The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Angiogenesis modulates adipogenesis and obesity
Open accessAbstract
Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The newly formed vascular network is crucial for adipogenesis and AT expansion (64,65).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Angiogenesis in life, disease and medicine
Carmeliet, P. (2005) · Nature · doi:10.1038/nature04478 · Cited by 3,551
Research works printed but not linked: 11
- Bouloumie, 2002, Ann. Endocrinol. (Paris)., 63, 91
- Lau, 1990, Int. J. Obes., 14(Suppl. 3), 153
- Lau, 1990, Int. J. Obes., 14(Suppl. 3), 193
- Bukowiecki, 1980, Am. J. Physiol., 239, E422
- Cannon, 1996, Int. J. Obes. Relat. Metab. Disord., 20(Suppl. 3), S36
- Cho, 2007, Circ. Res., 100, e47
- Baillargeon, 2006, Int. J. Oncol., 28, 737
- 10.1172/JCI200525102 · DOI · Paper page
- Ribatti, 2001, Int. J. Mol. Med., 8, 265
- Tigno, 2003, Clin. Hemorheol. Microcirc., 29, 409
- Olszanecka-Glinianowicz, 2005, Wiad. Lek., 58, 670
Cited by
Sorted by citations
Items 501–600 of 733
Weight loss induced by tyrosine kinase inhibitors of the vascular endothelial growth factor pathway
Desar, I. M. E., Thijs, A. M. J., Mulder, S. F., Tack, C. J., van Herpen, C. M. L., & van der Graaf, W. T. A. (2011) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32834b3fae · Cited by 7
Yoysungnoen, B., Srisawat, U., Piyabhan, P., Duansak, N., Sookprasert, N., Mathuradavong, N., Poomipark, N., Munkong, N., Tingpej, P., & Changtam, C. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1221935 · Cited by 7
“In response to hypoxia, adipose tissues produce hypoxia-inducible factor-1 α induced angiogenic factors such as VEGF, leptin, and TNF-α , all of which play roles in regulating angiogenesis (47).”
BackgroundAdjustment to dietary energy availability: from starvation to overnutrition
Alemany, M. (2012) · RSC Advances · doi:10.1039/c2ra21165c · Cited by 7
Nourshahi, M., Hedayati, M., & Ranjbar, K. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.08.008 · Cited by 7
“Leptin up-regulates VEGF mRNA expression via activation of the Jak/Stat3 signaling pathway [22].”
Deletion of Robo4 prevents high‐fat diet‐induced adipose artery and systemic metabolic dysfunction
Phuong, T. T. T., Walker, A. E., Henson, G. D., Machin, D. R., Li, D. Y., Donato, A. J., & Lesniewski, L. A. (2019) · Microcirculation · doi:10.1111/micc.12540 · Cited by 7
Rigotti, G., Chirumbolo, S., Cicala, F., Parnigotto, P. P., Nicolato, E., Calderan, L., Conti, G., & Sbarbati, A. (2019) · Aesthetic Surgery Journal · doi:10.1093/asj/sjz194 · Cited by 7
Angiopoietin-1 protects 3T3-L1 preadipocytes from saturated fatty acid–induced cell death
Son, Y., Cox, J. M., Stevenson, J. L., Cooper, J. A., & Paton, C. M. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.02.007 · Cited by 7
Ghrelin does not modulate angiogenesis in matrigel plug in normal and diet-induced obese mice.
Tahergorabi, Z., Rashidi, B., & Khazaei, M. (2013) · Europe PMC (PubMed Central) · Cited by 7
Distinct precursor landscape of subcutaneous and visceral fat in development and aging
Lin, F., & Sul, H. S. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116706 · Cited by 7
“25,26 During nutrient excess, WAT becomes dysfunctional through chronic inflammation and fibrosis, characterized by excessive accumulation of extracellular matrix proteins and tissue stiffening.”
Mouse vascularized adipose spheroids: an organotypic model for thermogenic adipocytes
Davidsen, L. I., Hagberg, C. E., Goitea, V. E., Lundby, S. M., Larsen, S., Ebbesen, M. F., Stanic, N. T., Topel, H., & Kornfeld, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1396965 · Cited by 8
“The vasculature of BAT is pivotal in non-shivering thermogenesis, making BAT one of the most highly vascularized tissues, with an extensive network of microvessels (19, 32).”
