The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
WITHDRAWAL SYMPTOMS FOLLOWING DISCONTINUATION OF IMIPRAMINE THERAPY
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“Clonazepam [73-76] has a long elimination half-life, induced less frequently rebound anxiety than alprazolam [77].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [77]
Citations
Cites
Schweizerische medizinische Wochenschrift
(1947) · JAMA · doi:10.1001/jama.1947.02880050057017 · Cited by 958
Withdrawal reactions from chlordiazepoxide (?Librium?)
Hollister, L. E., Motzenbecker, F. P., & Degan, R. O. (1961) · Psychopharmacologia · doi:10.1007/bf00429621 · Cited by 340
Clinical Experience with Imipramine (G 22355) in the Treatment of Depression
Mann, A. M., & Macpherson, A. S. (1959) · Canadian Psychiatric Association Journal · doi:10.1177/070674375900400111 · Cited by 57
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Research works printed but not linked: 2
- Hollister L. E., 1960, J. Clin. Exp. Psychopath., 21, 212
- Turner W. J., J. Neuropsychiat., 2, 1961
Cited by
Sorted by citations
Kramer, J. C. (1967) · JAMA · doi:10.1001/jama.201.5.305 · Cited by 367
Self-citationAcute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
Cosci, F., & Chouinard, G. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000506868 · Cited by 265
Clinical use of quetiapine in disease states other than schizophrenia.
Dl, D., Laird, L. K., Zajecka, J., Bailey, L., Sussman, N., & Seabolt, J. L. (2002) · PubMed · Cited by 229
Can long-term treatment with antidepressant drugs worsen the course of depression?
Fava, G. A. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0204 · Cited by 223
Antidepressant Discontinuation Syndromes: Clinical Relevance, Prevention and Management
Haddad, P. M. (2001) · Drug Safety · doi:10.2165/00002018-200124030-00003 · Cited by 214
Montgomery, S. A., Kennedy, S. H., Burrows, G. D., Lejoyeux, M., & Hindmarch, I. (2004) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000137184.64610.c8 · Cited by 196
The mechanisms of tolerance in antidepressant action
Fava, G. A., & Offidani, E. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.026 · Cited by 158
Effects of maintenance amitriptyline and psychotherapy on symptoms of depression
Paykel, E. S., DiMascio, A., HASKELL, D. S., & Prusoff, B. A. (1975) · Psychological Medicine · doi:10.1017/s0033291700007236 · Cited by 144
Antidepressant discontinuation: a review of the literature.
Lejoyeux, M., & Adès, J. (1997) · PubMed · Cited by 135
Abrupt Discontinuation of Tricyclic Antidepressant Drugs: Evidence for Noradrenergic Hyperactivity
Charney, D. S., Heninger, G. R., Sternberg, D. E., & Landis, D. H. (1982) · The British Journal of Psychiatry · doi:10.1192/bjp.141.4.377 · Cited by 126
The SSRI discontinuation syndrome
Haddad, P. M. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200311 · Cited by 123
Antidepressant Withdrawal and Rebound Phenomena
Henssler, J. F., Heinz, A., Brandt, L., & Bschor, T. (2019) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2019.0355 · Cited by 124
Recognising and managing antidepressant discontinuation symptoms
Haddad, P. M., & Anderson, I. M. (2007) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.105.001966 · Cited by 109
Incidence of antidepressant discontinuation symptoms: a systematic review and meta-analysis
Henssler, J., Schmidt, Y., Schmidt, U., Schwarzer, G., Bschor, T., & Baethge, C. (2024) · The Lancet Psychiatry · doi:10.1016/s2215-0366(24)00133-0 · Cited by 106
Nielsen, M., Hansen, E. H., & Gøtzsche, P. C. (2012) · Addiction · doi:10.1111/j.1360-0443.2011.03686.x · Cited by 103
Compliance with antidepressant therapy and antidepressant discontinuation symptoms
