrishnan, R., Greten, H., Merkel, M., & Rinninger, F. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000149381.16166.c6 · Cited by 117 · see citing works
Protein 8‐class secondary structure prediction using conditional neural fields
Wang, Z., Zhao, F., Peng, J., & Xu, J. (2011) · PROTEOMICS · doi:10.1002/pmic.201100196 · Cited by 102 · see citing works
Hoekstra, M., Meurs, I., Koenders, M. M. J. F., Out, R., Hildebrand, R. B., Kruijt, J. K., Eck, M. V., & van Berkel, T. J. C. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m700475-jlr200 · Cited by 91 · see citing works
Viñals, M., Xu, S., Vasile, E., & Krieger, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211073200 · Cited by 88 · see citing works
SR-BI and cholesterol uptake into steroidogenic cells
Connelly, M. A., & Williams, D. L. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.10.002 · Cited by 84 · see citing works
Thrombocytopenia and Platelet Abnormalities in High-Density Lipoprotein Receptor–Deficient Mice
Dole, V. S., Matuskova, J., Vasile, E., Yesilaltay, A., Bergmeier, W., Bernimoulin, M. P., Wagner, D. D., & Krieger, M. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.162347 · Cited by 82 · see citing works
Hoekstra, M., Ye, D., Hildebrand, R. B., Zhao, Y., Lammers, B., Stitzinger, M., Kuiper, J., van Berkel, T. J. C., & Eck, M. V. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800410-jlr200 · Cited by 80 · see citing works
Kassim, S. H., Li, H., Vandenberghe, L. H., Hinderer, C. J., Bell, P. L., Marchadier, D. H. L., Wilson, A., Cromley, D. A., Redon, V., Yu, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013424 · Cited by 77 · see citing works
Self-citationScavenger receptor BI modulates platelet reactivity and thrombosis in dyslipidemia
Ma, Y., Ashraf, M. Z., & Podrez, E. A. (2010) · Blood · doi:10.1182/blood-2010-02-268508 · Cited by 72 · see citing works
Kassim, S. H., Li, H., Bell, P. L., et al. (2012) · Human Gene Therapy · doi:10.1089/hum.2012.108 · Cited by 72 · see citing works
Functions of scavenger receptor class B, type I in atherosclerosis
Mineo, C., & Shaul, P. W. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328357ba61 · Cited by 71 · see citing works
Uptake and utilization of lipoprotein cholesteryl esters by rat granulosa cells
Azhar, S., Tsai, L., & REAVEN, E. P. (1990) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(90)90041-u · Cited by 68 · see citing works
Chen, S. J., Rader, D. J., Tazelaar, J., et al. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0122 · Cited by 65 · see citing works
Self-citationScavenger receptor BI: a multi-purpose player in cholesterol and steroid metabolism.
Hoekstra, M., van Berkel, T. J., & Eck, M. V. (2010) · PubMed Central · doi:10.3748/wjg.v16.i47.5916 · Cited by 64 · see citing works
Somanathan, S., Jacobs, F., Wang, Q., Hanlon, A. L., Wilson, J. M., & Rader, D. J. (2014) · Circulation Research · doi:10.1161/circresaha.115.304008 · Cited by 56 · see citing works
Self-citationKitajima, K., Marchadier, D. H. L., Miller, G. C., Gao, G.-P., Wilson, J. M., & Rader, D. J. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000231520.26490.54 · Cited by 54 · see citing works
Self-citationHildebrand, R. B., Lammers, B., Meurs, I., Korporaal, S. J. A., de Haan, W., Zhao, Y., Kruijt, J. K., Praticò, D., Schimmel, A. W. M., Holleboom, A. G., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.205153 · Cited by 54 · see citing works
Inflammation Warms Up the Metabolic Syndrome
Esposito, K., Ciotola, M., & Giugliano, D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000185830.17528.e3 · Cited by 50 · see citing works
Generation of analytic plasma lipoprotein profiles using two prepacked superose 6B columns
