Regional Deficits in Brain Volume in Schizophrenia: A Meta-Analysis of Voxel-Based Morphometry Studies
Abstract
Objective Voxel-based morphometry is a method for detecting group differences in the density or volume of brain matter. The authors reviewed the literature on use of voxel-based morphometry in schizophrenia imaging research to examine the capabilities of this method for clearly identifying specific structural differences in patients with schizophrenia, compared with healthy subjects. The authors looked for consistently reported results of relative deficits in gray and white matter in schizophrenia and evaluated voxel-based morphometry methods in order to propose a future strategy for using voxel-based morphometry in schizophrenia research. Method The authors reviewed all voxel-based morphometry studies of schizophrenia that were published to May 2004 (15 studies). The studies included a total of 390 patients with a diagnosis of schizophrenia and 364 healthy volunteers. Results Gray and white matter deficits in patients with schizophrenia, relative to healthy comparison subjects, were reported in a total of 50 brain regions. Deficits were reported in two of the 50 regions in more than 50% of the studies and in nine of the 50 regions in one study only. The most consistent findings were of relative deficits in the left superior temporal gyrus and the left medial temporal lobe. Use of a smaller smoothing kernel (4-8 mm) led to detection of a greater number of regions implicated in schizophrenia. Conclusions This review implicates the left superior temporal gyrus and the left medi…
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Neuroanatomical and electrophysiological alterations in the medial temporal lobe, including the hippocampus, and in different areas of the prefrontal cortex are robust and replicated clinical findings in schizophrenia.
“and the existence of neuroanatomical and electrophysiological alterations in the medial temporal lobe, including the hippocampus, and in different areas of the prefrontal cortex 48 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [48]
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- Authors
- Honea, R., Crow, T. J., Passingham, D., & Mackay, C. E.
- Affiliations
- Warneford Hospital (GB)
- Venue
- American Journal of Psychiatry
- Published
- 2005-12-01
- Volume
- 162
- Issue
- 12
- Pages
- 2233-2245
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2170644672
- Cited by
- 1,157
- References
- 4
- Citations by year
- 2026: 20 · 2025: 22 · 2024: 30 · 2023: 29 · 2022: 26 · 2021: 38 · 2020: 32 · 2019: 45 · 2018: 41 · 2017: 55 · 2016: 61 · 2015: 85 · 2014: 56 · 2013: 89 · 2012: 90
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- schizophrenia, gray matter, white matter, voxel-based morphometry, superior temporal gyrus, medial temporal lobe, structural brain differences
- MeSH terms
- Amygdala, Atrophy, Brain, Brain Mapping, Data Interpretation, Statistical, Female, Hippocampus, Humans, Image Interpretation, Computer-Assisted, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Schizophrenia, Temporal Lobe, Imaging, Three-Dimensional
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