Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

A role for glucagon-like peptide-1 in the central regulation of feeding

Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study

Zander, M., Madsbad, S., Madsen, J. L., & Holst, J. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07952-7 · Cited by 1,297

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., et al. (2002) · Nature Medicine · doi:10.1038/nm727 · Cited by 963

Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

Perley, M. J., & Kipnis, D. M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105685 · Cited by 917

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L., & Habener, J. F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3434 · Cited by 903

Antidiabetogenic effect of glucagon-like peptide-1 (7–36)amide in normal subjects and patients with diabetes mellitus

Gutniak, M., Ørkov, C., Holst, J. J., Ahrén, B., & Efendić, S. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205143262003 · Cited by 868

Alterations of glucose-dependent insulinotropic polypeptide (GIP) during cold acclimation

Irwin, N., Francis, J. M. E., & Flatt, P. R. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.12.001 · Cited by 15

Wnt and Incretin Connections

García‐Jiménez, C. (2010) · Vitamins and hormones · doi:10.1016/b978-0-12-381517-0.00014-x · Cited by 15

Plasma levels of glucagon‐like peptide 1 and markers of obesity among young and healthy adults

van der Stouwe, J. G., Aeschbacher, S., Krisai, P., Schoen, T., Meyre, P. B., Todd, J., Estis, J., Risch, M., Risch, L., & Conen, D. (2015) · Clinical Endocrinology · doi:10.1111/cen.12789 · Cited by 15

The Effect of Duodenal–Jejunal Bypass on Glucose-Dependent Insulinotropic Polypeptide Secretion in Wistar Rats

Kindel, T. L., Yoder, S. M., D’Alessio, D. A., & Tso, P. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0095-1 · Cited by 15

Effects of Pioglitazone on Glucose-Dependent Insulinotropic Polypeptide–Mediated Insulin Secretion and Adipocyte Receptor Expression in Patients With Type 2 Diabetes

Tharp, W. G., Gupta, D., Sideleva, O., Deacon, C. F., Holst, J. J., Elahi, D., & Pratley, R. E. (2019) · Diabetes · doi:10.2337/db18-1163 · Cited by 15

Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice

Liu, X., Harada, N., Yamane, S., Kitajima, L., Uchida, S., Hamasaki, A., Mukai, E., Toyoda, K., Yamada, C., Yamada, Y., et al. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.03.022 · Cited by 15

Evaluating glucose-dependent insulinotropic polypeptide and glucagon as key regulators of insulin secretion in the pancreatic islet

Lewandowski, S. L., EL, K. M., & Campbell, J. E. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00360.2023 · Cited by 15

Effects of γ-glutamyl linker on DPP-IV resistance, duration of action and biological efficacy of acylated glucagon-like peptide-1

Kerr, B. D., Flatt, P. R., & Gault, V. A. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.04.021 · Cited by 14

Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes

Irwin, N., Montgomery, I. A., O'Harte, F. P. M., Frizelle, P. A., & Flatt, P. R. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.179 · Cited by 14

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Takagi, Y., Kinoshita, K., Ozaki, N., Seino, Y., Murata, Y., Oshida, Y., & Hayashi, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138322 · Cited by 13

Increased insulin clearance in mice with double deletion of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors

Tura, A., Bizzotto, R., Yamada, Y., Seino, Y., Pacini, G., & Åhrén, B. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00181.2017 · Cited by 13

Evaluation of the long-term effects of gastric inhibitory polypeptide–ovalbumin conjugates on insulin resistance, metabolic dysfunction, energy balance and cognition in high-fat-fed mice

Irwin, N., Montgomery, I. A., & Flatt, P. R. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511005228 · Cited by 13

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Douros, J. D., Mowery, S. A., & Knerr, P. J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14113812 · Cited by 12

Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice

McMorrow, H. E., Cohen, A. B., Lorch, C. M., Hayes, N. W., Fleps, S. W., Frydman, J. A., Xia, J. L., Samms, R. J., & Beutler, L. R. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186652 · Cited by 12

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Dandona, P., Ghanim, H., & Chaudhuri, A. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13153 · Cited by 13