Gerdes, L. U., Gerdes, C., Klausen, I. C., et al. (1992) · Clinica Chimica Acta · doi:10.1016/0009-8981(92)90348-t · Cited by 44 · see citing works
Chen, S., Sanmiguel, J. C., Lock, M. W., McMenamin, D., Draper, C., Limberis, M. P., Kassim, S. H., Somanathan, S., Bell, P. L., Johnston, J., et al. (2013) · Human Gene Therapy Clinical Development · doi:10.1089/humc.2013.082 · Cited by 43 · see citing works
Self-citationHDL scavenger receptor class B type I and platelet function
Nofer, J., & Eck, M. V. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32834701de · Cited by 33 · see citing works
Tietge, U. J. F., Maugeais, C., Cain, W., & Rader, D. J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00576.2002 · Cited by 33 · see citing works
Self-citationNegatively Cooperative Binding of High-Density Lipoprotein to the HDL Receptor SR-BI
Nieland, T. J. F., Xu, S., Penman, M., & Krieger, M. (2011) · Biochemistry · doi:10.1021/bi101657j · Cited by 23 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [3]Frikke-Schmidt R JAMA 299 2524 2532 2008 18523221
- [26]Si-Tayeb K Hepatology 51 297 305 2010 19998274 PMC2946078
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Self-citationHegele, R. A., Borén, J., Ginsberg, H. N., Arca, M., Averna, M., Binder, C. J., Calabresi, L., Chapman, M. J., Cuchel, M., von Eckardstein, A., et al. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30264-5 · Cited by 204 · see citing works
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- Authors
- Zanoni, P., Khetarpal, S. A., Larach, D. B., Hancock-Cerutti, W. F., Millar, J. S., Cuchel, M., DerOhannessian, S., Kontush, A., Surendran, P., Saleheen, D., Trompet, S., Jukema, J. W., De Craen, A., Deloukas, P., Sattar, N., Ford, I., Packard, C., Majumder, A. A. S., Alam, D. S., Di Angelantonio, E., Abecasis, G., Chowdhury, R., Erdmann, J., Nordestgaard, B. G., Nielsen, S. F., Tybjærg-Hansen, A., Schmidt, R. F., Kuulasmaa, K., Liu, D. J., Perola, M., Blankenberg, S., Salomaa, V., Männistö, S., Amouyel, P., Arveiler, D., Ferrieres, J., Müller-Nurasyid, M., Ferrario, M., Kee, F., Willer, C. J., Samani, N., Schunkert, H., Butterworth, A. S., Howson, J. M. M., Peloso, G. M., Stitziel, N. O., Danesh, J., Kathiresan, S., Rader, D. J., CHD Exome+ Consortium, CARDIoGRAM Exome Consortium, Global Lipids Genetics Consortium, Watson, S., Schmidt, E. M., Sengupta, S., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H.-Y., Demirkan, A., Den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., Feitosa, M. F., Ferreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K., Hyppönen, E., Isaacs, A., Jackson, A. U., Johansson, Å., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikäinen, L.-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Nolte, I. M., O’Connell, J. R., Palmer, C. D., Petersen, A.-K., Sanna, S., Saxena, R., Service, S. K., Shah, S., Shungin, D., Sidore, C., Song, C., Strawbridge, R. J., Surakka, I., Tanaka, T., Teslovich, T. M., Thorleifsson, G., Van den Herik, E. G., Voight, B. F., Volcik, K. A., Waite, L. L., Wong, A., Wu, Y., Zhang, W., Absher, D., Asiki, G., Barroso, I., Been, L. F., Bolton, J. L., Bonnycastle, L. L., Brambilla, P., Burnett, M. S., Cesana, G., Dimitriou, M., Doney, A. S. F., Döring, A., Elliott, P., Epstein, S. E., Eyjolfsson, G. I., Gigante, B., Goodarzi, M. O., Grallert, H., Gravito, M. L., Groves, C. J., Hallmans, G., Hartikainen, A.-L., Hayward, C., Hernandez, D., Hicks, A. A., Holm, H., Hung, Y.-J., Illig, T., Jones, M. R., Kaleebu, P., Kastelein, J. J. P., Khaw, K.-T., Kim, E., Klopp, N., Komulainen, P., Kumari, M., Langenberg, C., Lehtimäki, T., Lin, S.