Cited by 222Barrier Structure and Function StudiesMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

Open access

Horng, Sam, Therattil, Anthony, Moyon, Sarah, Gordon, Alexandra, Kim, Karla, Argaw, Azeb Tadesse, Hara, Yuko, Mariani, John N., Sawai, Setsu, Flodby, Per, Crandall, Edward D., Borok, Zea, Sofroniew, Michael V., Chapouly, Candice, John, Gareth R.·2017·Journal of Clinical Investigation

DOI 10.1172/jci91301PMC PMC5531407

Open this paper in CoChat — free account Open PDF

Abstract

Lesions and neurologic disability in inflammatory CNS diseases such as multiple sclerosis (MS) result from the translocation of leukocytes and humoral factors from the vasculature, first across the endothelial blood-brain barrier (BBB) and then across the astrocytic glia limitans (GL). Factors secreted by reactive astrocytes open the BBB by disrupting endothelial tight junctions (TJs), but the mechanisms that control access across the GL are unknown. Here, we report that in inflammatory lesions, a second barrier composed of reactive astrocyte TJs of claudin 1 (CLDN1), CLDN4, and junctional adhesion molecule A (JAM-A) subunits is induced at the GL. In a human coculture model, CLDN4-deficient astrocytes were unable to control lymphocyte segregation. In models of CNS inflammation and MS, mice with astrocyte-specific Cldn4 deletion displayed exacerbated leukocyte and humoral infiltration, neuropathology, motor disability, and mortality. These findings identify a second inducible barrier to CNS entry at the GL. This barrier may be therapeutically targetable in inflammatory CNS disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci91301

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849
Development, maintenance and disruption of the blood-brain barrier
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., & Hinson, S. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050304 · Cited by 2,288
Pericytes are required for blood–brain barrier integrity during embryogenesis
Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512
Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging
Bell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.043 · Cited by 1,448
A Randomized, Controlled Trial of Corticosteroids in the Treatment of Acute Optic Neuritis
Beck, R. W., Cleary, P. A., Anderson, M. M., Keltner, J. L., Shults, W. T., Kaufman, D. I., Buckley, E. G., Corbett, J. J., Kupersmith, M. J., Miller, N. R., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199202273260901 · Cited by 1,349
Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling
Chung, Y., Chang, S. H., Martínez, G., Yang, X. O., Nurieva, R., Kang, H. S., Ma, L., Watowich, S. S., Jetten, A. M., Tian, Q., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.007 · Cited by 1,247
Astrocyte barriers to neurotoxic inflammation
Sofroniew, M. V. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3898 · Cited by 1,202
Self-citation

Flagged first, then by citations

Show all 69 references

Sorted by citations

The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
Arvanitis, C., Ferraro, G. B., & Jain, R. K. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0205-x · Cited by 1,919
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
Haruwaka, K., Ikegami, A., Tachibana, Y., Ohno, N., Konishi, H., Hashimoto, A., Matsumoto, M., Kato, D., Ono, R., Kiyama, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13812-z · Cited by 923
Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity
Sofroniew, M. V. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.004 · Cited by 721
Self-citation
Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease
Newcombe, E. A., Camats-Perna, J., Silva, M. L., Valmas, N., Huat, T. J., & Medeiros, R. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1313-3 · Cited by 532
Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging
Mou, Y., Du, Y., Zhou, L., Yue, J., Hu, X., Liu, Y., Chen, S., Lin, X., Zhang, G., Xiao, H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.796288 · Cited by 432
The Role of Astrocytes in Multiple Sclerosis
Ponath, G. D., Park, C., & Pitt, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00217 · Cited by 378
The anatomy and immunology of vasculature in the central nervous system
Mastorakos, P., & McGavern, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav0492 · Cited by 333
Astrocytes are necessary for blood–brain barrier maintenance in the adult mouse brain
Heithoff, B. P., George, K. K., Phares, A. N., Zuidhoek, I. A., Muñoz‐Ballester, C., & Robel, S. (2020) · Glia · doi:10.1002/glia.23908 · Cited by 271
The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis
Brambilla, R. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01980-7 · Cited by 246
Astrocyte-immune cell interactions in physiology and pathology
Han, R. T., Kim, R. D., Molofsky, A. V., & Liddelow, S. A. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.013 · Cited by 223
Astrocytes, the rising stars of the glioblastoma microenvironment
Brandao, M., Simon, T. R., Critchley, G. R., & Giamas, G. (2018) · Glia · doi:10.1002/glia.23520 · Cited by 218
Transcriptomic profiling of microglia and astrocytes throughout aging
Pan, J., Ma, N., Yu, B., Zhang, W., & Wan, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01774-9 · Cited by 188
Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury
Zhang, J., Zhang, F., & Dong, J. (2018) · Blood · doi:10.1182/blood-2017-11-784108 · Cited by 185
Brain endothelial cell junctions after cerebral hemorrhage: Changes, mechanisms and therapeutic targets
Keep, R. F., Andjelkovic, A. V., Xiang, J., Stamatovic, S. M., Antonetti, D. A., Hua, Y., & Xi, G. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18774666 · Cited by 188
Astrocyte Senescence and Alzheimer’s Disease: A Review
Han, X., Zhang, T., Liu, H., Mi, Y., & Gou, X. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00148 · Cited by 177
Pericytes regulate vascular immune homeostasis in the CNS
Török, O., Schreiner, B., Schaffenrath, J., Tsai, H.-C., Maheshwari, U., Stifter, S. A., Welsh, C., Amorim, A., Sridhar, S., Utz, S. G., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016587118 · Cited by 166
How Does the Immune System Enter the Brain?
Mapunda, J. A., Tibar, H., Regragui, W., & Engelhardt, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.805657 · Cited by 172
Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers
Dias, M. C., Mapunda, J. A., Vladymyrov, M., & Engelhardt, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215372 · Cited by 163
Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling
Göbel, J., Engelhardt, E., Pelzer, P., Sakthivelu, V., Jahn, H. M., Jevtic, M., Folz‐Donahue, K., Kukat, C., Schauss, A. C., Frese, C. K., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.005 · Cited by 160
Claudin-1-Dependent Destabilization of the Blood–Brain Barrier in Chronic Stroke
Sladojević, N., Stamatovic, S. M., Johnson, A., Choi, J. H. K., Hu, A., Dithmer, S., Blasig, I. E., Keep, R. F., & Andjelkovic, A. V. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1432-18.2018 · Cited by 142
Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system
Lannes, N., Eppler, E., Etemad, S., Yotovski, P., & Filgueira, L. (2017) · Oncotarget · doi:10.18632/oncotarget.23106 · Cited by 155
Resolution of inflammation during multiple sclerosis
Ruiz, F., Vigne, S., & Pot, C. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00765-0 · Cited by 136
The neurovascular unit and systemic biology in stroke — implications for translation and treatment
Tiedt, S., Buchan, A. M., Dichgans, M., Lizasoaín, I., Moro, M. Á., & Lo, E. H. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00703-z · Cited by 135
Cross‐talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury
Frik, J., Merl‐Pham, J., Plesnila, N., Mattugini, N., Kjell, J., Kraska, J., Gomez, R. M., Hauck, S. M., Sirko, S., & Götz, M. (2018) · EMBO Reports · doi:10.15252/embr.201745294 · Cited by 126
Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic System: Part I—Anatomy and Physiology
Klostranec, J. M., Vucevic, D., Bhatia, K. D., Kortman, H. G. J., Krings, T., Murphy, K., terBrugge, K. G., & Mikulis, D. J. (2021) · Radiology · doi:10.1148/radiol.2021202043 · Cited by 130
Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder
Wu, S., Yin, Y., & Du, L. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01153-9 · Cited by 127
Inflammation in multiple sclerosis: consequences for remyelination and disease progression
Klotz, L., Antel, J. P., & Kuhlmann, T. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00801-6 · Cited by 125
Blood–brain barrier and its function during inflammation and autoimmunity
Sonar, S. A., & Lal, G. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ru1117-428r · Cited by 114
Neuroinflammatory In Vitro Cell Culture Models and the Potential Applications for Neurological Disorders
Peng, Y., Chu, S., Yang, Y., Zhang, Z., Pang, Z., & Chen, N. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.671734 · Cited by 103
The Blood–Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders
Costea, L., Mészáros, Á., Bauer, H., Bauer, H., Traweger, A., Wilhelm, I., Farkas, A. E., & Krizbai, I. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215472 · Cited by 102
Astrocytes in the regulation of cerebrovascular functions
Cohen‐Salmon, M., Slaoui, L., Mazaré, N., Gilbert, A., Oudart, M., Alvear‐Perez, R., Elorza‐Vidal, X., Chever, O., & Boulay, A. (2021) · Glia · doi:10.1002/glia.23924 · Cited by 93
Microglia and the Blood–Brain Barrier: An External Player in Acute and Chronic Neuroinflammatory Conditions
Gullotta, G. S., Costantino, G., Sortino, M. A., & Spampinato, S. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119144 · Cited by 97
Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function
Zhang, Y., Bailey, J. T., Xu, E., Singh, K., Lavaert, M., Link, V. M., D’Souza, S., Hafiz, A., Cao, J., Cao, G., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01349-1 · Cited by 91
Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments
Alghamri, M. S., McClellan, B. L., Hartlage, C. S., Haase, S., Faisal, S. M., Thalla, R., Dabaja, A. A., Banerjee, K., Carney, S. V., Mujeeb, A., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.680021 · Cited by 94
A microengineered Brain-Chip to model neuroinflammation in humans
Pediaditakis, I., Kodella, K. R., Manatakis, D. V., Le, C. Y., Barthakur, S., Sorets, A. G., Gravanis, A., Ewart, L. C., Rubin, L. L., Manolakos, E. S., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104813 · Cited by 84
Perfluorooctane sulfonate disrupts the blood brain barrier through the crosstalk between endothelial cells and astrocytes in mice
Yu, Y., Wang, C., Zhang, X., Zhu, J., Wang, L., Ji, M., Zhang, Z., Ji, X., & Wang, S. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113429 · Cited by 87
Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease
Zhao, M., Jiang, X., Zhang, H., Sun, J., Pei, H., Ma, L., Cao, Y., & Li, H. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101483 · Cited by 86
Recent insights on astrocyte mechanisms in CNS homeostasis, pathology, and repair
Hart, C. G., & Karimi‐Abdolrezaee, S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24922 · Cited by 88
Glioblastoma Microenvironment and Cellular Interactions
Crivii, C.-B., Boșca, A. B., Melincovici, C. S., Constantin, A.-M., Mărginean, M., Dronca, E., Suflețel, R., Gonciar, D., Bungărdean, M., & Șovrea, A. (2022) · Cancers · doi:10.3390/cancers14041092 · Cited by 81
The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring Sequence
