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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
Open accessAbstract
Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a cancer therapeutic target, but whether GLS inhibitors affect cancer cell-autonomous growth or the host microenvironment or have off-target effects is unknown. Here, we report that loss of one copy of Gls blunted tumor progression in an immune-competent MYC-mediated mouse model of hepatocellular carcinoma. Compared with results in untreated animals with MYC-induced hepatocellular carcinoma, administration of the GLS-specific inhibitor bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) prolonged survival without any apparent toxicities. BPTES also inhibited growth of a MYC-dependent human B cell lymphoma cell line (P493) by blocking DNA replication, leading to cell death and fragmentation. In mice harboring P493 tumor xenografts, BPTES treatment inhibited tumor cell growth; however, P493 xenografts expressing a BPTES-resistant GLS mutant (GLS-K325A) or overexpressing GLS were not affected by BPTES treatment. Moreover, a customized Vivo-Morpholino that targets human GLS mRNA markedly inhibited P493 xenograft growth without affecting mouse Gls expression. Conversely, a Vivo-Morpholino directed at mouse Gls had no antitumor activity in vivo. Collectively, our studies demonstrate that GLS is required for tumorigenesis and support small molecule and genetic inhibition of GLS as potential approaches for targeting the tumor cell-autonomous dependence on GLS for cancer therapy.
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“Importantly, inhibiting glutamine entry into the TCA cycle can blunt tumor progression in a MYC-driven cancer model of liver cancer (Xiang et al., 2015; Yuneva et al., 2012) and a MYC-inducible Burkitt lymphoma model (Le et al., 2012; Xiang et al., 2015).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Xiang et al., 2015
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“Nevertheless, the specific metabolic importance of glutamine in tumorigenesis and tumor growth has also been reported194–196”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [195]
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Citations
Cites
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390
Self-citationMetabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Self-citationThe transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140
Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124
Self-citationWise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Self-citationGermline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,992
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003428107 · Cited by 1,742
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Mullen, A. R., Wheaton, W. W., Jin, E. S., Chen, P.-H., Sullivan, L. B., Cheng, T., Yang, Y., Linehan, W. M., Chandel, N. S., & DeBerardinis, R. J. (2012) · Nature · doi:10.1038/nature10642 · Cited by 1,328
Research works printed but not linked: 1
- Chandel NS. Navigating Metabolism. Cold Spring Harbor, New York, USA: Cold Spring Harbor Laboratory Press; 2014.
Cited by
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Items 301–400 of 413
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Aguilera, Ó., & Serna‐Blasco, R. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-02771-1_3 · Cited by 9
Targeting Metabolic Pathways in Kidney Cancer
Hoerner, C. R., Miao, S. Y., Hsieh, J. J.-D., & Fan, A. C. (2020) · The Cancer Journal · doi:10.1097/ppo.0000000000000472 · Cited by 9
Mishra, A. K., Singh, S., Dayanandan, S., Banerjee, S., Chakraborty, S., Gopal, A. B., Samal, S., Poirah, I., Chakraborty, D., & Bhattacharyya, A. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155917 · Cited by 8
Bridging the Metabolic Parallels Between Neurological Diseases and Cancer