-Y., Lindström, J., Loos, R. J. F., Mach, F., McArdle, W. L., Meisinger, C., Mitchell, B. D., Müller, G., Nagaraja, R., Narisu, N., Nieminen, T. V. M., Nsubuga, R. N., Olafsson, I., Ong, K. K., Palotie, A., Papamarkou, T., Pomilla, C., Pouta, A., Reilly, M. P., Ridker, P. M., Rivadeneira, F., Rudan, I., Ruokonen, A., Scharnagl, H., Seeley, J., Silander, K., Stancáková, A., Stirrups, K., Swift, A. J., Tiret, L., Uitterlinden, A. G., van Pelt, L. J., Vedantam, S., Wainwright, N., Wijmenga, C., Wild, S. H., Willemsen, G., Wilsgaard, T., Wilson, J. F., Young, E. H., Zhao, J. H., Adair, L. S., Arveiler, D., Assimes, T. L., Bandinelli, S., Bennett, F., Bochud, M., Boehm, B. O., Boomsma, D. I., Borecki, I. B., Bornstein, S. R., Bovet, P., Burnier, M., Campbell, H., Chakravarti, A., Chambers, J. C., Chen, Y.-D. I., Collins, F. S., Cooper, R. S., Dedoussis, G., de Faire, U., Feranil, A. B., Ferrucci, L., Freimer, N. B., Gieger, C., Groop, L. C., Gudnason, V., Gyllensten, U., Hamsten, A., Harris, T. B., Hingorani, A., Hirschhorn, J. N., Hofman, A., Hovingh, G. K., Hsiung, C. A., Humphries, S. E., Hunt, S. C., Hveem, K., Iribarren, C., Järvelin, M.-R., Jula, A., Kähönen, M., Kaprio, J., Kesäniemi, A., Kivimaki, M., Kooner, J. S., Koudstaal, P. J., Krauss, R. M., Kuh, D., Kuusisto, J., Kyvik, K. O., Laakso, M., Lakka, T. A., Lind, L., Lindgren, C. M., Martin, N. G., März, W., McCarthy, M. I., McKenzie, C. A., Meneton, P., Metspalu, A., Moilanen, L., Morris, A. D., Munroe, P. B., Njølstad, I., Pedersen, N. L., Power, C., Pramstaller, P. P., Price, J. F., Psaty, B. M., Quertermous, T., Rauramaa, R., Salomaa, V., Sanghera, D. K., Saramies, J., Schwarz, P. E. H., Sheu, W. H.-H., Shuldiner, A. R., Siegbahn, A., Spector, T. D., Stefansson, K., Strachan, D. P., Tayo, B. O., Tremoli, E., Tuomilehto, J., Uusitupa, M., van Duijn, C. M., Vollenweider, P., Wallentin, L., Wareham, N. J., Whitfield, J. B., Wolffenbuttel, B. H. R., Ordovas, J. M., Boerwinkle, E., Palmer, C. N. A., Thorsteinsdottir, U., Chasman, D. I., Rotter, J. I., Franks, P. W., Riatti, S., Cupples, L. A., Sandhu, M. S., Rich, S. S., Boehnke, M., Deloukas, P., Mohlke, K. L., Ingelsson, E., Gu, D., Roberts, R., Watkins, H., Blankenberg, S., Clarke, R., Collins, R., Kim, B.-J., McPherson, R., Nieminen, M. S., O'Donnell, C., Schreiber, S., Siegbahn, A., & Zalloua, P. A.
- Affiliations
- University of Pennsylvania (US)
- Inserm (FR)
- University of Cambridge (GB)
- Leiden University Medical Center (NL)
- Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands.
- British Heart Foundation (GB)
- University of Glasgow (GB)
- Western Infirmary (GB)
- National Institute of Cardiovascular Diseases (BD)
- International Centre for Diarrhoeal Disease Research (BD)
- Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
- Institute for Integrative and Experimental Genomics (DE)
- Herlev Hospital (DK)
- Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
- Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitals, Copenhagen, Denmark.
- Finnish Institute for Health and Welfare (FI)
- Pennsylvania State University (US)
- University of Helsinki (FI)
- Institut Pasteur de Lille (FR)
- Department of Epidemiology, Toulouse University-CHU Toulouse, Toulouse, France.
- Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany.
- Research Centre in Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
- Queen's University Belfast (GB)
- University of Michigan (US)
- University of Leicester (GB)
- Deutsches Herzzentrum München (DE)
- Broad Institute (US)
- Washington University in St. Louis (US)
- University of Copenhagen (DK)
- Universität Hamburg (DE)
- Université de Strasbourg (FR)
- Helmholtz Munich (DE)
- Corresponding author
- Zanoni, Paolo
- Khetarpal, Sumeet A.