Virtuoso, A., Giovannoni, R., Luca, C. D., Gargano, F., Cerasuolo, M., Maggio, N., Lavitrano, M., & Papa, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073301 · Cited by 83
Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance
Proulx, S. T., & Engelhardt, B. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13469 · Cited by 86
Astrocyte–Endotheliocyte Axis in the Regulation of the Blood–Brain Barrier
Pivoriūnas, A., & Verkhratsky, A. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03338-6 · Cited by 85
Intranasal delivery of interferon-β-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy
González, L. F., Acuña, E., Arellano, G., Morales, P., Sotomayor, P. C., Oyarzun-Ampuero, F. A., & Naves, R. F. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.019 · Cited by 80
Diversity of developing peripheral glia revealed by single-cell RNA sequencing
Tasdemir-Yilmaz, O. E., Druckenbrod, N. R., Olukoya, O., Dong, W., Yung, A. R., Bastille, I., Pazyra‐Murphy, M. F., Sitko, A. A., Hale, E., Vigneau, S., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.08.005 · Cited by 77
Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
Parodi‐Rullán, R. M., Javadov, S. A., & Fossati, S. (2021) · Cells · doi:10.3390/cells10112903 · Cited by 75
Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer’s disease
Yue, Q., & Hoi, M. P. M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.367832 · Cited by 78
Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis
Meier, U., Cipian, R. C., Karimi, A., Ramasamy, R., & Middeldorp, J. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.757302 · Cited by 82
The Specific Role of Reactive Astrocytes in Stroke
Li, L., Zhou, J., Han, L., Wu, X., Shi, Y., Cui, W., Zhang, S., Hu, Q., Wang, J., Bai, H., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.850866 · Cited by 71
Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice
Ding, J., Lee, S., Vlahos, L. J., Yuki, K., Rada, C. C., van Unen, V., Vuppalapaty, M., Chen, H., Sura, A., McCormick, A. K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37689-1 · Cited by 74
Astrocytes to the rescue! Glia limitans astrocytic endfeet control CNS inflammation
Quintana, F. J. (2017) · Journal of Clinical Investigation · doi:10.1172/jci95769 · Cited by 66
Trauma-Induced Coagulopathy: Overview of an Emerging Medical Problem from Pathophysiology to Outcomes
Savioli, G., Ceresa, I. F., Caneva, L., Gerosa, S., & Ricevuti, G. (2021) · Medicines · doi:10.3390/medicines8040016 · Cited by 66
Liposomes for drug delivery in stroke
Bruch, G. E., Fernandes, L. F., Bassi, B. L. T., Alves, M. T. R., Pereira, I. O., Frézard, F., & Massensini, A. R. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.07.015 · Cited by 68
Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina
Church, K. A., Rodriguez, D., Vanegas, D., Gutiérrez, I. L., Cardona, S. M., Madrigal, J. L. M., Kaur, T., & Cardona, A. E. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02659-9 · Cited by 65
Astrocytes in multiple sclerosis and experimental autoimmune encephalomyelitis: Star-shaped cells illuminating the darkness of CNS autoimmunity
Yi, W., Schlüter, D., & Wang, X. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.029 · Cited by 67
Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and clinical implications
Steinruecke, M., Lonergan, R. M., Selvaraj, B. T., Chandran, S., Castro, B. D., & Stavrou, M. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231153281 · Cited by 63
Crosstalk of Astrocytes and Other Cells during Ischemic Stroke
He, T., Yang, G., & Zhang, Z. (2022) · Life · doi:10.3390/life12060910 · Cited by 63
The Expanding Cell Diversity of the Brain Vasculature
Ross, J. M., Kim, C. N., Allen, D. E., Crouch, E. E., Narsinh, K. H., Cooke, D. L., Abla, A. A., Nowakowski, T. J., & Winkler, E. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.600767 · Cited by 66
How does neurovascular unit dysfunction contribute to multiple sclerosis?
