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The role of mitochondria in aging
Open accessAbstract
Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated with aging. Somatic mitochondrial DNA (mtDNA) mutations and respiratory chain dysfunction accompany normal aging, but the first direct experimental evidence that increased mtDNA mutation levels contribute to progeroid phenotypes came from the mtDNA mutator mouse. Recent evidence suggests that increases in aging-associated mtDNA mutations are not caused by damage accumulation, but rather are due to clonal expansion of mtDNA replication errors that occur during development. Here we discuss the caveats of the traditional mitochondrial free radical theory of aging and highlight other possible mechanisms, including insulin/IGF-1 signaling (IIS) and the target of rapamycin pathways, that underlie the central role of mitochondria in the aging process.
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In the citing paper
“accumulation of such damages occurs during aging [66].”
From Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s Disease (2014) · cites this paper as [66]
In the citing paper
“Mitochondrial function declines with aging in model organisms and humans (58).”
From Connecting aging biology and inflammation in the omics era (2022) · cites this paper as [58]
In the citing paper
“A progressive mitochondrial dysfunction is known to occur with age (31)(32)(33).”
From Human Aging and Longevity Are Characterized by High Levels of Mitokines (2019) · cites this paper as [33]
In the citing paper
“A direct relationship between mitochondrial dysfunction and aging has been suggested by many studies (for review, see ref. 93)”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [93]
In the citing paper
“secondary alterations in mitochondrial function driven by age-related cellular and metabolic changes may also contribute to the aging process93.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [93]
In the citing paper
“Defective mitophagy has also been linked with premature aging and many age-associated disorders, such as Alzheimer’s and Parkinson’s diseases (25–28).”
From Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary disease (2015) · cites this paper as [26]
In the citing paper
“Previous studies have reported diminished expressions of mitochondrial respiratory complex subunits, mitochondrial respiration, and ATP levels in skeletal muscle [66].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [66]
In the citing paper
“Mitochondrial function declines with age due either to ROS and/or an accumulation of mutations in mitochondrial DNA (151).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [151]
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Cites
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Self-citationStadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701
The moulding of senescence by natural selection
Hamilton, W. D. O. (1966) · Journal of Theoretical Biology · doi:10.1016/0022-5193(66)90184-6 · Cited by 2,289
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Flagged first, then by citations
Research works printed but not linked: 6
- Radák, Antioxid Redox Signal.
- Holme, 1993, Am J Hum Genet., 52, 551
- Müller-Höcker, 1989, Am J Pathol., 134, 1167
- Bjelakovic, 2012, Cochrane Database Syst Rev., 3, CD007176
- Walker, 2008, Am Fam Physician., 78, 1079
- 10.1161/CIRCRESAHA.111.246140 · DOI
Cited by
Sorted by citations
Items 601–700 of 1,000
Setz, C., Benischke, A., Bento, A. C. P. F., Brand, Y., Levano, S., Paech, F., Leitmeyer, K., & Bodmer, D. (2018) · Hearing Research · doi:10.1016/j.heares.2018.01.003 · Cited by 16
Metabolism of sleep and aging: Bridging the gap using metabolomics
Sengupta, A., & Weljie, A. M. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-180043 · Cited by 16
Correction: Somatic mtDNA Mutation Spectra in the Aging Human Putamen
Williams, S. L., Mash, D. C., Zuchner, S. L., & Moraes, C. T. (2013) · PLoS Genetics · doi:10.1371/annotation/4b800314-8d35-454d-afca-af6d0f57b5d1 · Cited by 16
Tashiro, R., Ozaki, D., Bautista-Garrido, J., Sun, G., Obertas, L., Mobley, A. S., Kim, G. S., Aronowski, J., & Jung, J. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065187 · Cited by 15
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Parkhitko, A. A., & Cracan, V. (2025) · Science Advances · doi:10.1126/sciadv.adu1710 · Cited by 15
Optimization of cell permeabilization in electron flow based mitochondrial function assays
Lei, X.-H., & Bochner, B. R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.10.014 · Cited by 15
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Sun, J., Chong, L., Liu, Y., & Guo, Z. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03686-y · Cited by 15