- Larach, Daniel B.
- Rader, Daniel J.
- ORCID
- Zanoni, Paolo
- Khetarpal, Sumeet A.
- Larach, Daniel B.
- Hancock-Cerutti, William F.
- Millar, John S.
- Cuchel, Marina
- Kontush, Anatol
- Surendran, Praveen
- Saleheen, Danish
- Trompet, Stella
- Jukema, J. Wouter
- Sattar, Naveed
- Ford, Ian
- Packard, Chris
- Alam, Dewan S.
- Chowdhury, Rajiv
- Erdmann, Jeanette
- Nordestgaard, Børge G.
- Nielsen, Sune F.
- Kuulasmaa, Kari
- Liu, Dajiang J.
- Perola, Markus
- Männistö, Satu
- Amouyel, Philippe
- Kee, Frank
- Willer, Cristen J.
- Samani, Nilesh
- Schunkert, Heribert
- Butterworth, Adam S.
- Howson, Joanna M. M.
- Peloso, Gina M.
- Stitziel, Nathan O.
- Danesh, John
- Kathiresan, Sekar
- Rader, Daniel J.
- Watson, Sarah
- Schmidt, Ellen M.
- Gustafsson, Stefan
- Kanoni, Stavroula
- Ganna, Andrea
- Buchkovich, Martin L.
- Mora, Samia
- Beckmann, Jacques S.
- Chang, Hsing-Yi
- Demirkan, Ayşe
- Do, Ron
- Donnelly, Louise A.
- Ehret, Georg B.
- Esko, Tõnu
- Feitosa, Mary F.
- Ferreira, Teresa
- Fischer, Krista
- Fontanillas, Pierre
- Fraser, Ross M.
- Freitag, Daniel F.
- Gurdasani, Deepti
- Hyppönen, Elina
- Isaacs, Aaron
- Jackson, Anne U.
- Johansson, Åsa
- Johnson, Toby
- Kaakinen, Marika
- Kettunen, Johannes
- Kleber, Marcus E.
- Li, Xiaohui
- Luan, Jian’an
- Lyytikäinen, Leo-Pekka
- Magnusson, Patrik K. E.
- Mangino, Massimo
- Montasser, May E.
- Nolte, Ilja M.
- O’Connell, Jeffrey R.
- Palmer, Cameron D.
- Sanna, Serena
- Saxena, Richa
- Service, Susan K.
- Shah, Sonia
- Shungin, Dmitry
- Sidore, Carlo
- Song, Ci
- Strawbridge, Rona J.
- Surakka, Ida
- Tanaka, Toshiko
- Voight, Benjamin F.
- Wong, Andrew
- Wu, Ying
- Zhang, Weihua
- Asiki, Gershim
- Barroso, Inês
- Been, Latonya F.
- Bonnycastle, Lori L.
- Brambilla, Paolo
- Cesana, Giancarlo
- Dimitriou, Maria
- Doney, Alex S. F.
- Elliott, Paul
- Gigante, Bruna
- Goodarzi, Mark O.
- Grallert, Harald
- Hallmans, Göran
- Hayward, Caroline
- Hernandez, Dena
- Hicks, Andrew A.
- Hung, Yi-Jen
- Jones, Michelle R.
- Kaleebu, Pontiano
- Kastelein, John J. P.
- Khaw, Kay-Tee
- Komulainen, Pirjo
- Langenberg, Claudia
- Lehtimäki, Terho
- Lindström, Jaana
- Loos, Ruth J. F.
- Mach, François
- McArdle, Wendy L.
- Meisinger, Christa
- Mitchell, Braxton D.
- Nagaraja, Ramaiah
- Narisu, Narisu
- Nieminen, Tuomo V. M.
- Nsubuga, Rebecca N.
- Ong, Ken K.
- Palotie, Aarno
- Papamarkou, Theodore
- Pomilla, Cristina
- Reilly, Muredach P.
- Ridker, Paul M.
- Rivadeneira, Fernando
- Rudan, Igor
- Scharnagl, Hubert
- Seeley, Janet
- Stirrups, Kathleen
- Vedantam, Sailaja
- Wijmenga, Cisca
- Wild, Sarah H.
- Willemsen, Gonneke
- Wilsgaard, Tom
- Wilson, James F.
- Zhao, Jing Hua
- Assimes, Themistocles L.
