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Angiogenesis modulates adipogenesis and obesity
Open accessAbstract
Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.
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“The newly formed vascular network is crucial for adipogenesis and AT expansion (64,65).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [64]
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“Maternal obesity may affect these factors via a number of adipokine-mediated pathways.(5) However, the relationship between maternal obesity, adipokines, and angiogenic factors is poorly characterized in human pregnancies.”
BackgroundBrown adipose tissue, thermogenesis, angiogenesis: pathophysiological aspects
Honek, J., Lim, S., Fischer, C., Iwamoto, H., Seki, T., & Cao, Y. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0014 · Cited by 20
“The increased number of blood vessels in the adipose tissue allows for a greater supply of oxygen and nutrients but also aids in the removal of metabolic waste products, thereby favoring the increased metabolic activity of the tissue [26, 58].”
BackgroundSelf-citationCan prokineticin prevent obesity and insulin resistance?
Hunolstein, J. V., & Nebigil, C. G. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000185 · Cited by 19
“During the development of adipose tissue, angiogenesis and adipogenesis interact reciprocally [13].”
BackgroundBevacuzimab May Be Less Effective in Obese Metastatic Colorectal Cancer Patients
Artaç, M., Korkmaz, L., Çoşkun, H. Ş., Dane, F., Karabulut, B., Karaağaç, M., Çabuk, D., Karabulut, S., Aykan, N. F., Doruk, H., et al. (2018) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-017-0047-2 · Cited by 19
“Therefore, therapy with bevacizumab may be affected [20].”
BackgroundIntravitreally Injected Anti-VEGF Antibody Reduces Brown Fat in Neonatal Mice
Jo, D. H., Park, S. W., Cho, C. S., Powner, M. B., Kim, J. H., Fruttiger, M., & Kim, J. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134308 · Cited by 19
Eleuterio, N. M., Palei, A. C., Machado, J. D. S. R., Tanus-Santos, J. E., Cavalli, R. D. C., & Sandrim, V. C. (2013) · Hypertension in Pregnancy · doi:10.3109/10641955.2013.837174 · Cited by 19
Park, S. B., Lee, S. Y., Jung, W. H., Lee, J., Jeong, H. G., Hong, J., Kang, D., & Kim, K. Y. (2019) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13628 · Cited by 19
“WAT contains several cell types such as fibroblasts, macrophages and endothelial cells in addition to adipocytes.(7,8) Adipose tissue is associated with type 2 diabetes *Co-first authors: S.”
BackgroundOquendo, M. B., Siegel-Axel, D. I., Gerst, F., Lorza‐Gil, E., Moller, A., Wagner, R. J., Machann, J., Fend, F., Königsrainer, A., Heni, M., et al. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00595.2020 · Cited by 18
Investigating the Adipogenic Effects of Different Tissue-Derived Decellularized Matrices
Tang, W., Qi, J., Wang, Q., Qu, Y., Fu, S., & Luan, J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.872897 · Cited by 18
“The development of mature adipose tissue requires the support of an extensive capillary network (Cao, 2007).”
BackgroundAdipose Tissue Dysfunction: Impact on Metabolic Changes?
Morais, J. B. S., Dias, T. M. D. S., Cardoso, B. E. P., Sousa, M. D. P., de Sousa, T. G. V., de Araújo, D. S. C., & Marreiro, D. D. N. (2022) · Hormone and Metabolic Research · doi:10.1055/a-1922-7052 · Cited by 20
“In WAT remodeling, the angiogenesis fre quently precedes adipogenesis, however, in an inefficiency situa tion, such process seems to play an important role in adipose tis sue dysfunction [28, 29].”
BackgroundWang, B., & Du, . (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2227258 · Cited by 20
“As mentioned previously, adipogenesis is spatially and temporally associated with vascular development (Cao 2007).”
Han, J., Chen, Y., Xu, X., Li, Q., Xiang, X., Shen, J., & Ma, X. (2024) · ACS Nano · doi:10.1021/acsnano.4c00403 · Cited by 18
Regulation of hepatocyte growth factor expression by NF-κB and PPARγ in adipose tissue
Yin, J., Lee, J. H., Zhang, J., Gao, Z., Polotsky, V. Y., & Ye, J. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00687.2013 · Cited by 20
A novel gene THSD7A is associated with obesity
Nizamuddin, S., Govindaraj, P., Saxena, S. K., Kashyap, M., Mishra, A., Singh, S. S., Rotti, H., Raval, R., Nayak, J., Bhat, B. K., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.144 · Cited by 18
Angiogenic biomarkers in children with congenital heart disease: possible implications
El-Melegy, N. T., & Mohamed, N. (2010) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/1824-7288-36-32 · Cited by 18
“Leptin is also, defined as a potent angiogenic factor [9,10].”
BackgroundChaudhary, N., Bhardwaj, J., Seo, H. J., Kim, M. Y., Shin, T. S., & Kim, J. D. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.01.008 · Cited by 18
Protein kinase C-beta: An emerging connection between nutrient excess and obesity
Mehta, N., & Mehta, K. D. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.07.011 · Cited by 17
Du, Y., Yang, W., Liu, H., Qin, C., Tang, X., & Xu, T. (2021) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2021.10.006 · Cited by 17
Liu, W., Liu, T., Zhao, Q., Ma, J., Jiang, J., & Shi, H. (2023) · Stem Cells International · doi:10.1155/2023/9517826 · Cited by 21
“…tissue is highly vascularized, and adipose tissue vascular endothelial cells are a class of cells present in the intima – media layer of adipose tissue blood vessels, which play a key role in the adipose tissue vascular system, regulating adipose tissue function and metabolic processes [149 – 153].”
