TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186 · see citing works

Calcium signalling: dynamics, homeostasis and remodelling

Berridge, M., Bootman, M., & Roderick, H. (2003) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1155 · Cited by 5,747 · see citing works

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541 · see citing works

Idiopathic pulmonary fibrosis

King, T. E., Pardo, A., & Selman, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60052-4 · Cited by 2,194 · see citing works

TRP Channels

Venkatachalam, K., & Montell, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142819 · Cited by 1,915 · see citing works

Prednisone, Azathioprine, and N -Acetylcysteine for Pulmonary Fibrosis

The Idiopathic Pulmonary Fibrosis Clinical Research Network (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113354 · Cited by 1,631 · see citing works

Targeting the TGFβ signalling pathway in disease

Akhurst, R. J., & Hata, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3810 · Cited by 1,466 · see citing works

Recent Developments in Myofibroblast Biology

Hinz, B., Phan, S. H., Thannickal, V. J., Prunotto, M., Desmoulière, A., Varga, J., De Wever, O., Mareel, M., & Gabbiani, G. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.02.004 · Cited by 1,193 · see citing works

TGF-β signaling in fibrosis

Biernacka, A., Dobaczewski, M. P., & Frangogiannis, N. G. (2011) · Growth Factors · doi:10.3109/08977194.2011.595714 · Cited by 1,175 · see citing works

Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis

Richeldi, L., Costabel, U., Selman, M., Kim, D. S., Hansell, D. M., Nicholson, A. G., Brown, K. K., Flaherty, K. R., Noble, P. W., Raghu, G., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103690 · Cited by 1,157 · see citing works

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

Liu, F., Mih, J. D., Shea, B. S., Kho, A. T., Sharif, A. S., Tager, A. M., & Tschumperlin, D. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004082 · Cited by 799 · see citing works

Bone marrow–derived progenitor cells in pulmonary fibrosis

Hashimoto, N., Jin, H., Liu, T., Chensue, S. W., & Phan, S. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18847 · Cited by 715 · see citing works

Integrins and Extracellular Matrix in Mechanotransduction

Schwartz, M. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005066 · Cited by 662 · see citing works

Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4

Vriens, J., Watanabe, H., Janssens, A., Droogmans, G., Voets, T., & Nilius, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0303329101 · Cited by 635 · see citing works

Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders

Piera-Velazquez, S., Li, Z., & Jimenez, S. A. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.001 · Cited by 580 · see citing works

Transient receptor potential channels as therapeutic targets

Moran, M. M., McAlexander, M. A., Bı́ró, T., & SZALLASI, A. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3456 · Cited by 546 · see citing works

Idiopathic Pulmonary Fibrosis

Selman, M., Mejía, M. E., & Pardo, A. (2007) · Springer eBooks · doi:10.1007/978-1-84628-326-0_6 · Cited by 500 · see citing works

A Placebo-Controlled Randomized Trial of Warfarin in Idiopathic Pulmonary Fibrosis

Noth, I., Anstrom, K. J., Calvert, S. B., de Andrade, J., Flaherty, K. R., Glazer, C., Kaner, R. J., & Olman, M. A. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201202-0314oc · Cited by 463 · see citing works

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

Zhou, Y., Huang, X., Hecker, L., Kurundkar, D., Kurundkar, A., Liu, H., Jin, T. H., Desai, L. P., Bernard, K. F., & Thannickal, V. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66700 · Cited by 452 · see citing works

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

Everaerts, W., Zhen, X.-G., Ghosh, D., Vriens, J., Gevaert, T., Gilbert, J. P., Hayward, N. J., McNamara, C. R., Xue, F., Moran, M. M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005333107 · Cited by 417 · see citing works

N-((1 S)-1-{[4-((2 S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

Thorneloe, K. S., Sulpizio, A. C., Lin, Z., Figueroa, D. J., Clouse, A. K., McCafferty, G. P., Chendrimada, T. P., Lashinger, E. S. R., Gordon, E., Evans, L. C., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.139295 · Cited by 413 · see citing works

Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis

Tanjore, H., Xu, X. C., Polosukhin, V. V., Degryse, A. L., Li, B., Han, W., Sherrill, T. P., Plieth, D., Neilson, E. G., Blackwell, T. S., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0322oc · Cited by 405 · see citing works

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

Hung, C. F., Linn, G. R., Chow, Y., Kobayashi, A., Mittelsteadt, K. L., Altemeier, W. A., Gharib, S. A., Schnapp, L. M., & Duffield, J. S. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201212-2297oc · Cited by 388 · see citing works

Tissue mechanics and fibrosis

Wells, R. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.007 · Cited by 384 · see citing works

Impaired osmotic sensation in mice lacking TRPV4

Mizuno, A., Matsumoto, N., Imai, M., & Suzuki, M. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00559.2002 · Cited by 378 · see citing works

