The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Open accessAbstract
High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism. WA dose-dependently either activates the nuclear factor-like 2 pathway through targeting of Kelch-like ECH-associated protein 1 (noncanonical ferroptosis induction) or inactivates glutathione peroxidase 4 (canonical ferroptosis induction). Noncanonical ferroptosis induction is characterized by an increase in intracellular labile Fe(II) upon excessive activation of heme oxygenase-1, which is sufficient to induce ferroptosis. This double-edged mechanism might explain the superior efficacy of WA as compared with etoposide or cisplatin in killing a heterogeneous panel of high-risk neuroblastoma cells, and in suppressing the growth and relapse rate of neuroblastoma xenografts. Nano-targeting of WA allows systemic application and suppressed tumor growth due to an enhanced accumulation at the tumor site. Collectively, our data propose a novel therapeutic strategy to efficiently kill cancer cells by ferroptosis.
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Self-citationCancer drug resistance: an evolving paradigm
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Self-citationModulation of oxidative stress as an anticancer strategy
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Ferroptosis as a p53-mediated activity during tumour suppression
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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
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Necroptosis and its role in inflammation
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Self-citationDixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088
Cited by
Targeting Ferroptosis as a Vulnerability in Cancer
Lei, G., Zhuang, L., & Gan, B. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00459-0 · Cited by 2,252
Ferroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
Role of GPX4 in ferroptosis and its pharmacological implication
Seibt, T. M., Proneth, B., & Conrad, M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.014 · Cited by 1,520
Self-citationFerroptosis: Mechanisms and links with diseases
Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00428-9 · Cited by 1,471
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
Friedmann Angeli, J. P., Krysko, D. V., & Conrad, M. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0149-1 · Cited by 1,259
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Metadata
- Authors
- Hassannia, B., Wiernicki, B., Ingold, I., Qu, F., Van Herck, S., Tyurina, Y. Y., Bayır, H., Abhari, B. A., Angeli, J. P. F., Choi, S. M., Meul, E., Heyninck, K., Declerck, K., Chirumamilla, C. S., Lahtela-Kakkonen, M., Van Camp, G., Krysko, D. V., Ekert, P. G., Fulda, S., De Geest, B. G., Conrad, M., Kagan, V. E., Vanden Berghe, W., Vandenabeele, P., & Vanden Berghe, T.
- Venue
- Journal of Clinical Investigation
- Published
- 2018-06-25
- Volume
- 128
- Issue
- 8
- Pages
- 3341-3355
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2809820903
- Cited by
- 627
- References
- 20
- FWCI
- 29.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hassannia, B., Wiernicki, B., Ingold, I., Qu, F., Van Herck, S., Tyurina, Y. Y., Bayır, H., Abhari, B. A., Angeli, J. P. F., Choi, S. M., Meul, E., Heyninck, K., Declerck, K., Chirumamilla, C. S., Lahtela-Kakkonen, M., Van Camp, G., Krysko, D. V., Ekert, P. G., Fulda, S., . . . Vanden Berghe, T. (2018). Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. Journal of Clinical Investigation. https://doi.org/10.1172/jci99032
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