Guo, S., Gu, Y., Qu, J., & Le, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65768-0_17 · Cited by 8
Self-citationGlutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6
Qie, S., & Diehl, J. A. (2019) · Molecular & Cellular Oncology · doi:10.1080/23723556.2019.1610257 · Cited by 8
Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism
Hsieh, A. L., Zheng, X., Yue, Z., Stine, Z. E., Mancuso, A., Rhoades, S. D., Brooks, R. C., Weljie, A. M., Eisenman, R. N., Sehgal, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.022 · Cited by 8
Self-citationZhang, L., Su, K., Liu, Q., Li, B., Wang, Y., Cheng, C., Li, Y., Xu, C., Chen, J., Wu, H., et al. (2023) · BMC Cancer · doi:10.1186/s12885-023-11601-y · Cited by 7
Reid, M. A., Sanderson, S. M., & Locasale, J. W. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-47674-4.00009-8 · Cited by 9
Targeting cancer metabolism through synthetic lethality-based combinatorial treatment strategies
Bajpai, R., & Shanmugam, M. (2018) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000467 · Cited by 8
Ghasemishahrestani, Z., Mattos, L. M. M., Tilli, T. M., dos Santos, A. L. S., & Pereira, M. D. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327999200819123357 · Cited by 6
Wei, X., Cheng, J., Geng, M., Chen, S., Gong, L., Meng, S., Chen, K., Wang, Z., Zhang, Y., Cai, K., et al. (2025) · Research · doi:10.34133/research.0858 · Cited by 6
Glutaminase 1 inhibitors: Therapeutic potential, mechanisms of action, and clinical perspectives
Wang, H., Li, X., Hu, H., & Gao, Z. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117275 · Cited by 10
Metabolic fingerprinting reveals extensive consequences of GLS hyperactivity
Rumping, L., Pras‐Raves, M. L., Gerrits, J., Tang, Y. F., Willemsen, M., Houwen, R. H. J., van Haaften, G. W., van Hasselt, P. M., Verhoeven‐Duif, N. M., & Jans, J. J. M. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.129484 · Cited by 6
Metabolic control of cancer progression as novel targets for therapy
Talukdar, S., Emdad, L., Gogna, R., Das, S. K., & Fisher, P. B. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.06.002 · Cited by 6
Szeliga, M., Ćwikła, J. B., Obara‐Michlewska, M., Cichocki, A. S., & Albrecht, J. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.11.017 · Cited by 6
Glutaminolysis gets the spotlight in cancer
Herranz, D. (2016) · Oncotarget · doi:10.18632/oncotarget.14384 · Cited by 6
The multifaceted modulation of mitochondrial metabolism in tumorigenesis
Keerthiga, R., Xie, Y., Pei, D., & Fu, A. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101977 · Cited by 7
Qi, Y., Ma, N., & Zhang, J. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5581 · Cited by 5
Glutamate Metabolism Regulates Immune Escape of Glioma
Cai, Y., Guo, T., Wang, Y., & Du, J. (2018) · Madridge Journal of Immunology · doi:10.18689/mjim-1000113 · Cited by 5
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled
Li, Y., Ramachandran, S., Nguyen, T. T., Stalnecker, C. A., Cerione, R. A., & Erickson, J. W. (2020) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)49889-9 · Cited by 5
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and ConsensusPreprint
Dang, C. V. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041530 · Cited by 5
Self-citationDownes, D. P., Barbieri, C. M., Connors, D., Ravindran, M. S., Tagore, D. M., Gopalakrishnan, S., Biswas, S., Huang, L., Zhao, Q., Perez, H. L., et al. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c00984 · Cited by 4
Recent insights into the roles and therapeutic potentials of GLS1 in inflammatory diseases
Sheng, J.-X., Liu, Y.-J., Yu, J., Wang, R., Chen, R.-Y., Shi, J., Yang, G., & Chen, J. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101292 · Cited by 5
Metabolic Reprogramming and Molecular Rewiring in Cancer: Therapeutic Opportunities