Cashion, J. M., Young, K. M., & Sutherland, B. A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106028 · Cited by 58
Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood–Brain Barrier
Hashimoto, Y., Campbell, M., Tachibana, K., Okada, Y., & Kondoh, M. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00408 · Cited by 54
Astroglia support, regulate and reinforce brain barriers
Verkhratsky, A., & Pivoriūnas, A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106054 · Cited by 59
Tumor Microenvironment in Glioma Invasion
Tamai, S., Ichinose, T., Tsutsui, T., Tanaka, S., Garaeva, F., Sabit, H., & Nakada, M. (2022) · Brain Sciences · doi:10.3390/brainsci12040505 · Cited by 59
The path to leptomeningeal metastasis
Remšík, J., & Boire, A. A. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00700-y · Cited by 71
Chronic colitis induces meninges traffic of gut-derived T cells, unbalances M1 and M2 microglia/macrophage and increases ischemic brain injury in mice
Feng, Y., He, X., Luo, S., Chen, X., Long, S., Liang, F., Shi, T., Pei, Z., & Li, Q. (2018) · Brain Research · doi:10.1016/j.brainres.2018.11.019 · Cited by 55
Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer’s Disease Immunotherapy
Castellani, G., & Schwartz, M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.005 · Cited by 53
Targetability of the neurovascular unit in inflammatory diseases of the central nervous system
Smith, B. C., Tinkey, R. A., Shaw, B. C., & Williams, J. L. (2022) · Immunological Reviews · doi:10.1111/imr.13121 · Cited by 57
Blood–brain barrier genetic disruption leads to protective barrier formation at the Glia Limitans
Mora, P., Hollier, P.-L., Guimbal, S., Abélanet, A., Diop, A., Cornuault, L., Couffinhal, T., Horng, S. H., Gadeau, A., Renault, M., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000946 · Cited by 52
Self-citation
Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System
Ivan, D. C., Walthert, S., Berve, K., Steudler, J., & Locatelli, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.609921 · Cited by 55
Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?
Kacířová, M., Zmeškalová, A., Kořínková, L., Železná, B., Kuneš, J., & Maletı́nská, L. (2020) · Clinical Science · doi:10.1042/cs20191313 · Cited by 56
Tight Junctions of the Neurovascular Unit
Hudson, N., & Campbell, M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.752781 · Cited by 53
Resveratrol Restores Neuronal Tight Junction Proteins Through Correction of Ammonia and Inflammation in CCl4-Induced Cirrhotic Mice
Vairappan, B., Sundhar, M. P., & Srinivas, B. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1389-x · Cited by 48
Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System
Antel, J. P., Becher, B., Ludwin, S. K., Prat, A., & Quintana, F. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900908 · Cited by 46
Function of Glia in Aging and the Brain Diseases
Vallés, S. L., Iradi, A., Aldasoro, M., Vila, J. M., Aldasoro, C., de la Torre, J., Campos-Campos, J., & Jorda, A. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.37769 · Cited by 45
Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model
Chen, J., Chu, L., Cheng, K., Hsieh, S., Juan, Y., & Wu, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-34915-5 · Cited by 44
Age-associated changes in microglia and astrocytes ameliorate blood-brain barrier dysfunction
Pan, J., Ma, N., Zhong, J., Yu, B., Wan, J., & Zhang, W. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.08.030 · Cited by 43
The blood–CSF–brain route of neurological disease: The indirect pathway into the brain
Cousins, O., Hodges, A., Schubert, J. J., Veronese, M., Turkheimer, F., Miyan, J. A., Engelhardt, B., & Roncaroli, F. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12789 · Cited by 49
Role of NADPH Oxidases in Blood–Brain Barrier Disruption and Ischemic Stroke
Hernandes, M. S., Xu, Q., & Griendling, K. K. (2022) · Antioxidants · doi:10.3390/antiox11101966 · Cited by 47
Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood–Brain Barrier Disruption after Ischemic Stroke
