Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256

Prevalence and trends in obesity among US adults, 1999–2000

Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637

Identification of targets of leptin action in rat hypothalamus.

Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,499

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1995) · Nature · doi:10.1038/374479a0 · Cited by 1,125

Obesity Wars

Flier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,124

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004

Ghrelin’s Role as a Major Regulator of Appetite and Its Other Functions in Neuroendocrinology

Lim, C. T., Kola, B., Korbonits, M., & Grossman, A. B. (2010) · Progress in Brain Research · doi:10.1016/s0079-6123(10)82008-4 · Cited by 34

Differential Pharmacologic Properties of the Two C75 Enantiomers: (+)‐C75 Is a Strong Anorectic Drug; (−)‐C75 Has Antitumor Activity

Makowski, K., Mera, P., Paredes, D., Herrero, L., Ariza, X., Asins, G., Hegardt, F. G., García, J., & Serra, D. (2013) · Chirality · doi:10.1002/chir.22139 · Cited by 36

Role of FAT/CD36 in fatty acid sensing, energy, and glucose homeostasis regulation in DIO and DR rats

Foll, C. L., Dunn-Meynell, A. A., & Levin, B. E. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00367.2014 · Cited by 38

Interaction of glucose sensing and leptin action in the brain

Li, R. J. W., Zhang, S., & Lam, T. K. T. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101011 · Cited by 36

A nexus of lipid and O-Glcnac metabolism in physiology and disease

Lockridge, A. D., & Hanover, J. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.943576 · Cited by 35

Long-Term Increased Carnitine Palmitoyltransferase 1A Expression in Ventromedial Hypotalamus Causes Hyperphagia and Alters the Hypothalamic Lipidomic Profile

Mera, P., Mir, J. F., Fabriàs, G., Casas, J., Costa, A. S. H., Malandrino, M. I., Fernández–Löpez, J., Remesar, X., Gao, S., Chohnan, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097195 · Cited by 38

Naloxone, but Not Valsartan, Preserves Responses to Hypoglycemia After Antecedent Hypoglycemia

Poplawski, M. M., Mastaitis, J. W., & Mobbs, C. V. (2010) · Diabetes · doi:10.2337/db10-0326 · Cited by 34

A metabolomic study of adipose tissue in mice with a disruption of the circadian system

Castro, C., Briggs, W., Paschos, G. K., FitzGerald, G. A., & Griffin, J. L. (2015) · Molecular BioSystems · doi:10.1039/c5mb00032g · Cited by 33

Hypothalamic sensing of circulating lactate regulates glucose production

Kokorovic, A., Cheung, G. W. C., Rossetti, L., & Lam, T. K. T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00596.x · Cited by 36

Hypothalamic Control of Hepatic Glucose Production and Its Potential Role in Insulin Resistance

Buettner, C., & Camacho, R. C. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.09.001 · Cited by 31

Sense and Nonsense in Metabolic Control of Reproduction

Schneider, J. E., Klingerman, C. M., & Abdulhay, A. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00026 · Cited by 30

Pregnancy-induced changes in the circadian expression of hepatic clock genes: implications for maternal glucose homeostasis

Wharfe, M. D., Wyrwoll, C. S., Waddell, B. J., & Mark, P. J. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00060.2016 · Cited by 32

Response of hepatic lipid and glucose metabolism to a mixture or single fatty acids: Possible presence of fatty acid-sensing mechanisms

Librán-Pérez, M., Figueiredo-Silva, A. C., Panserat, S., Geurden, I., Míguez, J. M., Polakof, S., & Soengas, J. L. (2012) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2012.09.012 · Cited by 29

Central administration of vaspin inhibits glucose production and augments hepatic insulin signaling in high-fat-diet-fed rat

Luo, X., Li, K., Zhang, C., Yang, G., Yang, M., Jia, Y., Zhang, L., Ma, Z. A., Boden, G., & Li, L. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.24 · Cited by 29

Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary

Raskin, P., & Cincotta, A. H. (2015) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2016.1131119 · Cited by 28

Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance

González‐García, I., Fernø, J., Diéguez, C., Nogueiras, R., & López, M. (2016) · Neuroendocrinology · doi:10.1159/000448432 · Cited by 30

Diabetic encephalopathy: the role of oxidative stress and inflammation in type 2 diabetes

Reis, F., Soares, Nunes, & Pereira, F. C. (2012) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s29322 · Cited by 26

Effect of bromocriptine-QR therapy on glycemic control in subjects with type 2 diabetes mellitus whose dysglycemia is inadequately controlled on insulin

Chamarthi, B., & Cincotta, A. H. (2017) · Postgraduate Medicine · doi:10.1080/00325481.2017.1315290 · Cited by 25

The gut-brain-liver axis: A new option to treat obesity and diabetes?