Meiliana, A., Dewi, N. M., & Wijaya, A. (2021) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v13i2.1598 · Cited by 3
Glutamine stabilizes myc via alpha-ketoglutarate and regulates paclitaxel sensitivity
Bhardwaj, V., He, J., & Jain, A. (2022) · Medical Oncology · doi:10.1007/s12032-022-01834-5 · Cited by 4
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled
Li, Y., Ramachandran, S., Nguyen, T. T., Stalnecker, C. A., Cerione, R. A., & Erickson, J. W. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010314 · Cited by 4
Jin, S., Cao, J., & Kong, L. (2022) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-22-895 · Cited by 4
Q-ing tumor glutaminase therapy
Stine, Z. E., & Dang, C. V. (2015) · Oncotarget · doi:10.18632/oncotarget.6301 · Cited by 4
Self-citationMyc family proteins: Molecular drivers of tumorigenesis and resistance in neuroendocrine tumors
Hylton-McComas, H. M., Cordes, A. F., Floros, K. V., Faber, A. C., Drapkin, B. J., & Miles, W. O. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189332 · Cited by 3
Enhanced LDL uptake and PPARα signaling support OSCC cell survival under glutamine deprivation
Cai, L., Chen, Y., Tang, S., Wang, Q. K., Xu, Y., Pan, Y., Yang, F., Chen, T., Chen, Q., Zhou, Y., et al. (2025) · Medical Oncology · doi:10.1007/s12032-025-02867-2 · Cited by 3
Zamani, A., Fan, H., & Luo, G. G. (2017) · Oncotarget · doi:10.18632/oncotarget.21821 · Cited by 3
MYC oncogenes as potential anticancer targets
Alexandrova, R., & Podlipnik, Č. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824156-1.00011-x · Cited by 3
Islam, S. S., Karakas, B., Aboussekhra, A., & Noman, A. S. M. (2023) · Cancers · doi:10.3390/cancers15205006 · Cited by 3
Optimized multi-voxel TE-averaged PRESS for glutamate detection in the human brain at 3T
Hatay, G. H., & Öztürk-Işık, E. (2023) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2023.107574 · Cited by 3
Yoshikawa, T., Endo, K., Moriyama‐Kita, M., Ueno, T., Nakanishi, Y., Dochi, H., Uno, D., Kondo, S., & Yoshizaki, T. (2024) · Auris Nasus Larynx · doi:10.1016/j.anl.2024.04.008 · Cited by 3
Shah, L., Nadeem, M. S., Khan, J. A., Zeyadi, M., Zamzami, M. A., & Mohammed, K. (2019) · RSC Advances · doi:10.1039/c8ra04740e · Cited by 3
Hossain, M. I., Thomas, A. G., Mahdi, F., Adam, A. T., Akins, N. S., Woodard, M. M., Paris, J. J., Slusher, B. S., & Le, H. V. (2021) · RSC Advances · doi:10.1039/d0ra08249j · Cited by 3
Self-citationMa, Q., Shi, W., Jahan, K., Wen Winston, Z. H. A. O., Xu, Q., Huo, Z., Fang, L., Yang, F., & Yan, X. (2022) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2022.101016 · Cited by 3
Redox and metabolic regulation of transcription
Marsboom, G., & Rehman, J. (2016) · Oncotarget · doi:10.18632/oncotarget.13459 · Cited by 3
van den Bosch, M. T. J., Telford, B. J., Yahyanejad, S., de Gunst, T., den Boer, H. C., Vos, R. M., Duurland, C. L., Biemans, R., Dubois, L. J., van Pinxteren, L. A. H., et al. (2023) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2023.1181637 · Cited by 2
Nutritional modulation of metabolic signaling within the tumor microenvironment for cancer therapy
Aghdam, M. M., Rezagholizadeh, L., Fazaeli, A., Moradi, A., & Ojarudi, M. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05462-1 · Cited by 3
WTAP-Mediated Glutaminase Splicing Bias Suppresses Ferroptosis in Hepatocellular Carcinoma
Zhu, C., Wu, K., Wu, K., Ma, J., Ding, B., Jiang, N., Du, K., Ju, G., Xie, H., Peng, C., et al. (2026) · 癌症：英文版 · doi:10.34133/cancomm.0005 · Cited by 2
Recent Advances in Drug Development Targeting Cancer Metabolism
Sugandha, N., Mittal, L., Awasthi, A., & Asthana, S. (2020) · Springer eBooks · doi:10.1007/978-981-15-1991-8_8 · Cited by 2
Hanse, E. A., & Kong, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.962928 · Cited by 2
[A Review of the Redox Regulation of Tumor Metabolism].