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Boer, G. A., Hunt, J. E., Gabe, M. B. N., Windeløv, J. A., Sparre‐Ulrich, A. H., Hartmann, B., Holst, J. J., & ROSENKILDE, M. M. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15894 · Cited by 11

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Irwin, N., Hunter, K., & Flatt, P. R. (2008) · Peptides · doi:10.1016/j.peptides.2008.01.006 · Cited by 11

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Morissette, A., & Mulvihill, E. E. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.012 · Cited by 12

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Tian, J. ‐., Wang, Y., Lin, N., Guo, Y., Sun, S., & Zou, D.-C. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02400.x · Cited by 11

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Chen, Y., Feng, R., Wang, H., Wei, R., Yang, J., Wang, L., Wang, H., Zhang, L., Hong, T., & Wen, J. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2572 · Cited by 11

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Cui, C., Leander, D. C., Gray, S. M., EL, K. M., Chen, A. Y., Grimsrud, P. A., Becker, J. O., Taylor, A. J., Zhang, G., Sloop, K. W., et al. (2025) · Science Advances · doi:10.1126/sciadv.ady8048 · Cited by 12

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Omar, B. A., Ahlkvist, L., Yamada, Y., Seino, Y., & Åhrén, B. (2016) · Peptides · doi:10.1016/j.peptides.2016.03.012 · Cited by 9

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Yavropoulou, M. P., & Yovos, J. G. (2010) · Vitamins and hormones · doi:10.1016/b978-0-12-381517-0.00006-0 · Cited by 10

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Irwin, N., Hunter, K., & Flatt, P. R. (2007) · Peptides · doi:10.1016/j.peptides.2007.08.008 · Cited by 9

Incretin hormones and pharmacomimetics rapidly inhibit AgRP neuron activity to suppress appetitePreprint

McMorrow, H. E., Lorch, C. M., Hayes, N. W., Fleps, S. W., Frydman, J. A., Xia, J. L., Samms, R. J., & Beutler, L. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.18.585583 · Cited by 10

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Angevine, K., Wuescher, L. M., Andrews, K., Alexander, L., McInerney, M. F., Kieffer, T. J., & Mensah‐Osman, E. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.30 · Cited by 10

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Zandvakili, I., & Pérez–Tilve, D. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.022 · Cited by 8

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Morissette, A., & Mulvihill, E. E. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.13065 · Cited by 8

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Previti, E., Salinari, S., BERTUZZI, A., Capristo, E., Bornstein, S. R., & Mingrone, G. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00042.2017 · Cited by 8

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Shama, N., Kumari, R., Bais, S., & Shrivastava, A. (2019) · Obesity Medicine · doi:10.1016/j.obmed.2019.100144 · Cited by 8

Maternal metabolic syndrome and selenium: Endocrine energy balance during early programming

Ojeda, M. L., Nogales, F., Serrano, A., Murillo, M. L. O., & Carreras, O. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116689 · Cited by 8

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Lafferty, R. A., Flatt, P. R., Gault, V. A., & Irwin, N. (2024) · Journal of Endocrinology · doi:10.1530/joe-23-0339 · Cited by 8

Future Drug Treatments for Type 2 Diabetes

Bailey, C. J. (2010) · Wiley eBooks · doi:10.1002/9781444324808.ch60 · Cited by 7

Incretin impact on gastric function in obesity: physiology, and pharmacological, surgical and endoscopic treatments

Camilleri, M. (2024) · The Journal of Physiology · doi:10.1113/jp287535 · Cited by 7

The role of foregut exclusion in the deterioration of glucose and lipid metabolism induced by a high-fat diet

Li, P., Zhu, L., Wang, G., Yang, X., Yi, B., & Zhu, S. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.01.009 · Cited by 6

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Åhrén, B., Yamada, Y., & Seino, Y. (2019) · Peptides · doi:10.1016/j.peptides.2019.170152 · Cited by 6

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Campbell, J. E., Beaudry, J. L., Svendsen, B., Baggio, L. L., Gordon, A. N., Ussher, J. R., Wong, C. K., Gribble, F. M., D’Alessio, D. A., Reimann, F. M., et al. (2022) · doi:10.2337/figshare.19184462 · Cited by 6

