Cited by 134Genetic Associations and EpidemiologyCardiac electrophysiology and arrhythmiasGenetics and Physical Performance

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

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Wild, Philipp S., Felix, Janine F., Schillert, Arne, Teumer, Alexander, Chen, Ming-Huei, Leening, Maarten J.G., Völker, Uwe, Großmann, Vera +116 more·2017·Journal of Clinical Investigation

Abstract

BACKGROUND: Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS: A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen consortium). The analysis included 16 traits of left ventricular (LV) structure, and systolic and diastolic function. RESULTS: The discovery analysis included 21 cohorts for structural and systolic function traits (n = 32,212) and 17 cohorts for diastolic function traits (n = 21,852). Replication was performed in 5 cohorts (n = 14,321) and 6 cohorts (n = 16,308), respectively. Besides 5 previously reported loci, the combined meta-analysis identified 10 additional genome-wide significant SNPs: rs12541595 near MTSS1 and rs10774625 in ATXN2 for LV end-diastolic internal dimension; rs806322 near KCNRG, rs4765663 in CACNA1C, rs6702619 near PALMD, rs7127129 in TMEM16A, rs11207426 near FGGY, rs17608766 in GOSR2, and rs17696696 in CFDP1 for aortic root diameter; and rs12440869 in IQCH for Doppler transmitral A-wave peak velocity. Findings were in part validated in other cohorts and in GWAS of related disease traits. The genetic loci showed associations with putative signaling pathways, and with gene expression in whole blood, monocytes, and myocardial tissue. CONCLUSION: The additional genetic loci identified in this large meta-analysis of cardiac structure and function provide insights into the underlying genetic architecture of cardiac structure and warrant follow-up in future functional studies. FUNDING: For detailed information per study, see Acknowledgments.

