The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
The role of mitochondria in aging
Open accessAbstract
Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated with aging. Somatic mitochondrial DNA (mtDNA) mutations and respiratory chain dysfunction accompany normal aging, but the first direct experimental evidence that increased mtDNA mutation levels contribute to progeroid phenotypes came from the mtDNA mutator mouse. Recent evidence suggests that increases in aging-associated mtDNA mutations are not caused by damage accumulation, but rather are due to clonal expansion of mtDNA replication errors that occur during development. Here we discuss the caveats of the traditional mitochondrial free radical theory of aging and highlight other possible mechanisms, including insulin/IGF-1 signaling (IIS) and the target of rapamycin pathways, that underlie the central role of mitochondria in the aging process.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“accumulation of such damages occurs during aging [66].”
From Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s Disease (2014) · cites this paper as [66]
In the citing paper
“Mitochondrial function declines with aging in model organisms and humans (58).”
From Connecting aging biology and inflammation in the omics era (2022) · cites this paper as [58]
In the citing paper
“A progressive mitochondrial dysfunction is known to occur with age (31)(32)(33).”
From Human Aging and Longevity Are Characterized by High Levels of Mitokines (2019) · cites this paper as [33]
In the citing paper
“A direct relationship between mitochondrial dysfunction and aging has been suggested by many studies (for review, see ref. 93)”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [93]
In the citing paper
“secondary alterations in mitochondrial function driven by age-related cellular and metabolic changes may also contribute to the aging process93.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [93]
In the citing paper
“Defective mitophagy has also been linked with premature aging and many age-associated disorders, such as Alzheimer’s and Parkinson’s diseases (25–28).”
From Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary disease (2015) · cites this paper as [26]
In the citing paper
“Previous studies have reported diminished expressions of mitochondrial respiratory complex subunits, mitochondrial respiration, and ATP levels in skeletal muscle [66].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [66]
In the citing paper
“Mitochondrial function declines with age due either to ROS and/or an accumulation of mutations in mitochondrial DNA (151).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [151]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Self-citationStadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701
The moulding of senescence by natural selection
Hamilton, W. D. O. (1966) · Journal of Theoretical Biology · doi:10.1016/0022-5193(66)90184-6 · Cited by 2,289
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Research works printed but not linked: 6
- Radák, Antioxid Redox Signal.
- Holme, 1993, Am J Hum Genet., 52, 551
- Müller-Höcker, 1989, Am J Pathol., 134, 1167
- Bjelakovic, 2012, Cochrane Database Syst Rev., 3, CD007176
- Walker, 2008, Am Fam Physician., 78, 1079
- 10.1161/CIRCRESAHA.111.246140 · DOI
Cited by
Sorted by citations
Items 901–1,000 of 1,000
Nichols, T. W. (2018) · Sleep Medicine and Disorders International Journal · doi:10.15406/smdij.2018.02.00043 · Cited by 1
Once we were bacteria... mitochondria to infinity and beyond
Bardanzellu, F., Pintus, M. C., Fanos, V., & Marcialis, M. A. (2018) · Journal of pediatric and neonatal individualized medicine · doi:10.7363/080106 · Cited by 2
Adjuvante Therapien in der Reproduktionsmedizin
