Cited by 1,295Liver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Diseases and Immunity

The DOI matches its Crossref record; 157 of the 158 references it cites were found in a registry or an index.

Liver inflammation and fibrosis

Open access

Koyama, Yukinori, Brenner, David A.·2017·Journal of Clinical Investigation

DOI 10.1172/jci88881PMC PMC5199698

Open this paper in CoChat — free account Open PDF

Abstract

Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and insulin resistance. Hepatic steatosis may be benign or progress to hepatocyte injury and the initiation of inflammation, which activates immune cells. While Kupffer cells are the resident macrophage in the liver, inflammatory cells such as infiltrating macrophages, T lymphocytes, neutrophils, and DCs all contribute to liver inflammation. The inflammatory cells activate hepatic stellate cells, which are the major source of myofibroblasts in the liver. Here we review the initiation of inflammation in the liver, the liver inflammatory cells, and their crosstalk with myofibroblasts.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci88881

Cites

157 of 157 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Liver fibrosis
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958
Self-citation
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578

Show all 158 references

Sorted by citations

Items 501–600 of 1,000

Galectin-9 in autoimmune hepatitis
Matsuoka, N., Kozuru, H., Koga, T., Abiru, S., Yamasaki, K., Komori, A., Fujita, Y., Tenmoku, J., Asano, T., Sato, S., et al. (2019) · Medicine · doi:10.1097/md.0000000000016924 · Cited by 19
Dietary-Induced Low-Grade Inflammation in the Liver
Guerra, N. P., Müller, L., Pilz, K., Glatzel, A., Jenderny, D., Janowitz, D., Vollmar, B., & Kuhla, A. (2020) · Biomedicines · doi:10.3390/biomedicines8120587 · Cited by 19
“The metabolic syndrome is associated with many other diseases [3,4] including non-alcoholic fatty liver disease (NAFLD), which is seen as the hepatic manifestation of Biomedicines 2020, 8, 587; doi:10.3390/biomedicines8120587 www.mdpi.com/journal/biomedicines it [5].”
BackgroundInfluential
Ethanolic extract of Coccinia grandis prevented glucose intolerance, hyperlipidemia and oxidative stress in high fat diet fed rats
Siddiqua, S., Jyoti, F. H., Saffoon, N., Miah, P., Lasker, S., Hossain, H., Akter, R., Ahmed, M. I., & Alam, M. A. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100046 · Cited by 22
Caveolin-1 Deficiency Protects Mice Against Carbon Tetrachloride-Induced Acute Liver Injury Through Regulating Polarization of Hepatic Macrophages
Yang, Z., Zhang, J., Wang, Y., Lü, J., & Sun, Q. X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.713808 · Cited by 19
“The inflammation and subsequent damage of the liver can be induced by a variety of stimuli, including chronic viral hepatitis B and C, autoimmune and biliary diseases, alcoholic steatohepatitis, and nonalcoholic steatohepatitis (1, 2).”
Background
CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways
Lin, I.-Y., Chiou, Y., Wu, L.-C., Tsai, C.-Y., Chen, C.-T., Chuang, W., Lee, M.-C., Lin, C.-C., Lin, T.-T., Chen, S., et al. (2018) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.09.008 · Cited by 19
“Inflammation is one of the important factor in liver fibrosis progression [18].”
Background
Chemotherapy-Induced Liver Injury: Unveiling Emerging Mechanisms and Exploring Mitigation Strategies
Alkabbani, M. A., Shatat, A.-A. S., Ghazy, A., & Ibrahim, K. M. (2024) · ERU Research Journal · doi:10.21608/erurj.2024.256957.1100 · Cited by 18
RNF2 Mediates Hepatic Stellate Cells Activation by Regulating ERK/p38 Signaling Pathway in LX-2 Cells
Qi, Y., Pan, L., Qi, S., Liu, F., Wang, Z., Qian, C., Chen, L., & Du, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.634902 · Cited by 18
“inflammation may generate and exacerbate liver injury and fibrosis (Koyama and Brenner, 2017).”
Background
Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes
Contreras-Zentella, M. L., & Hernández-Muñoz, R. E. (2021) · Antioxidants · doi:10.3390/antiox10111729 · Cited by 19
“This pathology causes a non-productive β-oxidation and accumulation of ceramides, diacylglycerols, and acylcarnitines, producing inflammation and resulting in liver insulin resistance [24]; progress of NAFLD can develop to nonalcoholic steatohepatitis and, occasionally, to cirrhosis, as a result of inflammation and fi…”
Background
Dihydrosanguinarine based RNA-seq approach couple with network pharmacology attenuates LPS-induced inflammation through TNF/IL-17/PI3K/AKT pathways in mice liver
Xiang, Y., Zhang, H., Zhang, Z. X., Qu, X. Y., & Zhu, F. X. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108779 · Cited by 18
Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells
Seo, H.-Y., Lee, S. H., Han, E., Hwang, J. S., Han, S., Kim, M. K., & Jang, B. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911636 · Cited by 18
“KC that are activated by LPS produce large amounts of ROS, proinflammatory cytokines, and chemokines, and induce the infiltration of other inflammatory cells; together, these actions impair the function and viability of adjacent cells [5,33].”
Background
Regulation of inflammatory macrophages by oral mineralized metal-organic framework nanoparticles for the synergistic treatment of ulcerative colitis and liver injury
