Cholesterol in islet dysfunction and type 2 diabetes

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A Receptor-Mediated Pathway for Cholesterol Homeostasis

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

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β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

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Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial

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PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA

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A genome-wide association study identifies novel risk loci for type 2 diabetes

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Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

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MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

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Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

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Islet cell failure in type 2 diabetes

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Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

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The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

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Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

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LDL-receptor-related proteins in Wnt signal transduction

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An LDL-receptor-related protein mediates Wnt signalling in mice

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Liver X receptors as integrators of metabolic and inflammatory signaling

Zelcer, N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27883 · Cited by 978 · see citing works

Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

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Pravastatin and the Development of Diabetes Mellitus: Evidence for a Protective Treatment Effect in the West of Scotland Coronary Prevention Study

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TCF7L2 Polymorphisms and Progression to Diabetes in the Diabetes Prevention Program

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

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Rosiglitazone Evaluated for Cardiovascular Outcomes — An Interim Analysis

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The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes

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Molecular biology of PCSK9: its role in LDL metabolism

HORTON, J., COHEN, J., & HOBBS, H. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.12.008 · Cited by 621 · see citing works

LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors

Mani, A., Radhakrishnan, J., Wang, H., Mani, A., Mani, M.-A., Nelson-Williams, C. J., Carew, K. S., Mane, S., Najmabadi, H., Wu, D., et al. (2007) · Science · doi:10.1126/science.1136370 · Cited by 587 · see citing works

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

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Prevention of Coronary and Stroke Events with Atorvastatin in Hypertensive Patients who have Average or Lower-than-Average Cholesterol Concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial???Lipid Lowering Arm (ASCOT-LLA)

Sever, P., Dahl??f, B., Poulter, N. R., Wedel, H., Beevers, G., Caulfield, M. J., Collins, R., Kjeldsen, S. E., Kristinsson, A., McInnes, G. T., et al. (2004) · Drugs · doi:10.2165/00003495-200464002-00005 · Cited by 524 · see citing works

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

Brunham, L. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27352 · Cited by 519 · see citing works

Molecular Cloning of the Human ATP-Binding Cassette Transporter 1 (hABC1): Evidence for Sterol-Dependent Regulation in Macrophages

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Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

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β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

Brunham, L. R., Kruit, J. K., Pape, T. D., Timmins, J. M., Reuwer, A. Q., Vasanji, Z., Marsh, B. J., Rodrigues, B. B., Johnson, J. D., Parks, J. S., et al. (2007) · Nature Medicine · doi:10.1038/nm1546 · Cited by 413 · see citing works

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

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Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects

Deng, S., Vatamaniuk, M. Z., Huang, X., Doliba, N. M., Lian, M.-M., Frank, A. M., Velidedeoğlu, E., Desai, N. M., Koeberlein, B., Wolf, B. A., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.3.624 · Cited by 346 · see citing works

Direct Effect of Cholesterol on Insulin Secretion

Hao, M., Head, W. S., Gunawardana, S. C., Hasty, A. H., & Piston, D. W. (2007) · Diabetes · doi:10.2337/db07-0056 · Cited by 321 · see citing works

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes

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Lipid Rafts and the Regulation of Exocytosis

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The Prevalence of NIDDM and Associated Risk Factors in Native Canadians

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Increased ABCA1 activity protects against atherosclerosis

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Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats

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Efflux and Atherosclerosis

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The Cholesterol Quartet

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Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats

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Inhibition by simvastatin, but not pravastatin, of glucose‐induced cytosolic Ca 2+ signalling and insulin secretion due to blockade of L‐type Ca 2+ channels in rat islet β‐cells

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Coronary Heart Disease Prevalence and Other Clinical Features in Familial High-Density Lipoprotein Deficiency (Tangier Disease)

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Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

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Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway

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Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study

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Insulin-secreting β-Cell Dysfunction Induced by Human Lipoproteins

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Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factors

Mozaffarian, D., Marfisi, R., Levantesi, G., Silletta, M. G., Tavazzi, L., Tognoni, G., Valagussa, F., & Marchioli, R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61343-9 · Cited by 179 · see citing works

Disruption of Pancreatic β-Cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis

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LXRβ Is Required for Adipocyte Growth, Glucose Homeostasis, and β Cell Function

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Polymorphisms within Novel Risk Loci for Type 2 Diabetes Determine β-Cell Function

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Mechanisms of the Triglyceride- and Cholesterol-Lowering Effect of Fenofibrate in Hyperlipidemic Type 2 Diabetic Patients

Forcheron, F., Cachefo, A., Thevenon, S., Pinteur, C., & Beylot, M. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3486 · Cited by 148 · see citing works