TRPV4-Mediated Calcium Influx Regulates Terminal Differentiation of Osteoclasts

Masuyama, R., Vriens, J., Voets, T., Karashima, Y., Owsianik, G., Vennekens, R., Lieben, L., Torrekens, S., Moermans, K., Bosch, A. V., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.002 · Cited by 372 · see citing works

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

Thodeti, C. K., Matthews, B., Ravi, A., Mammoto, A., Ghosh, K., Bracha, A., & Ingber, D. E. (2009) · Circulation Research · doi:10.1161/circresaha.108.192930 · Cited by 366 · see citing works

A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo

Davis, J., Burr, A. R., Davis, G. F., Birnbaumer, L., & Molkentin, J. D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.08.017 · Cited by 355 · see citing works

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

Thorneloe, K. S., Cheung, M., Bao, W., Alsaid, H., Lenhard, S., Jian, M.-Y., Costell, M., Maniscalco-Hauk, K., Krawiec, J. A., Olzinski, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004276 · Cited by 337 · see citing works

TRPM7-Mediated Ca 2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation

Du, J., Xie, J., Zhang, Z., Tsujikawa, H., Fusco, D. S., Silverman, D. I., Liang, B. T., & Yue, L. (2010) · Circulation Research · doi:10.1161/circresaha.109.206771 · Cited by 337 · see citing works

An essential role for fibronectin extra type III domain A in pulmonary fibrosis

Muro, A. F., Moretti, F. A., Moore, B. B., Yan, M., Atrasz, R. G., Wilke, C. A., Flaherty, K. R., Martinez, F. J., Tsui, J. L., Sheppard, D., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1291oc · Cited by 297 · see citing works

Megakaryoblastic Leukemia 1, a Potent Transcriptional Coactivator for Serum Response Factor (SRF), Is Required for Serum Induction of SRF Target Genes

Cen, B., Selvaraj, A., Burgess, R. C., Hitzler, J. K., Ma, Z., Morris, S. W., & Prywes, R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6597-6608.2003 · Cited by 289 · see citing works

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

Matthews, B. D., Thodeti, C. K., Tytell, J. D., Mammoto, A., Overby, D. R., & Ingber, D. E. (2010) · Integrative Biology · doi:10.1039/c0ib00034e · Cited by 280 · see citing works

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4

Deng, H., Klein, C. J., Yan, J., Shi, Y., Wu, Y., Fecto, F., Yau, H., Yang, Y., Zhai, H., Siddique, N., et al. (2009) · Nature Genetics · doi:10.1038/ng.509 · Cited by 271 · see citing works

Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C

Auer‐Grumbach, M., Olschewski, A., Papić, L., Kremer, H., McEntagart, M., Uhrig, S., Fischer, C., Fröhlich, E., Bálint, Z., Tang, B., et al. (2009) · Nature Genetics · doi:10.1038/ng.508 · Cited by 268 · see citing works

Identification and characterization of novel TRPV4 modulators

Vincent, F., Acevedo, A., Nguyen, M. T. L., Dourado, M., DeFalco, J., Gustafson, A. E., Spiro, P. A., Emerling, D. E., Kelly, M. G., & Duncton, M. A. J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.007 · Cited by 247 · see citing works

Functional Gene Screening System Identified TRPV4 as a Regulator of Chondrogenic Differentiation

Muramatsu, S., Wakabayashi, M., Ohno, T., Amano, K., Ooishi, R., Sugahara, T., Shiojiri, S., Tashiro, K., Suzuki, Y., Nishimura, R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706158200 · Cited by 225 · see citing works

TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals

Adapala, R. K., Thoppil, R. J., Luther, D. J., Paruchuri, S. M., Meszaros, J. G., Chilian, W. M., & Thodeti, C. K. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.10.016 · Cited by 215 · see citing works

Disorders of lung matrix remodeling

Chapman, H. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20729 · Cited by 213 · see citing works

TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs

Hamanaka, K., Jian, M., Weber, D. S., Alvarez, D. F., Townsley, M. I., Al‐Mehdi, A. B., KING, J. A. C., Liedtke, W., & Parker, J. C. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00221.2007 · Cited by 211 · see citing works

Actin cytoskeleton in myofibroblast differentiation: Ultrastructure defining form and driving function

Sandbo, N. K., & Dulin, N. O. (2011) · Translational research · doi:10.1016/j.trsl.2011.05.004 · Cited by 178 · see citing works

Cellular Mechanisms of Tissue Fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis

Barkauskas, C. E., & Noble, P. W. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00321.2013 · Cited by 166 · see citing works

Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse.

Olman, M. A., Mackman, N., Gladson, C. L., Moser, K. M., & Loskutoff, D. J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118201 · Cited by 165 · see citing works

A Multiwell Platform for Studying Stiffness-Dependent Cell Biology

Mih, J. D., Sharif, A. S., Liu, F., Marinković, А., Symer, M. M., & Tschumperlin, D. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019929 · Cited by 160 · see citing works

Mutations in TRPV4 cause an inherited arthropathy of hands and feet

Lamandé, S. R., Yuan, Y., Gresshoff, I. L., Rowley, L., Belluoccio, D., Kaluarachchi, K., Little, C. B., Botzenhart, E., Zerres, K., Amor, D. J., et al. (2011) · Nature Genetics · doi:10.1038/ng.945 · Cited by 157 · see citing works

Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness

Marinković, А., Mih, J. D., Park, J., Liu, F., & Tschumperlin, D. J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00108.2012 · Cited by 143 · see citing works

Myocardial Fibrosis Associated with Aldosterone or Angiotensin II Administration: Attenuation by Calcium Channel Blockade

Ramires, F. J. A., Sun, Y., & Weber, K. T. (1998) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0612 · Cited by 125 · see citing works

Regulation of myofibroblast activities: Calcium pulls some strings behind the scene

Castella, L. F., Gabbiani, G., McCulloch, C. A., & Hinz, B. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.033 · Cited by 123 · see citing works

Transforming Growth Factor β Stimulates Fibroblast–Collagen Matrix Contraction by Different Mechanisms in Mechanically Loaded and Unloaded Matrices

Grinnell, F., & Ho, C.-H. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5445 · Cited by 113 · see citing works

Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease

Zhu, G., ICGN Investigators, Gulsvik, A., Bakke, P. S., Ghatta, S., Anderson, W. H., Lomas, D. A., Silverman, E. K., & Pillai, S. G. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp111 · Cited by 111 · see citing works

Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β

Sandbo, N. K., Lau, A., Kach, J., Ngam, C. R., Yau, D. M., & Dulin, N. O. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00166.2011 · Cited by 104 · see citing works

Molecular Mechanisms of TRPV4‐Mediated Neural Signaling

Liedtke, W. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.012 · Cited by 83 · see citing works

Arachidonic Acid–Induced Dilation in Human Coronary Arterioles: Convergence of Signaling Mechanisms on Endothelial TRPV4‐Mediated Ca 2+ Entry

Zheng, X., Zinkevich, N. S., Gebremedhin, D., Gauthier, K. M., Nishijima, Y., Fang, J., Wilcox, D. A., Campbell, W. B., Gutterman, D. D., & Zhang, D. X. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000080 · Cited by 79 · see citing works

Transforming Growth Factor–β Evokes Ca2+ Waves and Enhances Gene Expression in Human Pulmonary Fibroblasts

Mukherjee, S., Kolb, M. R. J., Duan, F., & Janssen, L. J. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0223oc · Cited by 76 · see citing works

Extracellular matrix microenvironment contributes actively to pulmonary fibrosis

Shimbori, C., Gauldie, J., & Kolb, M. R. J. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328363f4de · Cited by 54 · see citing works

FAK-Related Nonkinase Is a Multifunctional Negative Regulator of Pulmonary Fibrosis

Ding, Q., Cai, G.-Q., Hu, M., Yang, Y., Zheng, A., Tang, Q., Gladson, C. L., Hayasaka, H., Wu, H., You, Z., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.01.026 · Cited by 53 · see citing works

Resident mesenchymal cells and fibrosis

Hutchison, N., Fligny, C., & Duffield, J. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.11.015 · Cited by 51 · see citing works

Urokinase-type Plasminogen Activator Receptor (uPAR) Ligation Induces a Raft-localized Integrin Signaling Switch That Mediates the Hypermotile Phenotype of Fibrotic Fibroblasts

Grove, L. M., Southern, B. D., Jin, T. H., White, K. E., Paruchuri, S. M., Harel, E., Wei, Y., Rahaman, S. O., Gladson, C. L., Ding, Q., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.498576 · Cited by 38 · see citing works

Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins

Zhu, S., Gladson, C. L., White, K. E., Ding, Q., Stewart, J. E., Jin, T. H., Chapman, H. A., & Olman, M. A. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90283.2008 · Cited by 19 · see citing works

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 618 · see citing works

Advances in TRP channel drug discovery: from target validation to clinical studies

Koivisto, A., Belvisi, M. G., Gaudet, R., & SZALLASI, A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00268-4 · Cited by 549 · see citing works

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 548 · see citing works

The Extracellular Matrix in Ischemic and Nonischemic Heart Failure

Frangogiannis, N. G. (2019) · Circulation Research · doi:10.1161/circresaha.119.311148 · Cited by 520 · see citing works

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

Russo, I., & Frangogiannis, N. G. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.011 · Cited by 481 · see citing works

Myofibroblasts and Fibrosis

Gibb, A., Lazaropoulos, M. P., & Elrod, J. W. (2020) · Circulation Research · doi:10.1161/circresaha.120.316958 · Cited by 443 · see citing works

Myofibroblasts

Hinz, B. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.009 · Cited by 424 · see citing works

TRPV4: molecular conductor of a diverse orchestra

White, J. P. M., Cibelli, M., Urban, L., Nilius, B., McGeown, J. G., & Nagy, I. (2016) · Physiological Reviews · doi:10.1152/physrev.00016.2015 · Cited by 405 · see citing works

Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches

López, B., Ravassa, S., Moreno, M. U., José, G. S., Beaumont, J., González, A., & Dı́ez, J. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00504-1 · Cited by 369 · see citing works

Mechanosensing and fibrosis

Tschumperlin, D. J., Ligresti, G., Hilscher, M. B., & Shah, V. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93561 · Cited by 338 · see citing works

Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

Hewlett, J. C., Kropski, J. A., & Blackwell, T. S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.021 · Cited by 327 · see citing works

Extracellular matrix in lung development, homeostasis and disease

Zhou, Y., Horowitz, J. C., Naba, A., Ambalavanan, N., Atabai, K., Balestrini, J. L., Bitterman, P. B., CORLEY, R. A., Ding, B., Engler, A. J., et al. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.005 · Cited by 285 · see citing works

Oxidative Stress in Pulmonary Fibrosis

Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190017 · Cited by 309 · see citing works

Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease

Aschner, Y., & Downey, G. P. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0391tr · Cited by 236 · see citing works

Mechanical control of cardiac myofibroblasts

van Putten, S., Shafieyan, Y., & Hinz, B. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.025 · Cited by 235 · see citing works

The Role of Myofibroblasts in Physiological and Pathological Tissue Repair

Schuster, R., Younesi, F., Ezzo, M., & Hinz, B. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041231 · Cited by 232 · see citing works

TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis

Scheraga, R. G., Abraham, S., Niese, K. A., Southern, B. D., Grove, L. M., Hite, R. D., McDonald, C., Hamilton, T. A., & Olman, M. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501688 · Cited by 202 · see citing works

TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation

Swain, S. M., Romac, J. M.-J., Shahid, R. A., Pandol, S. J., Liedtke, W., Vigna, S. R., & Liddle, R. A. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134111 · Cited by 201 · see citing works

Congenital diaphragmatic hernias: from genes to mechanisms to therapies

Kardon, G., Ackerman, K. G., McCulley, D. J., Shen, Y., Wynn, J., Shang, L., Bogenschutz, E. L., Sun, X., & Chung, W. K. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.028365 · Cited by 186 · see citing works

The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart

Herum, K. M., Lunde, I. G., McCulloch, A. D., & Christensen, G. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6050053 · Cited by 183 · see citing works

Mechanotransduction in Wound Healing and Fibrosis

Kuehlmann, B. A., Bonham, C. A., Zucal, I., Prantl, L., & Gurtner, G. C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051423 · Cited by 174 · see citing works

Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis

Chen, H., Qu, J., Huang, X., Kurundkar, A., Zhu, L., Yang, N., Venado, A. E., Ding, Q., Liu, G., Antony, V. B., et al. (2016) · Nature Communications · doi:10.1038/ncomms12564 · Cited by 153 · see citing works

Molecular networks underlying myofibroblast fate and fibrosis

Stempien‐Otero, A., Kim, D., & Davis, J. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.05.002 · Cited by 141 · see citing works

TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

Ryskamp, D. A., Frye, A. M., Phuong, T. T. T., Yarishkin, O., Jo, A. O., Xu, Y., Lakk, M., Iuso, A., Redmon, S. N., Ambati, B., et al. (2016) · Scientific Reports · doi:10.1038/srep30583 · Cited by 139 · see citing works

TRPV4—A Missing Link Between Mechanosensation and Immunity

Michalick, L., & Kuebler, W. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00413 · Cited by 139 · see citing works

Autotaxin in Pathophysiology and Pulmonary Fibrosis

Ninou, I., Magkrioti, C., & Aidinis, V. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00180 · Cited by 135 · see citing works

Modulation of the TRPV4 ion channel as a therapeutic target for disease

Grace, M. S., Bonvini, S. J., Belvisi, M. G., & McIntyre, P. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.019 · Cited by 133 · see citing works

TRPV4 plays a role in matrix stiffness-induced macrophage polarization

Dutta, B., Goswami, R., & Rahaman, S. O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.570195 · Cited by 124 · see citing works

Lipid Peroxidation and GPX4 Inhibition Are Common Causes for Myofibroblast Differentiation and Ferroptosis

Gong, Y., Wang, N., Liu, N., & Dong, H. (2019) · DNA and Cell Biology · doi:10.1089/dna.2018.4541 · Cited by 126 · see citing works

Extracellular Matrix Components and Mechanosensing Pathways in Health and Disease

Berdiaki, A., Neagu, M. T., Tzanakakis, P., Spyridaki, I., Pérez, S., & Nikitovic, D. (2024) · Biomolecules · doi:10.3390/biom14091186 · Cited by 116 · see citing works

TRPV 4 regulates matrix stiffness and TGF β1‐induced epithelial‐mesenchymal transition

Sharma, S., Goswami, R., Zhang, D. X., & Rahaman, S. O. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13972 · Cited by 108 · see citing works

Fibrosis: cross-organ biology and pathways to development of innovative drugs

Rieder, F., Nagy, L. E., Maher, T. M., Distler, J. H. W., Kramann, R., Hinz, B., & Prunotto, M. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01158-9 · Cited by 117 · see citing works

TRPV4 associates environmental temperature and sex determination in the American alligator

Yatsu, R., Miyagawa, S., Kohno, S., Saito, S., Lowers, R. H., Ogino, Y., Fukuta, N., Katsu, Y., Ohta, Y., Tominaga, M., et al. (2015) · Scientific Reports · doi:10.1038/srep18581 · Cited by 103 · see citing works

Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop

He, J., Cheng, X., Fang, B., Shan, S., & Li, Q. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06466-3 · Cited by 100 · see citing works

Targeting ferroptosis as a vulnerability in pulmonary diseases

Yang, L., Cao, L., Zhang, X., & Chu, B. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05070-7 · Cited by 97 · see citing works

TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension

Gilchrist, C. L., Leddy, H. A., Kaye, L., Case, N. D., Rothenberg, K. E., Little, D., Liedtke, W., Hoffman, B. D., & Guilak, F. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811095116 · Cited by 94 · see citing works

Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs

Chen, R., Zhang, K., Chen, H., Zhao, X., Wang, J., Li, L., Cong, Y., Ju, Z., Xu, D., Williams, B. R. G., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.681619 · Cited by 89 · see citing works

TRPV4 ion channel is a novel regulator of dermal myofibroblast differentiation

Sharma, S., Goswami, R., Merth, M., Cohen, J., Lei, K. Y., Zhang, D. X., & Rahaman, S. O. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00187.2016 · Cited by 90 · see citing works

A nano-conductive osteogenic hydrogel to locally promote calcium influx for electro-inspired bone defect regeneration

Yu, C., Ying, X., Shahbazi, M., Yang, L., Ma, Z., Ye, L., Yang, W., Sun, R., Gu, T., Tang, R., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122266 · Cited by 90 · see citing works

A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer

Canales, J., Morales, D., Blanco, C., Rivas, J., Díaz, N., Angelopoulos, I., & Cerda, O. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00757 · Cited by 87 · see citing works

Mechanical checkpoint regulates monocyte differentiation in fibrotic niches

Vining, K. H., Marneth, A. E., Adu‐Berchie, K., Grolman, J. M., Tringides, C. M., Liu, Y., Wong, W. J., Pozdnyakova, O., Severgnini, M., Stafford, A. G., et al. (2022) · Nature Materials · doi:10.1038/s41563-022-01293-3 · Cited by 89 · see citing works

TRPV4 channels: physiological and pathological role in cardiovascular system

Randhawa, P. K., & Jaggi, A. S. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0512-7 · Cited by 86 · see citing works

Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype

Southern, B. D., Grove, L. M., Rahaman, S. O., Abraham, S., Scheraga, R. G., Niese, K. A., Sun, H., Herzog, E. L., Liu, F., Tschumperlin, D. J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.712380 · Cited by 85 · see citing works

The matricellular protein CCN1 enhances TGF‐β1/SMAD3‐dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury

Kurundkar, A., Kurundkar, D., Rangarajan, S., Locy, M. L., Zhou, Y., Liu, R.-M., Zmijewski, J. W., & Thannickal, V. J. (2016) · The FASEB Journal · doi:10.1096/fj.201500173 · Cited by 83 · see citing works

Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin–mediated engagement of Piezo1

Ezzo, M., Spindler, K., Wang, J. B., Lee, D., Pecoraro, G., Cowen, J., Pakshir, P., & Hinz, B. (2024) · Science Advances · doi:10.1126/sciadv.adp4726 · Cited by 82 · see citing works

Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain

Kanju, P. M., Chen, Y., Lee, W., Yeo, M., Lee, S. H., Romac, J. M.-J., Shahid, R. A., Fan, P., Gooden, D. M., Simon, S. A., et al. (2016) · Scientific Reports · doi:10.1038/srep26894 · Cited by 81 · see citing works

Redirecting TGF-β Signaling through the β-Catenin/Foxo Complex Prevents Kidney Fibrosis

Qiao, X., Rao, P., Zhang, Y., Liu, L., Pang, M., Wang, H., Hu, M., Tian, X., Zhang, J., Zhao, Y., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016121362 · Cited by 80 · see citing works

TRP channels in cardiac and intestinal fibrosis

Inoue, R., Kurahara, L. H., & Hiraishi, K. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.11.002 · Cited by 77 · see citing works

Mechanosensing dysregulation in the fibroblast: A hallmark of the aging heart

Angelini, A., Trial, J., Ortiz-Urbina, J., & Cieslik, K. A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101150 · Cited by 79 · see citing works

TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells

Lakk, M., & Križaj, D. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00599.2020 · Cited by 79 · see citing works

Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel

Berna‐Erro, A., Izquierdo-Serra, M., Sepúlveda, R. V., Rubio-Moscardó, F., Doñate‐Macian, P., Serra, S. A., Carrillo-García, J., Perálvarez‐Marín, A., González-Nilo, F. D., Fernández‐Fernández, J. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11274-1 · Cited by 79 · see citing works

Role of macrophage TRPV4 in inflammation

Dutta, B., Arya, R. K., Goswami, R., Alharbi, M. O., Sharma, S., & Rahaman, S. O. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0334-6 · Cited by 78 · see citing works

C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation

Lei, H., Wu, D., Wang, J.-Y., Li, L., Zhang, C., Feng, H., Fu, F.-Y., & Wu, L. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0492-7 · Cited by 78 · see citing works

Research Progress in the Molecular Mechanisms, Therapeutic Targets, and Drug Development of Idiopathic Pulmonary Fibrosis

Ma, H., Wu, X., Li, Y., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.963054 · Cited by 78 · see citing works

Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases

Feng, J., Armillei, M. K., Yu, A. S., Liang, B. T., Runnels, L. W., & Yue, L. (2019) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd6040034 · Cited by 75 · see citing works

Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis

Yang, J.-T., Pan, X., Wang, L., & Yu, G.-Y. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00223-w · Cited by 70 · see citing works

Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach

Kuebler, W. M., Jordt, S., & Liedtke, W. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00161.2020 · Cited by 73 · see citing works

Methylation in pericytes after acute injury promotes chronic kidney disease

Chou, Y., Pan, S., Shao, Y., Shih, H., Wei, S.-Y., Lai, C., Chiang, W., Schrimpf, C., Yang, K., Lai, L., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135773 · Cited by 73 · see citing works

TRPV4 integrates matrix mechanosensing with Ca 2+ signaling to regulate extracellular matrix remodeling

Ji, C., & McCulloch, C. A. (2020) · FEBS Journal · doi:10.1111/febs.15665 · Cited by 73 · see citing works

Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology

Krishnan, R., Park, J., Seow, C. Y., Lee, P. V. S., & Stewart, A. G. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.10.005 · Cited by 73 · see citing works

Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases

Dietrich, A., Steinritz, D., & Gudermann, T. W. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.04.005 · Cited by 72 · see citing works

FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction

Smith, E. R., Holt, S. G., & Hewitson, T. D. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.09.009 · Cited by 72 · see citing works

Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A–mediated phosphorylation

Cao, S., Anishkin, A., Zinkevich, N. S., Nishijima, Y., Korishettar, A., Wang, Z., Fang, J., Wilcox, D. A., & Zhang, D. X. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.811075 · Cited by 72 · see citing works

TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching

Scheraga, R. G., Abraham, S., Grove, L. M., Southern, B. D., Crish, J. F., Perelas, A., McDonald, C., Asosingh, K., Hasday, J. D., & Olman, M. A. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901033 · Cited by 71 · see citing works

Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice

Swain, S. M., Romac, J. M.-J., Vigna, S. R., & Liddle, R. A. (2022) · JCI Insight · doi:10.1172/jci.insight.158288 · Cited by 71 · see citing works

Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation

Goswami, R., Arya, R. K., Sharma, S., Dutta, B., Stamov, D. R., Zhu, X., & Rahaman, S. O. (2021) · Science Signaling · doi:10.1126/scisignal.abd4077 · Cited by 68 · see citing works

TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema

Weber, J., Rajan, S., Schremmer, C., Chao, Y., Krasteva‐Christ, G., Kannler, M., Yildirim, A. Ö., Brosien, M., Schredelseker, J., Weißmann, N., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134464 · Cited by 67 · see citing works

Mechanical Feed-Forward Loops Contribute to Idiopathic Pulmonary Fibrosis

Freeberg, M. A. T., Perelas, A., Rebman, J. K., Phipps, R. P., Thatcher, T. H., & Sime, P. J. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.09.008 · Cited by 69 · see citing works

Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives

Vasse, G. F., Nizamoglu, M., Heijink, I. H., Schlepütz, M., van Rijn, P., Thomas, M. J., Burgess, J. K., & Melgert, B. N. (2021) · The Journal of Pathology · doi:10.1002/path.5632 · Cited by 66 · see citing works

Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis

Cao, P., Aoki, Y., Badri, L., Walker, N., Manning, C. M., Lagstein, A., Fearon, E. R., & Lama, V. N. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88896 · Cited by 65 · see citing works

Oxidative Stress in Pulmonary Fibrosis

Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/j.2040-4603.2020.tb00120.x · Cited by 65 · see citing works

Myofibroblasts and inflammatory cells as players of cardiac fibrosis

Kurose, H., & Mangmool, S. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0809-6 · Cited by 64 · see citing works

Calcium Homeostasis and Ionic Mechanisms in Pulmonary Fibroblasts

Janssen, L. J., Mukherjee, S., & Ask, K. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0269tr · Cited by 63 · see citing works

The emerging role of transient receptor potential channels in chronic lung disease

Belvisi, M. G., & Birrell, M. A. (2017) · European Respiratory Journal · doi:10.1183/13993003.01357-2016 · Cited by 63 · see citing works

Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis

Hofmann, K., Fiedler, S., Vierkotten, S., Weber, J., Klee, S., Jia, J., Zwickenpflug, W., Flockerzi, V., Storch, U., Yildirim, A. Ö., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.12.002 · Cited by 60 · see citing works

TRPV4 calcium-permeable channel is a novel regulator of oxidized LDL-induced macrophage foam cell formation

Goswami, R., Merth, M., Sharma, S., Alharbi, M. O., Aranda‐Espinoza, H., Zhu, X., & Rahaman, S. O. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.06.004 · Cited by 60 · see citing works

AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis

Francisco, J. J., Zhang, Y., Nakada, Y., Jeong, J. I., Huang, C.-Y., Ivessa, A., Oka, S., Babu, G. J., & Re, D. P. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-89989-5 · Cited by 60 · see citing works

Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement

Nishimoto, R., Derouiche, S., Eto, K., Deveci, A., Kashio, M., Kimori, Y., MATSUOKA, Y., Morimatsu, H., Nabekura, J., & Tominaga, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012894118 · Cited by 59 · see citing works

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

McCray, B. A., Diehl, E., Sullivan, J. M., Aisenberg, W. H., Zaccor, N. W., Lau, A. R., Rich, D. J., Goretzki, B., Hellmich, U. A., Lloyd, T. E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21699-y · Cited by 57 · see citing works

TRPV4 Mechanotransduction in Fibrosis

Adapala, R. K., Katari, V., Teegala, L. R., Thodeti, S., Paruchuri, S. M., & Thodeti, C. K. (2021) · Cells · doi:10.3390/cells10113053 · Cited by 59 · see citing works

Dicer1 Deficiency in the Idiopathic Pulmonary Fibrosis Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis

Herrera, J., Beisang, D. J., Peterson, M., Forster, C. L., Gilbertsen, A. J., Benyumov, A. O., Smith, K. A., Korenczuk, C. E., Barocas, V. H., Guenther, K. L., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201709-1823oc · Cited by 56 · see citing works

Ca2+ signalling in fibroblasts and the therapeutic potential of KCa3.1 channel blockers in fibrotic diseases

Roach, K. M., & Bradding, P. H. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14939 · Cited by 55 · see citing works

Disruption of Calcium Signaling in Fibroblasts and Attenuation of Bleomycin-Induced Fibrosis by Nifedipine

Mukherjee, S., Ayaub, E. A., Murphy, J. S., Lü, C., Kolb, M. R. J., Ask, K., & Janssen, L. J. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0009oc · Cited by 55 · see citing works

Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)–salt-induced hypertension

Wei, X., Gao, P., Pu, Y., Li, Q., Yang, T., Zhang, H., Xiong, S., Cui, Y., Li, L., Ma, X., et al. (2017) · Clinical Science · doi:10.1042/cs20160780 · Cited by 55 · see citing works

Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor‐β1/Smad2 and nuclear factor‐κB signaling pathways in human fetal lung fibroblasts

Zhang, Q., Tu, W., Tian, K., Han, L., Wang, Q., Chen, P., & Zhou, X. M. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27128 · Cited by 54 · see citing works

Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease

Dietrich, A. (2019) · Pharmaceuticals · doi:10.3390/ph12010023 · Cited by 54 · see citing works

Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation

Grove, L. M., Mohan, M. L., Abraham, S., Scheraga, R. G., Southern, B. D., Crish, J. F., Prasad, S. V. N., & Olman, M. A. (2019) · Science Signaling · doi:10.1126/scisignal.aau1533 · Cited by 52 · see citing works

Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas

Okada, Y., Shirai, K., Miyajima, M., Reinach, P. S., Yamanaka, O., Sumioka, T., Kokado, M., Tomoyose, K., & Saika, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167200 · Cited by 51 · see citing works

Role of TRPC1 channels in pressure-mediated activation of murine pancreatic stellate cells

Fels, B., Nielsen, N., & Schwab, A. (2016) · European Biophysics Journal · doi:10.1007/s00249-016-1176-4 · Cited by 51 · see citing works

Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis

Ma, H., Liu, S., Li, S., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.918771 · Cited by 51 · see citing works

TRP functions in the broncho-pulmonary system

Logu, F. D., Patacchini, R., Fontana, G. A., & Geppetti, P. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0557-1 · Cited by 50 · see citing works

Reversing Mechanoinductive DSP Expression by CRISPR/dCas9–mediated Epigenome Editing

Qu, J. T., Zhu, L., Zhou, Z., Chen, P., Liu, S., Locy, M. L., Thannickal, V. J., & Zhou, Y. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201711-2242oc · Cited by 50 · see citing works

Extracellular Matrix Stiffness in Lung Health and Disease

Guo, T., He, C., Venado, A. E., & Zhou, Y. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210032 · Cited by 100 · see citing works

Extracellular Matrix Stiffness in Lung Health and Disease

Guo, T., He, C., Venado, A. E., & Zhou, Y. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00222.x · Cited by 48 · see citing works

miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways

Ge, L., Habiel, D. M., Hansbro, P. M., Kim, R., Gharib, S. A., Edelman, J. D., Königshoff, M., Parimon, T., Brauer, R., Huang, Y., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.90301 · Cited by 50 · see citing works

DP1 (Prostaglandin D 2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II–Induced Hypertension in Mice

Zou, F., Li, Y., Zhang, S., & Zhang, J. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.17584 · Cited by 47 · see citing works

The role of TRPV4 in fibrosis

Zhan, L., & Li, J. (2017) · Gene · doi:10.1016/j.gene.2017.10.067 · Cited by 49 · see citing works

Cytokine–Ion Channel Interactions in Pulmonary Inflammation

Hamacher, J., Hadizamani, Y., Borgmann, M., Mohaupt, M. G., Männel, D. N., Moehrlen, U., Lucas, R., & Stammberger, U. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01644 · Cited by 47 · see citing works

The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases

Scheraga, R. G., Southern, B. D., Grove, L. M., & Olman, M. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00503 · Cited by 46 · see citing works

The TRPV4-TAZ Mechanotransduction Signaling Axis in Matrix Stiffness- and TGFβ1-Induced Epithelial-Mesenchymal Transition

Sharma, S., Goswami, R., & Rahaman, S. O. (2018) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-018-00565-w · Cited by 46 · see citing works

Role of Cation Channel TRPV4 in Mechanosensing, Myofibroblast Differentiation, and Pulmonary Fibrosis

Rahaman, S. O., Grove, L. M., Southern, B. D., Scheraga, R. G., Abraham, S., Niese, K. A., Ghosh, S., Tschumperlin, D. J., & Olman, M. A. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201411-531mg · Cited by 2 · see citing works

Transient receptor potential vanilloid four in macrophages mediates TGF-β activation to drive myofibroblast differentiation and pulmonary fibrosis

Grove, L. M., Snyder, C., Boulton, A. M., Mao, H., Abraham, S., Ricci, H., Orsini, E. M., Southern, B. D., Olman, M. A., & Scheraga, R. G. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111135 · Cited by 6 · see citing works

TRPV4 is a Key Mechanosensor in Macrophages That Drives Myofibroblast Differentiation Through Activation of TGF-β

Scheraga, R. G., Grove, L. M., Abraham, S., Mao, H., Boulton, A., Grund, M., Southern, B. D., Reinhardt, A., Orsini, E. M., & Olman, M. A. (2025) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.2025.211.abstracts.a7630 · Cited by 1 · see citing works

Transient Receptor Potential Vanilloid 4 (TRPV4) Regulates Fibroblast Differentiation in vitro and D. farinae ‐Induced Airway Remodeling in Asthma in vivo via Modulation of Matrix Synthesis and Matrix Degradation Mechanisms

Gombedza, F., Kondeti, V., Al‐Azzam, N. Z., Thodeti, C. K., & Paruchuri, S. M. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.772.2 · Cited by 1 · see citing works

TRPV4 ion channel is a novel regulator of dermal myofibroblast differentiation

Sharma, S., Goswami, R., Merth, M., Cohen, J., Lei, K. Y., Zhang, D. X., & Rahaman, S. O. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00187.2016 · Cited by 90 · see citing works