Demyttenaere, K., & Haddad, P. M. (2000) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2000.tb10948.x · Cited by 98
Rational Use of Antidepressant Drugs
Fava, G. A. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000362803 · Cited by 95
Death and Dependence: Current Controversies over the Selective Serotonin Reuptake Inhibitors
Nutt, D. (2003) · Journal of Psychopharmacology · doi:10.1177/0269881103174019 · Cited by 84
Fava, G. A. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320970325 · Cited by 84
Bogetto, F., Bellino, S., Revello, R. B., & Patria, L. (2002) · CNS Drugs · doi:10.2165/00023210-200216040-00006 · Cited by 80
Antidepressant Withdrawal Syndrome
Lejoyeux, M., Adès, J., Mourad, I., Solomon, J., & Dilsaver, S. C. (1996) · CNS Drugs · doi:10.2165/00023210-199605040-00006 · Cited by 82
Understanding and Managing Withdrawal Syndromes After Discontinuation of Antidepressant Drugs
Fava, G. A., & Cosci, F. (2019) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.19com12794 · Cited by 69
Antidepressant withdrawal symptoms treated with anticholinergic agents
Dilsaver, S. C., Feinberg, M. P., & Greden, J. F. (1983) · American Journal of Psychiatry · doi:10.1176/ajp.140.2.249 · Cited by 67
Potential Medical and Surgical Complications of Serotonergic Antidepressant Medications
Looper, K. J. (2007) · Psychosomatics · doi:10.1176/appi.psy.48.1.1 · Cited by 66
Long-Term Treatment with Antidepressant Drugs: The Spectacular Achievements of Propaganda
Fava, G. A. (2002) · Psychotherapy and Psychosomatics · doi:10.1159/000056279 · Cited by 66
Gastaldon, C., Schoretsanitis, G., Arzenton, E., Raschi, E., Papola, D., Ostuzzi, G., Moretti, U., Seifritz, E., Kane, J. M., Trifirò, G., et al. (2022) · Drug Safety · doi:10.1007/s40264-022-01246-4 · Cited by 68
Withdrawal phenomena associated with antidepressant and antipsychotic agents
Dilsaver, S. C. (1994) · Drug Safety · doi:10.2165/00002018-199410020-00002 · Cited by 60
Are benzodiazepines overused and abused?
Rickels, K. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01842.x · Cited by 61
Kruger, J., Conway, T., Kaneene, J., Perry, R. L., Hagenlocker, E., Golombek, A., & Stuhler, J. (2003) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.2003.222.749 · Cited by 64
Why do we need new and better antidepressants?
Montgomery, S. (2006) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000199455.39552.1c · Cited by 59
LADER, M. H. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.05.004 · Cited by 61
A review of antidepressant treatments today
Kennedy, S. H. (2006) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(06)70007-4 · Cited by 55
Withdrawal effects of phenothiazines
Simpson, G. M., Amin, M., & Kunz, E. (1965) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(65)80028-1 · Cited by 50
Rheker, J., Winkler, A., Doering, B. K., & Rief, W. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4466-8 · Cited by 52
Tricyclic Antidepressant Withdrawal Syndrome
Garner, E. M., Kelly, M. W., & Thompson, D. F. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302700912 · Cited by 49
Groot, P. C., & van Os, J. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320932452 · Cited by 49
Narayan, V., & Haddad, P. M. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109359094 · Cited by 48
The Damnation of Benzodiazepines
Taylor, F. K. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.5.697 · Cited by 45
Withdrawal symptoms after graduated cessation of imipramine in children
Law, W., Petti, T. A., & Kazdin, A. E. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.5.647 · Cited by 41
Drug withdrawal syndromes-- a literature review.