Loss of Stearoyl-CoA Desaturase-1 Improves Insulin Sensitivity in Lean Mice but Worsens Diabetes in Leptin-Deficient Obese Mice

Flowers, J. B., Rabaglia, M. E., Schueler, K. L., Flowers, M. T., Hong, L., Keller, M. P., Ntambi, J. M., & Attie, A. (2007) · Diabetes · doi:10.2337/db06-1142 · Cited by 148 · see citing works

Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells

Abderrahmani, A., Niederhäuser, G., Favre, D., Abdelli, S., Ferdaoussi, M., Yang, J. Y., Regazzi, R., Widmann, C., & Waeber, G. (2007) · Diabetologia · doi:10.1007/s00125-007-0642-z · Cited by 147 · see citing works

Accurate Prediction of the Functional Significance of Single Nucleotide Polymorphisms and Mutations in the ABCA1 Gene

Brunham, L. R., Singaraja, R. R., Pape, T. D., Kejariwal, A., Thomas, P. D., & Hayden, M. R. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010083 · Cited by 143 · see citing works

Variations on a Gene: Rare and Common Variants in ABCA1 and Their Impact on HDL Cholesterol Levels and Atherosclerosis

Brunham, L. R., Singaraja, R. R., & Hayden, M. R. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111214 · Cited by 142 · see citing works

Advanced Glycation End Product Precursors Impair ABCA1-Dependent Cholesterol Removal From Cells

Passarelli, M., Tang, C., McDonald, T. O., O’Brien, K. D., Gerrity, R. G., Heinecke, J. W., & Oram, J. F. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2198 · Cited by 138 · see citing works

Cholesterol is Required for the Formation of Regulated and Constitutive Secretory Vesicles from the trans‐Golgi Network

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Low Density Lipoprotein Can Cause Death of Islet β-Cells by Its Cellular Uptake and Oxidative Modification

Cnop, M., Hannaert, J. C., Grupping, A. Y., & PIPELEERS, D. G. (2002) · Endocrinology · doi:10.1210/en.2002-220273 · Cited by 136 · see citing works

Liver X Receptor Activation Stimulates Insulin Secretion via Modulation of Glucose and Lipid Metabolism in Pancreatic Beta-Cells

Efanov, A. M., Sewing, S., Bokvist, K. B., & Gromada, J. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s75 · Cited by 135 · see citing works

LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1

Wang, Y., Kurdi-Haidar, B., & Oram, J. F. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400011-jlr200 · Cited by 122 · see citing works

Common and Rare ABCA1 Variants Affecting Plasma HDL Cholesterol

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Association of the ATP-Binding Cassette Transporter A1 R230C Variant With Early-Onset Type 2 Diabetes in a Mexican Population

Villarreal-Molina, M. T., Flores-Dorantes, M. T., Arellano-Campos, O., Villalobos-Comparán, M., Rodríguez-Cruz, M., Miliar-García, Á., Huertas-Vázquez, A., Menjivar, M., Romero-Hidalgo, S., Wacher, N., et al. (2008) · Diabetes · doi:10.2337/db07-0484 · Cited by 104 · see citing works

Unsaturated Fatty Acids Phosphorylate and Destabilize ABCA1 through a Phospholipase D2 Pathway

Wang, Y., & Oram, J. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506210200 · Cited by 101 · see citing works

The ATP-Binding Cassette Transporter A1 R230C Variant Affects HDL Cholesterol Levels and BMI in the Mexican Population

Villarreal-Molina, M. T., Aguilar-Salinas, C., Rodríguez-Cruz, M., Riaño, D., Villalobos-Comparán, M., Coral-Vázquez, R., Menjivar, M., Yescas-Gómez, P., Königsoerg-Fainstein, M., Romero-Hidalgo, S., et al. (2007) · Diabetes · doi:10.2337/db06-0905 · Cited by 91 · see citing works

Abnormal sterols in cholesterol-deficiency diseases cause secretory granule malformation and decreased membrane curvature

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Distinct Effects of Pravastatin, Atorvastatin, and Simvastatin on Insulin Secretion from a β-cell Line, MIN6 Cells

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Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population

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Low Density Lipoprotein Binding and Uptake by Human and Rat Isletβ Cells*

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Expression Profiling Identifies Genes That Continue to Respond to Insulin in Adipocytes Made Insulin-resistant by Treatment with Tumor Necrosis Factor-α

Sartipy, P., & Loskutoff, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306922200 · Cited by 67 · see citing works

Pancreatic β-Cell Lipoprotein Lipase Independently Regulates Islet Glucose Metabolism and Normal Insulin Secretion

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Mutation in ABCA1Predicted Risk of Ischemic Heart Disease in the Copenhagen City Heart Study Population

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