Wu, C., Lu, N., Peng, L., Lin, M., Bai, Y., Lu, M., Wang, J., & Wang, J. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.143655 · Cited by 18
State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy
Zhong, X., Lv, M., Ma, M., Huang, Q., Hu, R., Li, J., Yi, J., Sun, J., & Zhou, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115131 · Cited by 20
Maresin1 prevents sepsis-induced acute liver injury by suppressing NF-κB/Stat3/MAPK pathways, mitigating inflammation
Sun, S., Wang, L., Wang, J., Chen, R., Pei, S., Yao, S., Lin, Y., Yao, C., & Xia, H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21883 · Cited by 18
MiRNAs in Alcohol-Related Liver Diseases and Hepatocellular Carcinoma: A Step toward New Therapeutic Approaches?
Jouve, M., Carpentier, R., Kraiem, S., Legrand, N., & Sobolewski, C. (2023) · Cancers · doi:10.3390/cancers15235557 · Cited by 18
Inflammatory Network of Liver Fibrosis and How It Can Be Targeted Therapeutically
Lowe, K., Tanase, C. E., Maghami, S., Fisher, L. E., & Ghaemmaghami, A. M. (2023) · Immuno · doi:10.3390/immuno3040023 · Cited by 19
Gut microbiota and metabolite interface-mediated hepatic inflammation
Yang, M. J., Massad, K., Kimchi, E. T., Staveley-O’Carroll, K. F., & Li, G. (2024) · Immunometabolism · doi:10.1097/in9.0000000000000037 · Cited by 18
“Liver inflammation accompanies most chronic liver diseases, such as alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), accelerating their progression to liver fibrosis, cirrhosis, and primary liver cancers [1,2] .”
Background
The multifaceted roles of B lymphocytes in metabolic dysfunction–associated steatotic liver disease
Li, H., & Xia, N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1447391 · Cited by 23
Hyperuricemia as an independent risk factor for non-alcoholic fatty liver disease (NAFLD) progression evaluated using controlled attenuation parameter-transient elastography: Lesson learnt from tertiary referral center
Sandra, S., Lesmana, C. R. A., Purnamasari, D., Kurniawan, J., & Gani, R. A. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.10.001 · Cited by 18
Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice
Hasenour, C. M., Kennedy, A. J., Bednarski, T., Trenary, I. A., Eudy, B. J., da Silva, R. P., Boyd, K. L., & Young, J. D. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000183 · Cited by 18
“NAFLD is a spectrum disorder that ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), a state of heightened liver inflammation, cellular injury, and fibrosis (1).”
Background
Identification lncRNA LOC102551149/miR‐23a‐5p pathway in hepatic fibrosis
Dong, Z., Li, S., Si, L., Ma, R., Bao, L., & Bo, A. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13243 · Cited by 18
Glycyrrhetinic Acid‐Induced MiR‐663a Alleviates Hepatic Stellate Cell Activation by Attenuating the TGF‐β/Smad Signaling Pathway
Guo, X.-X., Yang, W.-N., Dong, B.-S., Shang, J.-W., Su, S.-B., Yan, X., & Zhang, H. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/3156267 · Cited by 18
“As a result of liver damage, quiescent HSCs are exposed to inflammatory cytokines and growth factors and transdifferentiate into activated myofibroblast-like cells that are characterized by the expression of alpha-smooth muscle actin (α-SMA) and collagen, thereby contributing to hepatic fibrogenesis [4].”
Background
Yes‐associated protein regulates the hepatoprotective effect of vitamin D receptor activation through promoting adaptive bile duct remodeling in cholestatic mice
Xie, J., Fan, Y., Jia, R., Yang, F., Ma, L., & Li, L. (2021) · The Journal of Pathology · doi:10.1002/path.5750 · Cited by 18
“Considering that inflammation is an important inducer of liver fibrosis [53], we predicted that the antiinflammatory action of VDR may contribute to the attenuated liver fibrosis seen in PAL-BDL mice, and our studies verified that PAL reduced F4/80-positive cell infiltration in BDL mouse livers.”
Result
Novel Anti-inflammatory Treatments in Cirrhosis. A Literature-Based Study
Kronborg, T. M., Ytting, H., Hobolth, L., Møller, S., & Kimer, N. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.718896 · Cited by 18
“With ongoing systemic inflammation, endothelial dysfunction, and fibrogenesis (4) evolve in the liver and are associated with elevated inflammatory cytokines and immune cell activation (5).”
Background
An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation
de León‐Guerrero, S. D., Salazar‐León, J., Meza‐Sosa, K. F., Valle‐García, D., Aguilar‐León, D., Pedraza‐Alva, G., & Pérez‐Martínez, L. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.048936 · Cited by 20
“In liver, obesity induces lipid accumulation and the activation of different inflammatory pathways that contribute to insulin resistance and a dysregulation in both glucose and lipid metabolism (Koyama and Brenner, 2017).”
Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression
Ma, F., Liu, Y., Hu, Z., Xue, Y., Liu, Z., Cai, G., Su, W., Zheng, Z., Xia, F., Yan, X., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000042 · Cited by 19
“The secretion of profibrogenic mediators from stressed or injured hepatocytes or immune cells, including macrophages, T cells, and natural killer T cells[6,7] trigger the HSCs fibrogenic activity.[8,9] Interestingly, the extracellular matrix protein osteopontin (OPN) is recently identified as a hepatocyte-derived prof…”
Background
Biochemical and histological characterisation of an experimental rodent model of non-alcoholic steatohepatitis – Effects of a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist and a glucagon-like peptide-1 analogue