BackgroundLuk, C., Bridge, K., Warmke, N., Simmons, K. J., Drozd, M., Moran, A., MacCannell, A. D. V., Cheng, C. W., Straw, S., Scragg, J. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-54669-1 · Cited by 6
“In cases of obesity, the association between the expansion of WAT and neovascularisation becomes disrupted, resulting in insuf fi cient perfusion of adipoctyes 9 .”
Aktepe, O. H., Gündoğdu, F., Kösemehmetoğlu, K., Yeter, H. H., Aksoy, S., Güven, D. C., Şahin, T. K., Yüce, D., Kertmen, N., Dızdar, Ö., et al. (2021) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-021-02759-0 · Cited by 6
Cheng, L., Hu, J., Zhang, L., Shen, N., Chen, H., & Zhang, F. (2022) · Pharmaceuticals · doi:10.3390/ph15111305 · Cited by 6
“Thus, anti-angiogenic agents provide a novel therapeutic option for the prevention and treatment of human obesity and related disorders [28].”
BackgroundAhn, J. S., Son, G. H., Kwon, E.-G., Chung, K. Y., Jang, S. S., Kim, U., Song, J., Lee, H. J., & Park, B.-K. (2023) · Journal of Animal Science and Technology · doi:10.5187/jast.2023.e33 · Cited by 6
“As the formation of new blood vessels is required to grow and develop adipose tissue, angiogenesis occurs in adipose tissue [36,37].”
BackgroundOpioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation
Zhang, S., Chen, J., Li, Q., & Zeng, W. (2023) · Life Metabolism · doi:10.1093/lifemeta/load018 · Cited by 7
“For instance, the vascular system communicates with other cell types to control adipocyte differentiation, function, and metabolism [22–27], and growth factors or microRNA from stromal vascular fraction (SVF) derived from adipose tissues regulates beige adipocyte differentiation and thermogenesis…”
The Metabolic Syndrome and its Complex Pathophysiology
Vidal‐Puig, A. (2013) · Springer eBooks · doi:10.1007/978-3-319-01008-3_1 · Cited by 6
Kang, J., Jeong, I. S., & Kim, M.-Y. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/4381205 · Cited by 6
Low Subcutaneous Adiposity and Mortality in Esophageal Cancer
Zhou, M. J., Tseng, L., Guo, X., Jin, Z., Bentley-Hibbert, S. I., Shen, S., Araujo, J. L., Spinelli, C. F., Altorki, N. K., Sonett, J. R., et al. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0737 · Cited by 6
Svendstrup, M., & Vestergaard, H. (2014) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2014.08.008 · Cited by 6
Salemi, R., Sergi, V., Basile, M. S., Bravaccini, S., Frittitta, L., Graziano, A. C. E., Filippello, A., Malaguarnera, R., & Francesco, E. M. D. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06970-w · Cited by 6
Matter of Fat: Cancer‐Associated Adipocytes as Mediators of Tumor Progression and Immune Evasion
Sureka, N., Chohan, S., Zaheer, S., Aden, D., Ahuja, S., Agravat, A. H., Goel, S., Hassan, M. J., Chawgthu, L., Nobin, H., et al. (2025) · Cell Biology International · doi:10.1002/cbin.70085 · Cited by 5
“For instance, a study demonstrated that bevacizumab effectively inhibited tumor growth and vascularization in patients with inflammatory and locally advanced BC, showcasing its antiangiogenic and anti-tumor effects (Cao 2007).”
Zhu, C., Huang, Z., Zhou, H., Han, X., Li, L., & Yin, N. (2025) · Biofabrication · doi:10.1088/1758-5090/adb2e7 · Cited by 7
“…discussed, angiogenesis and adipogenesis are concomitant and interdependent processes during physiological AT development and expansion [16–18, 57 ], a relationship that starkly contrasts with the Given the promising results described preced-ingly, we wondered whether the addition of AT-EVs…”
Inhibitory effects of Siegesbeckiae herba extract on angiogenesis and adipogenesis
Hwang, J., & Kim, J. (2011) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-011-0012-z · Cited by 5
“Moreover, neoadipogenesis is preceded or accompanied by an angiogenic response (endothelial cell proliferation, vessel sprouting) [5-10].”