Hodding, G., Jann, M. W., & Ackerman, I. P. (1980) · PubMed Central · Cited by 39
O’Keane, V., O’Flynn, K., Lucey, J. V., & Dinan, T. G. (1992) · Psychological Medicine · doi:10.1017/s0033291700032724 · Cited by 38
Heterocyclic antidepressant, monoamine oxidase inhibitor and neuroleptic withdrawal phenomena
Dilsaver, S. C. (1990) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(90)90097-z · Cited by 36
Compliance and acceptance in antidepressant treatment
Demyttenaere, K. (2001) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651500152048423 · Cited by 35
Overdose of Tricyclic Anti-Depressants and Deductions Concerning their Cerebral Action
LEWIS, S. A., & Oswald, I. (1969) · The British Journal of Psychiatry · doi:10.1192/bjp.115.529.1403 · Cited by 35
Antidepressant withdrawal syndromes: phenomenology and pathophysiology
Dilsaver, S. C. (1989) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1989.tb08578.x · Cited by 33
Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate.
Duncan, J. S., Shorvon, S. D., & Trimble, M. R. (1988) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.7.924 · Cited by 33
Remembering the lost neuroscience of pharmaco‐EEG
Fink, M. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01467.x · Cited by 32
Self-citationAnticholinergic Drug Abuse and Misuse
Marken, P. A., Stoner, S. C., & Bunker, M. T. (1996) · CNS Drugs · doi:10.2165/00023210-199605030-00005 · Cited by 31
Delirium after abrupt withdrawal from doxepin: case report
Santos, A. B., & MCCURDY, L. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.2.239 · Cited by 28
SSRIs and SNRIs: A review of the Discontinuation Syndrome in Children and Adolescents.
Hosenbocus, S., & Chahal, R. (2011) · PubMed Central · Cited by 27
Withdrawal Symptoms After Abrupt Cessation of Amitriptyline in an Eight-Year-Old Boy
Gualtieri, C. T., & Staye, J. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.1979.136.4a.457 · Cited by 27
Withdrawal Symptoms after Abrupt Termination of Imipramine
Shatan, C. F. (1966) · Canadian Psychiatric Association Journal · doi:10.1177/070674376601101s27 · Cited by 27
Abrupt Cessation of High-Dose Imipramine Treatment in Children
Petti, T. A. (1981) · JAMA · doi:10.1001/jama.1981.03320070052026 · Cited by 24
Potential Sensitising Effects of Antidepressant Drugs on Depression
Fava, G. A. (1999) · CNS Drugs · doi:10.2165/00023210-199912040-00001 · Cited by 23
Clinical Consequences of Abrupt Drug Withdrawal
George, C. F., & Robertson, D. (1987) · Medical Toxicology · doi:10.1007/bf03259954 · Cited by 23
Antidepressants: A Clinical Update for Medical Practitioners
Richardson, J. W., & Richelson, E. (1984) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)61429-3 · Cited by 22
Amantadine-associated recurrence of psychosis
Hausner, R. S. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.2.240 · Cited by 22
Drug dependence as a criterion for differentiation of psychotropic drugs
Battegay, R. (1966) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(66)80030-5 · Cited by 20
Pharmacological stress diathesis syndromes
Healy, D., & Tranter, R. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300312 · Cited by 19
Jesberger, J. A., & Richardson, J. S. (1986) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(86)90044-3 · Cited by 15
Lithium discontinuation: Withdrawal or relapse?