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Feng, S., Zhou, Y. X., Guo, L., Liang, Y., & Zhu, W. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107921 · Cited by 6

Future Drug Treatments for Type 2 Diabetes

Bailey, C. J. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch67 · Cited by 4

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Liu, L., Fan, H., Li, L., & Fan, Y. (2023) · Respiratory Research · doi:10.1186/s12931-023-02619-8 · Cited by 5

GLP-1 receptor agonism and GIP receptor antagonism induce substantial alterations in enteroendocrine and islet cell populations in obese high fat fed mice

Sridhar, A., Khan, D., Flatt, P. R., Moffett, R. C., & Irwin, N. (2023) · Peptides · doi:10.1016/j.peptides.2023.171093 · Cited by 4

Medical Therapy for Obesity

Dayyeh, B. K. A., & Kaplan, L. M. (2011) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2011.02.006 · Cited by 4

EGLP-1 lowers body weight better than exendin-4 by reducing food intake and increasing basal energy expenditure in diet-induced obese mice

Gao, H., Zhao, Q., Li, K., Qin, F., Yin, X., Lu, Z., Song, Z., Wu, Y., Shen, Y., Pan, Y., et al. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112454 · Cited by 3

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Xu, Z., Wen, S., Dong, M., & Zhou, L. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16146 · Cited by 3

Predicting response to incretin-based therapy

Kalra, S., Kalra, B., Sahay, R. K., & Agrawal, N. K. (2011) · Research and Reports in Endocrine Disorders · doi:10.2147/rred.s16282 · Cited by 3

Sleeve Gastrectomy Improves High-Fat Diet–Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats

Barron, M., Hayes, H., Fernando, D. G., Geurts, A. M., & Kindel, T. L. (2022) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-022-05361-6 · Cited by 3

Role of the Gut Peptide Glucose-Induced Insulinomimetic Peptide in Energy Balance

Pfeiffer, A. F. H., Rudovich, N. N., Weickert, M. O., & Isken, F. (2010) · Results and problems in cell differentiation · doi:10.1007/978-3-642-14426-4_15 · Cited by 3

Vaccines for metabolic diseases: current perspectives

Monteiro, M. P., Morais, T., Andrade, S., & Pereira, S. S. (2014) · Vaccine Development and Therapy · doi:10.2147/vdt.s47623 · Cited by 3

Association of TCF7L2 rs7903146 Gene Polymorphism with the Risk of NAFLD and CAD in the Chinese Han Population

Yan, X., Jin, W., Zhang, J., Wang, M., Liu, S., & Xin, Y. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00071 · Cited by 3

The Paradox and Future of GLP-1/GIP Combination Therapies: Efficacy and Mechanisms

Davies, I., Holst, J. J., ROSENKILDE, M. M., & Tan, T. (2026) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061824-043740 · Cited by 2

Dipeptidyl peptidase IV inhibitor improves the salivary gland histology of spontaneously diabetic mice

Faria, A. L. D. D. S., Dias, M. A., Leme, V. B., Mayoral, É. E., da Silva, R. E., Mâncio, R. D., Ferreira, R. S., & Caldeira, E. J. (2012) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2012.09.015 · Cited by 2

Mouse genetics in drug target discovery and validation: no simple answers to complex problems

Russ, A. P., & Grosse, J. (2007) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2.10.1379 · Cited by 2

Pharmacotherapy for Weight Loss

Lutz, T. A., & Asarian, L. (2017) · CRC Press eBooks · doi:10.1201/9781315120171-13 · Cited by 3

Hepatic and Extrahepatic Insulin Clearance in Mice with Double Deletion of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Receptors

Morettini, M., Piersanti, A., Burattini, L., Pacini, G., Göbl, C. S., Åhrén, B., & Tura, A. (2021) · Biomedicines · doi:10.3390/biomedicines9080973 · Cited by 2

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Fujishima, Y., & Maeda, N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407869-7.00015-5 · Cited by 1

Adipokines in Health and Disease

Ahima, R. S., & Goncalves, M. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_4 · Cited by 1

Gastric inhibitory polypeptide receptor

Hoersch, D., & Schrader, J. (2007) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a001028.01 · Cited by 1