Beraza, N. (2008) · Hepatology · doi:10.1002/hep.22478 · Cited by 25

Appetite and Body Weight Regulation

Vasselli, J. R. (2012) · Wiley eBooks · doi:10.1002/9781394323142.ch8 · Cited by 25

Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease

Iyer, A., Brown, L., Whitehead, J. P., Prins, J. B., & Fairlie, D. P. (2015) · The FASEB Journal · doi:10.1096/fj.15-271155 · Cited by 25

Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: A promising strategy to regulate energy balance

Rodríguez‐Rodríguez, R., Fosch, A., García-Chica, J., Zagmutt, S., & Casals, N. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13234 · Cited by 25

The Role of Circulating Amino Acids in the Hypothalamic Regulation of Liver Glucose Metabolism

Arrieta‐Cruz, I., & Juárez, R. G. (2016) · Advances in Nutrition · doi:10.3945/an.115.011171 · Cited by 25

Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus

Yasumoto, Y., Miyazaki, H., Ogata, M., Kagawa, Y., Yamamoto, Y., Islam, A., Yamada, T., Katagiri, H., & Owada, Y. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1033-9 · Cited by 24

The AMPK-Malonyl-CoA-CPT1 Axis in the Control of Hypothalamic Neuronal Function

Zammit, V. A., & Arduini, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.009 · Cited by 23

Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism

Pietri, J. E., Pakpour, N., Napoli, E., Song, G., Pietri, E. J., Potts, R. A., Cheung, K. W., Walker, G., Riehle, M. A., Starcevich, H., et al. (2016) · Biochemical Journal · doi:10.1042/bcj20160271 · Cited by 23

Eat and Death: Chronic Over-Eating

Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_3 · Cited by 22

International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes

Rodríguez‐Rodríguez, R., Baena, M., Zagmutt, S., Paraiso, W. K. D., Reguera, A. C., Fadó, R., & Casals, N. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100051 · Cited by 22

Targeting lipid sensing in the central nervous system: new therapy against the development of obesity and type 2 diabetes

Stunff, H. L., Coant, N., Migrenne, S., & Magnan, C. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.768233 · Cited by 23

The skinny on brain-derived neurotrophic factor: evidence from animal models to GWAS

Waterhouse, E. G., & Xu, B. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1071-8 · Cited by 22

Cannabinoids in Health and Disease

Meccariello, R., & Chianese, R. (2016) · InTech eBooks · doi:10.5772/61595 · Cited by 22

Hypothalamic Fatty Acid Sensing in the Normal and Disease States

Chari, M., Lam, C., & Lam, T. K. T. (2009) · Frontiers in neuroscience · doi:10.1201/9781420067767-c20 · Cited by 21

Impact of Bromocriptine-QR Therapy on Glycemic Control and Daily Insulin Requirement in Type 2 Diabetes Mellitus Subjects Whose Dysglycemia Is Poorly Controlled on High-Dose Insulin: A Pilot Study

Roe, E. D., Chamarthi, B., & Raskin, P. (2015) · Journal of Diabetes Research · doi:10.1155/2015/834903 · Cited by 20

In vitro response of putative fatty acid-sensing systems in rainbow trout liver to increased levels of oleate or octanoate

Librán-Pérez, M., López‐Patiño, M. A., Míguez, J. M., & Soengas, J. L. (2013) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2013.03.024 · Cited by 20

Metabolic imaging in obesity: underlying mechanisms and consequences in the whole body

Iozzo, P. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12880 · Cited by 20

Reduced linoleic acid intake in early postnatal life improves metabolic outcomes in adult rodents following a Western-style diet challenge

Oosting, A., Kegler, D., van de Heijning, B. J. M., Verkade, H. J., & van der Beek, E. M. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.06.010 · Cited by 20

Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells

Paraiso, W. K. D., García-Chica, J., Ariza, X., Zagmutt, S., Fukushima, S., García, J., Mochida, Y., Serra, D., Herrero, L., Kinoh, H., et al. (2021) · Biomaterials Science · doi:10.1039/d1bm00689d · Cited by 18

Hyperglycemia Induces the Variations of 11 β -Hydroxysteroid Dehydrogenase Type 1 and Peroxisome Proliferator-Activated Receptor- γ Expression in Hippocampus and Hypothalamus of Diabetic Rats