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Wild, P. S., Felix, J. F., Schillert, A., Teumer, A., Chen, M.-H., Leening, M. J. G., Völker, U., Großmann, V., Brody, J. A., Irvin, M. R., Shah, S. J., Pramana, S., Lieb, W., Schmidt, R., Stanton, A. V., Malzahn, D., Smith, A. V., Sundström, J., Minelli, C., Ruggiero, D., Lyytikäinen, L.-P., Tiller, D., Smith, J. G., Monnereau, C., Di Tullio, M. R., Musani, S. K., Morrison, A. C., Pers, T. H., Morley, M., Kleber, M. E., Aragam, J., Benjamin, E. J., Bis, J. C., Bisping, E., Broeckel, U., Cheng, S., Deckers, J. W., Del Greco M, F., Edelmann, F., Fornage, M., Franke, L., Friedrich, N., Harris, T. B., Hofer, E., Hofman, A., Huang, J., Hughes, A. D., Kähönen, M., investigators, K., Kruppa, J., Lackner, K. J., Lannfelt, L., Laskowski, R., Launer, L. J., Leosdottir, M., Lin, H., Lindgren, C. M., Loley, C., MacRae, C. A., Mascalzoni, D., Mayet, J., Medenwald, D., Morris, A. P., Müller, C., Müller-Nurasyid, M., Nappo, S., Nilsson, P. M., Nuding, S., Nutile, T., Peters, A., Pfeufer, A., Pietzner, D., Pramstaller, P. P., Raitakari, O. T., Rice, K. M., Rivadeneira, F., Rotter, J. I., Ruohonen, S. T., Sacco, R. L., Samdarshi, T. E., Schmidt, H., Sharp, A. S. P., Shields, D. C., Sorice, R., Sotoodehnia, N., Stricker, B. H., Surendran, P., Thom, S., Töglhofer, A. M., Uitterlinden, A. G., Wachter, R., Völzke, H., Ziegler, A., Münzel, T., März, W., Cappola, T. P., Hirschhorn, J. N., Mitchell, G. F., Smith, N. L., Fox, E. R., Dueker, N. D., Jaddoe, V. W. V., Melander, O., Russ, M., Lehtimäki, T., Ciullo, M., Hicks, A. A., Lind, L., Gudnason, V., Pieske, B., Barron, A. J., Zweiker, R., Schunkert, H., Ingelsson, E., Liu, K., Arnett, D. K., Psaty, B. M., Blankenberg, S., Larson, M. G., Felix, S. B., Franco, O. H., Zeller, T., Vasan, R. S., & Dörr, M.
Affiliations
  • University Medical Center of the Johannes Gutenberg University Mainz (DE)
  • Erasmus MC (NL)
  • German Centre for Cardiovascular Research (DE)
  • Universitätsmedizin Greifswald (DE)
  • Boston University (US)
  • University of Washington (US)
  • University of Alabama at Birmingham (US)
  • Northwestern University (US)
  • Karolinska Institutet (SE)
  • Christian-Albrechts-Universität zu Kiel (DE)
  • Medical University of Graz (AT)
  • Royal College of Surgeons in Ireland (IE)
  • Universitätsmedizin Göttingen (DE)
  • University of Iceland (IS)
  • Uppsala University (SE)
  • Imperial College London (GB)
  • Institute of Genetics and Biophysics (IT)
  • Tampere University (FI)
  • Martin Luther University Halle-Wittenberg (DE)
  • Broad Institute (US)
  • University of Veterinary Medicine Hannover, Foundation (DE)
  • National Institutes of Health (US)
  • Hammersmith Hospital (GB)
  • Centre for Human Genetics (GB)
  • Universität Hamburg (DE)
  • Lund University (SE)
  • University of Turku (FI)
  • The Lundquist Institute (US)
  • Beaumont Hospital (IE)
ORCID
Venue
Journal of Clinical Investigation
Published
2017-04-10
Volume
127
Issue
5
Pages
1798-1812
ISSN
  • 0021-9738 (ISSN-L)
  • 1558-8238
OpenAlex
W2604500500
Cited by
129
References
54
Citations by year
2026: 7 · 2025: 12 · 2024: 10 · 2023: 7 · 2022: 18 · 2021: 15 · 2020: 18 · 2019: 21 · 2018: 15 · 2017: 4 · 2016: 1
FWCI
10.50
Type
journal article
Language
en
Open access
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  • Northwestern University (HHSN268201300027C, HHSN268201300028C, HHSN268200900041C, HHSN268201300026C, HHSN268201300025C, HHSN268201300029C)
  • University of Minnesota (HHSN268201300025C, HHSN268201300029C, HHSN268201300028C, HHSN268201300026C, HHSN268200900041C, HHSN268201300027C)
  • School of Medicine, Boston University
  • Foundation for Cardiovascular Research
  • Johns Hopkins University (HHSN268200900041C)
  • University of Alabama at Birmingham (HHSN268201300027C, HHSN268201300026 C, HHSN268201300028C, HHSN268201300025C and HHSN268201300026C, HHSN268201300029C, HHSN268200900041C, HHSN268201300025C)
  • Yrjö Jahnssonin Säätiö
  • University of Alabama (HHSN268201300026 C, HHSN268201300025C)
  • National Institute for Health and Care Research (NF-SI-0512-10165)
  • British Heart Foundation (RG/13/13/30194, RG/08/014/24067)