Incretins: new targets for the prevention of diabetes and obesity

Neff, K., & le Roux, C. W. (2013) · Clinical Lipidology · doi:10.2217/clp.12.80 · Cited by 1

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Ranganath, L. R., & Pinkney, J. H. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_17 · Cited by 2

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Smith, U., & Yang, X. (2011) · Wiley eBooks · doi:10.1002/9781444347319.ch14 · Cited by 1

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Duez, H., Smith, A. C., Xiao, C., Giacca, A., Szeto, L., Drucker, D. J., Lewis, G. F., & Lewis, D. G. F. (2015)

An adipocentric view of the development of insulin resistance

Szalowska, E. (2011) · University of Groningen research database (University of Groningen / Centre for Information Technology)

Rat Chromosome 8 Confers Protection against Dyslipidemia Caused by a High-Fat/ Low-Carbohydrate Diet

Woods, L. C. S., Woods, B. C., Leitschuh, C. M., Laurie, S. J., & Jacob, H. J. (2012) · Lifestyle Genomics · doi:10.1159/000338848

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Drucker, D. J. (2012) · Canadian Medical Association Journal · doi:10.1503/cmaj.112127

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Widenmaier, S. B. (2010) · cIRcle (University of British Columbia) · doi:10.14288/1.0071070

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Kamal, A., & Hassan, H. A. J. (2016) · International Journal of Pharma and Bio Sciences

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Hsieh, J. (2012) · TSpace (University of Toronto)

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Flock, G. B. (2012) · TSpace (University of Toronto)

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Strehle, A. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

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de Oliveira, D. R. C. F. (2016) · doi:10.11606/t.5.2016.tde-04112016-144020

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Bilasy, S. E. (2014) · Al-Azhar Journal of Pharmaceutical Sciences/Al-Azhar Journal of Pharmaceutical Sciences · doi:10.21608/ajps.2014.6955

Quantifying Appetite and Satiety

Gibbons, C., & Blundell, J. E. (2019) · Springer eBooks · doi:10.1007/978-3-030-11748-1_5

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Watanabe, H., Enoki, Y., & Maruyama, T. (2020) · Springer eBooks · doi:10.1007/978-981-15-2365-6_2

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Watanabe, H., Kato, H., Enoki, Y., Maeda, H., & Maruyama, T. (2020) · Springer eBooks · doi:10.1007/978-981-15-7793-2_9

Faculty Opinions recommendation of TGR5-mediated bile acid sensing controls glucose homeostasis.

Vinik, A. I., & Bourcier, M. E. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1164606.628139

Current World Literature

(2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282fba8b4

Current World Literature

(2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f4f084

Regional Intestinal Drug Absorption

Gonzalez-Alvarez, M. I., & Dahan, A. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-3657-6

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Lutz, T. A., & Asarian, L. (2017) · Routledge eBooks · doi:10.1201/9781315120171-14

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Laboratorio de Neuropéptidos, F. D. F., & Camacho, E. (2023) · Revista de la Facultad de Farmacia · doi:10.54305/rffucv.2023.86.3.19

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Okoro, P. N., Olarinoye, J. K., & Abayomi, B. S. (2024) · South Asian Journal of Health Sciences · doi:10.25259/sajhs_27_2023

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Varra, F., Varras, M. N., Varra, V., & Theodosis‐Nobelos, P. (2025) · Current Clinical Pharmacology · doi:10.2174/0127724328392698250818071803 · Cited by 1

Additional file 1 of Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice

Liu, L., Fan, H., Li, L., & Fan, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24819668

Additional file 2 of Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice

Liu, L., Fan, H., Li, L., & Fan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.24820070

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Derghal, A. (2015) · theses.fr (ABES) · doi:10.70675/52e93e9dz2fdcz4732z8882z42765965e0d8

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Ayari, S. (2017) · theses.fr (ABES) · doi:10.70675/1f6131a7z05ffz4c94zb22fz066a5605f59a

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Chui, Z. S. W., Xue, Y., Wu, X., & Xu, A. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100150

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Liu, C., Wang, Y., Liu, J., Tian, P., Liu, J., Li, M., Zhang, Z., & Zhang, P. (2026) · Peptides · doi:10.1016/j.peptides.2026.171524

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