Wang, K., Ming, H., Zuo, J., Tian, H., & Huang, C. (2021) · PubMed Central · doi:10.12182/20210160204 · Cited by 2
Targeting the Metabolism in Cancer Cells for Cancer Therapy
Mohan, M., Rafi, S. T. M., Muthusami, S., Ramalingam, S., Sambandam, Y., Selvendiran, K., Ramachandran, I., & Kumaran, R. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_216-1 · Cited by 2
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Gong, Y.-Y., Shao, H., Li, Y., Brafford, P. A., Stine, Z. E., Sun, J., Felsher, D. W., Orange, J. S., Albelda, S. Μ., & Dang, C. V. (2022) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0270 · Cited by 2
Self-citationEnergetics of whole genome doubling and genomic instability
Beck, R. J., Tagal, V., Amin, S. B., Bakhoum, S. F., Maley, C. C., Verhaak, R. G. W., Gomes, A. P., & Andor, N. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217878 · Cited by 3
Amino acid metabolism in cervical cancer: Mechanisms and implications in therapy
Murali, R., Singaraj, S., Govindh, I., Singh, P., Sundaram, S., Srinivas, S., Gopisetty, G., Chandramoorthy, H. C. K., & Gandhirajan, R. K. (2025) · Next research. · doi:10.1016/j.nexres.2025.100660 · Cited by 1
Zhao, C., & Chang, T. M. S. (2025) · Cancers · doi:10.3390/cancers17162698 · Cited by 1
Research progress on the regulation of cuproptosis-related genes by non-coding RNAs in tumors
Du, Y., Zhang, Z., Cao, M., Hou, X., & Wang, X. (2025) · ONCOLOGIE · doi:10.1515/oncologie-2025-0286 · Cited by 1
Patent Highlights December 2016–January 2017
Mucke, H. A. (2017) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2017-0007 · Cited by 1
Immunological and Genetic Biomarkers of Sarcomas
D’Ambrosio, L., Sangiolo, D., Merlini, A., Grignani, G., & Aglietta, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811785-9.00042-9 · Cited by 1
Wahl, D. R., & Venneti, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-61401-4_6 · Cited by 1
Shao, Q., Wang, C., Gu, H., Zhou, X., Nie, X., Huang, W., Gao, F., Wang, F., & You, Y. (2024) · Polymer Chemistry · doi:10.1039/d4py00591k · Cited by 1
Glutamine metabolism in liver cancer: role in progression and potential therapeutic targeting
Ratre, Y. K., Mehta, A., Sharma, R., Soni, V. K., Shukla, D., Tripathi, V. N., & Vishvakarma, N. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98806-3.00025-8 · Cited by 1
Targeting the Metabolism in Cancer Cells for Cancer Therapy
Mohan, M., Rafi, S. T. M., Muthusami, S., Ramalingam, S., Sambandam, Y., Selvendiran, K., Ramachandran, I., & Kumaran, R. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_216 · Cited by 1
Simón, J., Núñez-García, M., Fernández‐Tussy, P., Barbier‐Torres, L., Fernández‐Ramos, D., Gómez‐Santos, B., Buqué, X., Lopitz‐Otsoa, F., Zubiete‐Franco, I., Juan, V. G., et al. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3219265 · Cited by 1
The Role of Glutaminase 1 in HIV-1 Associated Neurocognitive Disorders and in Brain Development
Wang, Y. (2015) · DigitalCommons@UNMC
Dumas, S. J., Humbert, M. J. C., & Cohen‐Kaminsky, S. (2016) · Biologie Aujourd hui · doi:10.1051/jbio/2016022
Merlini, A., Tolomeo, F., Miano, S., D’Ambrosio, L., Sangiolo, D., & Grignani, G. (2017) · Cancer Breaking News · doi:10.19156/cbn.2017.0045
Study on the Effect of Glutamine on Proliferation and Survival of Bladder Cancer T24 Cells
Sun, L., Niu, H., Ningchuan, S., & Shu, L. (2019) · International Journal of Sciences · doi:10.18483/ijsci.2009