Li, F., Geng, X., Yip, J., & Ding, Y. (2018) · Cell Transplantation · doi:10.1177/0963689718819443 · Cited by 43
Public Volume Electron Microscopy Data: An Essential Resource to Study the Brain Microvasculature
Bonney, S. K., Coelho‐Santos, V., Huang, S., Takeno, M. M., Kornfeld, J. M. R., Keller, A., & Shih, A. Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.849469 · Cited by 43
Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood–Brain Barrier
Bony, B. A., Tarudji, A. W., Miller, H. A., Gowrikumar, S., Roy, S., Curtis, E. T., Gee, C. C., Vecchio, A., Dhawan, P., & Kievit, F. M. (2021) · ACS Nano · doi:10.1021/acsnano.1c08432 · Cited by 42
Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling
Sun, Z., Zhao, H., Fang, D., Davis, C. T., Shi, D., Lei, K., Rich, B. E., Winter, J. M., Guo, L., Sorensen, L. K., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.015 · Cited by 43
The gut microbiota‐astrocyte axis: Implications for type 2 diabetic cognitive dysfunction
Li, Z.-H., Jiang, Y., Long, C., Peng, Q., & Yue, R. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14077 · Cited by 41
Cryptococcal Meningitis and Anti-virulence Therapeutic Strategies
Vu, K., Garcia, J. A., & Gelli, A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00353 · Cited by 43
Response of the neurovascular unit to brain metastatic breast cancer cells
Haskó, J., Fazakas, C., Molnár, K., Mészáros, Á., Patai, R., Szabó, G., Erdélyi, F., Nyúl‐Tóth, Á., Győri, F., Kozma, M., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0788-1 · Cited by 39
Immune–vascular mural cell interactions: consequences for immune cell trafficking, cerebral blood flow, and the blood–brain barrier
Barkaway, A., Attwell, D., & Korte, N. (2022) · Neurophotonics · doi:10.1117/1.nph.9.3.031914 · Cited by 38
Challenges and Opportunities of Targeting Astrocytes to Halt Neurodegenerative Disorders
Valori, C. F., Possenti, A., Brambilla, L., & Rossi, D. (2021) · Cells · doi:10.3390/cells10082019 · Cited by 39
Regulatory role of oligodendrocyte gap junctions in inflammatory demyelination
Papaneophytou, C. P., Georgiou, E., Karaiskos, C., Sargiannidou, I., Markoullis, K., Freidin, M. M., Abrams, C. K., & Kleopa, K. A. (2018) · Glia · doi:10.1002/glia.23513 · Cited by 35
Regulation of blood-brain barrier integrity by brain microvascular endothelial cells in ischemic stroke: A therapeutic opportunity
Tang, Z., Li, R., Guo, X., Wang, Z., & Wu, J. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177553 · Cited by 35
T-cell surveillance of the human brain in health and multiple sclerosis
Smolders, J., van Luijn, M. M., Hsiao, C., & Hamann, J. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00926-8 · Cited by 37
Astroglial functions
Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00008-0 · Cited by 31
Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in salivary glands of Sjögren's syndrome
Cong, X., Zhang, X., Zhang, Y., Wei, T., He, Q., Zhang, L.-W., Hua, H., Lee, S.-W., Park, K., Yu, G., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.002 · Cited by 32
Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation
Tuñon-Ortiz, A., & Lamb, T. J. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007786 · Cited by 32
Anfibatide Preserves Blood–Brain Barrier Integrity by Inhibiting TLR4/RhoA/ROCK Pathway After Cerebral Ischemia/Reperfusion Injury in Rat
Gong, P., Li, R., Jia, H.-Y., Ma, Z., Li, X., Dai, X., & Luo, S. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01402-z · Cited by 31
Local Serpin Treatment via Chitosan-Collagen Hydrogel after Spinal Cord Injury Reduces Tissue Damage and Improves Neurologic Function
Kwiecień, J. M., Zhang, L., Yaron, J. R., Schutz, L. N., Kwiecien-Delaney, C. J., Awo, E. A., Burgin, M., Dąbrowski, W., & Lucas, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041221 · Cited by 33
Trauma-Induced Heterotopic Ossification Regulates the Blood-Nerve Barrier
Gugala, Z., Olmsted‐Davis, E. A., Xiong, Y., Davis, E. L., & Davis, A. R. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00408 · Cited by 31
Astrogliosis in multiple sclerosis and neuro-inflammation: what role for the notch pathway?