Daniels, S. J., Leeming, D. J., Detlefsen, S., Bruun, M. F., Hjuler, S. T., Henriksen, K., Hein, P., Karsdal, M. A., Brockbank, S., & Cruwys, S. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.130 · Cited by 17
“It is usually believed that NASH triggers the development of liver fibrosis, which ultimately can lead to the most severe histologic manifestation of NAFLD, liver cirrhosis [8,9].”
Background
Hepatocytes paradoxically affect intrahepatic IFN-γ production in autoimmune hepatitis due to Gal-9 expression and TLR2/4 ligand release
Mo, R., Feng, X., Wu, Y.-N., Wang, H., He, Y., Sun, H., Guo, F., Chen, Q., Yan, W., Li, P., et al. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.05.014 · Cited by 17
Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis
Mo, C., Xie, S., Zhong, W., Zeng, T., Huang, S., Lai, Y., Deng, G., Zhou, C., Yan, W., Chen, Y., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.038 · Cited by 17
The T Cell Receptor Immune Repertoire Protects the Liver From Reconsitution
Liang, Q. D., Hu, Y., Zhang, M., Lin, C., Zhang, W., Li, Y., Zhu, P., Xue, P., Chen, Y., Li, Q., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584979 · Cited by 16
Polyvinylpyrrolidone-Modified Taxifolin Liposomes Promote Liver Repair by Modulating Autophagy to Inhibit Activation of the TLR4/NF-κB Signaling Pathway
Ding, Q., Liu, W., Liu, X., Ding, C., Zhao, Y., Dong, L., Chen, H., Sun, S., Zhang, Y., Zhang, J., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.860515 · Cited by 17
“The infrared characteristic peaks of pure TAX, TAX-Lips, PVPTAX-Lips, and the physical mixture of SPC, TAX, and PVPK30 were measured in the range of 400–4,000 cm−1, using a Fourier transform infrared spectrophotometer (FTIR) (CT Norwalk PerkinElmer, United States).”
Influential
Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule
Agrahari, A. K., Dikshit, M., & Asthana, S. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.07.008 · Cited by 18
“It has become a serious public health problem in developed nations [2,6].”
Background
Treatment of Liver Fibrosis: A 20-Year Bibliometric and Knowledge-Map Analysis
Dai, Y., Zhao, Z., & Liu, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.942841 · Cited by 16
“antifibrotic effects) and the top 10 co-cited references were respectively associated with the three parts (Friedman, 2003; Bataller and Brenner, 2005; Gressner and Weiskirchen, 2006; Iredale, 2007; Seki et al., 2007; Friedman, 2008a; Friedman, 2008b; Schuppan and Afdhal, 2008; Wynn, 2008; European Association For The…”
BackgroundInfluential
Plasticity of monocytes and macrophages in cirrhosis of the liver
Geng, A., Flint, E., & Bernsmeier, C. (2022) · Frontiers in Network Physiology · doi:10.3389/fnetp.2022.937739 · Cited by 18
“Chronic liver injury and inflammation lead to progressive liver fibrosis and ultimately to the development of cirrhosis with formation of fibrous septa, regenerative nodules, sinusoidal resistance, intrahepatic shunting and PH (Koyama and Brenner, 2017; Laleman et al., 2018).”
Background
Crosstalk between liver macrophages and gut microbiota: An important component of inflammation-associated liver diseases
Zhou, Z., Pan, X., & Li, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1070208 · Cited by 19
“They are mainly responsible for triggering inflammatory responses to various insults but may also cause severe tissue injury and dysfunction (Koyama and Brenner, 2017; Tacke, 2017; Locati et al., 2020).”
Background
Risk of Liver Fibrosis Is Associated with More Severe Strokes, Increased Complications with Thrombolysis, and Mortality
Toh, E. M. S., Ravi, P. R. J., Ming, C., Lim, A. Y. L., Sia, C., Chan, B. P. L., Sharma, V. K., Ng, C. H., Tan, E. X. X., Yeo, L. L. L., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12010356 · Cited by 17
“Secondly, inflammation is a key underlying mechanism regulating liver fibrogenesis [27], and proinflammatory cytokines have a negative inotropic effect, reducing ventricular contractility [28].”
Background
Swainsonine Induces Liver Inflammation in Mice via Disturbance of Gut Microbiota and Bile Acid Metabolism
Fu, K., Chen, X., Shou, N., Wang, Z., Yuan, X., Wu, D., Wang, Q., Cheng, Y., Ling, N., & Shi, Z. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08519 · Cited by 19
Effects of supplemental octanoate on hepatic lipid metabolism, serum biochemical indexes, antioxidant capacity and inflammation-related genes expression of large yellow croaker (Larimichthys crocea) fed with high soybean oil diet
Zhao, M., Zhang, Z., Liu, Y., Zhang, W., Gong, Y., Tang, Y., Chen, F., Zhang, J., Liu, G., Zhang, H., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1162633 · Cited by 16
“IL-1b, TNF-a and IFNg are inflammatory cytokines, which initiate the production of a series of inflammatory mediators and produce inflammatory responses (48).”
Background
Preventive and therapeutic effects of natural products and herbal extracts on nonalcoholic fatty liver disease / nonalcoholic steatohepatitis
Cao, Y., Fang, X., Sun, M., Zhang, Y., Shan, M., Lan, X., Zhu, D., & Luo, H. (2023) · Phytotherapy Research · doi:10.1002/ptr.7932 · Cited by 17
Seladelpar combined with complementary therapies improves fibrosis, inflammation, and liver injury in a mouse model of nonalcoholic steatohepatitis