BackgroundGPR55 inhibits the pro-adipogenic activity of anandamide in human adipose stromal cells
Ruhl, T., Nuptybayeva, A., Kim, B., & Beier, J. P. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113908 · Cited by 5
Huang, Z., Yu, X., Jiang, Z., Tang, G., Gao, S., Xiang, Y., Luo, Y., Ye, B., Li, Y., Song, P., et al. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.08.006 · Cited by 5
Mirzaei, N. M., Kevrekidis, P. G., & Shahriyari, L. (2024) · Royal Society Open Science · doi:10.1098/rsos.240718 · Cited by 5
“However, with VEGFs present, this growth rate increases significantly [130, 16]; so, we utilize a VEGF-catalyzed logistic growth for their population.”
Angiopoietin-2: A Therapeutic Target for Vascular Protection in Hutchinson–Gilford Progeria Syndrome
Vakili, S., & Cao, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413537 · Cited by 5
“Constant vessel remodeling, growth, and regression are required for adult adipose tissue plasticity [82].”
Adipose Stem Cells and Adipogenesis
White, U. A., & Tchoukalova, Y. D. (2014) · Humana Press eBooks · doi:10.1007/978-1-62703-770-9_2 · Cited by 5
“These fi ndings support earlier studies indicating that angiogenesis and adipogenesis are tightly correlated (reviewed in [ 113 ]) and [ 114 , 115 ].”
BackgroundAngiogenese und Vaskularisation beim Tissue Engineering von Fettgewebe
Dolderer, J. H., Medved, F., Haas, R., Siegel-Axel, D. I., Schiller, S. M., & Schaller, H.-E. (2013) · Handchirurgie · Mikrochirurgie · Plastische Chirurgie · doi:10.1055/s-0032-1329944 · Cited by 5
Zhang, W., Chen, H.-J., Fan, J., Li, G.-L., Sun, A., Lan, L.-Y., Zhang, L., & Yan, Y. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.10.007 · Cited by 5
Hong, S. S., Choi, Y., Lee, J. A., Ahn, E., Suh, J., & Oh, J. S. (2013) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2013.34.12.3863 · Cited by 5
Calorie Restriction and Cancer Prevention: Established and Emerging Mechanisms
Hursting, S. D., Ford, N. A., Dunlap, S. M., Hursting, M. J., & Lashinger, L. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6819-6_14 · Cited by 5
Obesity, Inflammation, and Prostate Cancer
Blando, J. M., Saha, A., Kiguchi, K., & DiGiovanni, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6819-6_10 · Cited by 5
Ingenuity Pathway Analysis of Clozapine-Induced Obesity
Myslobodsky, M. S. (2008) · Obesity Facts · doi:10.1159/000127278 · Cited by 5
mTOR as a Modulator of Metabolite Sensing Relevant to Angiogenesis
Soumya, S. J., Athira, A. P., Binu, S., & Sudhakaran, P. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00014-1 · Cited by 5
Ford, H. R., & Strieder‐Barboza, C. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01265-y · Cited by 4
“As the primary route of nutrients into and out of adipose tissue, the vascular network plays important roles in adipogenic differentiation, inflammation, and hypoxia [80, 115–118].”
지역 특산 천연산물 전호, 파고지, 희첨 및 산수유의 항비만효과 규명
신진혁, 차구용, 김희진, 황재호, 한경호, 서효진, 신태선, 오석중, & 김종덕 (2009) · KSBB Journal · Cited by 4
CD14loCD301b+ macrophages gathering as a proangiogenic marker in adipose tissues
Lv, Y., Zheng, Y., Su, S., Xiao, J., Yang, J., Xiong, L., Guo, Y., Zhou, X., Guo, N., & Lei, P. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100720 · Cited by 4
Fibroblast Growth Factors and their Emerging Cancer-Related Aspects
Khalid, A., & Javaid, M. A. (2016) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000413 · Cited by 5
“Almost every step of angiogenesis expresses FGF whereas VEGF is usually observed at the initial phases of tumor development [181,182].”
BackgroundChen, H.-J., Zhang, W., Hu, L., Fan, J., Zhang, L., & Yan, Y. (2020) · Toxicology · doi:10.1016/j.tox.2020.152506 · Cited by 4
Joerger, M., Riesen, W., & Thurlimann, B. J. K. (2010) · Journal of Oncology Pharmacy Practice · doi:10.1177/1078155210378912 · Cited by 4
“Although no specific data can be found for antiangiogenic drugs and a potential association with lipid metabolism, there are some preliminary data on a potential relationship between angiogenesis and adipocyte activity.(11) It has also been shown that antiangiogenic drugs might have some antiatherogenic activity.”
