Cited by 842Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

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Hansen, Christian, Angot, Elodie, Bergström, Ann-Louise, Steiner, Jennifer A., Pieri, Laura, Paul, Gesine, Outeiro, Tiago F., Melki, Ronald, Kallunki, Pekka, Fog, Karina, Li, Jia-Yi, Brundin, Patrik·2011·Journal of Clinical Investigation

DOI 10.1172/jci43366PMC PMC3026723

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Abstract

Post-mortem analyses of brains from patients with Parkinson disease who received fetal mesencephalic transplants show that α-synuclein-containing (α-syn-containing) Lewy bodies gradually appear in grafted neurons. Here, we explored whether intercellular transfer of α-syn from host to graft, followed by seeding of α-syn aggregation in recipient neurons, can contribute to this phenomenon. We assessed α-syn cell-to-cell transfer using microscopy, flow cytometry, and high-content screening in several coculture model systems. Coculturing cells engineered to express either GFP- or DsRed-tagged α-syn resulted in a gradual increase in double-labeled cells. Importantly, α-syn-GFP derived from 1 neuroblastoma cell line localized to red fluorescent aggregates in other cells expressing DsRed-α-syn, suggesting a seeding effect of transmitted α-syn. Extracellular α-syn was taken up by cells through endocytosis and interacted with intracellular α-syn. Next, following intracortical injection of recombinant α-syn in rats, we found neuronal uptake was attenuated by coinjection of an endocytosis inhibitor. Finally, we demonstrated in vivo transfer of α-syn between host cells and grafted dopaminergic neurons in mice overexpressing human α-syn. In summary, intercellularly transferred α-syn interacts with cytoplasmic α-syn and can propagate α-syn pathology. These results suggest that α-syn propagation is a key element in the progression of Parkinson disease pathology.

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Additional file 8 of Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury
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Additional file 3 of Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury
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Additional file 1 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
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Additional file 7 of Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury
Liu, Y., Kalpana, S., Baride, A., Romanova, S., Callegari, E., Huber, C. C., Wang, X., & Wang, H. (2021) · Figshare · doi:10.6084/m9.figshare.13620100
Additional file 10 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891198
Additional file 1 of Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions
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Additional file 2 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891210
Additional file 6 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891222
Additional file 5 of Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury
Liu, Y., Kalpana, S., Baride, A., Romanova, S., Callegari, E., Huber, C. C., Wang, X., & Wang, H. (2021) · Figshare · doi:10.6084/m9.figshare.13620094
Additional file 1 of LRP1 is a neuronal receptor for α-synuclein uptake and spread
Chen, K., Martens, Y. A., Meneses, A. D., Ryu, D. H., Lü, W., Raulin, A. C., Li, F., Zhao, J., Chen, Y., Jin, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20861097
Additional file 7 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891225
Additional file 1 of Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury
Liu, Y., Kalpana, S., Baride, A., Romanova, S., Callegari, E., Huber, C. C., Wang, X., & Wang, H. (2021) · Figshare · doi:10.6084/m9.figshare.13620082
Additional file 5 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891219
Additional file 11 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891201
Additional file 4 of Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury
Liu, Y., Kalpana, S., Baride, A., Romanova, S., Callegari, E., Huber, C. C., Wang, X., & Wang, H. (2021) · Figshare · doi:10.6084/m9.figshare.13620091
Additional file 3 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891213
Additional file 4 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891216
Additional file 12 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891204
Additional file 2 of Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury
Liu, Y., Kalpana, S., Baride, A., Romanova, S., Callegari, E., Huber, C. C., Wang, X., & Wang, H. (2021) · Figshare · doi:10.6084/m9.figshare.13620085
Additional file 6 of Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury
Liu, Y., Kalpana, S., Baride, A., Romanova, S., Callegari, E., Huber, C. C., Wang, X., & Wang, H. (2021) · Figshare · doi:10.6084/m9.figshare.13620097
Additional file 9 of Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, A. J., Stackhouse, T. L., Weston, L. J., Kerstein, P. C., Osterberg, V. R., López, C. S., Dickson, D. W., Luk, K. C., Meshul, C. K., Woltjer, R. L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12891231
Additional file 1 of Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons
Ha, T.-Y., Choi, Y. R., Noh, H. R., Cha, S.-H., Kim, J.-B., & Park, S. M. (2021) · Figshare · doi:10.6084/m9.figshare.15071404
Investigating the Role of the Gut-Brain Axis in Parkinson's Disease: from Dysbiosis to the Vagus Nerve
Bi, R. (2025) · International journal of high school research · doi:10.36838/v7i12.87

Authors: Hansen, C., Angot, E., Bergström, A.-L., Steiner, J. A., Pieri, L., Paul, G., Outeiro, T. F., Melki, R., Kallunki, P., Fog, K., Li, J.-Y., & Brundin, P.
Affiliations: Lund University (SE)
Lundbeck (Denmark) (DK)
Laboratoire d'Enzymologie et Biochimie Structurales (FR)
University of Lisbon (PT)
Corresponding author: Brundin, Patrik
ORCID: Hansen, Christian
Bergström, Ann-Louise
Steiner, Jennifer A.
Pieri, Laura
Paul, Gesine
Outeiro, Tiago F.
Melki, Ronald
Kallunki, Pekka
Fog, Karina
Brundin, Patrik
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2011-02-01
Volume: 121
Issue: 2
Pages: 715-725
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci43366
PMC: PMC3026723
OpenAlex: W2046885195
Cited by: 842
References: 42
Citations by year: 2026: 13 · 2025: 26 · 2024: 25 · 2023: 31 · 2022: 43 · 2021: 69 · 2020: 70 · 2019: 59 · 2018: 51 · 2017: 72 · 2016: 68 · 2015: 68 · 2014: 64 · 2013: 77 · 2012: 64
FWCI: 50.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Lund University Publications (Lund University) (submittedVersion, other-oa)
Funders: Michael J. Fox Foundation for Parkinson's Research
Agence Nationale de la Recherche
Knut och Alice Wallenbergs Stiftelse
Vetenskapsrådet
Stiftelsen Lars Hiertas Minne
Centre National de la Recherche Scientifique
Parkinsonfonden
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: alpha-synuclein, Parkinson's disease, Lewy bodies, intercellular transfer, endocytosis, neuroblastoma cells, intracortical injection
MeSH terms: Animals, Brain, Cells, Cultured, Dopamine, Humans, Neurons, Parkinson Disease, Recombinant Fusion Proteins, Lewy Bodies, Culture Media, Conditioned, Cell Transplantation, Coculture Techniques, Mice, Rats, alpha-Synuclein, HEK293 Cells

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

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