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MYC on the Path to Cancer

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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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Reductive carboxylation supports growth in tumour cells with defective mitochondria

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Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction

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Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine‐Monophosphate–Activated Protein Kinase Alpha/Mammalian Target of Rapamycin Axis in Mice

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Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets

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MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma

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Lkb1 deficiency confers glutamine dependency in polycystic kidney disease

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Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer

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MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer

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Application of metabolomics technologies toward cancer prognosis and therapy

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Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment

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Deregulated transcription factors in cancer cell metabolisms and reprogramming

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The MYC mRNA 3′‐UTR couples RNA polymerase II function to glutamine and ribonucleotide levels

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Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy

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NAD+ regulates nucleotide metabolism and genomic DNA replication

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Glutamine Synthetase: Localization Dictates Outcome

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Inhibition of GLS suppresses proliferation and promotes apoptosis in prostate cancer

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Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters

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The ‘Achilles Heel’ of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy

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Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold

Zimmermann, S. C., Wolf, E. F., Luu, A., Thomas, A. G., Stathis, M. J., Poore, B., Nguyen, C. C., Le, A., Rojas, C. J., Slusher, B. S., et al. (2016) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.6b00060 · Cited by 68

Computational Model Predicts the Effects of Targeting Cellular Metabolism in Pancreatic Cancer

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Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype

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BAG3 promotes autophagy and glutaminolysis via stabilizing glutaminase

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A second Warburg‐like effect in cancer metabolism: The metabolic shift of glutamine‐derived nitrogen

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Cancer cell metabolism: Rewiring the mitochondrial hub

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Deciphering metabolic rewiring in breast cancer subtypes

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Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

Udupa, S., Nguyen, S. A., Hoang, G., Nguyen, T. A., Quinones, A., Pham, K., Asaka, R., Nguyen, K., Zhang, C., Elgogary, A., et al. (2019) · PROTEOMICS · doi:10.1002/pmic.201800451 · Cited by 62

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes

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Targeting cellular metabolism to reduce head and neck cancer growth

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IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3Preprint

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Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

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In vivo Reprogramming of Cancer Metabolism by MYC

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Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC

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Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy

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Regulation of hepatic glutamine metabolism by miR-122

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Acetyl-CoA metabolism as a therapeutic target for cancer

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The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy

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Targeting the glutamine-arginine-proline metabolism axis in cancer

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Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression

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The Heterogeneity of Liver Cancer Metabolism

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Glutamine metabolic reprogramming in hepatocellular carcinoma

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Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism

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Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer

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Targeting Cell Metabolism as Cancer Therapy

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Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer

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Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism

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The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy

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MYC-induced metabolic stress and tumorigenesis

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Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma

Huang, H., Li, S., Tang, Q., & Zhu, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680955 · Cited by 49

Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer

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The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells

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miR‐145 inhibits glutamine metabolism through c‐myc/GLS1 pathways in ovarian cancer cells

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The role of BAG3 in health and disease: A “Magic BAG of Tricks”

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Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy

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Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms

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PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress

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Neurotransmitters: promising immune modulators in the tumor microenvironment

Xiao, L., Li, X., Fang, C., Yu, J., & Chen, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1118637 · Cited by 46

Research into cancer metabolomics: Towards a clinical metamorphosis

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Revisiting prostate cancer metabolism: From metabolites to disease and therapy

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Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy

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HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer

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Metabolomic profiling reveals potential biomarkers in esophageal cancer progression using liquid chromatography-mass spectrometry platform

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Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease

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Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis

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How does metabolism affect cell death in cancer?

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Glutamine Deprivation Promotes the Generation and Mobilization of MDSCs by Enhancing Expression of G-CSF and GM-CSF

Sun, H.-W., Wu, W., Chen, H., Xu, Y.-T., Yang, Y., Chen, J., Yu, X.-J., Wang, Z., Shuang, Z., & Zheng, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.616367 · Cited by 40

Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors

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Exploiting the Achilles' heel of cancer: disrupting glutamine metabolism for effective cancer treatment

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Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site

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Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation

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Glutamate Dehydrogenase as a Neuroprotective Target Against Neurodegeneration

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Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer

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Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma

Pham, L. V., Bryant, J. L., Mendez, R., Chen, J., Tamayo, A. T., Xu-Monette, Z. Y., Young, K. H., Manyam, G. C., Yang, D. J., Medeiros, L. J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12413 · Cited by 38

Targeting glutaminase-mediated glutamine dependence in papillary thyroid cancer

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Glutamine affects T24 bladder cancer cell proliferation by activating STAT3 through ROS and glutaminolysis

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Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming

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Glutaminase inhibition in multiple myeloma induces apoptosisviaMYC degradation

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Metabolic Signaling Cascades Prompted by Glutaminolysis in Cancer

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Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability

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Autophagy Modulation and Cancer Combination Therapy: A Smart Approach in Cancer Therapy

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MYC, Metabolic Synthetic Lethality, and Cancer

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