- Bandinelli, Stefania
- Bennett, Franklyn
- Bochud, Murielle
- Boehm, Bernhard O.
- Boomsma, Dorret I.
- Borecki, Ingrid B.
- Bornstein, Stefan R.
- Bovet, Pascal
- Burnier, Michel
- Chakravarti, Aravinda
- Chambers, John C.
- Chen, Yii-Der Ida
- Collins, Francis S.
- Cooper, Richard S.
- Dedoussis, George
- Ferrucci, Luigi
- Gieger, Christian
- Groop, Leif C.
- Gudnason, Vilmundur
- Gyllensten, Ulf
- Hamsten, Anders
- Harris, Tamara B.
- Hingorani, Aroon
- Hirschhorn, Joel N.
- Hovingh, G. Kees
- Hsiung, Chao Agnes
- Humphries, Steve E.
- Hunt, Steven C.
- Hveem, Kristian
- Iribarren, Carlos
- Järvelin, Marjo-Riitta
- Kähönen, Mika
- Kaprio, Jaakko
- Kooner, Jaspal S.
- Koudstaal, Peter J.
- Krauss, Ronald M.
- Kuh, Diana
- Kyvik, Kirsten O.
- Laakso, Markku
- Lakka, Timo A.
- Lind, Lars
- Lindgren, Cecilia M.
- Martin, Nicholas G.
- März, Winfried
- McCarthy, Mark I.
- Meneton, Pierre
- Metspalu, Andres
- Moilanen, Leena
- Munroe, Patricia B.
- Njølstad, Inger
- Pedersen, Nancy L.
- Power, Chris
- Pramstaller, Peter P.
- Price, Jackie F.
- Psaty, Bruce M.
- Quertermous, Thomas
- Sanghera, Dharambir K.
- Schwarz, Peter E. H.
- Sheu, Wayne H.-H.
- Shuldiner, Alan R.
- Spector, Tim D.
- Strachan, David P.
- Tayo, Bamidele O.
- Tremoli, Elena
- Tuomilehto, Jaakko
- Uusitupa, Matti
- Wallentin, Lars
- Wareham, Nicholas J.
- Whitfield, John B.
- Wolffenbuttel, Bruce H. R.
- Boerwinkle, Eric
- Chasman, Daniel I.
- Rotter, Jerome I.
- Franks, Paul W.
- Cupples, L. Adrienne
- Sandhu, Manjinder S.
- Rich, Stephen S.
- Boehnke, Michael
- Mohlke, Karen L.
- Ingelsson, Erik
- Gu, Dongfeng
- Roberts, Robert
- Watkins, Hugh
- Clarke, Robert
- Collins, Rory
- Kim, Bong-Jo
- McPherson, Ruth
- Nieminen, Markku S.
- Zalloua, Pierre A.
- Venue
- Science
- Published
- 2016-03-11
- Volume
- 351
- Issue
- 6278
- Pages
- 1166-1171
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4889017
- OpenAlex
- W2296190881
- Cited by
- 545
- References
- 75
- Citations by year
- 2026: 27 · 2025: 33 · 2024: 40 · 2023: 46 · 2022: 45 · 2021: 60 · 2020: 48 · 2019: 56 · 2018: 63 · 2017: 79 · 2016: 45 · 2015: 2 · 2014: 1
- FWCI
- 89.67
- Type
- journal article
- Language
- en
- Open access
- green
- serval.unil.ch
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- UA Campus Repository (The University of Arizona) (acceptedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- IRIS (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- VU Research Portal (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- WOS
- Funders
- National Center for Research Resources (TL1RR024133)
- National Center for Advancing Translational Sciences of the NIH (TL1R000138)
- Doris Duke Charitable Foundation
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- scavenger receptor BI, scavenger receptor class B type I, HDL cholesterol, coronary heart disease risk, loss-of-function mutations, HDL metabolism, atherosclerosis, post-translational processing, induced pluripotent stem cell-derived hepatocytes
- MeSH terms
- Aged, Animals, Coronary Disease, DNA Mutational Analysis, Female, Heterozygote, Homozygote, Humans, Leucine, Cholesterol, HDL, Male, Middle Aged, Proline, Protein Processing, Post-Translational, Risk, Genetic Variation, Amino Acid Substitution, Scavenger Receptors, Class B, Mice
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