Self-citationOh, M. H., Sun, I., Zhao, L., Leone, R. D., Sun, I.-M., Xu, W., Collins, S. L., Tam, A. J., Blosser, R. L., Patel, C. H., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/656553
Self-citationRole of Mitochondria in Pancreatic Metabolism, Diabetes, and Cancer
Talari, N. K., Mattam, U., & Sepuri, N. B. V. (2019) · Springer eBooks · doi:10.1007/978-981-32-9393-9_5
Tumor metabolic reprogramming in therapeutic resistance
Siegel, P. M., & Ursini‐Siegel, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821310-0.00005-x · Cited by 1
Clemente, V., Nelson, A., Erickson, B. K., Baker, R., Rubin, N., Khalifa, M. A., Hoshino, A., Shetty, M., Lou, E., & Bazzaro, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.03.457161
Multi-omics characterization of pancreatic neuroendocrine neoplasms
Yang, C. F. K. (2021) · Summit (Simon Fraser University)
Targeting the Immuno-Oncology Metabolism in Cancer
Tripathi, S. C., Fahrmann, J. F., & Amle, D. B. (2022) · Springer eBooks · doi:10.1007/978-981-16-6226-3_5
Targeting glutaminase to starve lymphoma cells
Dumontet, C. (2022) · Haematologica · doi:10.3324/haematol.2022.282348
Structural basis for activation of glutaminasePreprint
Guo, C.-J., Wang, Z.-X., & Liu, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.30.534948
Lai, J., Cao, Y., Zhang, J. K., Wang, J., Du, Y., He, Y., Luo, Y., & Liao, N. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300003
Intracellular Compartments and Drug Resistance
Mehraj, S., Jan, S., Fatima, K., Shafi, A., & Khan, S. U. (2024) · Springer eBooks · doi:10.1007/978-981-97-1666-1_9
ibrahim, A. M., Elariny, E. Y. T., & M.Abdel-Hafez, L. (2024) · Bulletin of Faculty of Science Zagazig University · doi:10.21608/bfszu.2023.159388.1177
Xu, N., Wu, K., La, T., & Cao, B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35617
Research advances on amino acid starvation interventions for hepatocellular carcinoma
Li, Y., Li, L., Hou, Y., Peng, X., & Li, H. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189400
Sanka, K., Rapolu, K., Boyina, H. K., Chakraborty, S., & Muvvala, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33459-7.00008-9
Moreira Franco, Y. E., Alves, M. J. F., Uno, M., Moretti, I. F., Trombetta-Lima, M., de Siqueira Santos, S., dos Santos, A. F., Arini, G. S., Baptista, M. S., Lerário, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14509669
Zhang, L., Su, K., Liu, Q., Li, B., Wang, Y., Cheng, C., Li, Y., Xu, C., Chen, J., Wu, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24540601
Zhang, J., Wang, X., Song, C., & Li, Q. (2023) · Figshare · doi:10.6084/m9.figshare.22605250
Moreira Franco, Y. E., Alves, M. J. F., Uno, M., Moretti, I. F., Trombetta-Lima, M., de Siqueira Santos, S., dos Santos, A. F., Arini, G. S., Baptista, M. S., Lerário, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14509672
Moreira Franco, Y. E., Alves, M. J. F., Uno, M., Moretti, I. F., Trombetta-Lima, M., de Siqueira Santos, S., dos Santos, A. F., Arini, G. S., Baptista, M. S., Lerário, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14509675
Hereditary cancer syndromes linked to oxidative phosphorylation insufficiency
Kaplan, B., Duraj, T., Lee, D. C., & Seyfried, T. N. (2025) · ONCOLOGIE · doi:10.1515/oncologie-2025-0301
Lin, S., Berdan, C. A., Sandy, M., Lu, X., Ramani, V., Nomura, D. K., Chen, X., Lee, J. V., & Goga, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.28.702329
Cyriac, R., Lee, E. J., Kwon, Y., Yun, M. R., Jung, M. E., Ahn, S., Chae, C. H., Choi, G., Cho, B. C., & Lee, K. (2026) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2026.130595