Choi, Y., Johnson, J. D., Lee, J.-J., Song, J., Matthews, M. D., Hellerstein, M. K., & McWherter, C. A. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00158.2023 · Cited by 17
Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency
Rayes, R. F., Milette, S., Fernández, M. C., Ham, B., Wang, N., Bourdeau, F., Perrino, S., Yakar, S., & Brodt, P. (2018) · Oncotarget · doi:10.18632/oncotarget.24593 · Cited by 16
iNOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice
Becerril, S., Rodrı́guez, A., Catalán, V., Ramírez, B., Unamuno, X., Gómez‐Ambrosi, J., & Frühbeck, G. (2019) · Genes · doi:10.3390/genes10030184 · Cited by 17
“One of the key events in the promotion of liver diseases is the activation of HSCs [29].”
Background
MicroRNA‐708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88
Xu, T., Pan, L., Li, L., Hu, S., Zhou, H., Yang, C., Yang, J., Li, H., Liu, Y., Meng, X., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15119 · Cited by 17
A New Endemic of Concomitant Nonalcoholic Fatty Liver Disease and Chronic Hepatitis B
Hanif, H., Khan, M. M., Ali, M. J., Shah, P. A., Satiya, J., Lau, D., & Aslam, A. (2020) · Microorganisms · doi:10.3390/microorganisms8101526 · Cited by 17
“This theory is substantiated by the observation where the lipid-laden hepatocytes induce mitochondrial and peroxisomal dysfunction that result in oxidative stress, toxic fatty acid metabolite production, and hepatocyte damage [37] The ongoing chronic inflammation with activated myofibroblasts derived from hepatic stel…”
Background
Nut consumption and the prevalence and severity of non-alcoholic fatty liver disease
Semmler, G., Bachmayer, S., Wernly, S., Wernly, B., Niederseer, D., Huber-Schönauer, U., Stickel, F., Aigner, E. S., & Datz, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244514 · Cited by 17
“Of note, we show that inflammation markers gradually decline with more frequent nut consumption, presumably indicating less inflammation, being the most important driver of fibrogenesis [56].”
Background
Potential therapeutic effect of Chrysopogon zizanioides (Vetiver) as an anti-inflammatory agent
Grover, M., Behl, T., BUNGAU, S. G., & Aleya, L. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12652-z · Cited by 17
“The ongoing process, which is causing cellular and tissue damage, also leads to fibrosis of various tissues/organs like liver fibrosis/ cirrhosis which could be attributed to alcohol consumption or obesity (Koyama and Brenner 2017) ultimately projecting hepatic carcinoma (Seki et al.”
Background
RAGE: A potential therapeutic target during FGF1 treatment of diabetes‐mediated liver injury
Zheng, P., Tang, Z., Xiong, J., Wang, B., Xu, J., Chen, L., Cai, S., Wu, C., Ye, L., Xu, K., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16446 · Cited by 18
Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease
Wegrzyniak, O., Rosestedt, M., & Eriksson, O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147348 · Cited by 17
“It also stimulates HSCs to express collagen type I and enhances their differentiation into fibrogenic myofibroblasts [20].”
Background
Soluble TREM‐1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis
Liu, T., Chen, S., Xie, X., Liu, H., Wang, Y., Qi, S., Shi, L., Zhou, X., Zhang, J., Wang, S., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17033 · Cited by 15
Mechanisms of Metal-Induced Hepatic Inflammation
Subramaniam, N., & Mann, K. K. (2024) · Current Environmental Health Reports · doi:10.1007/s40572-024-00463-6 · Cited by 18
“However, chronic and sustained inflammation can lead to fibrosis [8].”
STING-inflammasome axis in autoimmune diseases and inflammation-related disease
Chai, S., Xu, H., Liu, R., & Cai, C. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103898 · Cited by 16
Endocrine Disorders and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review
Betlejewska, J., Hubska, J., Roszkowska, Z., Maciejczyk, A., Bachurska, D., Domański, J., Miarka, M., Raszeja‐Wyszomirska, J., Bobrowicz, M., & Ambroziak, U. (2025) · Biomedicines · doi:10.3390/biomedicines13102500 · Cited by 20
“Chronic hyperleptinemia promotes hepatic stellate cell activation and fibrogenesis [58,59], while elevated chemerin and retinol-binding protein 4 (RBP4) levels have been shown to be associated with increased liver fat content, IR and adverse metabolic profiles [60,61].”
Anti-fibrotic effects of brevilin A in hepatic fibrosis via inhibiting the STAT3 signaling pathway
Park, Y. J., Jeon, M. S., Lee, S., Kim, J. K., Jang, T. S., Chung, K. H., & Kim, K. H. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.127989 · Cited by 16
Sex-specific expression mechanism of hepatic estrogen inactivating enzyme and transporters in diabetic women
Fashe, M. M., Yi, M., Sueyoshi, T., & Negishi, M. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114662 · Cited by 16
The Impact of Inflammatory Immune Reactions of the Vascular Niche on Organ Fibrosis
Zhou, H., Sui, H. X., Zhao, Y.-J., Qian, H.-J., Yang, N., Liu, L., Guan, Q., Zhou, Y., Lin, H., & Wang, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.750509 · Cited by 15
“, pericytes of the hepatic vascular niche), and TGF-β and PDGF are two main cytokines that promote the activation and proliferation of hepatic stellate cells, which are mainly produced by macrophages gathered in circulation and macrophages in the vascular niche (Seki and Brenner, 2015; Koyama and Brenner, 2017; Trived…”
Background