Qi, W.-W., Li-yong, Z., Li, X., Li, G., Liu, Z., Hu, J., & Chen, N. (2012) · Experimental Diabetes Research · doi:10.1155/2012/107130 · Cited by 18

Effects of Neonatal Programming on Hypothalamic Mechanisms Controlling Energy Balance

Contreras, C., Novelle, M. G., Leis, R., Diéguez, C., Skrede, S., & López, M. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1351281 · Cited by 18

Effects of the increase in neuronal fatty acids availability on food intake and satiety in mice

Coccurello, R., Caprioli, A., Bellantuono, S., D'Amato, F. R., Conti, R., Giannessi, F., Borsini, F., & Moles, A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1820-0 · Cited by 18

INSR gene variation is associated with decreased insulin sensitivity in Iraqi women with PCOs.

Mutib, M. T., Hamdan, F. B., & Al-Salihi, A. R. (2014) · Europe PMC (PubMed Central) · Cited by 16

Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function

Chudoba, C., Wardelmann, K., & Kleinridders, A. (2019) · Biological Chemistry · doi:10.1515/hsz-2018-0477 · Cited by 16

Changes in the Expression of Hypothalamic Lipid Sensing Genes in Rat Model of Intrauterine Growth Retardation (IUGR)

Puglianiello, A., Germani, D., Antignani, S., Tomba, G., & Cianfarani, S. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180332d4e · Cited by 15

Effects of KGM and Degradation Products on Appetite Regulation and Energy Expenditure in High-Fat-Diet Mice via the Adipocyte–Hypothalamus Axis

Jin, H., Yao, L., Wang, S., Xia, P., Hou, T., Li, B., & Li, J. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c03819 · Cited by 15

Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats

Mansouri, A., Aja, S. M., Moran, T. H., Ronnett, G. V., Kuhajda, F. P., Arnold, M., Geary, N., Langhans, W., & Leonhardt, M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90381.2008 · Cited by 15

Central Control of Glucose Homeostasis

Puglianiello, A., & Cianfarani, S. (2006) · The Review of Diabetic Studies · doi:10.1900/rds.2006.3.54 · Cited by 14

Effect of central and peripheral leucine on energy metabolism in the Djungarian hamster (Phodopus sungorus)

Koch, C. E., Göddeke, S., Krüger, M., & Tups, A. (2012) · Journal of Comparative Physiology B · doi:10.1007/s00360-012-0699-y · Cited by 14

Mechanisms and significance of brain glucose signaling in energy balance, glucose homeostasis, and food-induced reward

Devarakonda, K., & Mobbs, C. V. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.012 · Cited by 14

The relationship between brain glucose metabolism and insulin resistance in subjects with normal cognition – a study based on 18F-FDG PET

Chen, Y., Qiu, C., Yu, W., Shao, X., Zhou, M., Wang, Y., & Shao, X. (2021) · Nuclear Medicine Communications · doi:10.1097/mnm.0000000000001511 · Cited by 13

Regulation of Energy and Glucose Homeostasis by the Nucleus of the Solitary Tract and the Area Postrema

Bruce, K., Garrido, A. N., Zhang, S., & Lam, T. K. T. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2024.2025 · Cited by 13

Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT

Kim, H.-Y., Cho, S., Yu, J.-M., Sung, S., & Kim, H. (2010) · BMB Reports · doi:10.3858/bmbrep.2010.43.8.547 · Cited by 13

Brain substrate metabolism and ß‐cell function in humans: A positron emission tomography study

Rebelos, E., Mari, A., Bucci, M., Honka, M., Hannukainen, J. C., Virtanen, K. A., Hirvonen, J., Nummenmaa, L., Heni, M., Iozzo, P., et al. (2020) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.136 · Cited by 14

A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats

Li, R. J. W., Chiu, J. F. M., Bruce, K., Zhang, S., Barros, D. R., Yue, J. T. Y., & Lam, T. K. T. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104633 · Cited by 12

Oleate induces K ATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge

Dadak, S., Beall, C., Walker, J. M. V., Soutar, M. P. M., McCrimmon, R. J., & Ashford, M. L. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.12.053 · Cited by 14

Brain Dopamine–Clock Interactions Regulate Cardiometabolic Physiology: Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed Bromocriptine-QR Therapy in Type 2 Diabetes Subjects

Cincotta, A. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713255 · Cited by 11

Hypothalamic Neurones Governing Glucose Homeostasis

Coppari, R. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12276 · Cited by 12

Nutritional programming in early life: the role of dietary lipid quality for future health

van der Beek, E. M., & Oosting, A. (2020) · OCL · doi:10.1051/ocl/2020012 · Cited by 12