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Воронина, Т. А. (2023) · Neurochemical Journal · doi:10.1134/s1819712423020198 · Cited by 15
Asgari, R., Mehran, Y. Z., Weber, H. M., Weber, M., Golestanha, S. A., Kazerouni, S. M. H., Panahi, F., Mohammadi, P., & Mansouri, K. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106715 · Cited by 17
Zhan, X.-Z., Luo, P., Zhang, C., Zhang, L.-J., Shen, X., Jiang, D., & Liu, W.-J. (2024) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2024.107540 · Cited by 15
Your Heart on a Chip: iPSC-Based Modeling of Barth-Syndrome-Associated Cardiomyopathy
Zweigerdt, R., Gruh, I., & Martin, U. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.06.015 · Cited by 15
Aging and aging-associated diseases: a microRNA-based endocrine regulation hypothesis
Umansky, S. R. (2018) · Aging · doi:10.18632/aging.101612 · Cited by 16
He, J., Huang, Y. Y., Du, G., Wang, Z., Yang, X., & Wang, Q. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.04.044 · Cited by 15
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Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2019) · Current Issues in Molecular Biology · doi:10.21775/cimb.031.021 · Cited by 15
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Hsieh, P. N., Sweet, D. R., Fan, L., & Jain, M. K. (2017) · PubMed · Cited by 15
Lovejoy, P. C., & Fiumera, A. C. (2019) · Insects · doi:10.3390/insects10110398 · Cited by 15
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Wang, H., Stevens, T., Lu, J. L., Airik, M., Airik, R., & Prochownik, E. V. (2022) · Cells · doi:10.3390/cells11244087 · Cited by 15
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Bouhlal, Y., Martinez, S. R., Gong, H. Z., Dumas, K., & Shieh, J. T. C. (2013) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.20 · Cited by 15
Choi, B.-H., Ji, S.-D., Son, J. G., Nguyen, P. A. H., Kim, K., Park, Y. H., & Koh, Y. H. (2017) · Journal of Asia-Pacific Entomology · doi:10.1016/j.aspen.2017.10.011 · Cited by 15
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Kal, S., Mahata, S., Jati, S., & Mahata, S. K. (2023) · Peptides · doi:10.1016/j.peptides.2023.171147 · Cited by 15
Yildirim, R. M., & Seli, E. U. (2024) · Human Reproduction · doi:10.1093/humrep/deae171 · Cited by 14
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Hyun, D., & Lee, J. (2021) · Antioxidants · doi:10.3390/antiox11010007 · Cited by 15
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Wang, G., Dai, L., Luo, L., Xu, W., Chenjing, Z., Zhu, Y., CHEN, Z., Hu, W., Xu, X. D., & Pan, W. (2014) · Oncology Reports · doi:10.3892/or.2014.3205 · Cited by 14
Tani, H., Mito, T., Velagapudi, V., Ishikawa, K., Umehara, M., Nakada, K., Suomalainen, A., & Hayashi, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-52372-6 · Cited by 14
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Self-citationKang, S., Park, J.-W., Cho, E., Kim, D., Ye, S., Jeong, E. T., Jun, S., & Kang, N. G. (2025) · Biomedicines · doi:10.3390/biomedicines13102395 · Cited by 13
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Xu, H., Lu, X., Wang, C., Ning, J., Chen, M., Wang, Y., & Yuan, K. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.872562 · Cited by 13
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Bonetto, V., Ferraresi, A., Sampò, S., & Isidoro, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104800 · Cited by 13
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Chen, P., Zhang, Y., Xu, M., Chen, H., Zou, H.-X., Zhang, X., Tong, H., You, C., & Wu, M. (2020) · Food & Function · doi:10.1039/d0fo00187b · Cited by 13
Arentson‐Lantz, E. J., Mikovic, J., Bhattarai, N., Fry, C. S., Lamon, S., Porter, C. C., & Paddon‐Jones, D. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00810.2020 · Cited by 13
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Yang, M., Luo, S., Chen, W., He, L., Liu, D., Wang, X., Xiao, L., & Sun, L. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867331666230822095924 · Cited by 12
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Suki, B., Parameswaran, H., Alves, C., Araújo, A. D., & Bartolák‐Suki, E. (2019) · Studies in mechanobiology, tissue engineering and biomaterials · doi:10.1007/978-3-030-20182-1_4 · Cited by 12
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Hung, S. W., Liang, B., Gao, Y., Zhang, R., Tan, Z., Zhang, T., Chung, J. P. W., Chan, T. H., & Wang, C. C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.714790 · Cited by 14
Gudenschwager, C., Chavez, I., Cárdenas, C., & González-Billault, C. E. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5586052 · Cited by 12
Li, N., Xu, H., Liu, X., Gao, R., Junlin, H., Ding, Y., Li, F., Geng, Y., Mu, X., & Chen, X. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.152759 · Cited by 13
Lefferts, W. K., Davis, M. M., & Valentine, R. J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.866792 · Cited by 13
