The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
Open accessAbstract
N-formyl peptide receptors (FPRs) are critical regulators of host defense in phagocytes and are also expressed in epithelia. FPR signaling and function have been extensively studied in phagocytes, yet their functional biology in epithelia is poorly understood. We describe a novel intestinal epithelial FPR signaling pathway that is activated by an endogenous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS by an epithelial NADPH oxidase, NOX1. We show that epithelial cell migration was regulated by this signaling cascade through oxidative inactivation of the regulatory phosphatases PTEN and PTP-PEST, with consequent activation of focal adhesion kinase (FAK) and paxillin. In vivo studies using intestinal epithelial specific Nox1(-/-IEC) and AnxA1(-/-) mice demonstrated defects in intestinal mucosal wound repair, while systemic administration of ANXA1 promoted wound recovery in a NOX1-dependent fashion. Additionally, increased ANXA1 expression was observed in the intestinal epithelium and infiltrating leukocytes in the mucosa of ulcerative colitis patients compared with normal intestinal mucosa. Our findings delineate a novel epithelial FPR1/NOX1-dependent redox signaling pathway that promotes mucosal wound repair.
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Cell Migration: Integrating Signals from Front to Back
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Self-citationSTAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
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Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature Reviews Immunology · doi:10.1038/nri3608 · Cited by 3,173
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
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Resolution of inflammation: an integrated view
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Self-citationThe Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites
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Metadata
- Authors
- Leoni, G., Alam, A., Neumann, P.-A., Lambeth, J. D., Cheng, G., McCoy, J., Hilgarth, R. S., Kundu, K., Murthy, N., Kusters, D., Reutelingsperger, C., Perretti, M., Parkos, C. A., Neish, A. S., & Nusrat, A.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-12-17
- Volume
- 123
- Issue
- 1
- Pages
- 443-454
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2146314181
- Cited by
- 295
- References
- 89
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Leoni, G., Alam, A., Neumann, P.-A., Lambeth, J. D., Cheng, G., McCoy, J., Hilgarth, R. S., Kundu, K., Murthy, N., Kusters, D., Reutelingsperger, C., Perretti, M., Parkos, C. A., Neish, A. S., & Nusrat, A. (2013). Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. Journal of Clinical Investigation. https://doi.org/10.1172/jci65831
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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