Cited by 1,295Liver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Diseases and Immunity

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Liver inflammation and fibrosis

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Koyama, Yukinori, Brenner, David A.·2017·Journal of Clinical Investigation

DOI 10.1172/jci88881PMC PMC5199698

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Abstract

Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and insulin resistance. Hepatic steatosis may be benign or progress to hepatocyte injury and the initiation of inflammation, which activates immune cells. While Kupffer cells are the resident macrophage in the liver, inflammatory cells such as infiltrating macrophages, T lymphocytes, neutrophils, and DCs all contribute to liver inflammation. The inflammatory cells activate hepatic stellate cells, which are the major source of myofibroblasts in the liver. Here we review the initiation of inflammation in the liver, the liver inflammatory cells, and their crosstalk with myofibroblasts.

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Authors: Koyama, Y., & Brenner, D. A.
Affiliations: University of California San Diego (US)
Corresponding author: Brenner, David A.
ORCID: Koyama, Yukinori
Brenner, David A.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2017-01-03
Volume: 127
Issue: 1
Pages: 55-64
ISSN: 0021-9738 (ISSN-L)
1558-8238
DOI: 10.1172/jci88881
PMC: PMC5199698
OpenAlex: W2562949639
Cited by: 1,295
References: 158
Citations by year: 2026: 139 · 2025: 162 · 2024: 159 · 2023: 171 · 2022: 173 · 2021: 177 · 2020: 151 · 2019: 85 · 2018: 63 · 2017: 13
FWCI: 12.30
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (ES010337, AA011999)
National Institute on Alcohol Abuse and Alcoholism (U01AA021856, P50AA011999)
National Institute of Environmental Health Sciences (P42ES010337)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords: liver inflammation, liver fibrosis, liver cirrhosis, hepatic steatosis, Kupffer cells, hepatic stellate cells, myofibroblasts, immune cell crosstalk, T cells, neutrophils, dendritic cells, metabolic syndrome, insulin resistance
MeSH terms: Animals, Dendritic Cells, Hepatitis, Humans, Inflammation, Kupffer Cells, Liver, Liver Cirrhosis, Neutrophils, T-Lymphocytes, Hepatic Stellate Cells, Myofibroblasts

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