Balon, R., Yeragani, V. K., Pohl, R. B., & Gershon, S. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90056-9 · Cited by 14
A study of abrupt lithium withdrawal
Rifkin, A. E., Quitkin, F. M., Howard, A., & Klein, D. F. (1975) · Psychopharmacology · doi:10.1007/bf00421003 · Cited by 14
Self-citationRecognition and management of antidepressant discontinuation syndrome
Bhat, V., & Kennedy, S. H. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170022 · Cited by 13
Clinical Applications of Antidepressant Drugs in Childhood Behavioral and Emotional Disorders
Rancurello, M. (1985) · Psychiatric Annals · doi:10.3928/0048-5713-19850201-07 · Cited by 13
Transient Mood Elevation Associated with Antidepressant Drug Decrease*
Corral, M., Sivertz, K., & Jones, B. D. (1987) · The Canadian Journal of Psychiatry · doi:10.1177/070674378703200906 · Cited by 11
Considerations in Drug Therapy of the Elderly
Lamy, P. P. (1979) · Journal of Drug Issues · doi:10.1177/002204267900900103 · Cited by 10
Are all antidepressants the same? The consumer has a point
Camino, S., Strejilevich, S., Godoy, A., Smith, J., & Szmulewicz, A. (2022) · Psychological Medicine · doi:10.1017/s0033291722000678 · Cited by 9
Evidence on antidepressant withdrawal: an appraisal and reanalysis of a recent systematic review
Moncrieff, J., Hobday, H., Sørensen, A., Read, J., Plöderl, M., Hengartner, M. P., Kamp, C. B., Jakobsen, J. C., Juul, S., Davies, J., et al. (2025) · Psychological Medicine · doi:10.1017/s0033291725100652 · Cited by 9
Protracted Vomiting following Abrupt Cessation of Psychotropics: A Case Report
Kalman, T. P., & Warner, G. M. (1978) · Canadian Psychiatric Association Journal · doi:10.1177/070674377802300307 · Cited by 9
Godt, H. H., Fredslund-Andersen, K., & Edlund, A. H. (1971) · Nordic Journal of Psychiatry · doi:10.3109/08039487109094663 · Cited by 8
Rennwald, A., & Hengartner, M. P. (2025) · Epidemiology and Psychiatric Sciences · doi:10.1017/s204579602500023x · Cited by 8
“Acute withdrawal syndromes have been reported over decades in various case reports (e.g. Bloch et al. , 1995; Kostic et al. , 2024; Kramer et al. , 1961) and were later confirmed in placebo-controlled treatment-interruption trials (e.g. Michelson et al. , 2000; Rosenbaum et al. , 1998), and…”
Reactions to withdrawal of antidepressants, antiparkinsonian drugs, and lithium
Lawrence, J. M. (1985) · Psychosomatics · doi:10.1016/s0033-3182(85)72778-8 · Cited by 7
Behavioral Toxicity of Psychiatric Drugs
Perl, M., Hall, R. C. W., & Gardner, E. R. (1980) · Psychiatric Presentations of Medical Illness · doi:10.1007/978-94-011-7677-4_18 · Cited by 6
Nielsen, M., Hansen, E. H., & Gøtzsche, P. C. (2013) · International Journal of Risk & Safety in Medicine · doi:10.3233/jrs-130594 · Cited by 6
Depression and Anxiety Disorders
Karamustafalıoğlu, O., & Yumrukçal, H. (2025) · Wiley eBooks · doi:10.1002/9781119870203.mpg003.pub2 · Cited by 8
Glanger, M. R., Peterson, G. M., & Abraham, A. (2021) · Internal Medicine Journal · doi:10.1111/imj.15320 · Cited by 5
Lee, E. A., Wong, C.-A., Barrio, L., Godoy, E. R., Hackett, D. L., Thompson, N., Dreskin, M., Kumar, S., Khang, P. S., Steinberg, S. G., et al. (2023) · The Permanente Journal · doi:10.7812/tpp/22.052 · Cited by 5
Chronic Amitriptyline Toxicity
Giller, E. L., Bialos, D., Docherty, J. P., Jatlow, P. I., & Harkness, L. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.1979.136.4a.458 · Cited by 5
Random Controlled Trial of Sham Electroconvulsive Therapy and Other Novel Therapies
Fink, M. (2021) · Journal of Ect · doi:10.1097/yct.0000000000000759 · Cited by 5
Self-citationTreatment-induced stress syndromes
Healy, D. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.01.038 · Cited by 5
Kielholz, P., Battegay, R., & Ladewig, D. (1972) · Springer eBooks · doi:10.1007/978-3-642-65280-6_11 · Cited by 5
Effects of Discontinuation of Antipanic Medication
Fyer, A. J. (1988) · Springer eBooks · doi:10.1007/978-3-642-73543-1_4 · Cited by 5
The use of antidepressant drugs: some reasons for concern
Fava, G. A., & Tomba, E. (1998) · International Journal of Risk & Safety in Medicine · doi:10.3233/jrs-1998-155 · Cited by 5
(2005) · CRC Press eBooks · doi:10.1201/b14455-5 · Cited by 5
Panic Anxiety after Abrupt Discontinuation of Mianserin
Kuniyoshi, M., Arikawa, K., Miura, C., & Inanaga, K. (1989) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1989.tb02564.x · Cited by 4
Psychiatric Reaction Patterns to Imipramine
Klein, D. F., & Fink, M. (2008) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.6.4.foc549 · Cited by 4
Self-citationDo withdrawal symptoms predict depression relapse after antidepressant cessation?
