The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice
Open accessAbstract
Skeletal muscle injury activates adult myogenic stem cells, known as satellite cells, to initiate proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle-specific microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined. Here, we show that miR-206 promotes skeletal muscle regeneration in response to injury. Genetic deletion of miR-206 in mice substantially delayed regeneration induced by cardiotoxin injury. Furthermore, loss of miR-206 accelerated and exacerbated the dystrophic phenotype in a mouse model of Duchenne muscular dystrophy. We found that miR-206 acts to promote satellite cell differentiation and fusion into muscle fibers through suppressing a collection of negative regulators of myogenesis. Our findings reveal an essential role for miR-206 in satellite cell differentiation during skeletal muscle regeneration and indicate that miR-206 slows progression of Duchenne muscular dystrophy.
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Cites
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“Activated SCs also undergo asymmetric division, generating progeny that replenish the pool of quiescent SCs (5).”
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Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
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Cited by
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis
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Metadata
- Authors
- Liu, N., Williams, A. H., Maxeiner, J. M., Bezprozvannaya, S., Shelton, J. M., Richardson, J. A., Bassel-Duby, R., & Olson, E. N.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-06-01
- Volume
- 122
- Issue
- 6
- Pages
- 2054-2065
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1970902340
- Cited by
- 353
- References
- 13
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, N., Williams, A. H., Maxeiner, J. M., Bezprozvannaya, S., Shelton, J. M., Richardson, J. A., Bassel-Duby, R., & Olson, E. N. (2012). microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci62656
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