Targeting Type 2 Diabetes

Schwanstecher, C., & Schwanstecher, M. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_1 · Cited by 11

Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single‐photon emission computed tomography (SPECT) studies

Al‐Alsheikh, A. S., Alabdulkader, S., Miras, A. D., & Goldstone, A. P. (2023) · Obesity Reviews · doi:10.1111/obr.13620 · Cited by 10

Fat sensing and metabolic syndrome

Youn, J. H. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9300-1 · Cited by 10

Variation in the FFAR1 Gene Modifies BMI, Body Composition and Beta-Cell Function in Overweight Subjects: An Exploratory Analysis

Walker, C. G., Goff, L. M., Bluck, L. J. C., Griffin, B. A., Jebb, S. A., Lovegrove, J. A., Sanders, T. A. B., Frost, G. S., & on behalf of the RISCK Study Group (2011) · PLoS ONE · doi:10.1371/journal.pone.0019146 · Cited by 10

Pharmacological and physiological activation of TGR5 in the NTS lowers food intake by enhancing leptin-STAT3 signaling

Bruce, K., Zhang, S., Garrido, A. N., Wang, M. T., Bachor, T. P., Wang, P., Xu, A. W., Yang, Z., & Lam, T. K. T. (2025) · Nature Communications · doi:10.1038/s41467-025-60331-1 · Cited by 9

Successful Weight Loss Surgery Improves Eating Control and Energy Metabolism: A Review of the Evidence

Schweitzer, D. H., Dubois, E. F., van den Doel-Tanis, N., & Oei, H. I. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9092-4 · Cited by 9

Differential regulation of sphingolipid metabolism in plasma, hippocampus, and cerebral cortex of mice administered sphingolipid modulating agents

Giles, C., Takechi, R., Mellett, N. A., Meikle, P. J., Dhaliwal, S. S., & Mamo, J. C. L. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13964 · Cited by 9

Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition

Wang, H., Taussig, M. D., DiPatrizio, N. V., Bruce, K. D., Piomelli, D., & Eckel, R. H. (2016) · Metabolism · doi:10.1016/j.metabol.2016.01.015 · Cited by 8

iTRAQ-Based Proteomics to Reveal the Mechanism of Hypothalamus in Kidney-Yin Deficiency Rats Induced by Levothyroxine

Guan, W., Liu, Y., Li, X., Yang, B., & Kuang, H. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/3703596 · Cited by 8

Anti-obesity Effects of Tae-Um-Jo-Wee-Tang and Do-Dam-Tang in Female Rats with Diet-induced Obesity

Park, S., Ahn, I.-S., Kim, D., Kang, S., Kwon, D., & Yang, H. (2010) · Journal of Applied Biological Chemistry · doi:10.3839/jabc.2010.008 · Cited by 8

Regulation of Peripheral Metabolism by Substrate Partitioning in the Brain

Moreno, C. L., Yang, L. C., Dacks, P. A., Isoda, F., Poplawski, M. M., & Mobbs, C. V. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.007 · Cited by 8

Diet-Induced Metabolic Dysfunction of Hypothalamic Nutrient Sensing in Rodents

Arrieta‐Cruz, I., Torres-Ávila, B. S., Martínez‐Coria, H., López-Valdés, H. E., & Juárez, R. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073958 · Cited by 6

Glucagon and lipid signaling in the hypothalamus

LaPierre, M. P., Abraham, M. A., Filippi, B., Yue, J. T. Y., & Lam, T. K. T. (2014) · Mammalian Genome · doi:10.1007/s00335-014-9510-6 · Cited by 6

[Mechanisms of regulation of the food intake: recent advances].

Loviselli, A., Secci, G., Lai, A., & Velluzzi, F. (2007) · PubMed · Cited by 5

Nutrient infusion in the dorsal vagal complex controls hepatic lipid and glucose metabolism in rats

Li, R. J. W., Batchuluun, B., Zhang, S., Abraham, M. A., Wang, B., Lim, Y.-M., Yue, J. T. Y., & Lam, T. K. T. (2021) · iScience · doi:10.1016/j.isci.2021.102366 · Cited by 7

Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis (JVS) mice: Involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus

Sakoguchi, T., Horiuchi, M., Asakawa, A., Ushikai, M., Yoshida, G., Fujimiya, M., Kato, I., Nakazato, M., Takeuchi, T., Saheki, T., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.09.001 · Cited by 5

The Endocannabinoid-Like Derivative Oleoylethanolamide at the Gut–Brain Interface: A “Lipid Way” to Control Energy Intake and Body Weight

Passani, M. B., & Coccurello, R. (2016) · InTech eBooks · doi:10.5772/63147 · Cited by 5

Paediatric endocrine aspects of ghrelin.