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Meira, L. B., Calvo, J. A., Shah, D., Klapacz, J., Moroski-Erkul, C. A., Bronson, R. T., & Samson, L. D. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.05.012 · Cited by 12
McKenzie, M., Chiotis, M., Hroudová, J., Lopez Sanchez, M. I. G., Lim, S. C., Cook, M. J., McKelvie, P., Cotton, R. G. H., Murphy, M., St John, J. C., et al. (2014) · Human Mutation · doi:10.1002/humu.22694 · Cited by 12
He, Y., Chen, X., Yan, D., Xiao, F., Lin, R., Liao, X.-P., Liu, Y.-W., Pu, S.-Y., Yu, Q., Sun, H., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.026 · Cited by 12
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Nuerlan, G., Yu, M., Wang, X., Zhang, Y., Li, Y., Zhang, K., Pan, L., Ozathaley, A., Wu, Y., Li, Q., et al. (2024) · Nano Research · doi:10.26599/nr.2025.94907375 · Cited by 11
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Tellería, F., Mansilla, S., Méndez, D., Sepúlveda, M., Araya‐Maturana, R., Castro, L., Trostchansky, A., & Eduardo Fuentes, Q. (2023) · Pharmaceuticals · doi:10.3390/ph16020210 · Cited by 11
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Vats, S., Sundquist, K., Li, Y., Wang, X., Hong, M., Sundquist, J., Zarrouk, M., Gottsäter, A., & Memon, A. A. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.029248 · Cited by 10
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Small, I. (2013) · BMC Biology · doi:10.1186/1741-7007-11-30 · Cited by 10
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Devi, S. A., & Satpati, A. (2016) · Springer eBooks · doi:10.1007/978-981-10-2155-8_8 · Cited by 10
Xu, L., Lin, M.-J., Li, Y.-P., Li, S., Shao-jun, C., & Wei, C. (2017) · Journal of Visualized Experiments · doi:10.3791/55741 · Cited by 10
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Martín‐Fernández, B., & Gredilla, R. (2018) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2017.12.002 · Cited by 10
Lemon, J. A., Aksenov, V., Samigullina, R., Aksenov, S., Rodgers, W. H., Rollo, C. D., & Boreham, D. R. (2016) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22019 · Cited by 12
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Development of AD-Like Pathology in Skeletal Muscle
Chen, X., Miller, N. M., Afghah, Z., & Geiger, J. D. (2019) · Journal of Parkinson’s Disease and Alzheimer’s Disease · doi:10.13188/2376-922x.1000028 · Cited by 10
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Cavezzi, A., Colucci, R., & d’Errico, G. (2022) · Current Aging Science · doi:10.2174/1874609815666220606140754 · Cited by 10
Brennan, A. M., Coen, P. M., Mau, T., Hetherington‐Rauth, M., Toledo, F. G. S., Kershaw, E. E., Cawthon, P. M., Kramer, P. A., Ramos, S. V., Newman, A. B., et al. (2024) · Obesity · doi:10.1002/oby.24008 · Cited by 9
LI, Y., HONDA, S., Iwami, K., Ohta, Y., & Umeda, N. (2015) · Journal of Microscopy · doi:10.1111/jmi.12277 · Cited by 9
Rocha‐Rodrigues, S., Alves, E. S., Coxito, P. M., Marques‐Aleixo, I., Passos, E., Guimarães, J. T., Martins, M. J., Oliveira, P. J., Magalhães, J., & Ascensão, A. A. M. R. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.07.004 · Cited by 9
Mito, T., Tani, H., Suzuki, M., Ishikawa, K., Nakada, K., & Hayashi, J. (2018) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.18-0060 · Cited by 9
Zhao, H., Shen, J., Leung, E., Zhang, X., Chow, W., & Zhang, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-72083-7 · Cited by 9
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Murdocca, M., Spitalieri, P., Cappello, A., Colasuonno, F., Moreno, S., Candi, E., D’Apice, M. R., Novelli, G., & Sangiuolo, F. C. (2022) · Aging · doi:10.18632/aging.203910 · Cited by 9
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Hottin, C., Perron, M., & Roger, J. E. (2022) · Cells · doi:10.3390/cells11182898 · Cited by 9
Metadata
- Authors
- Bratic, A., & Larsson, N.-G.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Larsson, Nils-Göran
- ORCID
- Larsson, Nils-Göran
- Venue
- Journal of Clinical Investigation
- Published
- 2013-03-01
- Volume
- 123
- Issue
- 3
- Pages
- 951-957
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3582127
- OpenAlex
- W2112299930
- Cited by
- 1,087
- References
- 128
- Citations by year
- 2026: 68 · 2025: 88 · 2024: 72 · 2023: 82 · 2022: 98 · 2021: 77 · 2020: 102 · 2019: 73 · 2018: 86 · 2017: 76 · 2016: 87 · 2015: 81 · 2014: 66 · 2013: 30
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondria, aging, mitochondrial dysfunction, somatic mtDNA mutations, respiratory chain deficiency, progeroid phenotype, clonal expansion, free radical theory of aging, insulin/IGF-1 signaling, mTOR signaling
- MeSH terms
- Aging, Animals, DNA, Mitochondrial, Free Radicals, Humans, Mitochondria, Mutation, Signal Transduction, Mutagenesis, Cellular Senescence
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