BackgroundHuang, K., Que, L., Ding, Y., Chu, N., Qian, Z., Shi, Y., Qin, W., Zhenni, L., Chen, Y., Gu, X., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.694375 · Cited by 4
“It has been found that there was some potential link between angiogenesis and adipocyte activity, activated adipocytes could produce multiple angiogenic factors (VEGF, leptin, angiopoietins, HGF and so on) (Cao, 2007).”
BackgroundBlood Vessels in White and Brown Adipose Tissues
Lim, S., Honek, J., & Cao, Y. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8069-3_5 · Cited by 4
Self-citationAnti-angiogenesis and anti-adipogenesis effects of Anthrisci radix extract
Hwang, J., Lee, S., Han, K., Seo, H.-J., & Kim, J. (2013) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-012-0470-y · Cited by 4
“Neovascularization and adipogenesis are temporally and spatially coupled processes occurring during prenatal life, and they continue to interact reciprocally throughout adult life, via paracrine signaling systems [5].”
BackgroundPsoriasis y su relación con el síndrome metabólico
Londoño, Á., González-Ardila, C., Castro, L. A., & Puig, L. (2013) · Revista Colombiana de Reumatología · doi:10.1016/s0121-8123(13)70137-3 · Cited by 4
Ono, Y., Kennard, S., Wall, B. T., Ma, J., & de Chantemèle, E. J. B. (2026) · Physiology · doi:10.1152/physiol.2026.41.s1.2294849 · Cited by 3
Cao, Y. (2026) · Immunity & Inflammation · doi:10.1007/s44466-025-00021-1 · Cited by 5
“The adipocyte-derived cytokines, including adipokines, often directly and indirectly act on adipose microvasculatures to initiate angiogenesis and vascular remodeling [269].”
Self-citationDu, Q., He, F., Zhang, S., Lan, X., Pan, Y., & Wang, J. F. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1755423 · Cited by 4
“…vascular cells serve as a crucial platform for bidirectional immunometabolic crosstalk by maintaining adipose tissue structural integrity (25, 26). his ensures the ef fi cient execution of lipolysis and ketogenesis central to the ‘ Metabolic Defense Priority ’ hypothesis (27), while…”
Berclaz, L. M., Gioia, D. D., Völkl, M., Jurinović, V., Klein, A., Dürr, H. R., Knösel, T., Teodorescu, B., Enßle, S., Rippl, M., et al. (2025) · BMC Cancer · doi:10.1186/s12885-025-14050-x · Cited by 3
“As a potential mechanism of action, higher levels of angiogenic factors such as VEGF, IGF-1 or leptin were observed in obese patients, leading to che-moresistance and enhanced tumor proliferation [42, 43].”
Animal Models of Angiogenesis and Lymphangiogenesis
D., L., Honek, J., Hosaka, K., Rouhi, P., Lim, S., Ji, H. L., Cao, Z., M., E., Zhang, J., & Cao, Y. (2012) · InTech eBooks · doi:10.5772/20211 · Cited by 3
“Amongst these diseases are dyslipidemias, fatty liver, sleep apnea, cardiovascular complications, stroke, type 2 diabetes as well as certain types of cancer such as prostate, breast and colon cancer (Y Cao, 2010; Y Cao, 2007).”
BackgroundSelf-citationOliva‐Olivera, W., Coín‐Aragüez, L., Lhamyani, S., Salas, J., Gentile, A., Romero‐Zerbo, S., Zayed, H., Valderrama, J., Tinahones, F. J., & Bekay, R. E. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2585 · Cited by 3
“Considering that the growth of adipose depots depends on the availability of blood vessels (Cao, 2007), we assume that thymic adipose tissue expansion during ageing could be favoured by the neovascular properties of the thymASCs.”
BackgroundSong, H., Zhou, H., Gu, P., Bao, B., Sun, Q., Mei, T.-M., Cui, W., Yao, K., Yao, H., Zhang, S., et al. (2024) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v16.i2.331 · Cited by 3
“Previous studies have demonstrated that adipose tissue secretes various growth factors and cytokines, including leptin, adiponectin, vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and angiopoietins (Angs) [20].”
Tissue Engineering von Fettgewebe mittels bioabbaubaren Biomaterialien zur Weichteildefektdeckung
Klein, S., Aung, T., Haas, R. M., Medved, F., Schiller, S. M., Felthaus, O., & Dolderer, J. H. (2018) · Handchirurgie · Mikrochirurgie · Plastische Chirurgie · doi:10.1055/s-0043-115117 · Cited by 3
“Integrine), die die hohe interzelluläre Stabilität bedingen [12].”
BackgroundThe Role of Adipose Tissue Vasculature in Energy Balance
Kim, H.-J., Choi, S.-H., Chun, B., & Kim, D.-H. (2011) · Journal of Korean Society of Pediatric Endocrinology · doi:10.6065/jkspe.2011.16.3.139 · Cited by 3
Analysis of gene expression profiles from subcutaneous adipose tissue of two pig breeds
Lim, D., Lee, K., Park, J., Kim, H., Kim, T.-H., Choi, B., Kim, M. J., Park, H., & Jang, G.-W. (2011) · Genes & Genomics · doi:10.1007/s13258-011-0083-4 · Cited by 3
“Angiogenesis is an important indicator of adipogenesis (Cao, 2007; Hausman and Richardson, 2004).”
BackgroundNazmy, M., & Abd‐Elghany, M. I. (2015) · International Research Journal of Medicine and Medical Sciences · Cited by 3
Bioreactors and microphysiological systems for adipose-based pharmacologic screening
Griffin, M. D., & Abbott, R. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819376-1.00011-1 · Cited by 3
Bagchi, D., Zafra‐Stone, S., Sen, C. K., & Bagchi, M. (2007) · Nutraceutical science and technology · doi:10.1201/9781420015584.ch22 · Cited by 3
Suchyta, M. A., Gibreel, W. O., Bakri, K., Amer, H., & Mardini, S. (2019) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2019.06.021 · Cited by 3
Cao, Y. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002406 · Cited by 3
“[6,7] Despite the existence of exceptionally high density of capillaries in adipose tissues, it is likely that only a fraction of microvessels is perfused to sustain physiological functions, especially under metabolically inert WATs.”
BackgroundInfluentialSelf-citationThe secretome of brown adipose tissue
Hansen, I. R. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 3
Li, Y., Sun, X., Lv, Y., Liu, J., Mao, X., Yu, J., Feng, Y., Cheng, L., Xiang, Y., Yu, X., et al. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01276-9 · Cited by 2
“Using our 3D culture model, we identified nutrients regulating angiogenesis, a key process that is spatially and temporally associated with adipogenesis [66].”
Zanganeh, A. H., Ghorbani-Khosroshahi, R., Khosroshahi, R. A., Zamanian, N., Bayat, S., Darabi, P., Ahani, N., Asadolah, A., & Soori, R. (2026) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-026-01565-4 · Cited by 2
Fat Grafting Techniques in Regenerative Medicine: A Narrative Review
Svolacchia, F., & Svolacchia, L. (2026) · Journal of Bio-X Research · doi:10.34133/jbioxresearch.0077 · Cited by 2
Computational study on the interaction of flavonoids with fat mass and obesity associated protein.
Alharbi, K. K., Syed, R., & Khan, I. A. (2015) · PubMed · Cited by 2
Majid, A. S. A., Farsi, E., EMAN Biodiscoveries Sdn Bhd. Penang, M., Vijayalakshmi, N., Amran, S. A. S. S., Unit Farmasi, K. K. T. B., Kanakal, M. M., & Zainudeen, Z. T. (2019) · Journal of Angiotherapy · doi:10.25163/angiotherapy.31206861406240619 · Cited by 2
Sherman, B., Calderón, E. J., & Price, R. S. (2023) · Nutrition and Cancer · doi:10.1080/01635581.2023.2176198 · Cited by 2
Oki, S., Kageyama, S., Machihara, K., & Namba, T. (2023) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b23-00523 · Cited by 2
Follistatin like-1 ( Fstl1 ) regulates adipose tissue development in zebrafish
Guggeri, L., Sosa-Redaelli, I., Cárdenas-Rodríguez, M., Alonso, M., González, G., Naya, H., Prieto-Echagüe, V., Lepanto, P., & Badano, J. L. (2024) · Adipocyte · doi:10.1080/21623945.2024.2435862 · Cited by 2
“…FSTL1 in endothelial cells and angiogenesis [64,79,80] that is potentially relevant to our research given the intimate relationship between adipose tissue vasculature and preadipocytes, adipogenesis and overall tissue functionality as a critical factor for healthy adipose tissue expansion [81–84].”