  • European Commission (018947, 201668, 01ZZ0103, 286284, 305739, 01ZZ0403, 03ZIK012, 01ZZ9603, LSHG-CT-2006-018947)
  • Deutsche Forschungsgemeinschaft (01ZZ0403, 01ZZ9603, 03ZIK012, 01EO1003, 01ZZ0103)
  • Stiftelsen för Strategisk Forskning (ICA08-0047)
  • ZonMw (BMBF 01EO1003, 050-060-810)
  • Kela
  • Bundesministerium für Bildung und Forschung (01ZZ9603, 01ZZ0103, and 01ZZ0403, BMBF 01EO1003, 03ZIK012, 01ZZ0403, and 01ZZ0403, 01GS0837, 01EO1003, 01GS0422, 01ZZ0103, 01ZZ9603)
  • Austrian Science Fund
  • Suomen Kulttuurirahasto
  • Crafoordska Stiftelsen
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (050.060.810, 911-03-012, 175.010.200, 175.010.2005.011)
  • Lunds Universitet
  • Lundbeckfonden (R190 2014-3904)
  • Hjärt-Lungfonden (20120197)
  • Juho Vainion Säätiö
  • Signe ja Ane Gyllenbergin Säätiö
  • Vetenskapsrådet (70374401, 80576801, 2012-01397)
  • Emil Aaltosen Säätiö (286284, 201668, X51001)
  • Akademiska Sjukhuset
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  • Tampereen Tuberkuloosisäätiö (286284, 201668, X51001)
  • Uppsala Universitet
  • Svenska Läkaresällskapet
  • Diabetesliitto
  • Paavo Nurmen Säätiö
  • Science for Life Laboratory
  • Novo Nordisk Fonden (NNF16OC0021496)
  • Skånes universitetssjukhus
  • Provincia autonoma di Bolzano - Alto Adige
  • National Institutes of Health (HHSN268200900041C, n01hc085082-026, n01hc085081-021, HHSN268201300026C, HHSN268201300028C, n01hc085079-024, HHSN268201300027C, n01hc085084-005, 1r01hl120393-01a1, HHSN268201300025C, n01hc085083-027, n01hc085080-026, UL1TR000124, n01hc085086-022, 201668, HHSN268201300050C, 305739, HHSN268201300029C, 01EO1003, 5u01hl054472-10, n01hc25195-41-0-1, n01hc55222-0-0-0, n01hc035129-010, HHSN 268201300048C, R24OD017870)
  • Kaiser Foundation Research Institute (HHSN268201300029C, HHSN268201300028C, HHSN268200900041C, HHSN268201300025C, HHSN268201300026C, U01-HG004729, HHSN268201300027C)
  • Medical Research Council (MR/L003120/1)
  • European Regional Development Fund
  • Helmholtz Zentrum München
  • Universitätsmedizin der Johannes Gutenberg-Universität Mainz
  • National Institute on Aging (HHSN268201300029C, HHSN268201300026C, HHSN268201300025C, HHSN268201300028C, R01AG023629, HHSN268200900041C, HHSN268201300027C)
  • National Heart, Lung, and Blood Institute (HHSN268201300050C, HHSN268201300028C, U10HL054497, N01 HC085086, HHS-N2-68201300029C, HHSN268201300027C, U01-HL054472, N01 HC085079, R01-HL120393, N01 HC085083, HHSN268201500001I, U10HL054509, U01HL054495, U01HL054497, N01 HC085080, R01HL087652, R01HL103612, HHSN268200900041C, HHSN 268200800007C, N01 HC035129, HHSN268201300048C, HHSN268201500001C, U10HL054473, U01HL054496, U10HL054471, R01HL093328, U01HL130114, HHSN268201300026C, U01HL054471, HHS-N2-68201300025C, HHSN268201300049C, N01-HC-025195, HHSN268201200036C, R01HL107385, U10HL054495, N01HC085082, R01HL105756, U01HL080295, N01 HC055222, R01 HL, R00HL107642, U01HL054509, N01 HC085081, HHSN268201300047C, U01HL054473, R01HL126136, R01HL105993, U10HL054472, N01 HC085084, R01HL055673, R01HL131532, U10HL054496)
  • National Human Genome Research Institute (U01HG04424, U01HG004446, U01HG004729, U01HG004424, HG004446)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063491, P30DK079626)
  • National Institute of Neurological Disorders and Stroke (Z01NS002993, HHSN268200900041C, HHSN268201300028C, HHSN268201300026C, R01NS036286, HHSN268201300025C, HHSN268201300029C, R01 NS-36286, HHSN268201300027C)
  • National Center for Advancing Translational Sciences
  • National Institute on Minority Health and Health Disparities (HHSN268201300050C, HHSN268201300048C)
  • Interreg
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords
cardiac structure, cardiac function, left ventricular function, diastolic function, systolic function, aortic root diameter, genetic variants, single nucleotide polymorphisms, MTSS1, ATXN2, CACNA1C, TMEM16A
MeSH terms
Female, Heart Diseases, Humans, Male, Myocardium, Quantitative Trait, Heritable, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci

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