Diagnostic and prognostic significance of cell death markers in patients with cirrhosis and acute decompensation
Stoffers, P., Guckenbiehl, S., Welker, M. W., Zeuzem, S., Lange, C. M., Trebicka, J., Herrmann, E. M., & Welsch, C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263989 · Cited by 16
Extrahepatic factors in hepatic immune regulation
Zhang, S., Lu, S., & Li, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.941721 · Cited by 18
Comprehensive Effect of Carbon Tetrachloride and Reversal of Gandankang Formula in Mice Liver: Involved in Oxidative Stress, Excessive Inflammation, and Intestinal Microflora
Wei, Y., Wang, H., Zhang, Y., Gu, J., Zhang, X., Gong, X.-H., & Hao, Z. (2022) · Antioxidants · doi:10.3390/antiox11112234 · Cited by 16
“Inflammatory responses also cause liver fibrosis [19].”
NAFLD is associated with less severe liver fibrosis in chronic hepatitis B: A multi-center, retrospective study
Yao, R., Lu, S., Xue, R., Wang, J., Qiu, Y., Chen, Y., Liu, J., Zhu, L., Zhan, J., Jiang, S., et al. (2023) · Annals of Hepatology · doi:10.1016/j.aohep.2023.101155 · Cited by 16
Lactobacillus helveticus Isolated from Raw Milk Improves Liver Function, Hepatic Steatosis, and Lipid Metabolism in Non-Alcoholic Fatty Liver Disease Mouse Model
Kim, H., Lee, K., Kim, J., Shim, J.-J., Lim, J., Kim, J.-Y., & Lee, J.-L. (2023) · Microorganisms · doi:10.3390/microorganisms11102466 · Cited by 16
Research progress of traditional Chinese medicine in improving hepatic fibrosis based on inhibiting pathological angiogenesis
Li, Z., Zhu, J., & Ouyang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1303012 · Cited by 16
Mitochondrial quality control in liver fibrosis: Epigenetic hallmarks and therapeutic strategies
Jia, L., Yang, Y., Sun, F., Tao, H., Lu, C., & Yang, J. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111035 · Cited by 16
Environmental Enrichment Prevents Gut Dysbiosis Progression and Enhances Glucose Metabolism in High-Fat Diet-Induced Obese Mice
Manzo, R., Gallardo-Becerra, L., de León‐Guerrero, S. D., Villaseñor, T., Cornejo‐Granados, F., Salazar‐León, J., Ochoa‐Leyva, A., Pedraza‐Alva, G., & Pérez‐Martínez, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136904 · Cited by 16
“In the liver, obesity increases lipid accumulation and activates various inflammatory pathways that contribute to insulin resistance and dysregulation of both glucose and lipid metabolism [7].”
Background
Novel insights into the role of immunomodulatory extracellular vesicles in the pathogenesis of liver fibrosis
Li, J., Yuan, Y., Fu, Q., Chen, M., Liang, H., Chen, X., Long, X., Zhang, B., Zhao, J., & Chen, Q. (2024) · Biomarker Research · doi:10.1186/s40364-024-00669-8 · Cited by 17
“Persistent hepatic inflammation with the participation of intrahepatic immune cells is the driving force of the development and remission of liver fibrosis [32].”
BackgroundInfluential
Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice
Zhang, W., Hu, X.-F., Wan, N., Zhang, J., Yang, P. C., Wen, Q., Chen, W., Zhu, F., Liang, M., Cheng, L., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.160 · Cited by 16
Fasting-mediated metabolic and toxicity reprogramming impacts circulating microRNA levels in humans
Ravanidis, S., Grundler, F., de Toledo, F. W., Dimitriou, E., Tekos, F., Skaperda, Z., Kouretas, D., & Doxakis, E. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112187 · Cited by 17
DHFR silence alleviated the development of liver fibrosis by affecting the crosstalk between hepatic stellate cells and macrophages
Peng, Y., Li, Z., Chen, S., & Zhou, J. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16935 · Cited by 16
Wanted: Dead or Alive Cells with Propidium Iodide Staining in Liver Tissue
Krapoth, T. C., Henle, G. S., Avdyli, M., Bektić, B., Schwarzkopf, K. M., Bešić, L., Zeuzem, S., Welsch, C., Kraus, N., & Ortiz, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413521 · Cited by 15
Pericytes in tissue fibrosis
Tuleta, I., & Frangogiannis, N. G. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00403.2025 · Cited by 16
Nanotechnology-based targeted regulation of NLRP3 Inflammasome: therapeutic strategies and clinical application prospects in inflammatory diseases
Zhao, X., Xu, Z., Wang, D., Li, T., Xu, L., Li, Z., Bai, X., Zhu, H., Liu, Y., & Wang, Y.-C. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2580730 · Cited by 15
“These diseases affect multiple organs and systems, including the liver (Koyama and Brenner 2017), pancreas (Habtezion 2015), heart (Prabhu and Frangogiannis 2016), brain (Lee et al. 2023), lungs (Savin et al. 2022), kidneys (Neumann and Tiegs 2021), digestive tract (Harold 2022), and reproductive…”
Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis
Clavería-Cabello, A., Colyn, L., Uriarte, I., Latasa, M. U., Arechederra, M., Herranz, J. M., Alvarez, L., Urmán, J., Martínez‐Chantar, M. L., Bañales, J. M., et al. (2020) · Cancers · doi:10.3390/cancers12123748 · Cited by 15
“Therefore fibrosis progression is the net result of many diverse and regulated actions [17].”
Background
Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors
Saydmohammed, M., Jha, A., Mahajan, V., Gavlock, D. C., Shun, T. Y., DeBiasio, R., Lefever, D. E., Li, X., Reese, C. E., Kershaw, E. E., et al. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211009228 · Cited by 16
A triterpenoid-enriched extract of bitter melon leaves alleviates hepatic fibrosis by inhibiting inflammatory responses in carbon tetrachloride-treated mice