Krüssel, J.-S., Baston-Büst, D.-M., & Bielfeld, A. P. (2019) · Springer Reference Medizin · doi:10.1007/978-3-662-57636-6_47 · Cited by 1
The current stage of neuroprotection: development of mitochondria-targeted approaches
Шакова, Ф. М., Кирова, Ю. И., & Романова, Г. А. (2020) · Nauchno-prakticheskii zhurnal «Patogenez» · doi:10.25557/2310-0435.2020.02.4-19 · Cited by 1
Abdullaev, S. A., Evdokimovskii, E. V., & Gaziev, A. I. (2020) · Biology Bulletin · doi:10.1134/s1062359020110023 · Cited by 1
Khuda‐Bukhsh, A. R., Das, S., & Samadder, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00008-6 · Cited by 2
Dreyling, C., & Hasselmann, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270550 · Cited by 2
Melatonin’s Antioxidative Characteristic in Human Aging Retinal Pigment Epithelial Cells
Tawfeeq, G., & Kakey, I. S. (2022) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.spl.492 · Cited by 1
Effect of gluten on the digestive tract and fat body of Telodeinopus aoutii (Diplopoda)
Błaszczyk, F., Sosinka, A., Wilczek, G., Student, S., & Rost-Roszkowska, M. M. (2022) · Journal of Morphology · doi:10.1002/jmor.21546 · Cited by 1
Pang, Y., Zhu, S., Xu, J., Su, C., Wu, B. Y., Zhang, C., & Gao, J. (2023) · Advanced Biology · doi:10.1002/adbi.202200321 · Cited by 1
Aging and mitochondrial transplantation
Baran, M., Güney, Ş., Öztürk, G., & Çaykara, B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18858-9.00023-8 · Cited by 1
Modern scientific and practical approaches to searching for biomarkers of aging
Aa, M., Корчажкина, Н. Б., Reshetova, I. V., Dymova, O. V., & Kotenko, K. V. (2024) · Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина. · doi:10.17116/rbpdpm2024103146 · Cited by 1
Lee, L., Jan, I., Chou, W.-R., Liu, W., Kuo, Y., Chang, C.-Y., Chang, H.-C., Liu, J.-L., Hsu, C., Lin, C., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031378 · Cited by 1
Mechanisms of Cardiovascular Aging
Paneni, F., Costantino, S., Cosentino, F., & Lüscher, T. F. (2013) · Current Translational Geriatrics and Experimental Gerontology Reports · doi:10.1007/s13670-013-0061-6 · Cited by 1
Role of Autophagy in Liver Regeneration
Toshima, T., Shirabe, K., Matsumoto, Y., Itoh, S., Harimoto, N., Ikegami, T., Yoshizumi, T., & Maehara, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00023-8 · Cited by 1
Developing Circadian Therapeutics Against Age-Related Metabolic Decline
Nohara, K., Yoo, S. H., & Chen, Z. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-64543-8_11 · Cited by 1
Cacabelos, R., & Teijido, Ó. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00074-9 · Cited by 1
Role of Mitochondria in Generation of Phenotypic Heterogeneity in Yeast
Dhar, R. (2020) · Journal of the Indian Institute of Science · doi:10.1007/s41745-020-00176-3 · Cited by 2
Mediterranean Diet for Active and Healthy Aging
Noreen, N., Shah, M. A., Khan, F., Niaz, K., Muhammad, F., Shah, I., & Abdollahi, M. R. (2020) · Springer eBooks · doi:10.1007/978-981-15-3552-9_11 · Cited by 1
The Aging Epigenome and The Rejuvenation Strategies
Meiliana, A., Dewi, N. M., & Wijaya, A. (2022) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v14i1.1777 · Cited by 1
Super DNAging—New Insights Into DNA Integrity, Genome Stability, and Telomeres in the Oldest Old
Wagner, K., Franzke, B., & Neubauer, O. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00076-2 · Cited by 1
Mitochondrial decline and chronic conditions of older adults
Marzetti, E., Landi, F., Martini, F., Leeuwenburgh, C., & Calvani, R. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198701590.003.0046 · Cited by 1
Aging, mitochondrial dysfunctions, and vitamin E
Napolitano, G., Fasciolo, G., & Venditti, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00025-4 · Cited by 1
Bezrukov, V. V., Sykalo, N. V., Kuprash, L., & Panteleymonova, T. (2022) · Ageing & Longevity · doi:10.47855/jal9020-2022-4-1 · Cited by 1