Volkmann, C., Abulikemu, S., Berwian, I. M., Huys, Q. J. M., & Walter, H. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02005-z · Cited by 4
La dépendance aux médicaments psychotropes. De la psychopharmacologie aux usages
Moigne, P. L. (2009) · Drogues santé et société · doi:10.7202/019619ar · Cited by 3
Cardiac arrhythmia following rapid imipramine withdrawal
Regan, W. M., Margolin, R. A., & Mathew, R. J. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90201-1 · Cited by 3
Lack of withdrawal symptoms after discontinuation of mianserin
Otani, K., Sasa, H., Kaneko, S., & Fukushima, Y. (1991) · The Lancet · doi:10.1016/0140-6736(91)92487-m · Cited by 3
PHYSICAL TREATMENTS FOR DEPRESSION
Merson, S., & Tyrer, P. J. (1991) · Elsevier eBooks · doi:10.1016/b978-0-12-356510-5.50008-x · Cited by 3
PSYCHOPHARMACOLOGY AND PHYSIOLOGICAL TREATMENT
WORTIS, J. (1963) · American Journal of Psychiatry · doi:10.1176/ajp.119.7.621 · Cited by 3
Do discontinuation symptoms predict depression relapse after antidepressant cessation?
Volkmann, C., Abulikemu, S., Berwian, I. M., Huys, Q. J., & Walter, H. (2023) · doi:10.31234/osf.io/fxye5 · Cited by 2
Evaluating Antidepressants and Anxiolytics
Rickels, K. (1990) · Springer eBooks · doi:10.1007/978-3-642-75370-1_1 · Cited by 2
Flu-like illness after discontinuance of imipramine
Shrivastava, R. K., & Itil, T. M. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90159-3 · Cited by 2
Psychosomatic medicine:alive and well in the new century
Fava, G. A., Fabbri, S., Belaise, C., & Tossani, E. (2002) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 1
Chemotherapy of Affective Disorders
Sullivan, J. L., Taska, R. J., Wise, T. N., & GOLDSTEIN, D. M. (1984) · Elsevier eBooks · doi:10.1016/b978-0-409-95151-6.50009-2 · Cited by 1
Le syndrome de sevrage des antidépresseurs
Lejoyeux, M., & Adès, J. (1989) · Psychiatry and Psychobiology · doi:10.1017/s0767399x00001395 · Cited by 1
Comment on Lorazepam Withdrawal
Einarson, T. R. (1981) · Annals of Pharmacotherapy · doi:10.1177/106002808101500218 · Cited by 1
Depression and Anxiety Disorders
(2021) · Wiley eBooks · doi:10.1002/9781119870203.mpg003 · Cited by 1
Metadata
- Authors
- KRAMER, J. C., KLEIN, D. F., & FINK, M.
- ORCID
- KRAMER, JOHN C.
- Venue
- American Journal of Psychiatry
- Published
- 1961-12
- Volume
- 118
- Issue
- 6
- Pages
- 549-550
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2017775384
- Semantic Scholar
- 67ab2b254e05d6f71317a5f6063102943268efa6
- Cited by
- 113
- References
- 3
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 2 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- imipramine, drug withdrawal symptoms, antidepressant discontinuation, tricyclic antidepressants, adverse drug reactions
- MeSH terms
- Imipramine, Psychopharmacology, Substance Withdrawal Syndrome
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