BackgroundDamned If You Do, Damned If You Don’t: The Conundrum of Adipose Tissue Vascularization
Yilmaz, M., & Hotamışlıgil, G. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.014 · Cited by 17
“Multiple angiogenic factors such as vascular endothelial, fibroblast, or hepatocyte growth factors (VEGF, FGF, HGF) and leptin are mechanisms by which to ensure tissue homeostasis among adipocytes, adipose stromal cells, and resident or recruited immune cells (Cao, 2007).”
BackgroundSvendstrup, M., Allin, K. H., Sørensen, T. I. A., Hansen, T. H., Grarup, N., Hansen, T. H., & Vestergaard, H. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.279 · Cited by 17
Wei, F., Yang, S., Xu, H. M., Guo, Q., Li, Q., Hu, L., Liu, D., & Wang, C. (2015) · Mediators of Inflammation · doi:10.1155/2015/215761 · Cited by 17
The Evolving Function of Vasculature and Pro-angiogenic Therapy in Fat Grafting
Xining, Z., & Luo, S. (2024) · Cell Transplantation · doi:10.1177/09636897241264976 · Cited by 18
“Mounting evidence indicates that ASCs along with other types of mesenchymal stem cells (MSCs) are closely linked to vascular and perivascular niches in different tissues 33 .”
BackgroundIncreased hypoxia-inducible factor-1α in striated muscle of tumor-bearing mice
Devine, R. D., Bicer, S., Reiser, P. J., & Wold, L. E. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00090.2016 · Cited by 16
Adipose-Derived Molecules–Untouched Horizons in Alzheimer’s Disease Biology
Pichiah, P. B. T., Sankarganesh, D., Arunachalam, S., & Achiraman, S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00017 · Cited by 16
“Adipose tissues release a variety of angiogenic growth factors, including VEGF, FGFs, etc., for neovascularization (Cao, 2007).”
BackgroundWhite to brown adipocyte transition mediated by Apigenin via VEGF‐PRDM16 signaling
Sreekumar, S., Vijayan, V., Singh, F., Sudhakar, M., Lakra, R., Korrapati, P. S., & Kiran, M. S. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30316 · Cited by 16
“Angiogenesis plays significant role in adipogenesis.(7) Interestingly, angiogenesis which plays important role during adipogenesis significantly gets reduced once white adipose tissue maturation completes leaving behind a hypoxic microenvironment.”
BackgroundTuryn, J., Korczyńska, J., Presler, M., Stelmańska, E., Goyke, E., & Świerczyński, J. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9733-5 · Cited by 16
“Moreover, adiponectin displays antiinflammatory [35] and anti-angiogenic [36] properties, whereas leptin has proinflammatory [37] and proangiogenic [36] properties.”
BackgroundKim, H., Bartley, G. E., Young, S. A., Davis, P. A., & Yokoyama, W. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200082 · Cited by 16
Impact of Body Composition on Clinical Outcomes in Metastatic Renal Cell Cancer
Tang, P. A., Heng, D. Y. C., & Choueiri, T. K. (2011) · The Oncologist · doi:10.1634/theoncologist.2011-0337 · Cited by 16
“Adipocytes produce multiple angiogenic factors such as VEGF and leptin [13].”
BackgroundVali, A., Dalle, H., Loubaresse, A., Gilleron, J., Havis, E., Garcia, M., Beaupère, C., Denis, C., Roblot, N., Poussin, K., et al. (2023) · Diabetes · doi:10.2337/db23-0165 · Cited by 15
Na, H.-N., Hong, Y.-M., Ye, M. B., Park, S., Kim, I., & Nam, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114534 · Cited by 16
“However, recent research in the area of obesity has shown that inflammatory factors are required for angiogenesis in fat tissue [46], which may maintain the ‘robustness’ Figure 5.”
Background
Metadata
- Authors
- Cao, Y.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Cao, Yihai
- ORCID
- Cao, Yihai
- Venue
- Journal of Clinical Investigation
- Published
- 2007-09-04
- Volume
- 117
- Issue
- 9
- Pages
- 2362-2368
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1963348
- OpenAlex
- W2027442301
- Cited by
- 736
- References
- 120
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 24 · 2023: 32 · 2022: 32 · 2021: 25 · 2020: 43 · 2019: 47 · 2018: 59 · 2017: 48 · 2016: 40 · 2015: 42 · 2014: 66 · 2013: 67 · 2012: 43
- FWCI
- 21.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Cancer Foundation
- European Commission
- Hjärt-Lungfonden
- Karolinska Institutet
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- angiogenesis, adipogenesis, obesity, neovascularization, adipocytes, angiogenic factors, leptin, vascular endothelial growth factor, angiopoietins, paracrine signaling, anti-angiogenic therapy
- MeSH terms
- Animals, Cell Communication, Humans, Neovascularization, Pathologic, Obesity, Adipocytes, Endothelial Cells, Angiogenesis Inducing Agents, Adipogenesis
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