Perspective Chapter: Ovarian Reproductive Aging and Rejuvenation Strategies
Díez‐Juan, A., & Vladimirov, I. K. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110524 · Cited by 1
Measurement of Mitochondrial Toxicity by Flow Cytometry
Narayanan, P. K., & Li, N. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch16 · Cited by 1
Analysis of MTORC2 in regulating aging, metabolism and cardiac disease in Drosophila melanogaster
Chang, K. (2020) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-20210114-24 · Cited by 1
Hemin decreases cellular aging and enhances healthspan and lifespan through the AMPK pathwayPreprint
Zhang, Y., Naaz, A., Faidzinn, N. A., Yogasundaram, S., Cheng, T. Y. N., Jing, J. L., Gan, I. W.-H. J. M., Chen, J., & Alfatah, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.15.553367 · Cited by 1
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing micePreprint
Kremer, L. S., Gao, G., Rigoni, G., Filograna, R., Mennuni, M., Wibom, R., Végvári, Á., Koolmeister, C., & Larsson, N. (2025) · eLife · doi:10.7554/elife.104461.1 · Cited by 1
Self-citationEngineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular LifespanPreprint
Oz, N., Su, H., Sari, V., Patnaik, P. K., Hameed, R., Song, J. H., Prosser, D. C., Labunskyy, V. M., Gladyshev, V. N., Hao, N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.14.648769 · Cited by 1
Chattopadhyaya, S., Smith‐Berdan, S., Huerta, S., & Forsberg, E. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.10.687744 · Cited by 1
Single-nucleoid imaging in whole cells defines the dynamics of the mtDNA life cyclePreprint
Wolf, D. M., Mjeku, E., Segawa, M., Casey, A. M., Belaadi, N., Franklin, R., Murphy, M. P., Prudent, J., Jones, N. S., & Chinnery, P. F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.01.725017 · Cited by 1
DNA Damage and Checkpoint Responses in Adult Stem Cells
Romanov, V. S., Shukla, A., & Ju, Z. (2014) · Else Kröner-Fresenius Symposia · doi:10.1159/000366568
Bolotin‐Fukuhara, M. (2014) · Diseases · doi:10.3390/diseases2010024
EFFECTS OF EXERCISE TRAINING ON BRAIN BIOENERGETICS: LACTATE AS A KEY MEDIATOR
Lezi, E. (2013) · KU ScholarWorks (University of Kansas)
Feldman, R. (2015) · Spectrum Research Repository (Concordia University)
Stratmann, H. G. (2015) · Science and fiction · doi:10.1007/978-3-319-16015-3_9
Chandrashekar, P. (2016) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/67320
Genomics of Lung Aging and Idiopathic Pulmonary Fibrosis
Juan-Guardela, B. M., & Kaminski, N. (2015) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814635011_0015
ATPases and Mitochondrial Supercomplexes
Cogliati, S., Acín‐Pérez, R., & Enrı́quez, J. A. (2015) · CRC Press eBooks · doi:10.1201/b19087-4
Stem Cells in Diseases of Aging
Li, M., & Ikehara, S. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-29149-9_4
Mitochondrial dysfunction and treatment strategies
Krishnan, S. (2016) · Figshare
Roy, N. (2015) · KU ScholarWorks (University of Kansas)
Tan, S. (2017) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/72655
The role of autophagy in aging-related osteoarthritis
de Figueroa, P. L. (2017) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Quarles, E. K. (2017) · ResearchWorks at the University of Washington (University of Washington)
Cheema, N. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r33r0q585
Aging and idiopathic pulmonary fibrosis
Bueno, M., Mora, A. L., & Rojas, M. M. (2015) · doi:10.2217/fmeb2013.13.225
Mitochondrial Dysfunction in Aging and Neurodegeneration
Walia, V., & Garg, M. (2018) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-5225-5282-6.ch004
Effects of AMP-activated kinase modulators on intracellular Ca2+ signalling and C. elegans lifespan
Arias-del-Val, J. (2018) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/33455
Melatonin, Mitochondria and Successful Aging
Idowu, A. (2018) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2018.09.001788
Prasun, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817006-9.00016-2
Mangalhara, K. C., & Bamezai, R. N. K. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_11
Redox mechanisms in pulmonary disease: Emphasis on pulmonary fibrosis
Janssen-Heininger, Y. M. W., & Anathy, V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818606-0.00035-3
Role of Mitochondria in Fungal Drug Resistance
Pasrija, R., & Kundu, D. (2019) · Springer eBooks · doi:10.1007/978-981-32-9449-3_8
RECQL4; Linking DNA Replication and Bone Tumourigenesis
Author, U. (2019) · Lincoln Repository (University of Lincoln) · doi:10.24385/lincoln.24326188
A novel phylogenetic analysis and machine learning predict pathogenicity of human mtDNA variantsPreprint
Akpınar, B. A., Carlson, P., Paavilainen, V. O., & Dunn, C. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.10.902239
Mitochondria as a Key Player in Aging
Banerjee, R., & Rath, P. C. (2020) · Springer eBooks · doi:10.1007/978-981-32-9005-1_10
de Snoo, M. L. (2018) · TSpace (University of Toronto)
Heart Failure as a Consequence of Genetic Cardiomyopathy
Judge, D. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-60987-6.00024-7
Mechanical View on the Mitochondria
Mierke, C. T. (2020) · Biological and medical physics, biomedical engineering · doi:10.1007/978-3-030-58532-7_6
Tiantian, Z. O. U., Wu, J., Long, Y. A. N. G., Tailaiti, T., Chen, S., & Wang, J. (2021) · Food Science and Technology · doi:10.1590/fst.59121
Chistyakov, V. A., Smirnova, Y. O., & Alperovich, I. (2021) · International Journal of Mathematics and Computers in Simulation · doi:10.46300/9102.2021.15.20
Richard, V. R. (2014) · Spectrum Research Repository (Concordia University)
Rychlik‐Sych, M., Barańska, M., Dudarewicz, M., Skrętkowicz, J., Żebrowska, A., Owczarek, J., Wiktorowska‐Owczarek, A., Orszulak–Michalak, D., & Waszczykowska, E. (2021) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.2478/ahem-2021-0018
Mitochondrial Dysfunction in Aging and Neurodegeneration
Walia, V., & Garg, M. (2022) · IGI Global eBooks · doi:10.4018/978-1-6684-5295-0.ch016
Sarcopenia in Chronic Kidney Disease: Mechanism and Treatment
李, 嘉. (2022) · Advances in Clinical Medicine · doi:10.12677/acm.2022.123231
Yates, J. R. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727680133.793557922
Mitochondriogenesis and brain aging
Sekiya, F. S., & Marie, S. K. N. (2018) · Revista de Medicina · doi:10.11606/issn.1679-9836.v97i6p604-606
Adjuvante Therapien in der Reproduktionsmedizin
Krüssel, J.-S., Baston-Büst, D.-M., & Bielfeld, A. P. (2019) · Springer Reference Medizin · doi:10.1007/978-3-662-55601-6_47-1
Exploring solutions to ovarian aging through systemic to subcellular approaches
MacDonald, J. A. (2019) · Digital Repository Service (Northeastern University) · doi:10.17760/d20316320
Aging in Stem Cells: Traditional Review
DURMAZ, C., & ŞEN, E. (2022) · Turkiye Klinikleri Journal of Health Sciences · doi:10.5336/healthsci.2021-84348
Sarmento‐Ribeiro, A. B., Botelho, M. F., Gonçalves, A. C., Melo, J. B., Laranjo, M., Alves, R., Jorge, J., Ribeiro, I. P., Pires, S., Abrantes, A. M., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00026-4
Machine learning in the context of better healthcare in aging
Henriques, J. M. O., Ribeiro, C., Rocha, T., Paredes, S., Carvalho, P., Duarte, A. I., Freitas, A. A., Cunha‐Oliveira, T., & Pereira, F. B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00015-x
Mitochondrial Dysfunction and Their Management by Antioxidants
Koteeswaran, K., & Keerthana, N. (2022) · Asian Plant Research Journal · doi:10.9734/aprj/2022/v9i430215
Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins
TABIBZADEH, S. S. (2022) · Aging and Disease · doi:10.14336/ad.2022.0414
Elderly Aged People’s Diet Peculiarities and Genetic Characteristics of Antioxidant Protection
Воронина, Л. П., Михаленко, Е. П., Кильчевский, А. В., & Андреева, И. Н. (2022) · Рецепт · doi:10.34883/pi.2022.25.6.012
Leucker, T. M., Goldenberg, J., & Gerstenblith, G. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-16594-8_4
Mitochondrial DNA Poly-C length heteroplasmy as a marker for risk of critical COVID-19Preprint
Coto, E., Vázquez‐Coto, D., Albaiceta, G. M., Amado‐Rodríguez, L., González-Fernández, M., García-Lago, C., Velázquez-Cuervo, L., Cuesta‐Llavona, E., & Gómez, J. (2023) · doi:10.22541/au.168182291.18633856/v1
Chen, C., Zhang, S., Han, G., & Yang, T. (2023) · Research Square · doi:10.21203/rs.3.rs-3200357/v1
Ciampa, E. J., Flahardy, P., Srinivasan, H., Jacobs, C. L., Tsai, L. T.-Y., Karumanchi, S. A., & Parikh, S. M. (2023) · eLife · doi:10.7554/elife.85597.3.sa4
A spotlight on the aged pulmonary artery
Horvat, D., & Agoşton-Coldea, L. (2024) · Advances in clinical chemistry · doi:10.1016/bs.acc.2024.06.006
Causes and Consequences of Perturbations of the Mitochondrial Genome
King, D. E., Copeland, W. C., Wallace, K. B., & Meyer, J. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00128-5
Life Cycle From Conception to Senility
(2024) · Advances in religious and cultural studies (ARCS) book series · doi:10.4018/978-1-6684-8509-5.ch009
Li, X., Pan, F., Wang, L., Zhang, J., Wang, X., Qi, D., Chai, X., Wang, Q., Yi, Z., Ma, Y., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1432592
Баландин, А. А., Kobeleva, A. S., Баландина, И. А., & Gulyaeva, N. I. (2024) · Bulletin of the Medical Institute REAVIZ (REHABILITATION DOCTOR AND HEALTH) · doi:10.20340/vmi-rvz.2024.4.morph.2
Maternal ancestry reveals cyclical aging of the mammary gland.Preprint
Germain, D., Mashaka, T., Chattopadhyay, M., Polushakov, D., Torres‐Martín, M., Sia, D., & Jenkins, E. C. (2024) · Research Square · doi:10.21203/rs.3.rs-4926839/v1
Bjerknes, T. L., Rubiolo, A., Shadad, O., Tysnes, O., & Tzoulis, C. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-01980-7
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing micePreprint
Kremer, L. S., Gao, G., Rigoni, G., Filograna, R., Mennuni, M., Wibom, R., Végvári, Á., Koolmeister, C., & Larsson, N. (2025) · eLife · doi:10.7554/elife.104461.2
Self-citationINNOVATIVE APPROACHES TO COMBAT SKIN AGING: ADVANCES IN WRINKLE AND SAGGING TREATMENTS
NIKAM, K. D., ELANGO, V., VENTRIAL, K., M., Y., & Murugappan, M. (2025) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2025v17i3.52837 · Cited by 1
Pláteník, J. (2020) · Klinická biochemie a metabolismus · doi:10.61568/kbm.2020.027
Leiden, N. S. V., Potapova, N. A., & Ree, N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.09.648561
Tripathi, A. P., Verma, M., Tripathi, M., & Singh, B. K. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1009875
Metadata
- Authors
- Bratic, A., & Larsson, N.-G.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Larsson, Nils-Göran
- ORCID
- Larsson, Nils-Göran
- Venue
- Journal of Clinical Investigation
- Published
- 2013-03-01
- Volume
- 123
- Issue
- 3
- Pages
- 951-957
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3582127
- OpenAlex
- W2112299930
- Cited by
- 1,087
- References
- 128
- Citations by year
- 2026: 68 · 2025: 88 · 2024: 72 · 2023: 82 · 2022: 98 · 2021: 77 · 2020: 102 · 2019: 73 · 2018: 86 · 2017: 76 · 2016: 87 · 2015: 81 · 2014: 66 · 2013: 30
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondria, aging, mitochondrial dysfunction, somatic mtDNA mutations, respiratory chain deficiency, progeroid phenotype, clonal expansion, free radical theory of aging, insulin/IGF-1 signaling, mTOR signaling
- MeSH terms
- Aging, Animals, DNA, Mitochondrial, Free Radicals, Humans, Mitochondria, Mutation, Signal Transduction, Mutagenesis, Cellular Senescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