Su, S., Han, J., Liu, Z., & Tian, K. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1735093
Kaminski, L. (2018) · theses.fr (ABES) · doi:10.70675/7f6ae88bz4f3cz49d3zafcdz8682254b2be3
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Sancerni, T. (2019) · theses.fr (ABES) · doi:10.70675/c0f1a3a3z992az4717zb426z210e51dadf82
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Bodineau, C. (2020) · theses.fr (ABES) · doi:10.70675/9d5aaabdz81bdz4118zb3edze237bdd8dee0
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Yolba, R. L. (2021) · theses.fr (ABES) · doi:10.70675/9cadea77z03ccz4a54zb381zf34a432615a5
Malard, E. (2023) · theses.fr (ABES) · doi:10.70675/74964e84zb117z490dzb121zf85fa183d480
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Anane, Y. (2026) · Cureus · doi:10.7759/cureus.108373
王, 家. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1662262
Zhang, J., Zhu, Y., Liu, G., Liao, M., Wu, J., Chen, C., Guo, M., Jiang, Y., Zhao, J., & Xu, L. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1806160
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Ghosh, B., Shil, S., & Kumavath, R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-43846-2.00017-9
He, H., 乔志恒, Gai, X., Ji, G., & Liu, S. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105457
Metadata
- Authors
- Xiang, Y., Stine, Z. E., Xia, J., Lu, Y., O’Connor, R. S., Altman, B. J., Hsieh, A. L., Gouw, A. M., Thomas, A. G., Gao, P., Sun, L., Song, L., Yan, B., Slusher, B. S., Zhuo, J., Ooi, L. L., Lee, C. G. L., Mancuso, A., McCallion, A. S., Le, A., Milone, M. C., Rayport, S., Felsher, D. W., & Dang, C. V.
- Affiliations
- Abramson Cancer Center (US)
- University of Pennsylvania (US)
- Johns Hopkins University (US)
- University of Science and Technology of China (CN)
- Sun Yat-sen University Cancer Center (CN)
- KK Women's and Children's Hospital (SG)
- National Cancer Centre Singapore (SG)
- Singapore General Hospital (SG)
- National University of Singapore (SG)
- New York State Psychiatric Institute (US)
- Stanford Medicine (US)
- Corresponding author
- Xiang, Yan
- Stine, Zachary E.
- Dang, Chi V.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2015-04-27
- Volume
- 125
- Issue
- 6
- Pages
- 2293-2306
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4497742
- OpenAlex
- W2004574994
- Cited by
- 409
- References
- 61
- Citations by year
- 2026: 19 · 2025: 22 · 2024: 31 · 2023: 33 · 2022: 43 · 2021: 49 · 2020: 48 · 2019: 39 · 2018: 30 · 2017: 50 · 2016: 29 · 2015: 16
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Institute
- National Natural Science Foundation of China (81372148)
- National Institute of Mental Health (R01MH117128)
- National Cancer Institute (R01CA057341, F32CA174148, P30 CA16620, R01CA051497, P30CA016520)
- Abramson Family Cancer Research Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- glutaminase, BPTES, hepatocellular carcinoma, B-cell lymphoma, cancer metabolism, glutamine metabolism, cancer therapy, morpholino antisense, DNA replication inhibition
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Glutaminase, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Experimental, Mice, Inbred BALB C, Mice, Transgenic, Neoplasm Transplantation, Sulfides, Thiadiazoles, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Amino Acid Substitution, Mutation, Missense, Mice, Heterografts
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