Chang, M.-L., Lin, Y.-T., Kung, H., Hou, Y.-C., Liu, J., Pan, M., Chen, H., Yu, C.-H., & Tsai, P. (2021) · Food & Function · doi:10.1039/d1fo00884f · Cited by 15
Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection
Ung, N. M., Goldbeck, C. S., Man, C., Hoeflich, J., Sun, R., Barbetta, A., Matasci, N., Katz, J. E., Lee, J. S. H., Chopra, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.831103 · Cited by 15
TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
Liu, Q., Lei, X., Cao, Z., Zhang, J., Yan, L., Fu, J., Tong, Q., Qin, W., Shao, Y., Liu, C., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00789-4 · Cited by 16
“Activation of proinflammatory cytokines and chemokines, including IL-6, IL-1β, TNFα, and MCP-1, can activate HSCs, promote ECM secretion and deposition, and then exacerbate liver fibrosis [7].”
Background
Endogenous Follistatin-like 1 guarantees the immunomodulatory properties of mesenchymal stem cells during liver fibrotic therapy
Zheng, X., Zhou, X., Ma, G., Yu, J., Zhang, M., Yang, C., Hu, Y., Ma, S., Han, Z., Ning, W., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03042-4 · Cited by 15
“Persistent hepatic inflammation activates HSCs to produce extracellular matrix (ECM) and precedes the progression of liver fibrosis [12].”
Background
Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation
Li, X., Xie, W., Pan, Q., Zhang, X., Zhang, L., Zhao, N., Xie, Q., Ding, J., & Chai, J. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-01024-w · Cited by 16
“Immunoinflammatory responses to those chemokines and cytokines, especially tumour necrosis factor α (TNF-α) and interleukin-1β (IL-1β), are almost ubiquitous [15, 16].”
Background
Therapeutic interventions of acute and chronic liver disorders: A comprehensive review
Ali, F. E. M., El‐Aziz, M. K. A., Sharab, E. I., & Bakr, A. G. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i1.19 · Cited by 16
RETRACTED ARTICLE: Exposure to polycyclic aromatic hydrocarbons and liver function: a systematic review of observational studies
Efriza, E., Alshahrani, S. H., Zekiy, A. O., Al‐Awsi, G. R. L., Sharma, S. K., Ramírez‐Coronel, A. A., Shakeel, N., Riadi, Y., Aminov, Z., Zabibah, R. S., et al. (2023) · Air Quality Atmosphere & Health · doi:10.1007/s11869-023-01324-1 · Cited by 17
“In the absence of infection, excessive inflammation can lead to aseptic liver injury, hepatic tissue damage, and hepatic remodeling (Robinson et al. 2016; Koyama and Brenner 2017; Harini et al. 2021; Shnewer Mahdi Al-Turfi et al. 2022; Tretyakova et al. 2022).”
Retracted
HOXC8/TGF-β1 positive feedback loop promotes liver fibrosis and hepatic stellate cell activation via activating Smad2/Smad3 signaling
Zhang, N., Guo, F., & Song, Y. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.011 · Cited by 17
Expanding germ-organ theory: Understanding non-communicable diseases through enterobacterial translocation
Boopathi, S., Priya, P. S., Haridevamuthu, B., Nayak, S. P. R. R., Chandrasekar, M., Arockiaraj, J., & Jia, A. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106856 · Cited by 17
Sodium alginate combined with oxymatrine ameliorates CCl4-induced chemical hepatic fibrosis in mice
He, C., Wang, W., Wei, G., Wang, Y., Wei, Y., Wang, J., & Zhang, Z. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111144 · Cited by 15
Metabolic Dysfunction-Associated Steatotic Liver Disease in Chronic Hepatitis C Virus Infection: From Basics to Clinical and Nutritional Management
González-Aldaco, K., Torres-Reyes, L. A., Ojeda‐Granados, C., Leal-Mercado, L., Román, S., & Panduro, A. (2024) · Clinics and Practice · doi:10.3390/clinpract14060200 · Cited by 15
Transforming Growth Factor β Acts as a Regulatory Molecule for Lipogenic Pathways among Hepatitis C Virus Genotype-Specific Infections
Patra, T., Sasaki, R., Meyer, K., Ray, R. B., & Ray, R. (2019) · Journal of Virology · doi:10.1128/jvi.00811-19 · Cited by 15
“accumulation via activation of PPAR (22).”
Effects of low and moderate treadmill exercise on liver of d ‐galactose‐exposed aging rat model
Wasityastuti, W., Habib, N. A., Sari, D. C. R., & Arfian, N. (2019) · Physiological Reports · doi:10.14814/phy2.14279 · Cited by 16
The gamma-glutamyl transpeptidase to platelet ratio predicts liver inflammation in chronic hepatitis B with normal or mildly elevated alanine transaminase
Wang, J., Xia, J., Yan, X., Yang, Y., Wei, J., Xiong, Y., Wu, W., Liu, Y., Chen, Y., Jia, B., et al. (2020) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2020.01.011 · Cited by 15
HDL cholesterol protects from liver injury in mice with intestinal specific LXRα activation
Pierantonelli, I., Lioci, G., Gurrado, F., Giordano, D. M., Rychlicki, C., Bocca, C., Trozzi, L., Novo, E., Panera, N., Stefanis, C. D., et al. (2020) · Liver International · doi:10.1111/liv.14712 · Cited by 14
Upregulation of RIP3 promotes necroptosis via a ROS‑dependent NF‑κB pathway to induce chronic inflammation in HK‑2 cells
Wei, J., Chen, L., Wang, D., Tang, L., Xie, Z., Chen, W., Zhang, S., & Weng, G. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12423 · Cited by 15
“Inflammation is a physiological defense mechanism against adverse stimuli, such as tissue damage and infection (5).”
Background
Characterization and role of collagen gene expressing hepatic cells following partial hepatectomy in mice
Kimura, Y., Koyama, Y., Taura, K., Kudoh, A., Echizen, K., Nakamura, D., Li, X., Nam, N. H., Uemoto, Y., Nishio, T., et al. (2022) · Hepatology · doi:10.1002/hep.32586 · Cited by 18
“[15–17] Activated HSCs transform to develop phenotypic and morphological characteristics that are typical of myofibroblasts.[10] Once activated during fibrogenesis, they are known to express collagen gene and produce an extracellular matrix and express α‐smooth muscle actin (αSMA).”
BackgroundSelf-citation
Development of an activatable hydrogen sulfide-specific two-photon fluorescent probe for bioimaging in an air pouch inflammation model
Ding, D., Li, J., Xu, L., Wang, J., Tan, D., & Lin, W. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00681b · Cited by 15
Inhibition of Epidermal Growth Factor Receptor (EGFR) Reduces Lipopolysaccharide (LPS)-Induced Activation and Inflammatory Cytokines in Hepatic Stellate Cells In Vitro
Qian, Y., Han, J., Zhou, L., Yu, Q., Xu, J., Jin, Z., Yang, Y., Jiang, L., & Lou, D. (2018) · Medical Science Monitor · doi:10.12659/msm.909901 · Cited by 14
“Discussion Hepatic fibrosis represents healing that follows chronic inflammation and is a response to frequent and repeated chronic liver injury, which can eventually lead to cirrhosis and even liver cancer [18].”
Background
Postbiotics for the management of obesity, insulin resistance/type 2 diabetes and NAFLD. Beyond microbial viability
Arellano-García, L., Portillo, M. P., Martínez, J. A., Courtois, A., & Milton‐Laskibar, I. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2437143 · Cited by 15
“Lastly, a third clinical trial, also in the recruitment phase, will focus on subjects diagnosed with NASH (rather than NAFLD) and will administer a mixture of viable bacterial strains ( Anaerobutyricum soehngenii CH-106 and Bifidobacterium animalis subsp. lactis BLC1), a postbiotic (pasteurized Akkermansia muciniphila…”
Immunological Landscape and Molecular Therapeutic Targets of the Tumor Microenvironment in Hepatocellular Carcinoma
Zarlashat, Y., Ghaffar, A., Guerra, F., & Picca, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167836 · Cited by 17
“Activated macrophages and KCs in ASH produce pro-inflammatory cytokines (IL-1 β , TNF-α , IL-6), causing fibrosis and damage to the liver [107].”
Molecular Genetic and Immune Functional Responses Distinguish Bone Marrow Mesenchymal Stromal Cells from Hepatic Stellate Cells
Chinnadurai, R., Sands, J. S., Rajan, D., Liu, X., Arafat, D., Das, R., Anania, F. A., Gibson, G. C., Kisseleva, T., & Galipeau, J. (2019) · Stem Cells · doi:10.1002/stem.3028 · Cited by 14
Altered ethanol metabolism and increased oxidative stress enhance alcohol‐associated liver injury in farnesoid X receptor‐deficient mice
Morel, C., Chowdhary, V., Nagesh, P. T., Ribeiro, M. D. C., Hawryluk, D., Catalano, D. E., Adorini, L., & Szabó, G. (2022) · Liver International · doi:10.1111/liv.15374 · Cited by 14
Myc-mediated circular RNA circMcph1/miR-370-3p/Irak2 axis is a progressive regulator in hepatic fibrosis
Xu, J., Chen, X., Zhu, S., Jiang, L.-F., Ma, W., Chen, S., Meng, X., Huang, C. Z., & Li, J. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121182 · Cited by 14
NAFLD and nutraceuticals: a review of completed phase III and IV clinical trials
Hegazi, O. E., Alalalmeh, S. O., Alnuaimi, G. R. H., Shahwan, M. J., Jairoun, A. A., Alorfi, N. M., Majrashi, S. A., Alkhanani, M., Alkhattabi, A., Alourfi, M. M., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1227046 · Cited by 16
“NAFLD typically presents non-specific symptoms such as fatigue, thirst, and sleep disturbances, necessitating a differential diagnosis to distinguish it from conditions like alcoholic liver disease, Reye syndrome, and Hepatitis C (11, 15).”
Background
Lobeglitazone inhibits LPS-induced NLRP3 inflammasome activation and inflammation in the liver
Seo, H.-Y., Lee, S. H., Park, J. Y., Han, E., Han, S., Hwang, J. S., Kim, M. K., & Jang, B. K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0290532 · Cited by 13
“Activation of KCs through the NLPR3 inflammasome pathway leads to release of proinflammatory cytokines, hepatocyte injury, and HSC activation [10, 28, 29].”
Background
Association between novel inflammatory markers and non-alcoholic fatty liver disease: a cross-sectional study
Wang, G., Zhao, Y., Li, Z., Li, D., Zhao, F., Hao, J., Yang, C., Song, J., Gu, X., & Huang, R. (2023) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002686 · Cited by 13
“The hepatic inflammatory response is a crucial factor driving the progression of NAFLD, leading to progressive liver fibrosis and, ultimately, the development of cirrhosis [21].”
Background
L-AP Alleviates Liver Injury in Septic Mice by Inhibiting Macrophage Activation via Suppressing NF-κB and NLRP3 Inflammasome/Caspase-1 Signal Pathways
Liu, L., Lin, L., Wang, Y., Yan, X., Li, R., He, M., Li, H., Zhuo, C., Li, W., Zhang, D., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02781 · Cited by 14
Selective Targeting of α4β7/MAdCAM-1 Axis Suppresses Fibrosis Progression by Reducing Proinflammatory T Cell Recruitment to the Liver
Gupta, B., Rai, R. P., Pal, P. B., Rossmiller, D., Chaudhary, S., Chiaro, A., Seaman, S., Singhi, A. D., Liu, S., Monga, S. P., et al. (2024) · Cells · doi:10.3390/cells13090756 · Cited by 14
“Wound healing and repair are fundamental biological processes critical to maintaining tissue architecture and restoring organ homeostasis following injury [1].”
BackgroundInfluential

