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MicroRNA-7a regulates pancreatic β cell function
Open accessAbstract
Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following pathological stress and are the underlying cause of several disease conditions. In pancreatic β cells, miRNAs have been largely unstudied and little is known about how specific miRNAs regulate glucose-stimulated insulin secretion (GSIS) or impact the adaptation of β cell function to metabolic stress. In this study, we determined that miR-7 is a negative regulator of GSIS in β cells. Using Mir7a2 deficient mice, we revealed that miR-7a2 regulates β cell function by directly regulating genes that control late stages of insulin granule fusion with the plasma membrane and ternary SNARE complex activity. Transgenic mice overexpressing miR-7a in β cells developed diabetes due to impaired insulin secretion and β cell dedifferentiation. Interestingly, perturbation of miR-7a expression in β cells did not affect proliferation and apoptosis, indicating that miR-7 is dispensable for the maintenance of endocrine β cell mass. Furthermore, we found that miR-7a levels are decreased in obese/diabetic mouse models and human islets from obese and moderately diabetic individuals with compensated β cell function. Our results reveal an interconnecting miR-7 genomic circuit that regulates insulin granule exocytosis in pancreatic β cells and support a role for miR-7 in the adaptation of pancreatic β cell function in obesity and type 2 diabetes.
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“GIIS is enhanced in mir-7a knockout mice (371), despite there being no obvious effect on [Ca2+]i or the number of docked granules.”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [371]
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“MiR-7 is the 2nd most abundant miR in human β-cells.”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [371]
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Cites
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626
Self-citationA pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102
Self-citationα-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
Burré, J., Sharma, M., Tsetsenis, T., Buchman, V. L., Etherton, M. R., & Südhof, T. C. (2010) · Science · doi:10.1126/science.1195227 · Cited by 1,907
MicroRNAs in Stress Signaling and Human Disease
Mendell, J. T., & Olson, E. N. (2012) · Cell · doi:10.1016/j.cell.2012.02.005 · Cited by 1,673
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
Chandra, S. S., Gallardo, G., Fernández‐Chacón, R., Schlüter, O. M., & Südhof, T. C. (2005) · Cell · doi:10.1016/j.cell.2005.09.028 · Cited by 990
Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
St‐Onge, L., Sosa‐Pineda, B., Chowdhury, K., Mansouri, A., & Gruß, P. (1997) · Nature · doi:10.1038/387406a0 · Cited by 792
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Items 101–200 of 280
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis
Grieß, K., Rieck, M., Müller, N., Karsai, G., Hartwig, S., Pelligra, A., Hardt, R., Schlegel, C., Kuboth, J., Uhlemeyer, C., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-01027-2 · Cited by 37
Taylor, H. J., Hung, Y.-H., Narisu, N., Erdos, M. R., Kanke, M., Yan, T., Grenko, C. M., Swift, A. J., Bonnycastle, L. L., Sethupathy, P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2206797120 · Cited by 35
Pfeiffer, S., Sánchez-Lechuga, B., Donovan, P., Halang, L., Prehn, J. H. M., Campos‐Caro, A., Byrne, M. M., & López‐Tinoco, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-57838-6 · Cited by 39
Circular RNAs in metabolism and metabolic disorders
Zeng, Y.-Z., Zheng, Z., Liu, F., & Yi, G. (2021) · Obesity Reviews · doi:10.1111/obr.13220 · Cited by 40
A Review of micro RNAs changes in T2DM in animals and humans
Afsharmanesh, M. R., Mohammadi, Z., Mansourian, A. R., & Jafari, S. M. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13431 · Cited by 39
Serbis, A., Giapros, V. I., Tsamis, K. I., Balomenou, F., Galli‐Τsinopoulou, A., & Siomou, E. C. (2023) · Nutrients · doi:10.3390/nu15092217 · Cited by 42
Implication of epigenetics in pancreas development and disease
Quilichini, E., & Haumaître, C. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.10.010 · Cited by 35
Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2
Lockridge, A. D., Jo, S., Gustafson, E. C., DAMBERG, N. E., Mohan, R., Olson, M., Abrahante, J. E., & Alejandro, E. U. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107609 · Cited by 33
Non-Coding RNAs: Novel Players in Insulin Resistance and Related Diseases
Formichi, C., Nigi, L., Grieco, G. E., Maccora, C., Fignani, D., Brusco, N., Licata, G., Sebastiani, G., & Dotta, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147716 · Cited by 34
Pancreatic PCSK9 controls the organization of the β-cell secretory pathway via LDLR-cholesterol axis
Marku, A., Dalt, L. D., Galli, A., Dule, N., Corsetto, P. A., Rizzo, A. M., Moregola, A., Uboldi, P., Bonacina, F., Marciani, P., et al. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155291 · Cited by 36
Islet microRNAs in health and type-2 diabetes
Wendt, A., Esguerra, J. L. S., & Eliasson, L. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.08.003 · Cited by 32
Self-citationVezza, T., Marañón, A., Canet, F., Díaz-Pozo, P., Marti, M., D’Ocón, P., Apostolova, N., Rocha, M., & Víctor, V. M. (2021) · Antioxidants · doi:10.3390/antiox10050802 · Cited by 34
A nexus of lipid and O-Glcnac metabolism in physiology and disease
Lockridge, A. D., & Hanover, J. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.943576 · Cited by 35
López, Y. O. N., Casu, A., Kováčová, Z., Petrilli, A. M., Sideleva, O., Tharp, W. G., & Pratley, R. E. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.955593 · Cited by 32
de Lima, T. I., Araújo, H. N., Menezes, E. S., Sponton, C. H., de Araújo, M. B., Bomfim, L. H. M., Queiroz, A. L., Passos, M. A., Sousa, T. A. E., Hirabara, S. M., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25645 · Cited by 34
de Jesus, D. S., Mak, T. C. S., Wang, Y.-F., von Ohlen, Y., Bai, Y., Kane, E., CHABOSSEAU, P. L., Chahrour, C., Distaso, W., Salem, V., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101248 · Cited by 36
Self-citationEpigenetic Regulation of β Cell Identity and Dysfunction
Sun, X., Wang, L., Obayomi, S. M. B., & Wei, Z. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.725131 · Cited by 32
MicroRNAs and the functional β cell mass: For better or worse
Guay, C., & Regazzi, R. (2015) · Diabetes & Metabolism · doi:10.1016/j.diabet.2015.03.006 · Cited by 30
Antisense MicroRNA Therapeutics in Cardiovascular Disease: Quo Vadis?
Philippen, L. E., Dirkx, E., Wit, J. B. M., Burggraaf, K., Windt, L. J. D., & Martins, P. A. D. C. (2015) · Molecular Therapy · doi:10.1038/mt.2015.133 · Cited by 29
Natalicchio, A., Montagnani, M., Gallo, M., Marrano, N., Faggiano, A., Zatelli, M. C., Mazzilli, R., Argentiero, A., Danesi, R., D’Oronzo, S., et al. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.101573 · Cited by 30
An ‘alpha-beta’ of pancreatic islet microribonucleotides
Dalgaard, L. T., & Eliasson, L. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.01.009 · Cited by 27
Self-citationGao, Y.-X., Li, J., Zhang, Z., Zhang, R., Pollock, A., & Sun, T. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1618-y · Cited by 27
Epigenetics: key to improve delayed wound healing in type 2 diabetes
Dubey, R., Prabhakar, P. K., & Gupta, J. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04285-0 · Cited by 30
The recent advancements in circRNA research: From biogenesis to therapeutic interventions
Malviya, A., & Bhuyan, R. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154697 · Cited by 31
Epigenetic Modifications Associated with the Pathogenesis of Type 2 Diabetes Mellitus
Hossan, T., Kundu, S., Alam, S. S., & Nagarajan, S. (2019) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666190301145545 · Cited by 33
Zhang, Y., Qian, B., Yang, Y., Niu, F., Lin, C., Yuan, H., Wang, J., Wu, T., Shao, Y., Shao, S., et al. (2024) · Diabetes · doi:10.2337/db24-0177 · Cited by 28
Fričová, D., Harsányiová, J., & Trancikova, A. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228666 · Cited by 29
Berry, C., Lal, M., & Binukumar, B. K. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00210 · Cited by 27
Gregg, B. E., Botezatu, N., Brill, J. D., Hafner, H., Vadrevu, S., Satin, L. S., Alejandro, E. U., & Bernal‐Mizrachi, E. (2018) · Scientific Reports · doi:10.1038/s41598-018-23965-4 · Cited by 25
MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides
Agbu, P., Cassidy, J. J., Braverman, J., Jacobson, A., & Carthew, R. W. (2019) · Endocrinology · doi:10.1210/endocr/bqz040 · Cited by 24
Emergent Roles of Circular RNAs in Metabolism and Metabolic Disorders
Wu, Y.-L., Li, H.-F., Chen, H.-H., & Lin, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031032 · Cited by 25
Bhushan, R., Rani, A., Gupta, D., Ali, A., Tripathi, A., & Dubey, P. K. (2022) · MicroRNA · doi:10.2174/2211536611666220413100636 · Cited by 25
Non-coding genome functions in diabetes
Cebola, I., & Pasquali, L. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0197 · Cited by 25
Noncoding RNAs in β cell biology
Singer, R. A., Arnes, L., & Sussel, L. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000141 · Cited by 25
Zheng, W., Ji, D., Xu, Y., Li, Z., Huang, L., Yunfu, C., & Xingming, J. (2017) · Journal of Cancer · doi:10.7150/jca.21785 · Cited by 24
Yoshimatsu, G., Takita, M., Kanak, M. A., Haque, W. Z., Chang, C., Saravanan, P. B., Lawrence, M. C., Levy, M. F., & Naziruddin, B. (2016) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.377 · Cited by 24
MicroRNAs in the pathogenesis of type 2 diabetes: new research progress and future direction
Miao, C., Zhang, G., Xie, Z., & Chang, J. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0452 · Cited by 23
microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3
Wang, Z., Mohan, R., Chen, X., Matson, K., Waugh, J., Mao, Y., Zhang, S., Li, W., Tang, X., Satin, L. S., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab031 · Cited by 23
miRNA expression in PCOS: unveiling a paradigm shift toward biomarker discovery
Rashid, G., Khan, N. A., Elsori, D. H., Youness, R. A., Hassan, H., Siwan, D., Seth, N., Kamal, M. A., Rizvi, S., Babker, A. M. A., et al. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-024-07379-4 · Cited by 24
Sun, Q., Yang, Q., Xu, H., Xue, J., Chen, C., Yang, X., Gao, X., & Liu, Q. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy150 · Cited by 23
Circular RNAs: history, metabolism, mechanisms of function, and regulatory roles at a glance
Karimi, R., Javandoost, E., Asadmasjedi, N., Atashi, A., Soleimani, A., & Behzadifard, M. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002761 · Cited by 25
miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent manner
Cerda, C., Kim, S. J., Thomas, G., Farsi, Z., Zolotarov, G., Dube, G., Deter, A., Bahry, E., Georgii, E., Woehler, A., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00168-9 · Cited by 24
Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases
Pomatto, M. A. C., Gai, C., Deregibus, M. C., Tetta, C., & Camussi, G. (2018) · International Journal of Endocrinology · doi:10.1155/2018/4302096 · Cited by 26
Epigenetics in β-cell adaptation and type 2 diabetes
Kim, H., & Kulkarni, R. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.10.008 · Cited by 22
Alexandru, N., Procopciuc, A., Vîlcu, A., Comariţa, I. K., Bădilă, E., & Georgescu, A. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09664-y · Cited by 21
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Lee, H.-B., Park, H., Choi, H., Lee, S., Lee, S.-J., Lee, J., Cho, E.-H., Han, H., Seok, J., & Son, W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103048 · Cited by 21
Circular RNAs in diabetes and its complications: Current knowledge and future prospects
Yin, W., Zhang, Z., Xiao, Z., Li, X., Luo, S., & Zhou, Z. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1006307 · Cited by 20
Antisense therapy: a potential breakthrough in the treatment of neurodegenerative diseases
Romanò, R., & Bucci, C. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385285 · Cited by 21
AAV8-mediated gene transfer of microRNA-132 improves beta cell function in mice fed a high-fat diet
Mulder, N. L., Havinga, R., Kluiver, J. L., Groen, A. K., & Kruit, J. K. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0287 · Cited by 18
Jin, W. L., Mulas, F., Gaertner, B., Sui, Y., Wang, J., Matta, I., Zeng, C., Vinckier, N. K., Wang, A., Nguyen-Ngoc, K.-V., et al. (2019) · iScience · doi:10.1016/j.isci.2019.10.063 · Cited by 19
Ji, Z., Luo, J., Su, T., Chen, C., & Su, Y. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s288482 · Cited by 20
Santosa, D., Castoldi, M., Paluschinski, M., Sommerfeld, A., & Häussinger, D. (2015) · Scientific Reports · doi:10.1038/srep12292 · Cited by 19
The power of microRNA regulation—insights into immunity and metabolism
Oliveto, S., Manfrini, N., & Biffo, S. (2025) · FEBS Letters · doi:10.1002/1873-3468.70039 · Cited by 21
MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis
LaPierre, M. P., Lawler, K., Godbersen, S., Farooqi, I. S., & Stoffel, M. (2022) · Nature Communications · doi:10.1038/s41467-022-33367-w · Cited by 18
Self-citationQi, H., Li, Y., & Liu, Q. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.09.001 · Cited by 18
Localised Cdr1as activity is required for fear extinction memory
Zajaczkowski, E. L., Zhao, Q., Liau, W., Gong, H., Madugalle, S. U., Periyakaruppiah, A., Leighton, L. J., Musgrove, M. R. B., Ren, H., Davies, J., et al. (2023) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2023.107777 · Cited by 15
Mechanisms of adult human β‐cell in vitro dedifferentiation and redifferentiation
Efrat, S. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12724 · Cited by 17
Isaacs, S. R., Wang, J., Kim, K. W., Yin, C., Zhou, L., Mi, Q. S., & Craig, M. E. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0819-2 · Cited by 18
Singh, A. P., Hung, Y.-H., Shanahan, M. T., Kanke, M., Bonfini, A., Dame, M. K., Biraud, M., Peck, B. C. E., Oyesola, O. O., Freund, J. M., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.11.001 · Cited by 17
He, J. N., Xu, S., Ji, Z., Sun, Y.-H., Cai, B., Zhang, S., & Wang, P. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110969 · Cited by 17
The Landscape of microRNAs in βCell: Between Phenotype Maintenance and Protection
Grieco, G. E., Brusco, N., Licata, G., Fignani, D., Formichi, C., Nigi, L., Sebastiani, G., & Dotta, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020803 · Cited by 18
Yongblah, K., Alford, S. C., Ryan, B. C., Chow, R. L., & Howard, P. L. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.08.018 · Cited by 16
Mendonca, A., Thandapani, P., Nagarajan, P., Venkatesh, S., & Sujatha, S. (2022) · Journal of Biosciences · doi:10.1007/s12038-022-00295-2 · Cited by 17
Novel insights regarding the role of noncoding RNAs in diabetes
Mačvanin, M., Gluvic, Z. M., Bajić, V., & Isenović, E. R. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i7.958 · Cited by 16
Xu, F., Liu, J., Na, L., & Chen, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00748 · Cited by 16
RetractedHe, L., Bao, T., Yang, Y., Wang, H., Gu, C., Chen, J., Zhai, T., He, X., Wu, M., Zhao, L., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114786 · Cited by 16
Glucose stimulates microRNA-199 expression in murine pancreatic β-cells
Werneck‐de‐Castro, J. P., Blandino-Rosano, M., Hilfiker‐Kleiner, D., & Bernal‐Mizrachi, E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010356 · Cited by 15
Fine-tuning of microRNAs in Type 2 Diabetes Mellitus
Rosado, J. A., Diez-Bello, R., Salido, G. M., & Jardín, I. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867325666171205163944 · Cited by 16
Sema3G activates YAP and promotes VSMCs proliferation and migration via Nrp2/PlexinA1
Luo, X.-Y., Fu, X., Liu, F., Luo, J., & Chen, A. F. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110613 · Cited by 15
Insulin secretion in health and disease: nutrients dictate the pace
Regazzi, R., Rodriguez‐Trejo, A., & Jacovetti, C. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115004152 · Cited by 17
ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells
Uhlemeyer, C., Müller, N., Grieß, K., Wessel, C., Schlegel, C., Kuboth, J., & Belgardt, B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237669 · Cited by 16
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LaPierre, M. P., Godbersen, S., Esteban, M. T., Schad, A. N., Treier, M., Ghoshdastider, U., & Stoffel, M. (2020) · Endocrinology · doi:10.1210/endocr/bqaa220 · Cited by 15
Self-citationRoles of Noncoding RNAs in Islet Biology
Guay, C., Jacovetti, C., Bayazit, M. B., Brozzi, F., Rodriguez‐Trejo, A., Wu, K., & Regazzi, R. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190032 · Cited by 16
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Toropko, M., Chuvpilo, S. A., & Karabelsky, A. V. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16080986 · Cited by 14
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Sharma, S., Mathew, A. B., & Chugh, J. (2017) · Advances in clinical chemistry · doi:10.1016/bs.acc.2017.06.003 · Cited by 14
Epigenetic Modifications Linked to T2D, the Heritability Gap, and Potential Therapeutic Targets
Szabó, M. I., Máté, B., Csép, K., & Benedek, T. (2018) · Biochemical Genetics · doi:10.1007/s10528-018-9863-8 · Cited by 17
Todero, J. E., Koch‐Laskowski, K., Shi, Q., Kanke, M., Hung, Y.-H., Beck, R., Stýblo, M., & Sethupathy, P. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03263-9 · Cited by 15
Interplay between circular RNA, microRNA, and human diseases
Kour, B., Gupta, S., Singh, R., Sophiarani, Y., & Paul, P. (2022) · Molecular Genetics and Genomics · doi:10.1007/s00438-022-01856-8 · Cited by 14
Beyond the Protein-Coding Sequence: Noncoding RNAs in the Pathogenesis of Type 2 Diabetes
DiStefano, J. K. (2015) · The Review of Diabetic Studies · doi:10.1900/rds.2015.12.260 · Cited by 14
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Chen, Y., Jiang, Q., Xing, X., Yuan, T., & Li, P. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-024-09914-9 · Cited by 14
Differential MicroRNA Expression Involved in Endometrial Receptivity of Goats
Zang, X., Zhou, C., Wang, W., Gan, J., Li, Y., Liu, D., Liu, G., & Hong, L. (2021) · Biomolecules · doi:10.3390/biom11030472 · Cited by 13
miRNAs in the Beta Cell—Friends or Foes?
Karagiannopoulos, A., Cowan, E., & Eliasson, L. (2023) · Endocrinology · doi:10.1210/endocr/bqad040 · Cited by 14
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Metadata
- Authors
- Latreille, M., Hausser, J., Stützer, I., Zhang, Q., Hastoy, B., Gargani, S., Kerr-Conte, J., Pattou, F., Zavolan, M., Esguerra, J. L. S., Eliasson, L., Rülicke, T., Rorsman, P., & Stoffel, M.
- Affiliations
- Inserm (FR)
- University of Basel (CH)
- Churchill Hospital (GB)
- Université de Lille (FR)
- University of Veterinary Medicine Vienna (AT)
- Corresponding author
- Stoffel, Markus
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2014-05-01
- Volume
- 124
- Issue
- 6
- Pages
- 2722-2735
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4038573
- OpenAlex
- W2129743050
- Cited by
- 281
- References
- 63
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 26 · 2021: 27 · 2020: 26 · 2019: 30 · 2018: 32 · 2017: 24 · 2016: 15 · 2015: 35 · 2014: 11
- FWCI
- 28.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- Fondation de l'Avenir pour la Recherche Médicale Appliquée
- Wellcome Trust (095531/Z/11/Z, 095531)
- European Genomic Institute for Diabetes (ANR-10-LABX-46)
- European Foundation for the Study of Diabetes
- Agence Nationale de la Recherche (ANR‐10‐LABX‐46, 10-LABX-46, ANR-10)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (127307)
- Eidgenössische Technische Hochschule Zürich
- Crafoordska Stiftelsen
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Veterinärmedizinische Universität Wien
- Region Skåne
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- microRNA, pancreatic beta cells, glucose-stimulated insulin secretion, insulin granule exocytosis, SNARE complex, beta-cell dedifferentiation, type 2 diabetes, obesity, islets, beta-cell function
- MeSH terms
- Insulin Secretion, Animals, Diabetes Mellitus, Exocytosis, Humans, Insulin, Mice, Inbred C57BL, Mice, Obese, Mice, Transgenic, Obesity, Mice, Knockout, MicroRNAs, Insulin-Secreting Cells, SNARE Proteins, Mice, Cell Dedifferentiation
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