The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Angiogenesis modulates adipogenesis and obesity
Open accessAbstract
Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The newly formed vascular network is crucial for adipogenesis and AT expansion (64,65).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Angiogenesis in life, disease and medicine
Carmeliet, P. (2005) · Nature · doi:10.1038/nature04478 · Cited by 3,551
Flagged first, then by citations
Research works printed but not linked: 11
- Bouloumie, 2002, Ann. Endocrinol. (Paris)., 63, 91
- Lau, 1990, Int. J. Obes., 14(Suppl. 3), 153
- Lau, 1990, Int. J. Obes., 14(Suppl. 3), 193
- Bukowiecki, 1980, Am. J. Physiol., 239, E422
- Cannon, 1996, Int. J. Obes. Relat. Metab. Disord., 20(Suppl. 3), S36
- Cho, 2007, Circ. Res., 100, e47
- Baillargeon, 2006, Int. J. Oncol., 28, 737
- 10.1172/JCI200525102 · DOI · Paper page
- Ribatti, 2001, Int. J. Mol. Med., 8, 265
- Tigno, 2003, Clin. Hemorheol. Microcirc., 29, 409
- Olszanecka-Glinianowicz, 2005, Wiad. Lek., 58, 670
Cited by
Sorted by citations
Items 701–733 of 733
Huang, X., Xie, C., Tang, J., He, W., Yang, F., Tian, W., Li, J., Yang, Q., Shen, J., Xia, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13049201
Huang, X., Xie, C., Tang, J., He, W., Yang, F., Tian, W., Li, J., Yang, Q., Shen, J., Xia, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13049222
Huang, X., Xie, C., Tang, J., He, W., Yang, F., Tian, W., Li, J., Yang, Q., Shen, J., Xia, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13049213
Huang, X., Xie, C., Tang, J., He, W., Yang, F., Tian, W., Li, J., Yang, Q., Shen, J., Xia, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13049219
Huang, X., Xie, C., Tang, J., He, W., Yang, F., Tian, W., Li, J., Yang, Q., Shen, J., Xia, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13049192
From detection to intervention: nanotechnology-driven precision strategies in obesity management
Tantray, J., Khadam, V. K. R., Patel, A., Nagdev, S., & Prajapati, B. (2026) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-026-01397-9
“It is a natural process that mostly happens when tissue grows, contracts, and heals (Cao 2007).”
Ferreira, M. Y., Cardoso, L. J. C., Pereira, A. L., Ribeiro, F. V., Nascimento, F. G. O., Cheidde, L., & Ben-Shalom, N. (2026) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000012356
Impact of LYL1 deficiency on adipocyte differentiation
Hussain, A. (2015) · theses.fr (ABES) · doi:10.70675/510acdbcz6a62z475ezb193z274bc1a6d27d
Rôle des flux de lactate dans le métabolisme des tissus adipeux beiges et bruns
Lagarde, D. (2020) · theses.fr (ABES) · doi:10.70675/6dfcfe91z26c5z42a8z8f53zb5a5be6082a4
Rôle des macrophages dans le remodelage pathologique du tissu adipeux au cours de l'obésité
Askia, H. (2022) · theses.fr (ABES) · doi:10.70675/0d09beffzcdaez4950za6c0z29a0dd68a41b
Intermittent hypoxia induces premature adipose tissue senescence leading to cardiac remodelling
Naushad, S. (2022) · theses.fr (ABES) · doi:10.70675/8490fe58zf0fdz45a9zaa53z703053f519c1
Brown, O. I., Bridge, K., Bruns, A.-F., Luk, C., Makava, N., Cheng, C. W., Wijayagoonawardana, P., Tayebjee, M. H., Saunderson, C. E. D., Straw, S., et al. (2026) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2026.101527
Rapid Remodeling of Human White Adipose Tissue Following Bariatric SurgeryPreprint
Loureiro, Z. Y., Westcott, G. P., Gulko, A., Essene, A. L., Zhou, Z., Liang, W., Jacobs, C. L., Nagesh, S., Bozadjieva-Kramer, N., Seeley, R. J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.09.717542
Pilot Study of Gallic Acid Cream as a Potential Treatment for Plaque Psoriasis
Greenway, R. R., Coulter, A. A., Zhang, D., & Greenway, F. L. (2026) · Journal of Medicinal Food · doi:10.1177/1096620x261458593
“No weight loss or reduction in food intake was observed after 8 weeks in subjects with a body mass index of 25 – 35 kg/m 2 .”
Inflammation in atherosclerosis: Drivers, mechanisms and therapies
Su, Z., & Xu, S. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.06.047 · Cited by 1
“Simultaneously, adipose tissue expansion leads to adipocyte hypertrophy, insufficient angiogenesis, reduced capillary density, and hypoxia 242 .”
Nonnarath, C., & Serratrice, N. (2026) · Cell Transplantation · doi:10.1177/09636897261469003
“8,21,22 ( 23–26 Aging, obesity, metabolic dysfunction, and chronic inflammation may alter these cellular functions.”
Wang, B. (2026) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-026-01475-y
“Adipose tissue is highly vascularized [202] and the surrounding capillaries not only supply nutrients, oxygen, and hormones while removing waste [20, 203], and also act as a stem cell/progenitor pool for adipocyte replenishment Fig.”
The role of adipose tissue macrophages in adipose tissue fibrosis
Zhang, D., & Wu, N. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156752
Targeting adipose tissue-vascular crosstalk in tumor angiogenesis
Zhang, Y., Wang, B., Sun, Y., Shao, R., Chen, Y., Qiu, F., Kang, N., & Zhang, Q. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105644
Quantitative Methods to Study Adipose Angiogenesis
Lim, S., Honek, J., Cao, Z., Seki, T., Xue, Y., & Cao, Y. (2012) · Springer eBooks · doi:10.1007/978-94-007-4581-0_5
Self-citationSirois‐Gagnon, D. (2011) · Constellation (Université du Québec à Chicoutimi) · doi:10.1522/030175066
Vascular Targeting of Adipose Tissue
Salameh, A., & Kolonin, M. G. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6819-6_15
Metadata
- Authors
- Cao, Y.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Cao, Yihai
- ORCID
- Cao, Yihai
- Venue
- Journal of Clinical Investigation
- Published
- 2007-09-04
- Volume
- 117
- Issue
- 9
- Pages
- 2362-2368
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1963348
- OpenAlex
- W2027442301
- Cited by
- 736
- References
- 120
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 24 · 2023: 32 · 2022: 32 · 2021: 25 · 2020: 43 · 2019: 47 · 2018: 59 · 2017: 48 · 2016: 40 · 2015: 42 · 2014: 66 · 2013: 67 · 2012: 43
- FWCI
- 21.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Cancer Foundation
- European Commission
- Hjärt-Lungfonden
- Karolinska Institutet
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- angiogenesis, adipogenesis, obesity, neovascularization, adipocytes, angiogenic factors, leptin, vascular endothelial growth factor, angiopoietins, paracrine signaling, anti-angiogenic therapy
- MeSH terms
- Animals, Cell Communication, Humans, Neovascularization, Pathologic, Obesity, Adipocytes, Endothelial Cells, Angiogenesis Inducing Agents, Adipogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