Authors: Koyama, Y., & Brenner, D. A.
Affiliations: University of California San Diego (US)
Corresponding author: Brenner, David A.
ORCID: Koyama, Yukinori
Brenner, David A.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2017-01-03
Volume: 127
Issue: 1
Pages: 55-64
ISSN: 0021-9738 (ISSN-L)
1558-8238
DOI: 10.1172/jci88881
PMC: PMC5199698
OpenAlex: W2562949639
Cited by: 1,295
References: 158
Citations by year: 2026: 139 · 2025: 162 · 2024: 159 · 2023: 171 · 2022: 173 · 2021: 177 · 2020: 151 · 2019: 85 · 2018: 63 · 2017: 13
FWCI: 12.30
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (ES010337, AA011999)
National Institute on Alcohol Abuse and Alcoholism (U01AA021856, P50AA011999)
National Institute of Environmental Health Sciences (P42ES010337)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords: liver inflammation, liver fibrosis, liver cirrhosis, hepatic steatosis, Kupffer cells, hepatic stellate cells, myofibroblasts, immune cell crosstalk, T cells, neutrophils, dendritic cells, metabolic syndrome, insulin resistance
MeSH terms: Animals, Dendritic Cells, Hepatitis, Humans, Inflammation, Kupffer Cells, Liver, Liver Cirrhosis, Neutrophils, T-Lymphocytes, Hepatic Stellate Cells, Myofibroblasts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Liver inflammation and fibrosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks