Cited by 736Adipokines, Inflammation, and Metabolic DiseasesAngiogenesis and VEGF in CancerAdipose Tissue and Metabolism

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Angiogenesis modulates adipogenesis and obesity

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Cao, Yihai·2007·Journal of Clinical Investigation

DOI 10.1172/jci32239PMC PMC1963348

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Abstract

Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.

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Background
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Background
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Self-citation
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Background
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Retracted
Depression and BMI influences the serum vascular endothelial growth factor level
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BackgroundInfluential
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Background
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Self-citation
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“It has been shown that adipogenesis requires accompanying angiogenesis, 24 and the extent of angiogenesis may determine the partial pressure of tissue oxygen and affect metabolic functions of the generated adipocytes.”
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Background
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Background
Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation
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PIVL, a snake venom Kunitz-type serine protease inhibitor, inhibits in vitro and in vivo angiogenesis
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Higher daily peritoneal protein clearance when initiating peritoneal dialysis is independently associated with peripheral arterial disease (PAD): A possible new marker of systemic endothelial dysfunction?
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Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature
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Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway
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Basic fibroblast growth factor regulates glucose metabolism through glucose transporter 1 induced by hypoxia-inducible factor-1α in adipocytes
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BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue
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Peptide-functionalized quantum dots for potential applications in the imaging and treatment of obesity
Thovhogi, N., Sibuyi, N. R. S., Onani, M. O., Meyer, M., & Madiehe, A. M. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s158687 · Cited by 33
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15(S)-HETE-induced angiogenesis in adipose tissue is mediated through activation of PI3K/Akt/mTOR signaling pathway
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Effects of quercetin on cell differentiation and adipogenesis in 3T3-L1 adipocytes
Hong, S. Y., Ha, A. W., & Kim, W. (2021) · Nutrition Research and Practice · doi:10.4162/nrp.2021.15.4.444 · Cited by 33
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Ethanol Exposure Depletes Hepatic Pigment Epithelium-Derived Factor, a Novel Lipid Regulator
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Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis
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Environmental Exposures Such as Smoking and Low Vitamin D Are Predictive of Poor Outcome in Cutaneous Melanoma rather than Other Deprivation Measures
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Notch1 mediates visfatin-induced FGF-2 up-regulation and endothelial angiogenesis
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Authors: Cao, Y.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Cao, Yihai
ORCID: Cao, Yihai
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2007-09-04
Volume: 117
Issue: 9
Pages: 2362-2368
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci32239
PMC: PMC1963348
OpenAlex: W2027442301
Cited by: 736
References: 120
Citations by year: 2026: 18 · 2025: 18 · 2024: 24 · 2023: 32 · 2022: 32 · 2021: 25 · 2020: 43 · 2019: 47 · 2018: 59 · 2017: 48 · 2016: 40 · 2015: 42 · 2014: 66 · 2013: 67 · 2012: 43
FWCI: 21.41
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Swedish Cancer Foundation
European Commission
Hjärt-Lungfonden
Karolinska Institutet
Vetenskapsrådet
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: angiogenesis, adipogenesis, obesity, neovascularization, adipocytes, angiogenic factors, leptin, vascular endothelial growth factor, angiopoietins, paracrine signaling, anti-angiogenic therapy
MeSH terms: Animals, Cell Communication, Humans, Neovascularization, Pathologic, Obesity, Adipocytes, Endothelial Cells, Angiogenesis Inducing Agents, Adipogenesis

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Angiogenesis modulates adipogenesis and obesity

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