Wu, Y., Wang, C., & Tian, X. Y. (2025) · STAR Protocols · doi:10.1016/j.xpro.2024.103337 · Cited by 2
Role of Adipose Stem Cells Therapy in Obesity
Illouz, Y.-G., Sterodimas, A., & Green, A. C. (2011) · Springer eBooks · doi:10.1007/978-3-642-20012-0_13 · Cited by 2
Potential of Herbs in Prevention of Obesity- A Review Article.
Singh, S., PoojaVerma, & Mishra, S. (2013) · International Journal of Health Sciences and Research · Cited by 2
Adipokines and Adipose Tissue Angiogenesis in Obesity
(2015) · Immunoendocrinology · doi:10.14800/ie.918 · Cited by 2
“This in turn influences AT metabolic environment ([3]).”
BackgroundADIPOGENESIS TUMBUH KEMBANG ADIPOSIT
Wangko, W. S., & Wangko, S. (2013) · Jurnal Biomedik JBM · doi:10.35790/jbm.2.3.2010.1194 · Cited by 2
Review Article: An Adipocentric View of the Metabolic Syndrome and Cardiovascular Disease
Dennedy, M. C., & Vidal‐Puig, A. (2014) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-014-0379-4 · Cited by 2
Yürekli, M., & Culum, A. A. (2016) · Medical Science and Discovery · doi:10.17546/msd.31121 · Cited by 2
“Although inhibiting angiogenesis of adipose tissue was suggested as the first treatment approach of obesity, this concept now contradicts with the paradox that energy expenditure also may require angiogenesis (21, 22).”
Genetic risk scores link body fat distribution with specific cardiometabolic profiles
Svendstrup, M., Sandholt, C. H., Galijatovic, E. A. A., Linneberg, A. R., Jørgensen, T., Sørensen, T. I. A., Pedersen, O. B., Grarup, N., Hansen, T. F., & Vestergaard, H. (2016) · Obesity · doi:10.1002/oby.21473 · Cited by 2
“There is a well-established link between angiogenesis and adipogenesis and both are important for a healthy functioning of adipose tissue (22-29).”
BackgroundKammerer‐Jacquet, S., Brunot, A., Bensalah, K., Campillo‐Gimenez, B., Lefort, M., Bayat, S., Ravaud, A., Dupuis, F., Yacoub, M., Verhoest, G., et al. (2017) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2017.05.015 · Cited by 2
“Indeed, insulin-like growth factors produced by adipocytes and the release of inflammatory cytokines by infiltrating lymphocytes have cancerpromoting and angiogenic effects, by stimulating VEGF production [27].”
BackgroundSánchez, J. C., López, D. F. L., Duque, O. A. P., & Arias, J. C. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 2
White Adipose Tissue Development and Function in Children and Adolescents: Preclinical Models
Fischer‐Posovszky, P., Roos, J., Zoller, V., & Wabitsch, M. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-68192-4_5 · Cited by 2
Angiogenic Potential, Circulating Angiogenic Factors and Insulin Resistance in Subjects with Obesity
Sudhakar, M., Silambanan, S., Prabhakaran, A. A., & Ramakrishnan, R. (2019) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-019-0816-8 · Cited by 2
Culum, A. A., & Yürekli, M. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05256-2 · Cited by 2
Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
Diaz-Marin, R., Crespo‐Garcia, S., Wilson, A. M., Buscarlet, M., Dejda, A., Fournier, F., Juneau, R., Alquier, T., & Sapieha, P. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-95064-w · Cited by 2
Alduraywish, A. A. (2017) · Journal of Endocrinology and Metabolism · doi:10.14740/jem405w · Cited by 2
Emerging paracrine functions of the endothelium in the setting of diabetes
Haywood, N. J., & Kearney, M. T. (2023) · Current Opinion in Physiology · doi:10.1016/j.cophys.2023.100668 · Cited by 2
To eat or not to eat – Anti‐ageing effects of energy restriction
Neves, D., Martins, M. J., Passos, E., & Tomada, I. (2015) · Wiley eBooks · doi:10.1002/9781118823408.ch2 · Cited by 2