Mora, P., & Chapouly, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1254586 · Cited by 35
Self-citation
Reactive Astrocytes Display Pro-inflammatory Adaptability with Modulation of Notch-PI3K-AKT Signaling Pathway Under Inflammatory Stimulation
Cheng, Y., Ding, Y., Bian, G., Chen, L.-W., Yao, X.-Y., Lin, Y.-B., Wang, Z., & Chen, B. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.023 · Cited by 31
Targeting Non-coding RNA for Glioblastoma Therapy: The Challenge of Overcomes the Blood-Brain Barrier
Sharma, R. K., Calderon, C., & Vivas‐Mejía, P. E. (2021) · Frontiers in Medical Technology · doi:10.3389/fmedt.2021.678593 · Cited by 29
Connexin 43 Controls the Astrocyte Immunoregulatory Phenotype
Boulay, A.-C., Gilbert, A., Moreira, V. O., Blugeon, C., Perrin, S., Pouch, J., Crom, S. L., Ducos, B., & Cohen‐Salmon, M. (2018) · Brain Sciences · doi:10.3390/brainsci8040050 · Cited by 27
Astrocyte Heterogeneity in Multiple Sclerosis: Current Understanding and Technical Challenges
Lo, C. H., Škarica, M., Mansoor, M., Bhandarkar, S., Toro, S., & Pitt, D. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.726479 · Cited by 27
Physical associations of microglia and the vascular blood-brain barrier and their importance in development, health, and disease
Knopp, R. C., Banks, W. A., & Erickson, M. A. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102648 · Cited by 27

Authors: Horng, S., Therattil, A., Moyon, S., Gordon, A., Kim, K., Argaw, A. T., Hara, Y., Mariani, J. N., Sawai, S., Flodby, P., Crandall, E. D., Borok, Z., Sofroniew, M. V., Chapouly, C., & John, G. R.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
University of Southern California (US)
University of California, Los Angeles (US)
ORCID: Horng, Sam
Therattil, Anthony
Moyon, Sarah
Hara, Yuko
Mariani, John N.
Flodby, Per
Crandall, Edward D.
Borok, Zea
Sofroniew, Michael V.
Chapouly, Candice
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2017-07-24
Volume: 127
Issue: 8
Pages: 3136-3151
ISSN: 0021-9738 (ISSN-L)
1558-8238
DOI: 10.1172/jci91301
PMC: PMC5531407
OpenAlex: W2737157719
Cited by: 221
References: 69
Citations by year: 2026: 13 · 2025: 17 · 2024: 21 · 2023: 29 · 2022: 26 · 2021: 34 · 2020: 26 · 2019: 23 · 2018: 29 · 2017: 3
FWCI: 11.05
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL AMU (submittedVersion, cc-by)
eScholarship (California Digital Library) (submittedVersion)
Funders: Icahn School of Medicine at Mount Sinai
Guthy-Jackson Charitable Foundation
Hastings Foundation
Beker Foundation
National Institutes of Health
National Heart, Lung, and Blood Institute (P01HL119165, R01HL126877, U01HL108634, R01HL112638)
National Cancer Institute (R24CA095823)
National Institute of Neurological Disorders and Stroke (R01NS062703, R25NS079102, R01NS084030, R01NS085103)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: glia limitans, multiple sclerosis, blood-brain barrier, claudin-4, claudin-1, JAM-A, reactive astrocytes, leukocyte transmigration, neuroinflammation, motor impairment
MeSH terms: Animals, Astrocytes, Blood-Brain Barrier, Central Nervous System, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Female, Humans, Inflammation, Mice, Inbred C57BL, Multiple Sclerosis, Nervous System Diseases, Receptors, Cell Surface, Cell Adhesion Molecules, Cytokines, Mice, Knockout, Coculture Techniques, Tight Junctions, Mice, Claudin-1, Claudin-4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks