Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Regulation of cancer cell metabolism

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MYC on the Path to Cancer

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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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Reductive carboxylation supports growth in tumour cells with defective mitochondria

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Targeting glutaminase 1 (GLS1) by small molecules for anticancer therapeutics

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Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

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Immuno-Metabolism: The Role of Cancer Niche in Immune Checkpoint Inhibitor Resistance

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Different Tumor Microenvironments Lead to Different Metabolic Phenotypes

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MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2

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Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness

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The peculiarities of cancer cell metabolism: A route to metastasization and a target for therapy

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Atypical immunometabolism and metabolic reprogramming in liver cancer: Deciphering the role of gut microbiome

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A glutamine ‘tug-of-war’: targets to manipulate glutamine metabolism for cancer immunotherapy

Pallett, L. J., Dimeloe, S., Sinclair, L. V., Byrne, A. J., & Schurich, A. (2021) · Immunotherapy Advances · doi:10.1093/immadv/ltab010 · Cited by 28

Glutamine metabolism targeting liposomes for synergistic chemosensitization and starvation therapy in ovarian cancer

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Targeting glutamine metabolism in myeloproliferative neoplasms

Zhan, H., Ciano, K., Dong, K., & Zucker, S. (2015) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2015.07.007 · Cited by 27

Upregulation of GLS1 Isoforms KGA and GAC Facilitates Mitochondrial Metabolism and Cell Proliferation in Epstein–Barr Virus Infected Cells

Krishna, G., Pillai, V. S., & Veettil, M. V. (2020) · Viruses · doi:10.3390/v12080811 · Cited by 26

Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy

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c-Myc protects hepatocellular carcinoma cell from ferroptosis induced by glutamine deprivation via upregulating GOT1 and Nrf2

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Critical roles and clinical perspectives of RNA methylation in cancer

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Metabolomics and cellular altered pathways in cancer biology: A review

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Gastric Cancer Stem Cells: A Glimpse on Metabolic Reprogramming

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Implications of a Neuronal Receptor Family, Metabotropic Glutamate Receptors, in Cancer Development and Progression

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Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis

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Application of Metabolomics in Cancer Research: As a Powerful Tool to Screen Biomarker for Diagnosis, Monitoring and Prognosis of Cancer

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Redox-Regulation in Cancer Stem Cells

Lendeckel, U., & Wolke, C. (2022) · Biomedicines · doi:10.3390/biomedicines10102413 · Cited by 24

A photodynamic-mediated glutamine metabolic intervention nanodrug for triple negative breast cancer therapy

Yu, C., Wang, N., Chen, X., Jiang, Y., Luan, Y., Qin, W., & He, W. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100577 · Cited by 24

BAG3: Nature’s Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue

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MYC and AMPK–Save Energy or Die!

Haikala, H. M., Anttila, J. M., & Klefström, J. T. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00038 · Cited by 25

Targeting Cancer Metabolism and Current Anti-Cancer Drugs

Sukjoi, W., Ngamkham, J., Attwood, P. V., & Jitrapakdee, S. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55035-6_2 · Cited by 23

NASH, Fibrosis and Hepatocellular Carcinoma: Lipid Synthesis and Glutamine/Acetate Signaling

Sunami, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186799 · Cited by 24

Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC

Lee, J., Kang, J. H., Lee, S.-H., Lee, C. H., Son, J., & Kim, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.095 · Cited by 23

Heterogeneity of glutamine metabolism in acquired-EGFR-TKI-resistant lung cancer

Kim, S., Jeon, J. S., Choi, Y. J., Baek, G. H., Kim, S. K., & Kang, K. W. (2022) · Life Sciences · doi:10.1016/j.lfs.2021.120274 · Cited by 22

GAPDH in neuroblastoma: Functions in metabolism and survival

Cornett, K., Puderbaugh, A., Back, O., & Craven, R. J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.979683 · Cited by 25

Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity

Wang, X., Xiao-xia, Y., Peng-Fei, S., Zong-Xue, Z., & Xiu-li, G. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175323 · Cited by 23

Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma

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Nuclear factor-κB p65 regulates glutaminase 1 expression in human hepatocellular carcinoma

Dong, M., Miao, L., Zhang, F., Sheng-shui, L., Han, J., Yu, R., & Qie, S. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s167408 · Cited by 22

Glutaminolysis-ammonia-urea Cycle Axis, Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies

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Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy

Fernandez, M. R., Schaub, F. X., Yang, C., Li, W., Yun, S., Schaub, S. K., Dorsey, F. C., Liu, M., Steeves, M. A., Ballabio, A., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-1168 · Cited by 24

An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition

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Effects of metabolic cancer therapy on tumor microenvironment

Hyroššová, P., Milošević, M., Škoda, J., Vachtenheim, J., Jr., Rohlena, J., & Rohlenová, K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1046630 · Cited by 23

Rethinking the Roles of Cancer-Associated Fibroblasts in Pancreatic Cancer

Francescone, R., Crawford, H. C., & Costa, D. B. V. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.01.022 · Cited by 20

YAP governs cellular adaptation to perturbation of glutamine metabolism by regulating ATF4-mediated stress response

Kim, M., Hwang, S., Kim, B.-J., Shin, S., Yang, S., Gwak, J., & Jeong, S. M. (2023) · Oncogene · doi:10.1038/s41388-023-02811-6 · Cited by 21

MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis

Cazarin, J., DeRollo, R. E., Shahidan, S. N. A. B. A., Burchett, J. B., Mwangi, D., Krishnaiah, S., Hsieh, A. L., Walton, Z. E., Brooks, R. C., Mello, S. S., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010904 · Cited by 22

The cuproptosis-related gene glutaminase promotes alveolar macrophage copper ion accumulation in chronic obstructive pulmonary disease

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Neurotransmitters: Impressive regulators of tumor progression

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The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?

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Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα

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Increased glutathione utilization augments tumor cell proliferation in Waldenstrom Macroglobulinemia

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Targeting Metabolic Vulnerabilities to Combat Drug Resistance in Cancer Therapy

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Modification in Structures of Active Compounds in Anticancer Mitochondria-Targeted Therapy

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Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

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Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer

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Turbulence of glutamine metabolism in pan-cancer prognosis and immune microenvironment

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Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells

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Inhibition of glutaminase to reverse fibrosis in iatrogenic laryngotracheal stenosis

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Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppressionPreprint

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Cancer Stem Cell Metabolism

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Ganfule capsule alleviates bile duct ligation-induced liver fibrosis in mice by inhibiting glutamine metabolism

Ke, C., Gao, J., Tu, J., Wang, Y., Xiao, Y., Wu, Y. S., Liu, Y., & Zhou, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.930785 · Cited by 17

Identification of four metabolic subtypes and key prognostic markers in lung adenocarcinoma based on glycolytic and glutaminolytic pathways

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Analysis of Differential Metabolites in Lung Cancer Patients Based on Metabolomics and Bioinformatics

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Drugging in the absence of p53

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Synthetic lethality and synergetic effect: the effective strategies for therapy of IDH-mutated cancers

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Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer

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Cancer knocks you out by fasting: Cachexia as a consequence of metabolic alterations in cancer

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Efficacy of Dual Inhibition of Glycolysis and Glutaminolysis for Therapy of Renal Lesions in Tsc2+/− Mice

Jones, A. T., Narov, K., Yang, J. M., Sampson, J. R., & Shen, M. H. (2019) · Neoplasia · doi:10.1016/j.neo.2018.12.003 · Cited by 16

GLS1 is a Protective Factor in Patients with Ovarian Clear Cell Carcinoma and its Expression Does Not Correlate with ARID1A-mutated Tumors

Clemente, V., Hoshino, A., Shetty, M., Nelson, A., Erickson, B. K., Baker, R., Rubin, N., Khalifa, M. A., Weroha, S. J., Lou, E., et al. (2022) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0122 · Cited by 16

Integrative pan-cancer analysis and experiment validation identified GLS as a biomarker in tumor progression, prognosis, immune microenvironment, and immunotherapy

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Right on TARGET: glutamine metabolism in cancer

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A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia

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Kr-POK (ZBTB7c) regulates cancer cell proliferation through glutamine metabolism

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Small molecules remain on target for c-Myc

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A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer

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Spine‑specific downregulation of LAPTM5 expression promotes the progression and spinal metastasis of estrogen receptor‑positive breast cancer by activating glutamine‑dependent mTOR signaling

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Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma

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Metabolic Gatekeepers of Pathological B Cell Activation

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Defective Endothelial Glutaminolysis Contributes to Impaired Angiogenesis and Poor Ischemic Tissue Repair in Diabetes

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Role of ammonia and glutamine in the pathogenesis and progression of metabolic dysfunction‐associated steatotic liver disease: A systematic review

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Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo

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The critical function of metabolic reprogramming in cancer metastasis

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Amino Acid Metabolic Vulnerabilities in Acute and Chronic Myeloid Leukemias

Bhingarkar, A., Vangapandu, H. V., Rathod, S., Hoshitsuki, K., & Fernandez, C. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.694526 · Cited by 11

CLEC12A sensitizes differentially responsive breast cancer cells to the anti-cancer effects of artemisinin by repressing autophagy and inflammation

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Biochemical hallmarks-targeting antineoplastic nanotherapeutics

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Landscape of metabolic alterations and treatment strategies in breast cancer

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Altered Metabolism of Leukemic Cells: New Therapeutic Opportunity

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GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency

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