Lewis, N. S. (2018) · Enlighten: Theses (The University of Glasgow) · Cited by 2
Coban, F., & Yürekli, M. (2024) · Medical Science and Discovery · doi:10.36472/msd.v11i3.1117 · Cited by 1
From, S., Walker, J., Gillis, C. J., Ronald, J. A., Hess, D. A., & Flynn, L. E. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.01.048 · Cited by 1
Reciprocal Crosstalk Between Angiogenesis and Metabolism
Laurent, G., & Mechta‐Grigoriou, F. (2014) · Springer eBooks · doi:10.1007/978-2-8178-0466-8_10 · Cited by 1
The Role of Adipose Tissue-Derived Stem Cells and of Angiogenesis
Pallua, N., & Kim, B. (2014) · Springer eBooks · doi:10.1007/978-3-642-45207-9_22 · Cited by 1
Özdemir, G., Tolun, F. İ., & Imrek, S. S. (2011) · Turkiye Klinikleri Journal of Medical Sciences · doi:10.5336/medsci.2010-19371 · Cited by 1
Psoraleae semen extract inhibits angiogenesis and adipogenesis
Hwang, J., Rha, S., Cho, J.-K., Shin, T.-S., Kim, M.-Y., & Kim, J. (2013) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-013-0379-0 · Cited by 1
“angiogenic response (endothelialcell proliferation, vessel sprouting) [5-10].”
BackgroundHuman adipose tissue contains erythroid progenitors expressing fetal hemoglobin
Navarro, A. (2013) · World Journal of Stem Cells · doi:10.4252/wjsc.v5.i4.205 · Cited by 1
Proangiogenic factors in obese patients with type 1 diabetes
Rybarczyk-Kapturska, K., Zorena, K., Malinowska, E., & Smardzewski, M. (2009) · Cited by 1
The effects of vascular endothelial growth factor (VEGF) on human orbital preadipocyte
Choi, H. Y., Jung, J. H., Name, S.-B., Lee, J. E., Byon, I. S., & Seo, J. H. (2015) · Orbit · doi:10.3109/01676830.2015.1082606 · Cited by 1
“VEGF165, like the other isoforms, binds to specific co-receptor proteins, neuropilin-1 and -2, and activates two different tyrosine kinase receptors, vascular endothelial growth factor receptor-1 (VEGFR-1; also known as FLT-1) and vascular endothelial growth factor receptor-2 (also known as KDR/Flk-1), the stimulation…”
BackgroundInfluentialVascularization in Engineered Adipose Tissue
Vaicik, M. K., Cohen, R., & Brey, E. M. (2014) · CRC Press eBooks · doi:10.1201/b16777-20 · Cited by 1
Shao, I., Chang, Y., Sheng, T., Tan, C.-C., Wang, L.-J., Chuang, C., Wu, C., & Pang, S. (2021) · Anticancer Research · doi:10.21873/anticanres.15339 · Cited by 1
Angiogenesis in Diseases and Therapy
Cao, Y. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8069-3_1 · Cited by 1
Self-citationVolz, A. (2018) · ALTEX · doi:10.14573/altex.1802191s · Cited by 1
Metadata
- Authors
- Cao, Y.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Cao, Yihai
- ORCID
- Cao, Yihai
- Venue
- Journal of Clinical Investigation
- Published
- 2007-09-04
- Volume
- 117
- Issue
- 9
- Pages
- 2362-2368
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1963348
- OpenAlex
- W2027442301
- Cited by
- 736
- References
- 120
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 24 · 2023: 32 · 2022: 32 · 2021: 25 · 2020: 43 · 2019: 47 · 2018: 59 · 2017: 48 · 2016: 40 · 2015: 42 · 2014: 66 · 2013: 67 · 2012: 43
- FWCI
- 21.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Cancer Foundation
- European Commission
- Hjärt-Lungfonden
- Karolinska Institutet
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- angiogenesis, adipogenesis, obesity, neovascularization, adipocytes, angiogenic factors, leptin, vascular endothelial growth factor, angiopoietins, paracrine signaling, anti-angiogenic therapy
- MeSH terms
- Animals, Cell Communication, Humans, Neovascularization, Pathologic, Obesity, Adipocytes, Endothelial Cells, Angiogenesis Inducing Agents, Adipogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
