The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
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In addition to APP, there was an increase in the surface expression of several proteins involved in APP processing and amyloid-β response in VPS35-suppressed neuronal cultures, including BACE1, APLP1, APLP2, ABCC1, EPHA4, IGFR1, and SYP.
“In addition to APP, we found an increase in the surface expression of several proteins involved in APP processing and amyloid-β response in the VPS35 suppressed neuronal cultures.These included βsecretase 1 (BACE1), [92], APP-like β-secretase substrates APLP1 and APLP2 [93], transporter ABCC1 [94][95][96], ephrin type-A receptor 4 (EPHA4) [97,98], and insulin-like growth factor-1 (IGFR1) [99], and”
From Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling (2026) · cites this paper as [96]
Some studies have reported a role for ABCB1 in Aβ peptide elimination from the brain.
“Whereas some studies have reported a role for ABCB1 in A peptide elimination from the brain [37,67]”
ABCB1 and probably ABCC1 restrict Aβ re-entry into the brain.
“whereas ABCB1 and probably ABCC1 restrict A re-entry into the brain [25,37,38].”
ABCB1 is involved in Aβ peptide transport across the BBB.
“but it is now clear that ABCB1 is also involved in A peptide transport across the BBB.”
ABCC1 mediates Aβ peptide transport across the BBB.
“More recently, it has been suggested that ABCC1 (another efflux pump expressed by BBB cells) mediates A peptide transport across the BBB [37].”
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1 retracted
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Role of Blood-Brain Barrier in Alzheimer’s Disease
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Blood–Brain Barrier Breakdown in Alzheimer’s Disease: Mechanisms and Targeted Strategies
Alkhalifa, A. E., Al-Ghraiybah, N. F., Odum, J., Shunnarah, J. G., Austin, N., & Kaddoumi, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216288 · Cited by 212
Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders
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The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer’s disease
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Revisiting rodent models: Octodon degus as Alzheimer’s disease model?
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Metadata
- Authors
- Krohn, M., Lange, C., Hofrichter, J., Scheffler, K., Stenzel, J., Steffen, J., Schumacher, T., Brüning, T., Plath, A.-S., Alfen, F., Schmidt, A., Winter, F., Rateitschak, K., Wree, A., Gsponer, J., Walker, L. C., & Pahnke, J.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-10-03
- Volume
- 121
- Issue
- 10
- Pages
- 3924-3931
- ISSN
- 0021-9738
- Cited by
- 183
- References
- 11
- Language
- en
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