Lim, C. T., & Korbonits, M. (2012) · PubMed · Cited by 5

The Unrestrained Overeating Behavior and Clinical Perspective

Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_6 · Cited by 3

Glucose and fat sensing in the human hypothalamus

van Opstal, A. M. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820683-6.00024-5 · Cited by 3

mTORC1 and mTORC2 in Energy Homeostasis

Cornu, M., & Hall, M. N. (2010) · The Enzymes · doi:10.1016/s1874-6047(10)28013-7 · Cited by 3

Blocking Fas signaling in adipose tissue ameliorates obesity-associated inflammation, insulin resistance, and hepatosteatosis

Beloor, J., Ullah, I., Kim, J.-K., Choi, C., Kim, S., Chung, K., Jyothi, K. R., Yi, Y., Rhim, T., Kumar, P., et al. (2024) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-024-00668-9 · Cited by 2

Obesity and Diabetes

Fatouros, I. G., & Mitrakou, A. (2012) · CRC Press eBooks · doi:10.1201/b12085-16 · Cited by 2

Ferroptosis in diabetes-associated cognitive dysfunction: mechanisms and therapeutic potential

Liu, H., Qian, S., Liu, S., Xiao, W., You, Y., & Zeng, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1756129 · Cited by 1

Correlation of secretory phospholipase-A2 activity and fatty acids in cerebrospinal fluid with liver enzymes tests

Ghodoosifar, S., Jafari-Rouhi, A. H., Pashapour, A., Mehdizadeh, A., Shaaker, M., & Darabi, M. (2016) · Journal of Analytical Research in Clinical Medicine · doi:10.15171/jarcm.2016.007 · Cited by 1

Ghrelin Regulation of AMPK in the Hypothalamus and Peripheral Tissues

Scerif, M., Kola, B., & Korbonits, M. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-903-7_5 · Cited by 1

Beneficial effect of Combination with Korean Red Ginseng and Morus alba in metabolic syndrome

Lee, Y. J., Kim, H. Y., Yoon, J. J., Lee, S. M., Ahn, Y. M., Kho, J. H., Kho, M. C., Lee, H. S., Choi, K. M., & Kang, D. G. (2012) · The Korea Journal of Herbology · doi:10.6116/kjh.2012.27.6.99 · Cited by 1

Design and implementation of electrical engineering experiment based on the Arduino platform

Chen, Y., Li, Y., Shi, X., & Zhang, C. (2023) · Journal of Physics Conference Series · doi:10.1088/1742-6596/2435/1/012013 · Cited by 1

Hypothalamic Nutrient Sensing

Heeley, N. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.18622 · Cited by 1

Perspectives of “PUFA-GPR40 Signaling” Crucial for Adult Hippocampal Neurogenesis

Yamashima, T. (2011) · Springer eBooks · doi:10.1007/978-4-431-53945-2_8

Essential Fatty Acid Metabolism in Metabolic Syndrome and Neurological Disorders

Farooqui, A. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7318-3_3

Nutritional sensing and its utility in treating obesity

Amin, A., & Murphy, K. G. (2012) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.12.6

How the hypothalamus controls glucose production: an update

Prodi, E., Demuro, G., & Obici, S. (2006) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.1.5.601

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Martins, L., Whittle, A. J., Nogueiras, R., Vidal‐Puig, A., Diéguez, C., & López, M. (2013) · Springer eBooks · doi:10.1007/978-3-319-01008-3_7

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Horváth, T. L. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3492-4_5

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Oosting, A. (2014)

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Lam, K. L. C. (2010) · TSpace (University of Toronto)

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Obici, S., Feng, Z., Arduini, A., Conti, R., & Rossetti, L. (2003) · Nature Medicine · doi:10.1038/nm873 · Cited by 548

New strategies in the modulation of fatty acid oxidation as a treatment for obesity

Herrero, L., Mera, P., Orellana‐Gavaldà, J. M., Gurunathan, C., Malandrino, M. I., Bonnín, J. F. M., Makowski, K., Pozo, M., Arasa, M. D. M., Ariza, X., et al. (2013) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) · Cited by 1

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Scherer, T., Lindtner, C., Zieliński, E., O’Hare, J., Filatova, N., & Buettner, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.307348 · Cited by 72

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Arduini, A., & Bonomini, M. (2011) · Hepatology · doi:10.1002/hep.24348 · Cited by 1